LOCUS       NM_027963               2201 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus cilia and flagella associated protein 52 (Cfap52),
            mRNA.
ACCESSION   NM_027963
VERSION     NM_027963.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2201)
  AUTHORS   Tai,L., Yin,G., Huang,X., Sun,F. and Zhu,Y.
  TITLE     In-cell structural insight into the stability of sperm microtubule
            doublet
  JOURNAL   Cell Discov 9 (1), 116 (2023)
   PUBMED   37989994
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2201)
  AUTHORS   Chen,Z., Shiozaki,M., Haas,K.M., Skinner,W.M., Zhao,S., Guo,C.,
            Polacco,B.J., Yu,Z., Krogan,N.J., Lishko,P.V., Kaake,R.M.,
            Vale,R.D. and Agard,D.A.
  TITLE     De novo protein identification in mammalian sperm using in situ
            cryoelectron tomography and AlphaFold2 docking
  JOURNAL   Cell 186 (23), 5041-5053 (2023)
   PUBMED   37865089
REFERENCE   3  (bases 1 to 2201)
  AUTHORS   Wu,B., Li,R., Ma,S., Ma,Y., Fan,L., Gong,C., Liu,C., Sun,L. and
            Yuan,L.
  TITLE     The cilia and flagella associated protein CFAP52 orchestrated with
            CFAP45 is required for sperm motility in mice
  JOURNAL   J Biol Chem 299 (7), 104858 (2023)
   PUBMED   37236356
REFERENCE   4  (bases 1 to 2201)
  AUTHORS   Zhou,L., Liu,H., Liu,S., Yang,X., Dong,Y., Pan,Y., Xiao,Z.,
            Zheng,B., Sun,Y., Huang,P., Zhang,X., Hu,J., Sun,R., Feng,S.,
            Zhu,Y., Liu,M., Gui,M. and Wu,J.
  TITLE     Structures of sperm flagellar doublet microtubules expand the
            genetic spectrum of male infertility
  JOURNAL   Cell 186 (13), 2897-2910 (2023)
   PUBMED   37295417
REFERENCE   5  (bases 1 to 2201)
  AUTHORS   Han,X., Shen,X., Wang,M., Wang,X., Jian,Y., Yang,C. and Guo,W.
  TITLE     Loss of RNA-Binding Protein HuR Leads to Defective Ependymal Cells
            and Hydrocephalus
  JOURNAL   J Neurosci 42 (2), 202-219 (2022)
   PUBMED   34815315
REFERENCE   6  (bases 1 to 2201)
  AUTHORS   Stauber,M., Weidemann,M., Dittrich-Breiholz,O., Lobschat,K.,
            Alten,L., Mai,M., Beckers,A., Kracht,M. and Gossler,A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   7  (bases 1 to 2201)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   8  (bases 1 to 2201)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Wdr16 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
REFERENCE   9  (bases 1 to 2201)
  AUTHORS   Silva,F.P., Hamamoto,R., Nakamura,Y. and Furukawa,Y.
  TITLE     WDRPUH, a novel WD-repeat-containing protein, is highly expressed
            in human hepatocellular carcinoma and involved in cell
            proliferation
  JOURNAL   Neoplasia 7 (4), 348-355 (2005)
   PUBMED   15967112
  REMARK    GeneRIF: Human WDRPUH is a novel WD-repeat-containing protein
            involved in cell proliferation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK006118.1, BC118541.1 and AU015948.2.
            
            On Mar 24, 2007 this sequence version replaced NM_027963.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK006118.1, BC118541.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849380 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1250              AK006118.1         1-1250
            1251-1996           BC118541.1         1250-1995
            1997-2201           AU015948.2         1-205               c
FEATURES             Location/Qualifiers
     source          1..2201
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 41.16 cM"
     gene            1..2201
                     /gene="Cfap52"
                     /gene_synonym="1700019F09Rik; 4933417B11Rik; Wdr16;
                     WDRPUH"
                     /note="cilia and flagella associated protein 52"
                     /db_xref="GeneID:71860"
                     /db_xref="MGI:MGI:1919110"
     exon            1..121
                     /gene="Cfap52"
                     /gene_synonym="1700019F09Rik; 4933417B11Rik; Wdr16;
                     WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1914
                     /gene="Cfap52"
                     /gene_synonym="1700019F09Rik; 4933417B11Rik; Wdr16;
                     WDRPUH"
                     /note="WD40-repear protein upregulated in HCC; WD
                     repeat-containing protein 16; WD repeat domain 16"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 52"
                     /protein_id="NP_082239.2"
                     /db_xref="CCDS:CCDS24862.1"
                     /db_xref="GeneID:71860"
                     /db_xref="MGI:MGI:1919110"
                     /translation="MEEQVLPELDVAELELQAVIGFNGHVPNGLKCHPDQEHLIYPLG
                     CTVLIQAINTNEQNFLHGHGNNVSCVTISKEGDYIASGQVTFMGFKADIILWDFKKRE
                     LIARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGN
                     ATSVVFSRCRDEMFVTAGNGTIRVWELDLPNRKIWPTECQTGQMKRIVLSTGMADDDS
                     FFYLGTTTGDILKMNPKTKLLADTGPVKDKFSLGVSALRCLKMGGLLVGSGAGLLIFC
                     KSPSYKPIKKVQLQGGITSITLRGEGHQFFVGTEESHIYRVNFTDFKETLIATCHFEA
                     VQDIVFPFGTAELFATCAKKDIRVWHTMSKRELLRITVPNMTCHGIDFMRDGKSIISA
                     WDDGKIRAFAPESGRLMYTINSAHRIGVTAIATTSDCKRIISGGGEGEVRVWQVGCQT
                     QKLEEALKEHKSSVSCIRVKKNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCV
                     CYHPEEFQIITSGTDRKIAYWEVFDGSVIRELEGSLSGSINGMDITQEGGHFVTGGHD
                     HLVKVWDYNEGEVTHVGVGHSGNIMAMRISPGNQYIVSVSADGAILRWKYPFAS"
     exon            122..321
                     /gene="Cfap52"
                     /gene_synonym="1700019F09Rik; 4933417B11Rik; Wdr16;
                     WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            322..458
                     /gene="Cfap52"
                     /gene_synonym="1700019F09Rik; 4933417B11Rik; Wdr16;
                     WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            459..587
                     /gene="Cfap52"
                     /gene_synonym="1700019F09Rik; 4933417B11Rik; Wdr16;
                     WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            588..687
                     /gene="Cfap52"
                     /gene_synonym="1700019F09Rik; 4933417B11Rik; Wdr16;
                     WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            688..804
                     /gene="Cfap52"
                     /gene_synonym="1700019F09Rik; 4933417B11Rik; Wdr16;
                     WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            805..905
                     /gene="Cfap52"
                     /gene_synonym="1700019F09Rik; 4933417B11Rik; Wdr16;
                     WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1076
                     /gene="Cfap52"
                     /gene_synonym="1700019F09Rik; 4933417B11Rik; Wdr16;
                     WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1225
                     /gene="Cfap52"
                     /gene_synonym="1700019F09Rik; 4933417B11Rik; Wdr16;
                     WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1371
                     /gene="Cfap52"
                     /gene_synonym="1700019F09Rik; 4933417B11Rik; Wdr16;
                     WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1523
                     /gene="Cfap52"
                     /gene_synonym="1700019F09Rik; 4933417B11Rik; Wdr16;
                     WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1626
                     /gene="Cfap52"
                     /gene_synonym="1700019F09Rik; 4933417B11Rik; Wdr16;
                     WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1738
                     /gene="Cfap52"
                     /gene_synonym="1700019F09Rik; 4933417B11Rik; Wdr16;
                     WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..2201
                     /gene="Cfap52"
                     /gene_synonym="1700019F09Rik; 4933417B11Rik; Wdr16;
                     WDRPUH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagacgctg caccctggag ttgaagaatc aatgagctga aactctccag gatggaagaa
       61 caagttttac ccgagctgga tgtagcagaa ctggagcttc aggctgtgat cggcttcaat
      121 ggacatgttc ccaatggtct caaatgccat cctgaccagg agcacctgat ttatcccctg
      181 ggttgcactg tcctcatcca ggcaataaat actaatgagc agaatttcct acatggccat
      241 ggtaacaacg tctcctgtgt gaccatctcc aaggaaggag attatattgc ctctggacaa
      301 gtcaccttca tgggtttcaa ggcagacatc attctgtggg actttaagaa gagggagctg
      361 atcgctcggc tgtcacttca caagggcaaa atcgaagcct tggccttttc gcccaatgat
      421 ttgtacttgg tttcacttgg tggcccagat gatggaagtg tggtggtttg gagcatagcc
      481 aagagagatg ccatttgtgg cagccccgcg gcgggcctca atgtcggcaa tgccaccagc
      541 gtggtcttct ctaggtgccg agatgagatg tttgtcactg ctgggaatgg gacaattcga
      601 gtgtgggaac tggatcttcc aaatagaaaa atctggccaa ccgagtgcca aacaggacag
      661 atgaaaagaa tagtcttgag tactggaatg gccgacgacg acagcttctt ctaccttggc
      721 accacaaccg gggatattct caaaatgaac cccaagacca aactgctggc agatactggg
      781 cctgtgaagg acaaattcag cttgggagtg tcggctctca ggtgcctgaa gatgggtggt
      841 ttgttggtcg gctctggagc tggcttgctg atcttctgta aaagccccag ctacaagcct
      901 atcaagaaag tccagctgca aggtggtatc acctctatca cgctccgggg agaaggacac
      961 cagttttttg tggggacgga agaatcgcac atctaccgcg ttaacttcac cgatttcaaa
     1021 gagactctca ttgcaacttg tcactttgaa gctgtccagg acattgtctt tccatttggt
     1081 actgctgagc tgtttgctac ctgtgccaag aaagacatca gggtgtggca caccatgtcc
     1141 aaacgggagc tgcttcggat cacggtgccc aacatgacct gccatggcat tgacttcatg
     1201 agagatggga agagcatcat ctcagcatgg gatgatggaa aaatcagagc ctttgctcca
     1261 gaatcaggtc ggctgatgta caccattaac agtgctcaca ggatcggagt gacggccatt
     1321 gctaccacca gtgactgtaa aaggatcatc agtggaggag gagaagggga ggtgagggtg
     1381 tggcaggtag gctgccagac tcagaagctg gaggaggctc tgaaggagca caagtcttcc
     1441 gtgtcctgca tcagggtgaa gaagaacaac gaggagtgtg tcactgccag caccgatggg
     1501 acatgcatca tttgggacct cgtgcgactt agaaggaatc agatgatcct ggccaacacc
     1561 ctattccagt gtgtttgtta ccacccggaa gaattccaga tcatcaccag tggcacagac
     1621 aggaagattg cttactggga agtatttgat ggatcagtaa tcagagagtt ggaaggctcc
     1681 ttgtctgggt ccatcaatgg tatggatatc actcaggaag gagggcactt tgttacaggt
     1741 ggccatgacc atctggtcaa agtctgggac tacaacgagg gtgaagtgac tcacgtcggg
     1801 gtggggcaca gcggcaacat catggccatg cggataagtc caggaaacca gtatatcgtc
     1861 agtgtgagcg cagatggagc catcttgagg tggaaatacc catttgcttc gtgatgggct
     1921 ctggatctcc gcagcttcca ccctgtgtcg agcacaggcc tgtccagggc caagtttgca
     1981 taactccaga accgggtttg atttctcaca cctatttttg ccctatagtc aaattacttt
     2041 atcttgaagt tatttgttta ctttatacaa tatgttaaca cttactatct tacattgtat
     2101 gttgaaattg aaatatacta aagagaaagt ttatcctata tatatatata tgtactggat
     2161 aaactttcaa attattaata aattagaagg ttctgaccat g
//
