LOCUS       NP_082248                551 aa            linear   ROD 19-SEP-2024
DEFINITION  cilia- and flagella-associated protein 45 [Mus musculus].
ACCESSION   NP_082248 XP_001002046 XP_355284
VERSION     NP_082248.1
DBSOURCE    REFSEQ: accession NM_027972.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 551)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 551)
  AUTHORS   Tai,L., Yin,G., Huang,X., Sun,F. and Zhu,Y.
  TITLE     In-cell structural insight into the stability of sperm microtubule
            doublet
  JOURNAL   Cell Discov 9 (1), 116 (2023)
   PUBMED   37989994
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 551)
  AUTHORS   Chen,Z., Shiozaki,M., Haas,K.M., Skinner,W.M., Zhao,S., Guo,C.,
            Polacco,B.J., Yu,Z., Krogan,N.J., Lishko,P.V., Kaake,R.M.,
            Vale,R.D. and Agard,D.A.
  TITLE     De novo protein identification in mammalian sperm using in situ
            cryoelectron tomography and AlphaFold2 docking
  JOURNAL   Cell 186 (23), 5041-5053 (2023)
   PUBMED   37865089
REFERENCE   4  (residues 1 to 551)
  AUTHORS   Wu,B., Li,R., Ma,S., Ma,Y., Fan,L., Gong,C., Liu,C., Sun,L. and
            Yuan,L.
  TITLE     The cilia and flagella associated protein CFAP52 orchestrated with
            CFAP45 is required for sperm motility in mice
  JOURNAL   J Biol Chem 299 (7), 104858 (2023)
   PUBMED   37236356
REFERENCE   5  (residues 1 to 551)
  AUTHORS   Zhou,L., Liu,H., Liu,S., Yang,X., Dong,Y., Pan,Y., Xiao,Z.,
            Zheng,B., Sun,Y., Huang,P., Zhang,X., Hu,J., Sun,R., Feng,S.,
            Zhu,Y., Liu,M., Gui,M. and Wu,J.
  TITLE     Structures of sperm flagellar doublet microtubules expand the
            genetic spectrum of male infertility
  JOURNAL   Cell 186 (13), 2897-2910 (2023)
   PUBMED   37295417
REFERENCE   6  (residues 1 to 551)
  AUTHORS   Dougherty,G.W., Mizuno,K., Nothe-Menchen,T., Ikawa,Y., Boldt,K.,
            Ta-Shma,A., Aprea,I., Minegishi,K., Pang,Y.P., Pennekamp,P.,
            Loges,N.T., Raidt,J., Hjeij,R., Wallmeier,J., Mussaffi,H.,
            Perles,Z., Elpeleg,O., Rabert,F., Shiratori,H., Letteboer,S.J.,
            Horn,N., Young,S., Strunker,T., Stumme,F., Werner,C., Olbrich,H.,
            Takaoka,K., Ide,T., Twan,W.K., Biebach,L., Grosse-Onnebrink,J.,
            Klinkenbusch,J.A., Praveen,K., Bracht,D.C., Hoben,I.M., Junger,K.,
            Gutzlaff,J., Cindric,S., Aviram,M., Kaiser,T., Memari,Y.,
            Dzeja,P.P., Dworniczak,B., Ueffing,M., Roepman,R., Bartscherer,K.,
            Katsanis,N., Davis,E.E., Amirav,I., Hamada,H. and Omran,H.
  TITLE     CFAP45 deficiency causes situs abnormalities and asthenospermia by
            disrupting an axonemal adenine nucleotide homeostasis module
  JOURNAL   Nat Commun 11 (1), 5520 (2020)
   PUBMED   33139725
  REMARK    GeneRIF: CFAP45 deficiency causes situs abnormalities and
            asthenospermia by disrupting an axonemal adenine nucleotide
            homeostasis module.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 551)
  AUTHORS   Stauber,M., Weidemann,M., Dittrich-Breiholz,O., Lobschat,K.,
            Alten,L., Mai,M., Beckers,A., Kracht,M. and Gossler,A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   8  (residues 1 to 551)
  AUTHORS   Doudney,K., Murdoch,J.N., Paternotte,C., Bentley,L., Gregory,S.,
            Copp,A.J. and Stanier,P.
  TITLE     Comparative physical and transcript maps of approximately 1 Mb
            around loop-tail, a gene for severe neural tube defects on distal
            mouse chromosome 1 and human chromosome 1q22-q23
  JOURNAL   Genomics 72 (2), 180-192 (2001)
   PUBMED   11401431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY229665.1 and AK006449.1.
            
            On or before Jul 25, 2009 this sequence version replaced
            XP_001002046.1, XP_355284.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK006449.1, BC151048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..551
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.91 cM"
     Protein         1..551
                     /product="cilia- and flagella-associated protein 45"
                     /note="nasopharyngeal epithelium specific protein 1;
                     coiled-coil domain-containing protein 19; coiled-coil
                     domain containing 19"
                     /calculated_mol_wt=65695
     Region          1..52
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D9U9.1)"
     Region          184..524
                     /region_name="TPH"
                     /note="Trichohyalin-plectin-homology domain; pfam13868"
                     /db_xref="CDD:464007"
     Region          232..256
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D9U9.1)"
     Region          385..415
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D9U9.1)"
     CDS             1..551
                     /gene="Cfap45"
                     /gene_synonym="1700028D05Rik; Ccdc19; Nesg1"
                     /coded_by="NM_027972.1:50..1705"
                     /db_xref="CCDS:CCDS48447.1"
                     /db_xref="GeneID:71870"
                     /db_xref="MGI:MGI:1919120"
ORIGIN      
        1 mplrpgdass sastasnrsr trtryrtkam nsevdeslfg gvkpssqgks dspivvihdk
       61 hairktlsal glehktetiq litrdmvrel ivptedpsge sliispeefe rikwasqvlt
      121 keelnareqa lkkekegile avtirkkimk qkemtwnnnk klsdleevar eraqnllqra
      181 dklrmeqeee lkdmskiiln akchairdaq ilekqqiqke ldeeerrldh mmeidrresl
      241 qrqedrerkr reervrgkrh iveqikknee erslqaehre qekeqmlayl drlqeedlqd
      301 lerrhqeklk mqaeikrind enqrqkaeml aqerladqmv meftkkkmar eaeyeaeqek
      361 irrekekeia rlralqekaq dyqaeqdalr akrnqevadr ewrrkekena qkkieteekl
      421 rksrleqvaf kehtlavqvq rdrdeferil raqreqiere kqeqekkakg clqhanelrr
      481 qvrenqqkhv qnrlatfeeg rrlkeeaekr reriedikkq kleelratgl pekyciever
      541 kanilpatsv n
//
