LOCUS       NM_001033247            6583 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cilia and flagella associated protein 44 (Cfap44),
            mRNA.
ACCESSION   NM_001033247 XM_489567 XM_991190
VERSION     NM_001033247.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6583)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6583)
  AUTHORS   Martinez,G., Coutton,C., Loeuillet,C., Cazin,C., Muronova,J.,
            Boguenet,M., Lambert,E., Dhellemmes,M., Chevalier,G.,
            Hograindleur,J.P., Vilpreux,C., Neirijnck,Y., Kherraf,Z.E.,
            Escoffier,J., Nef,S., Ray,P.F. and Arnoult,C.
  TITLE     Oligogenic heterozygous inheritance of sperm abnormalities in mouse
  JOURNAL   Elife 11, e75373 (2022)
   PUBMED   35451961
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6583)
  AUTHORS   Kherraf,Z.E., Conne,B., Amiri-Yekta,A., Kent,M.C., Coutton,C.,
            Escoffier,J., Nef,S., Arnoult,C. and Ray,P.F.
  TITLE     Creation of knock out and knock in mice by CRISPR/Cas9 to validate
            candidate genes for human male infertility, interest, difficulties
            and feasibility
  JOURNAL   Mol Cell Endocrinol 468, 70-80 (2018)
   PUBMED   29522859
REFERENCE   4  (bases 1 to 6583)
  AUTHORS   Coutton,C., Vargas,A.S., Amiri-Yekta,A., Kherraf,Z.E., Ben
            Mustapha,S.F., Le Tanno,P., Wambergue-Legrand,C., Karaouzene,T.,
            Martinez,G., Crouzy,S., Daneshipour,A., Hosseini,S.H., Mitchell,V.,
            Halouani,L., Marrakchi,O., Makni,M., Latrous,H., Kharouf,M.,
            Deleuze,J.F., Boland,A., Hennebicq,S., Satre,V., Jouk,P.S.,
            Thierry-Mieg,N., Conne,B., Dacheux,D., Landrein,N., Schmitt,A.,
            Stouvenel,L., Lores,P., El Khouri,E., Bottari,S.P., Faure,J.,
            Wolf,J.P., Pernet-Gallay,K., Escoffier,J., Gourabi,H.,
            Robinson,D.R., Nef,S., Dulioust,E., Zouari,R., Bonhivers,M.,
            Toure,A., Arnoult,C. and Ray,P.F.
  TITLE     Mutations in CFAP43 and CFAP44 cause male infertility and flagellum
            defects in Trypanosoma and human
  JOURNAL   Nat Commun 9 (1), 686 (2018)
   PUBMED   29449551
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6583)
  AUTHORS   Tang,S., Wang,X., Li,W., Yang,X., Li,Z., Liu,W., Li,C., Zhu,Z.,
            Wang,L., Wang,J., Zhang,L., Sun,X., Zhi,E., Wang,H., Li,H., Jin,L.,
            Luo,Y., Wang,J., Yang,S. and Zhang,F.
  TITLE     Biallelic Mutations in CFAP43 and CFAP44 Cause Male Infertility
            with Multiple Morphological Abnormalities of the Sperm Flagella
  JOURNAL   Am J Hum Genet 100 (6), 854-864 (2017)
   PUBMED   28552195
  REMARK    GeneRIF: biallelic mutations in either CFAP43 or CFAP44 can cause
            sperm flagellar abnormalities and impair sperm motility.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC147045.2.
            
            On or before Aug 30, 2009 this sequence version replaced
            XM_489567.4, XM_991190.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384,
                              SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AC147045.2         89907-89956         c
            51-146              AC147045.2         83239-83334         c
            147-272             AC147045.2         80608-80733         c
            273-426             AC147045.2         79991-80144         c
            427-589             AC147045.2         77284-77446         c
            590-692             AC147045.2         75770-75872         c
            693-909             AC147045.2         74244-74460         c
            910-1024            AC147045.2         73229-73343         c
            1025-1189           AC147045.2         70943-71107         c
            1190-1345           AC147045.2         68702-68857         c
            1346-1393           AC147045.2         68357-68404         c
            1394-1493           AC147045.2         67846-67945         c
            1494-1588           AC147045.2         66577-66671         c
            1589-1798           AC147045.2         65421-65630         c
            1799-1909           AC147045.2         64556-64666         c
            1910-2068           AC147045.2         63475-63633         c
            2069-2311           AC147045.2         62265-62507         c
            2312-2457           AC147045.2         54793-54938         c
            2458-2728           AC147045.2         52553-52823         c
            2729-2784           AC147045.2         51281-51336         c
            2785-2947           AC147045.2         50949-51111         c
            2948-3078           AC147045.2         49186-49316         c
            3079-3275           AC147045.2         47432-47628         c
            3276-3450           AC147045.2         45584-45758         c
            3451-3628           AC147045.2         35548-35725         c
            3629-4138           AC147045.2         32787-33296         c
            4139-4342           AC147045.2         29090-29293         c
            4343-4538           AC147045.2         24413-24608         c
            4539-4649           AC147045.2         16273-16383         c
            4650-4780           AC147045.2         13892-14022         c
            4781-4897           AC147045.2         10828-10944         c
            4898-5099           AC147045.2         9371-9572           c
            5100-5260           AC147045.2         5690-5850           c
            5261-5395           AC147045.2         4781-4915           c
            5396-6583           AC147045.2         2327-3514           c
FEATURES             Location/Qualifiers
     source          1..6583
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 28.72 cM"
     gene            1..6583
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /note="cilia and flagella associated protein 44"
                     /db_xref="GeneID:212517"
                     /db_xref="MGI:MGI:1277238"
     exon            1..50
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            51..146
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..5587
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /note="WD repeat domain 52"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 44"
                     /protein_id="NP_001028419.1"
                     /db_xref="CCDS:CCDS49854.1"
                     /db_xref="GeneID:212517"
                     /db_xref="MGI:MGI:1277238"
                     /translation="MKEPDDQDTSDGGRSGSRNEGKLAHKSILKSSQDTTADSYTDGE
                     ESYLGDDLDLDDMDESSHSSQEYVQAPAPSQEPPVEVKEEPEADVKKVLSETFYYDYP
                     ELVSIPYVSSEERIPLYFLTLNHSFGYDCRKRANLQLLDSNTLLYVAGNQMVLLDFKD
                     KTQIYLQSSSGQGIGAIGVHPKKTYFAVAEKGSFPKIIIYEYPSLKPYRILRDGAEKA
                     YAYVDFNNEGNLLASVGCHPDYTITIWGWKEEQPILRTKAFSQDVFKVTFNPDNDEQL
                     TTSGSGHIKFWEMAFTFTGLKLQGSLGRFGKTSTSDIEGYAELPDGKVLSGSEWGNLL
                     LWEGSLIKVELCRTGMKSCHSGSINQIMLDEGEVITAGSDGSVRIWDFETIDTADVID
                     DTGLLEIEPINELHIDKSVNLFSMIKMNEVGNNFWLAQDANGAIWKLDLSFSNITQDP
                     ECLFSFHSGPIAALAVSPLTYLMATTAMDCSVRVYDFSSKNPLVHMKFKQGGTSLIWA
                     PRSVSVSASQIVVGFQDGVVRVLELFDPKGLTVYAGRKKIPDAELHLKYVFKPHTDEV
                     TALAYERDGDILATGSEDKTVFFFDVEKEYKPIGFFNTPGPICQLMWSPASHPEKTLL
                     IICENGYILESLCPTIKDVDDQNVITFAIPNVFLRCFHFTSVKSKILRFLEVQRREQQ
                     KMLKEKEKLERRMKLAEEREAFGEEEIPEEETSEEGEEEEPPLPEIFMPPTPSPILCG
                     FYSEPGKFWVSLGNYDAGFLYHCQFPSYLHNSDFQKQENEPFDFRVLENTEDNPIRNI
                     TFSNDQTMMFCGMTNGAIRVYVLSENDPFLVSLQHYWHFNVHDNNYGSIKSITSSFDD
                     QYLLTAGEDGNIFVFDIFSEFIVPKGIKAKVPSPRFGIESEAAPEDIEDPKAYSIENA
                     RKKREHDKLMKKVEELKAHKREQIKILRNEFWKLLELNKELPAHMQFQRTDFNIDAKI
                     HAEIHKKTSLKIEQVEKELAWEKQKHELGLKKLQDRFREPLESDTIVVYATQSDHQIA
                     SYRLVKPSKYSKLKRPSQSERRQSKMERLEKEGPGKKESQRDTGGSISLQEESVLEKG
                     KKFRPRTLSEIMVENQIEKTKKLIQQAERAQFKILQRKKEWEELYKSKPDDDYEDPKD
                     VQAIKEAQTYMGDFNLKTAPDYKIPEHMRINAAKKEEELGYLDTMAHGKKRYMNKCIL
                     SLRDLKLAVIEEIQCLVQELKNIQSSIPASKHMPIPQVPQIYPEEVPERRFQYDEETL
                     LRFQRKQKKRQDKSSSKQSGTGSGGSAGGGLVGFLKLSSGKEGDLTTRDSLSRSSKAS
                     ALLELPKPVEFEKAEPSDAELEIMKRDEVKHLYMQQFLCNRINELTVTFDAELHLLRH
                     QKLKLDTKMKLSDLHHLTLFQEMLLLKNFEKQENILQERVNSLDKEEQDMQWKINETL
                     KEMEEKKNEITKLQDQEKALYAGFQAALGENNKFANFLMKVLKKKIKRAKKKEVEGDA
                     DEDEESEESSEEESSLESDEDASGSEDDVFDDSICPTNCDVSLFELALQLREKRLDIE
                     EALVEEKKIVDNLKKEYDTISKKVKVVATNLNAAEEALEAYQREKQQRLNELLVVIPL
                     KLHQIEYMEFGEVPEDLSGTLVFSNHSLDRLQERIVQLQEENAKQQKLNKECRERRKL
                     LIREKREMAKTISKMEETVRELMISKFGRVIDLEALQTLSVNTTLEELKIKKLRKELS
                     NAKELRMWEEKIAQVRWDLMMKTKEHTKKLHQMNDLCLEKKKLDSRLNTLQNQQGNAF
                     QGLRKADIVAKQKVTELVQTQLEKITALKEEIELLRKKGGLLLPPITPKPKNEMKPMD
                     T"
     exon            147..272
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            273..426
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            427..589
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            590..692
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            693..909
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1024
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1189
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1345
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1393
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1493
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1588
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1798
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1909
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2068
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2311
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2457
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2728
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            2729..2784
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2947
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3078
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3275
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            3276..3450
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            3451..3628
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..4138
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            4139..4342
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            4343..4538
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            4539..4649
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            4650..4780
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            4781..4897
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            4898..5099
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            5100..5260
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            5261..5395
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     exon            5396..6583
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5923..5928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /note="hexamer: AAGAAA"
     polyA_site      5944
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
     regulatory      5988..5993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /note="hexamer: AATAAA"
     polyA_site      6007
                     /gene="Cfap44"
                     /gene_synonym="6330444M21Rik; D16Ertd642e; Gm1750; Wdr52"
                     /note="major polyA site"
ORIGIN      
        1 gtccttgggc gggtgtgact agaaaccagc tgctgtagcg aacacctccg acaatatgaa
       61 ggagccagat gaccaagaca cttctgatgg ggggagatcg ggatcaagga atgagggaaa
      121 gctggctcat aagtccattt tgaaatcttc acaagacacc acagctgact catataccga
      181 cggggaagag tcgtatctgg gcgatgactt agatttggac gacatggacg aaagctcgca
      241 ttcatctcaa gagtacgttc aggctcctgc accttcccag gaacctcctg ttgaagttaa
      301 ggaagaacca gaagccgacg taaagaaggt gctctccgag accttctatt acgattaccc
      361 ggagcttgtt tccataccat atgtgtcttc ggaagagagg atcccacttt attttctcac
      421 cctcaaccat tcttttggtt atgactgcag aaagcgagcc aacctacagc ttctggacag
      481 caacacttta ttgtacgtgg ctgggaacca gatggtcctg ctggatttta aagacaagac
      541 acaaatttac ctgcagagta gcagtggcca agggattggt gccattgggg tccatccaaa
      601 gaaaacttac ttcgcagttg ccgaaaaagg aagtttccca aagattatca tctacgagta
      661 cccttctctg aagccctaca ggatcttgag agatggggca gaaaaagcct atgcttatgt
      721 ggactttaac aacgagggga acttgctggc ctctgttggc tgtcatcctg attacacaat
      781 aaccatctgg ggctggaagg aagagcagcc catactgaga acgaaagcgt tttctcagga
      841 cgtctttaag gtcactttca atcctgataa tgatgagcaa ttaactacct caggatccgg
      901 ccacatcaag ttctgggaga tggcttttac attcactggt ctcaagctgc aaggatcact
      961 ggggcgattt ggcaaaacat ctaccagtga catagagggc tatgcagagc ttcccgacgg
     1021 gaaggttctc tcagggtcag aatggggcaa cctgctgctt tgggaaggca gcctcatcaa
     1081 ggtggaactc tgtcggactg gcatgaagtc ttgtcacagc ggttccatta accagataat
     1141 gctggatgag ggagaagtga tcaccgccgg ttcggatggc agcgttagga tatgggattt
     1201 tgagacaatc gacactgctg acgttataga tgatactgga ttgttggaga tagaacctat
     1261 taatgaactt cacatagaca agagtgtcaa cctcttctca atgatcaaga tgaatgaagt
     1321 tggaaataat ttttggctgg ctcaggatgc caatggagcc atatggaagc ttgaccttag
     1381 cttttcaaat attacccagg atccagaatg cctcttctct ttccactctg gaccgattgc
     1441 agccttggct gtttctcctc tcacttatct catggccaca actgctatgg actgctctgt
     1501 tcgtgtctat gatttttcta gtaaaaaccc tttggtccat atgaaattta aacaaggagg
     1561 cacatccctc atttgggcac cccgatcagt aagcgtttct gcatcacaga ttgtagtagg
     1621 attccaagac ggcgttgtcc gagttcttga actttttgac ccaaaaggac ttacagttta
     1681 tgcaggacgg aagaaaatcc cagatgctga gttacatttg aaatatgtct tcaaacccca
     1741 tactgatgaa gttacagctt tagcttatga acgtgatggg gatatcttag ccactgggag
     1801 tgaagacaag actgtcttct tttttgatgt ggagaaagaa tacaagccga ttggtttttt
     1861 taacactcct gggcccattt gccagttgat gtggtctcca gccagtcatc ctgaaaaaac
     1921 tttattgatc atctgtgaga atggctacat tcttgaaagt ctatgcccaa ccattaagga
     1981 cgtagatgac cagaatgtta tcacgtttgc aatcccgaac gtgttcctcc gatgcttcca
     2041 tttcacgagt gtcaaatcta agattttgag atttttagaa gtacaaagga gagaacaaca
     2101 gaagatgttg aaggagaagg aaaagttaga aaggaggatg aagctagcag aagagaggga
     2161 agcctttgga gaagaggaaa taccagagga ggagaccagt gaggaagggg aagaggagga
     2221 gccgccgctg cctgagatct tcatgccacc aacaccctcc cctatcctgt gtggctttta
     2281 ctcggagcca gggaagttct gggtgtcgtt gggcaactat gatgctggct ttctctatca
     2341 ctgtcagttt ccgtcatatc tccacaacag tgatttccaa aaacaggaaa atgaaccatt
     2401 tgatttccga gttcttgaga atacagaaga caaccccatc agaaatatca ctttcagtaa
     2461 tgaccaaact atgatgttct gcgggatgac aaatggagcg attcgagtgt atgtcttaag
     2521 tgagaacgac cccttcctgg tcagtttgca gcactactgg catttcaatg tgcatgacaa
     2581 taattatgga tctattaaaa gtatcacttc gagttttgat gaccagtatt tgctgacggc
     2641 tggggaagat ggtaatatct ttgttttcga cattttttct gaatttattg tcccgaaagg
     2701 aatcaaagcc aaagtaccat cacccaggtt tgggattgaa tcagaggccg ctccagaaga
     2761 catcgaagat cccaaagcct acagcattga gaacgccagg aagaaacgag agcatgacaa
     2821 gttaatgaag aaagtagaag aactaaaagc tcacaagaga gaacaaataa aaattttgag
     2881 gaatgagttt tggaagctgt tagagttgaa taaagagtta ccagcgcata tgcagttcca
     2941 aaggacggat ttcaatattg atgccaaaat tcacgctgag atccacaaga aaacaagttt
     3001 gaaaatagaa caagtggaaa aggaactagc ttgggaaaaa cagaaacacg agctcggtct
     3061 gaagaagctg caggacagat ttcgtgaacc attggaaagt gacaccatcg tggtttacgc
     3121 cacccagagt gaccaccaga tagcctccta tagactggtg aagccctcta aatattccaa
     3181 gttaaagcgt ccaagccagt ctgagagaag acaaagcaaa atggagaggc ttgaaaagga
     3241 agggccgggc aagaaggaga gccagagaga tacaggtgga agtattagcc tacaagaaga
     3301 gtcagtgttg gaaaaaggga agaaatttcg gcctagaact ttaagtgaaa ttatggtaga
     3361 aaaccaaatc gagaaaacaa agaaactcat acaacaagct gagcgggctc aatttaagat
     3421 tctccagcgc aaaaaggaat gggaggagct ttacaaaagc aaacctgacg atgactatga
     3481 agatcccaaa gatgttcagg ccatcaaaga agcccaaaca tacatggggg atttcaatct
     3541 gaagacagcc ccggactaca agatccctga gcacatgaga ataaatgcag ccaagaagga
     3601 ggaggagctg gggtaccttg acacgatggc ccacgggaag aagaggtaca tgaacaagtg
     3661 catcctttcc cttcgagatc tcaagttggc tgtcattgag gaaatccagt gcctggtcca
     3721 agaactgaag aacattcagt cttccatccc cgcgtccaag cacatgccca tcccccaggt
     3781 cccgcagatc tatcctgagg aagtcccaga aaggagattc cagtacgacg aggaaacact
     3841 cttgagattt cagagaaagc agaagaaacg gcaggataag agcagcagca agcagtcggg
     3901 aacaggatct gggggctcag ccggaggagg gctagtaggg ttcctcaaac tgtcctcggg
     3961 aaaggaggga gacctgacaa ccagagactc cctgtctcgc tcgtccaagg catcagcgct
     4021 cctggagctt ccgaagcccg tcgagtttga gaaggcggag ccaagcgacg cggagctgga
     4081 gattatgaaa agagacgagg ttaaacattt atacatgcaa cagtttttgt gcaacaggat
     4141 caacgaactg actgtcactt tcgacgcaga actccatctt ctaagacatc agaaactgaa
     4201 gctagatacg aaaatgaaat tatctgacct tcaccatctc acattatttc aagaaatgct
     4261 tctcctgaag aattttgaaa aacaggaaaa tattcttcaa gagagagtta actccttaga
     4321 caaagaggag caagacatgc aatggaaaat aaatgaaact cttaaagaga tggaagagaa
     4381 aaagaatgaa atcaccaaac tccaggatca ggaaaaggcg ctctacgctg gcttccaggc
     4441 agcccttgga gaaaacaata aatttgcaaa cttcctcatg aaggtcctga agaagaagat
     4501 taagcgggca aagaagaagg aagttgaggg agatgctgat gaggatgaag agagtgagga
     4561 gtccagtgaa gaggagtcca gcctggagag cgacgaggat gcgtccggat ctgaagatga
     4621 cgttttcgat gattctatct gcccgacaaa ttgtgatgta agtctctttg aactggccct
     4681 ccaactccga gagaaaagac tggacattga ggaagcctta gttgaagaaa agaaaattgt
     4741 tgataacctg aaaaaagaat atgatacaat ctccaaaaag gtaaaagttg tggcaaccaa
     4801 tctgaatgca gccgaggagg ccctggaggc ttatcagcga gagaaacagc agaggctgaa
     4861 cgagctgctg gtcgtcatcc ctctgaagct ccaccagata gagtatatgg aatttgggga
     4921 ggtgcctgaa gacctttctg ggaccttggt cttctccaac cactccctcg atcggctgca
     4981 agaacgaatt gtacagctcc aggaggaaaa cgccaagcaa caaaaactga acaaagaatg
     5041 cagggagagg cggaagctgc tcatccggga aaagagagag atggcaaaaa ccatcagcaa
     5101 aatggaagaa actgtccggg agctgatgat cagcaagttt ggccgcgtga tcgatctgga
     5161 agccctccag accctttctg ttaacacaac ccttgaagaa ctgaagatca aaaagcttcg
     5221 gaaggagcta tccaacgcaa aggagctaag gatgtgggag gagaagatcg ctcaagtgcg
     5281 ctgggacctg atgatgaaga cgaaggaaca caccaaaaag cttcaccaga tgaacgacct
     5341 gtgcctcgag aagaagaaac ttgattccag gttgaacact ctccagaacc agcagggaaa
     5401 cgccttccag ggccttcgga aagccgatat agtggcaaag cagaaggtca ccgaactggt
     5461 ccaaacccag ttagagaaga tcacggcctt aaaagaagag attgagcttt tgcggaagaa
     5521 gggggggctc ctcctcccgc ctatcacccc caagccaaag aacgagatga agcccatgga
     5581 cacttaaggt tgccgtcgtc tcatttccac caagaggccc agtggacttc accgatctac
     5641 ttccccgtca cccacaacaa tcctctcgct ttaaagtgaa ccgtagtgtg aacttaaaaa
     5701 aaggggtcct gccccgtgac ttaatatttc cccaggttag aaatcaccgg gacgctgacc
     5761 tgtactgtac ttgtgactgt gctgaggaga ccagttagac gttttcaccc taggttggat
     5821 atgaagaagg ccgagtcccg tggttgcaag agagcaagct gttagatgtg ttttcagaag
     5881 agtaatctgt ttctctggta ttccgaatat gtagccattg gcaagaaaaa ctattattca
     5941 gcaacccatg aggaaacgtc cttttcttag tccttggatc tttagaaaat aaactgtttg
     6001 tgttaaacag tctgtgaaag gacataagag aaaaggcaaa ccatcctgcc aataagaact
     6061 tagaatacga aacgcaaacg caagcgttgc tattgttgac ttcacaaagc tcgggactga
     6121 ggaaatgcag acagacgcgg ggaaacagct cgcgttgggc tggcagaggc gactccctga
     6181 tttacccagt ttctgaaaac tcctcaattc cgaggctcac gttttccaaa acaactcagt
     6241 cagggaagct ttgctctagc ggctctcggc ggctccagca gaattctacc ttctgtcagg
     6301 cttcacctga gtctttcctg gttccgatcc agacaaggga agaaaataga ttttcatctc
     6361 tcctaggttc taactcttac agtcagtcgc ttttgactgt gggtgacatt ttaaactcaa
     6421 gagtgcagtc tccagctcag ggaagggttt attgaaattc atggctgcac ccctcacagc
     6481 ttgatctccc tgacactcgg tgtcgtgtcc ctccagcggt gacactttga tttcccaggt
     6541 gaattgttac cagaagcccc tgctatggca gagggctgtg ctg
//
