LOCUS       NM_027972               1822 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus cilia and flagella associated protein 45 (Cfap45),
            mRNA.
ACCESSION   NM_027972 XM_001002046 XM_355284
VERSION     NM_027972.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1822)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1822)
  AUTHORS   Tai,L., Yin,G., Huang,X., Sun,F. and Zhu,Y.
  TITLE     In-cell structural insight into the stability of sperm microtubule
            doublet
  JOURNAL   Cell Discov 9 (1), 116 (2023)
   PUBMED   37989994
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1822)
  AUTHORS   Chen,Z., Shiozaki,M., Haas,K.M., Skinner,W.M., Zhao,S., Guo,C.,
            Polacco,B.J., Yu,Z., Krogan,N.J., Lishko,P.V., Kaake,R.M.,
            Vale,R.D. and Agard,D.A.
  TITLE     De novo protein identification in mammalian sperm using in situ
            cryoelectron tomography and AlphaFold2 docking
  JOURNAL   Cell 186 (23), 5041-5053 (2023)
   PUBMED   37865089
REFERENCE   4  (bases 1 to 1822)
  AUTHORS   Wu,B., Li,R., Ma,S., Ma,Y., Fan,L., Gong,C., Liu,C., Sun,L. and
            Yuan,L.
  TITLE     The cilia and flagella associated protein CFAP52 orchestrated with
            CFAP45 is required for sperm motility in mice
  JOURNAL   J Biol Chem 299 (7), 104858 (2023)
   PUBMED   37236356
REFERENCE   5  (bases 1 to 1822)
  AUTHORS   Zhou,L., Liu,H., Liu,S., Yang,X., Dong,Y., Pan,Y., Xiao,Z.,
            Zheng,B., Sun,Y., Huang,P., Zhang,X., Hu,J., Sun,R., Feng,S.,
            Zhu,Y., Liu,M., Gui,M. and Wu,J.
  TITLE     Structures of sperm flagellar doublet microtubules expand the
            genetic spectrum of male infertility
  JOURNAL   Cell 186 (13), 2897-2910 (2023)
   PUBMED   37295417
REFERENCE   6  (bases 1 to 1822)
  AUTHORS   Dougherty,G.W., Mizuno,K., Nothe-Menchen,T., Ikawa,Y., Boldt,K.,
            Ta-Shma,A., Aprea,I., Minegishi,K., Pang,Y.P., Pennekamp,P.,
            Loges,N.T., Raidt,J., Hjeij,R., Wallmeier,J., Mussaffi,H.,
            Perles,Z., Elpeleg,O., Rabert,F., Shiratori,H., Letteboer,S.J.,
            Horn,N., Young,S., Strunker,T., Stumme,F., Werner,C., Olbrich,H.,
            Takaoka,K., Ide,T., Twan,W.K., Biebach,L., Grosse-Onnebrink,J.,
            Klinkenbusch,J.A., Praveen,K., Bracht,D.C., Hoben,I.M., Junger,K.,
            Gutzlaff,J., Cindric,S., Aviram,M., Kaiser,T., Memari,Y.,
            Dzeja,P.P., Dworniczak,B., Ueffing,M., Roepman,R., Bartscherer,K.,
            Katsanis,N., Davis,E.E., Amirav,I., Hamada,H. and Omran,H.
  TITLE     CFAP45 deficiency causes situs abnormalities and asthenospermia by
            disrupting an axonemal adenine nucleotide homeostasis module
  JOURNAL   Nat Commun 11 (1), 5520 (2020)
   PUBMED   33139725
  REMARK    GeneRIF: CFAP45 deficiency causes situs abnormalities and
            asthenospermia by disrupting an axonemal adenine nucleotide
            homeostasis module.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1822)
  AUTHORS   Stauber,M., Weidemann,M., Dittrich-Breiholz,O., Lobschat,K.,
            Alten,L., Mai,M., Beckers,A., Kracht,M. and Gossler,A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   8  (bases 1 to 1822)
  AUTHORS   Doudney,K., Murdoch,J.N., Paternotte,C., Bentley,L., Gregory,S.,
            Copp,A.J. and Stanier,P.
  TITLE     Comparative physical and transcript maps of approximately 1 Mb
            around loop-tail, a gene for severe neural tube defects on distal
            mouse chromosome 1 and human chromosome 1q22-q23
  JOURNAL   Genomics 72 (2), 180-192 (2001)
   PUBMED   11401431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY229665.1 and AK006449.1.
            
            On or before Jul 25, 2009 this sequence version replaced
            XM_001002046.1, XM_355284.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK006449.1, BC151048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BY229665.1         2-10
            10-1822             AK006449.1         2-1814
FEATURES             Location/Qualifiers
     source          1..1822
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.91 cM"
     gene            1..1822
                     /gene="Cfap45"
                     /gene_synonym="1700028D05Rik; Ccdc19; Nesg1"
                     /note="cilia and flagella associated protein 45"
                     /db_xref="GeneID:71870"
                     /db_xref="MGI:MGI:1919120"
     exon            1..52
                     /gene="Cfap45"
                     /gene_synonym="1700028D05Rik; Ccdc19; Nesg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1705
                     /gene="Cfap45"
                     /gene_synonym="1700028D05Rik; Ccdc19; Nesg1"
                     /note="nasopharyngeal epithelium specific protein 1;
                     coiled-coil domain-containing protein 19; coiled-coil
                     domain containing 19"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 45"
                     /protein_id="NP_082248.1"
                     /db_xref="CCDS:CCDS48447.1"
                     /db_xref="GeneID:71870"
                     /db_xref="MGI:MGI:1919120"
                     /translation="MPLRPGDASSSASTASNRSRTRTRYRTKAMNSEVDESLFGGVKP
                     SSQGKSDSPIVVIHDKHAIRKTLSALGLEHKTETIQLITRDMVRELIVPTEDPSGESL
                     IISPEEFERIKWASQVLTKEELNAREQALKKEKEGILEAVTIRKKIMKQKEMTWNNNK
                     KLSDLEEVARERAQNLLQRADKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQ
                     KELDEEERRLDHMMEIDRRESLQRQEDRERKRREERVRGKRHIVEQIKKNEEERSLQA
                     EHREQEKEQMLAYLDRLQEEDLQDLERRHQEKLKMQAEIKRINDENQRQKAEMLAQER
                     LADQMVMEFTKKKMAREAEYEAEQEKIRREKEKEIARLRALQEKAQDYQAEQDALRAK
                     RNQEVADREWRRKEKENAQKKIETEEKLRKSRLEQVAFKEHTLAVQVQRDRDEFERIL
                     RAQREQIEREKQEQEKKAKGCLQHANELRRQVRENQQKHVQNRLATFEEGRRLKEEAE
                     KRRERIEDIKKQKLEELRATGLPEKYCIEVERKANILPATSVN"
     exon            53..178
                     /gene="Cfap45"
                     /gene_synonym="1700028D05Rik; Ccdc19; Nesg1"
                     /inference="alignment:Splign:2.1.0"
     exon            179..321
                     /gene="Cfap45"
                     /gene_synonym="1700028D05Rik; Ccdc19; Nesg1"
                     /inference="alignment:Splign:2.1.0"
     exon            322..466
                     /gene="Cfap45"
                     /gene_synonym="1700028D05Rik; Ccdc19; Nesg1"
                     /inference="alignment:Splign:2.1.0"
     exon            467..637
                     /gene="Cfap45"
                     /gene_synonym="1700028D05Rik; Ccdc19; Nesg1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..816
                     /gene="Cfap45"
                     /gene_synonym="1700028D05Rik; Ccdc19; Nesg1"
                     /inference="alignment:Splign:2.1.0"
     exon            817..946
                     /gene="Cfap45"
                     /gene_synonym="1700028D05Rik; Ccdc19; Nesg1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1093
                     /gene="Cfap45"
                     /gene_synonym="1700028D05Rik; Ccdc19; Nesg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1207
                     /gene="Cfap45"
                     /gene_synonym="1700028D05Rik; Ccdc19; Nesg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1401
                     /gene="Cfap45"
                     /gene_synonym="1700028D05Rik; Ccdc19; Nesg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1626
                     /gene="Cfap45"
                     /gene_synonym="1700028D05Rik; Ccdc19; Nesg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1822
                     /gene="Cfap45"
                     /gene_synonym="1700028D05Rik; Ccdc19; Nesg1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1799..1804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfap45"
                     /gene_synonym="1700028D05Rik; Ccdc19; Nesg1"
                     /note="hexamer: ATTAAA"
     polyA_site      1821
                     /gene="Cfap45"
                     /gene_synonym="1700028D05Rik; Ccdc19; Nesg1"
                     /note="major polyA site"
ORIGIN      
        1 agctccggcg gagccggtgg aggtgcctgc agctgaagcg gccgcaacga tgccactaag
       61 gccaggggat gcctcaagct ctgcttccac cgcttccaac cggtcacgga ctaggactcg
      121 ctatcgaacc aaagccatga actctgaggt agacgagagc ctctttggag gtgtcaagcc
      181 ttcatcccag ggcaagagcg acagccctat cgtggtgatc catgataaac acgctatccg
      241 gaaaactctc agtgctctgg gcttggagca caagacggag acgatccagc tcatcactag
      301 agacatggtc agagaactca ttgttcccac agaggacccc tctggggaat cgctaatcat
      361 cagccccgag gagtttgagc ggatcaaatg ggcatcccaa gtcctgacca aagaagaact
      421 gaatgccaga gaacaggccc tcaagaagga gaaggaaggc atcttggaag ccgtcacaat
      481 tcgcaagaag attatgaagc agaaggagat gacttggaac aataacaaga agctcagtga
      541 cctggaggag gtggccaggg aacgggccca gaacctcctg cagagagccg acaagctccg
      601 tatggagcag gaggaggagc tcaaggacat gagcaagatt attctgaatg ccaagtgcca
      661 cgcaatccgg gatgcccaga ttctggagaa gcagcagata caaaaggaat tggatgaaga
      721 ggagaggcgg ttggatcaca tgatggaaat agaccggcgg gaatccctcc aaaggcagga
      781 ggatcgggaa aggaaacgga gggaggagag agtacgggga aaacggcaca tcgtggagca
      841 gataaagaag aacgaggagg agagatcgct gcaggcggag caccgtgaac aggagaagga
      901 gcagatgctg gcctacctgg accggctcca ggaggaggat ttgcaggatc tggaacgaag
      961 acatcaggaa aaactgaaga tgcaagctga aattaaacgt atcaatgatg aaaaccagag
     1021 acagaaagca gagatgctgg cacaggagag actggcagac cagatggtga tggaatttac
     1081 caagaagaag atggctcgag aggcagagta tgaagctgag caggagaaaa tccggaggga
     1141 gaaagagaag gagatcgccc gcctgagggc cttgcaggag aaggcgcagg attatcaagc
     1201 agagcaggat gccttgcggg ccaagcgcaa ccaggaggtt gcagatcgag agtggcgtcg
     1261 aaaggaaaag gaaaatgcgc agaagaagat agagacagag gaaaagctgc gcaaaagccg
     1321 gctggagcag gtggcattca aggaacacac gctggccgtt caggttcagc gtgaccgaga
     1381 tgagttcgag aggatccttc gggctcagag agagcagatt gagagggaga agcaggaaca
     1441 ggagaagaaa gccaaggggt gcctccagca tgccaacgag ctccgacggc aggtgcgtga
     1501 gaaccagcag aaacacgtgc agaaccggct cgctaccttc gaagagggcc gccgcctcaa
     1561 ggaggaagct gagaagcgcc gcgagcgcat cgaggacatc aagaaacaga agctggaaga
     1621 gctgagagcc accggccttc ctgagaagta ctgcatcgaa gttgagcgta aagccaacat
     1681 cctgccagcc acttctgtta actgaagggg aacctctatg gtctctggga gagcacggat
     1741 tcagcttgct ccccggggca tccaaactgc tgctaaccta cacatttcat agttacagat
     1801 taaagctatt ctattctcta ag
//
