LOCUS       NP_083224                514 aa            linear   ROD 28-APR-2025
DEFINITION  cilia- and flagella-associated protein 53 [Mus musculus].
ACCESSION   NP_083224 XP_001001936 XP_001001947 XP_128864 XP_900053 XP_921903
            XP_929593
VERSION     NP_083224.2
DBSOURCE    REFSEQ: accession NM_028948.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 514)
  AUTHORS   Lu,H., Twan,W.K., Ikawa,Y., Khare,V., Mukherjee,I., Schou,K.B.,
            Chua,K.X., Aqasha,A., Chakrabarti,S., Hamada,H. and Roy,S.
  TITLE     Localisation and function of key axonemal microtubule inner
            proteins and dynein docking complex members reveal extensive
            diversity among vertebrate motile cilia
  JOURNAL   Development 151 (14) (2024)
   PUBMED   39007638
REFERENCE   2  (residues 1 to 514)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 514)
  AUTHORS   Ho,K.H., Candat,A., Scarpetta,V., Faucourt,M., Weill,S., Salio,C.,
            D'Este,E., Meschkat,M., Wurm,C.A., Kneussel,M., Janke,C.,
            Magiera,M.M., Genovesio,A., Meunier,A., Sassoe-Pognetto,M.,
            Brill,M.S., Spassky,N. and Patrizi,A.
  TITLE     Choroid plexuses carry nodal-like cilia that undergo axoneme
            regression from early adult stage
  JOURNAL   Dev Cell 58 (23), 2641-2651 (2023)
   PUBMED   37890489
REFERENCE   4  (residues 1 to 514)
  AUTHORS   Tai,L., Yin,G., Huang,X., Sun,F. and Zhu,Y.
  TITLE     In-cell structural insight into the stability of sperm microtubule
            doublet
  JOURNAL   Cell Discov 9 (1), 116 (2023)
   PUBMED   37989994
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 514)
  AUTHORS   Chen,Z., Shiozaki,M., Haas,K.M., Skinner,W.M., Zhao,S., Guo,C.,
            Polacco,B.J., Yu,Z., Krogan,N.J., Lishko,P.V., Kaake,R.M.,
            Vale,R.D. and Agard,D.A.
  TITLE     De novo protein identification in mammalian sperm using in situ
            cryoelectron tomography and AlphaFold2 docking
  JOURNAL   Cell 186 (23), 5041-5053 (2023)
   PUBMED   37865089
REFERENCE   6  (residues 1 to 514)
  AUTHORS   Wu,B., Yu,X., Liu,C., Wang,L., Huang,T., Lu,G., Chen,Z.J., Li,W.
            and Liu,H.
  TITLE     Essential Role of CFAP53 in Sperm Flagellum Biogenesis
  JOURNAL   Front Cell Dev Biol 9, 676910 (2021)
   PUBMED   34124066
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 514)
  AUTHORS   Butterfield,N.C., Curry,K.F., Steinberg,J., Dewhurst,H.,
            Komla-Ebri,D., Mannan,N.S., Adoum,A.T., Leitch,V.D., Logan,J.G.,
            Waung,J.A., Ghirardello,E., Southam,L., Youlten,S.E.,
            Wilkinson,J.M., McAninch,E.A., Vancollie,V.E., Kussy,F.,
            White,J.K., Lelliott,C.J., Adams,D.J., Jacques,R., Bianco,A.C.,
            Boyde,A., Zeggini,E., Croucher,P.I., Williams,G.R. and
            Bassett,J.H.D.
  TITLE     Accelerating functional gene discovery in osteoarthritis
  JOURNAL   Nat Commun 12 (1), 467 (2021)
   PUBMED   33473114
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3302. doi:
            10.1038/s41467-021-23768-8. PMID: 34050183]
            Publication Status: Online-Only
REFERENCE   8  (residues 1 to 514)
  AUTHORS   Ide,T., Twan,W.K., Lu,H., Ikawa,Y., Lim,L.X., Henninger,N.,
            Nishimura,H., Takaoka,K., Narasimhan,V., Yan,X., Shiratori,H.,
            Roy,S. and Hamada,H.
  TITLE     CFAP53 regulates mammalian cilia-type motility patterns through
            differential localization and recruitment of axonemal dynein
            components
  JOURNAL   PLoS Genet 16 (12), e1009232 (2020)
   PUBMED   33347437
  REMARK    GeneRIF: CFAP53 regulates mammalian cilia-type motility patterns
            through differential localization and recruitment of axonemal
            dynein components.
            Publication Status: Online-Only
REFERENCE   9  (residues 1 to 514)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   10 (residues 1 to 514)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN835862.1 and BC099500.1.
            
            On Oct 22, 2009 this sequence version replaced NP_083224.1.
            
            Transcript Variant: This variant (1) represents the shorter,
            protein-coding transcript.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is supported by available conservation data.
            The use of an alternative upstream start codon would result in a
            protein that is 86 aa longer.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099500.1, ERR3363658.427624.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 50.7 cM"
     Protein         1..514
                     /product="cilia- and flagella-associated protein 53"
                     /note="coiled-coil domain-containing protein 11;
                     coiled-coil domain containing 11"
                     /calculated_mol_wt=61780
     Region          158..467
                     /region_name="TPH"
                     /note="Trichohyalin-plectin-homology domain; pfam13868"
                     /db_xref="CDD:464007"
     Region          261..296
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D439.3)"
     Region          495..514
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D439.3)"
     CDS             1..514
                     /gene="Cfap53"
                     /gene_synonym="4933415I03Rik; Ccdc11"
                     /coded_by="NM_028948.2:99..1643"
                     /db_xref="CCDS:CCDS37857.2"
                     /db_xref="GeneID:74453"
                     /db_xref="MGI:MGI:1921703"
ORIGIN      
        1 mysqqfgtvp refkgptpka viirakppka qraeqhlkri qrsyhkyhtt lasiksneen
       61 rlkcdwiqrn nhktfdslvq arvqdamqgf vinteerrnk lrellaseen eyfsemqlkg
      121 etieekkdkm rertkllrek kekerqefva ekldqqfrer ceelrtklas ihekkvveer
      181 naqiefnkel krqklveehl farlweedrl akerreaqee krqrelvqnt rlgldaqvts
      241 iqaqrqgarr mkeeearile qnkaqikred eqeklqkqkr rqetrsslkk avqdkiesmq
      301 reyredldln mklvgralqd lqdeadkkkq kreemgreqk iyndylmqrr eeekaqekel
      361 nrlledikak klaekdrela lqraarkqlm nevmntrklq vqerlqrklr eqeelalheq
      421 riseslkvlh qedmedfarr calaeeyrnq lqmqiahqqq areaekeeer qefeaglaan
      481 kacldkiqri lsenqalsqn vhpmrrgypd kppl
//
