LOCUS       NM_027559               5947 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cilia and flagella associated protein 43 (Cfap43),
            mRNA.
ACCESSION   NM_027559 NM_029124 XM_001479249 XM_129357
VERSION     NM_027559.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5947)
  AUTHORS   Martinez,G., Coutton,C., Loeuillet,C., Cazin,C., Muronova,J.,
            Boguenet,M., Lambert,E., Dhellemmes,M., Chevalier,G.,
            Hograindleur,J.P., Vilpreux,C., Neirijnck,Y., Kherraf,Z.E.,
            Escoffier,J., Nef,S., Ray,P.F. and Arnoult,C.
  TITLE     Oligogenic heterozygous inheritance of sperm abnormalities in mouse
  JOURNAL   Elife 11, e75373 (2022)
   PUBMED   35451961
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5947)
  AUTHORS   Rachev,E., Schuster-Gossler,K., Fuhl,F., Ott,T., Tveriakhina,L.,
            Beckers,A., Hegermann,J., Boldt,K., Mai,M., Kremmer,E., Ueffing,M.,
            Blum,M. and Gossler,A.
  TITLE     CFAP43 modulates ciliary beating in mouse and Xenopus
  JOURNAL   Dev Biol 459 (2), 109-125 (2020)
   PUBMED   31884020
  REMARK    GeneRIF: CFAP43 modulates ciliary beating in mouse and Xenopus.
REFERENCE   3  (bases 1 to 5947)
  AUTHORS   Morimoto,Y., Yoshida,S., Kinoshita,A., Satoh,C., Mishima,H.,
            Yamaguchi,N., Matsuda,K., Sakaguchi,M., Tanaka,T., Komohara,Y.,
            Imamura,A., Ozawa,H., Nakashima,M., Kurotaki,N., Kishino,T.,
            Yoshiura,K.I. and Ono,S.
  TITLE     Nonsense mutation in CFAP43 causes normal-pressure hydrocephalus
            with ciliary abnormalities
  JOURNAL   Neurology 92 (20), e2364-e2374 (2019)
   PUBMED   31004071
  REMARK    GeneRIF: Cfap43-KO mice exhibited a hydrocephalus phenotype with
            morphologic abnormality of motile cilia.
REFERENCE   4  (bases 1 to 5947)
  AUTHORS   Kherraf,Z.E., Conne,B., Amiri-Yekta,A., Kent,M.C., Coutton,C.,
            Escoffier,J., Nef,S., Arnoult,C. and Ray,P.F.
  TITLE     Creation of knock out and knock in mice by CRISPR/Cas9 to validate
            candidate genes for human male infertility, interest, difficulties
            and feasibility
  JOURNAL   Mol Cell Endocrinol 468, 70-80 (2018)
   PUBMED   29522859
REFERENCE   5  (bases 1 to 5947)
  AUTHORS   Coutton,C., Vargas,A.S., Amiri-Yekta,A., Kherraf,Z.E., Ben
            Mustapha,S.F., Le Tanno,P., Wambergue-Legrand,C., Karaouzene,T.,
            Martinez,G., Crouzy,S., Daneshipour,A., Hosseini,S.H., Mitchell,V.,
            Halouani,L., Marrakchi,O., Makni,M., Latrous,H., Kharouf,M.,
            Deleuze,J.F., Boland,A., Hennebicq,S., Satre,V., Jouk,P.S.,
            Thierry-Mieg,N., Conne,B., Dacheux,D., Landrein,N., Schmitt,A.,
            Stouvenel,L., Lores,P., El Khouri,E., Bottari,S.P., Faure,J.,
            Wolf,J.P., Pernet-Gallay,K., Escoffier,J., Gourabi,H.,
            Robinson,D.R., Nef,S., Dulioust,E., Zouari,R., Bonhivers,M.,
            Toure,A., Arnoult,C. and Ray,P.F.
  TITLE     Mutations in CFAP43 and CFAP44 cause male infertility and flagellum
            defects in Trypanosoma and human
  JOURNAL   Nat Commun 9 (1), 686 (2018)
   PUBMED   29449551
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5947)
  AUTHORS   Tang,S., Wang,X., Li,W., Yang,X., Li,Z., Liu,W., Li,C., Zhu,Z.,
            Wang,L., Wang,J., Zhang,L., Sun,X., Zhi,E., Wang,H., Li,H., Jin,L.,
            Luo,Y., Wang,J., Yang,S. and Zhang,F.
  TITLE     Biallelic Mutations in CFAP43 and CFAP44 Cause Male Infertility
            with Multiple Morphological Abnormalities of the Sperm Flagella
  JOURNAL   Am J Hum Genet 100 (6), 854-864 (2017)
   PUBMED   28552195
  REMARK    GeneRIF: biallelic mutations in either CFAP43 or CFAP44 can cause
            sperm flagellar abnormalities and impair sperm motility.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK015497.1,
            AC126679.2 and AC131719.5.
            
            On or before Sep 22, 2010 this sequence version replaced
            XM_001479249.1, XM_129357.7, NM_027559.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.119914.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AK015497.1         2-148
            148-401             AC126679.2         165471-165724
            402-498             AC131719.5         212554-212650       c
            499-666             AC131719.5         207932-208099       c
            667-817             AC131719.5         205199-205349       c
            818-977             AC131719.5         197983-198142       c
            978-1045            AC131719.5         196098-196165       c
            1046-1177           AC131719.5         194238-194369       c
            1178-1294           AC131719.5         184033-184149       c
            1295-1375           AC131719.5         179279-179359       c
            1376-1524           AC131719.5         177773-177921       c
            1525-1628           AC131719.5         173589-173692       c
            1629-1769           AC131719.5         170482-170622       c
            1770-1945           AC131719.5         169091-169266       c
            1946-2095           AC131719.5         167450-167599       c
            2096-2226           AC131719.5         164449-164579       c
            2227-2377           AC131719.5         162431-162581       c
            2378-2461           AC131719.5         160564-160647       c
            2462-2539           AC131719.5         158190-158267       c
            2540-2665           AC131719.5         155193-155318       c
            2666-2770           AC131719.5         153726-153830       c
            2771-2887           AC131719.5         152550-152666       c
            2888-3118           AC131719.5         147970-148200       c
            3119-3325           AC131719.5         145811-146017       c
            3326-3418           AC131719.5         144112-144204       c
            3419-3499           AC131719.5         143807-143887       c
            3500-3625           AC131719.5         143029-143154       c
            3626-3745           AC131719.5         138172-138291       c
            3746-3853           AC131719.5         135135-135242       c
            3854-3940           AC131719.5         133997-134083       c
            3941-4029           AC131719.5         133238-133326       c
            4030-4243           AC131719.5         130012-130225       c
            4244-4356           AC131719.5         128799-128911       c
            4357-4516           AC131719.5         127614-127773       c
            4517-4681           AC131719.5         121840-122004       c
            4682-4762           AC131719.5         120948-121028       c
            4763-4916           AC131719.5         120199-120352       c
            4917-5947           AC131719.5         119027-120057       c
FEATURES             Location/Qualifiers
     source          1..5947
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 40.41 cM"
     gene            1..5947
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /note="cilia and flagella associated protein 43"
                     /db_xref="GeneID:100048534"
                     /db_xref="MGI:MGI:1289258"
     exon            1..147
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..5083
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /note="WD repeat domain 96"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 43"
                     /protein_id="NP_081835.2"
                     /db_xref="CCDS:CCDS57146.1"
                     /db_xref="GeneID:100048534"
                     /db_xref="MGI:MGI:1289258"
                     /translation="MSQDPERDDVTASATASASASAPASASAHYSGSSLSVRWVQGFP
                     SQNVHFVNDQTICYPSGNFVIFINLETKKKTVLQCINGIVGVMATNVPSEVVAFSDRR
                     FKPVIYIYSFPSLTRKNKLKGDILLDYTLLCFSYCGTYLASYSSLPEFELALWNWEAS
                     AILCKKSNPGMDVSQMSFNPMNWHQMCLSSSSAMSVWTIERSNQEHHFRIRSVKLPLE
                     DATFLNEPDMLFPTTLPKDLIYGPVLPLSAIAGLVGEEAETFRPKDDIYPLLHPTMHC
                     WTPSSDLYVGCEEGHLLMINTETLKVTVLQKAEEFPLPDGAPLINPLTLVYQKDGILA
                     SGIDGVIYSFIIKDSKYQVKTFLEFDGPVTHLVFSPSYKMLLIQTDKGSVYIYTFGAE
                     MPLDKLLDACDGKVQAVSFITPGTKYFLTLTSSGEVSTVSLEDCNCTSRIFLKTQATA
                     LACSPSSPTAAVGTVDGYVYFLNILDVESPQMIHQAFLSQSPVKIVTYDQRGIFLLVG
                     TEEGNIFVIDARPSKSFQIFGFTETGKDILQISTVSVMESDVVEVLVLYPLPDMGRSR
                     LEYFTLPVMLPEVVPENFSDERGRLKDDLTHKYLYEVEHTLSSAVLGFTGSKIFGFCS
                     QVPYICSYVMPVKEHTGVLVLKPHQKVQSKQYGSGTIYLSSHGLWLMTIAKCGILCIR
                     DMFSMETFVRCRSHSHQGRGIQNMKMSLDGQHILVNGKDDNTLVCLKWKRLGANIASE
                     IFEHSRPLVLHLSQTVESESVYLALSRESTNEQQEETTESQKHLNSDSSEEEAVIDHK
                     MIPWIQQKMEEAIKKEVRIFSPRRKEIKRGIKELAQVIAMMMEENEKVDIIAKLDEQE
                     FCLDADELERLHDECEEEVAKIRKDVEMHNLAQSYLTELIKEECWNSMAVKGRALKCF
                     HIPYVVDNFPMKERTEEELQELSKVMQQKKTEIECLKLRKEIVEVQATTTIAKKHHEE
                     EEEEEEDEERTIKTTSLPNYLLGSLSTDFGADTSLLTSQLDLHSREEKINQIILLKDI
                     IYNIKRNFNSEFDAAYKQKEIEIARVKEKNVRIAEIISDLELEETVWQPVFEDSEKPE
                     RALVVEDDEISFKKYIAPWQRAKIKEVVSTYEMERLQQARISDERQRGLMDMMGGVLE
                     VKKEDILRMVIPQPPFMAKADALWSEDERKQFKEYEKKVKELNEERDKYRKSLEAELK
                     KLQNSIQESTQNFDDHLKRLFERRVKAEMVINQEELKINNIIFSLLLDEELSSREQFL
                     NNYLLKKQEEKTKTAEAIQKAREDLDVFKEHHDMLVAEDKILDRSFKKEFSDILGHQV
                     DVLYKLFKRRPRVHKQKTQADVTSLVPYGERPGSAKLNKENLAQLMKSMDELDNINNM
                     PEGLDPSVWEHFCSTRRAKVENEYKVKQKAACLLEMTTFLRKRMEEDDVVHHEIEKVF
                     HELIRLQDEKVRFQVNLTVQILLKQGQVELENFQLMLEYSDAILINKNIIEDLNSVIR
                     TQGQKKVASMMESKEVHKGIYQIEWEHKKMEMEMEDLNQRAWDIEMLFFSRDRQKYLN
                     EPNYENVIAIQIGIMEQTISVIDKTHKKNVENCKKLLKKLGKYSNQKDVANYTLSCNL
                     REELVAVSERQDICNEIGSKLTCEKIARERYDNQLKQQKLLNISKQQAEQISILQAEV
                     ERLRMKTFPALIPM"
     exon            148..401
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            402..498
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            499..666
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            667..817
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            818..977
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1045
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1177
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1294
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1375
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1524
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1628
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1769
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1945
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2095
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2226
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2377
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2461
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2539
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2665
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2770
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2887
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            2888..3118
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            3119..3325
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3418
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..3499
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            3500..3625
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            3626..3745
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            3746..3853
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            3854..3940
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            3941..4029
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            4030..4243
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            4244..4356
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            4357..4516
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            4517..4681
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            4682..4762
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            4763..4916
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     exon            4917..5947
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5225..5230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /note="hexamer: AATAAA"
     polyA_site      5244
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /note="major polyA site"
     regulatory      5264..5269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /note="hexamer: ATTAAA"
     polyA_site      5293
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
     regulatory      5741..5746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
                     /note="hexamer: AATAAA"
     polyA_site      5759
                     /gene="Cfap43"
                     /gene_synonym="4632415N18Rik; 4930428C11Rik;
                     4930463G05Rik; D19Ertd652e; Wdr96"
ORIGIN      
        1 aacggccgca gccccgggtg cgctgggagt cggcatgtcg caagacccgg agcgcgacga
       61 cgtcactgcc tctgccactg cctctgcctc agcctcagcc cctgcctctg cctctgccca
      121 ctactccgga tcctccctgt cggtgagatg ggtgcaagga ttccctagtc agaacgtcca
      181 ctttgtcaat gaccagacca tctgctaccc ttctgggaac tttgtaatat tcattaacct
      241 ggaaaccaag aagaagactg tactccagtg tattaatggg attgtgggcg tcatggcaac
      301 taatgtgccc agtgaagtcg tggctttctc tgaccgaaga tttaaacctg ttatctacat
      361 atacagcttc ccatcgctga ccagaaaaaa caagttaaaa ggtgacatcc tcctggacta
      421 cactctactt tgcttcagtt actgtggcac ctacctggcc agttactcgt ctctcccaga
      481 gtttgagctg gccctctgga actgggaagc cagtgccatc ttgtgcaaga aatcaaatcc
      541 cggcatggat gtgagccaga tgtccttcaa ccccatgaac tggcaccaaa tgtgtttatc
      601 aagttcaagt gcgatgagcg tgtggaccat tgagagaagt aaccaggagc accatttcag
      661 gataaggtct gtcaagctac ccctagaaga cgcgaccttc ctaaacgagc ccgacatgct
      721 tttccccacc actctgccaa aggatctcat ttatggaccc gtattgccac tgtcggccat
      781 tgccgggctg gtaggcgaag aggcagagac tttcaggccg aaagatgaca tatatcctct
      841 gcttcaccca actatgcact gctggactcc gtcaagcgac ctgtacgttg ggtgtgaaga
      901 gggtcatctt ctgatgatta acacagaaac cctgaaggtg accgtgctcc agaaggcgga
      961 ggagtttcca cttccggatg gagccccgct catcaaccca ctcacgctgg tgtaccaaaa
     1021 ggacggcata ctcgcttctg gaattgatgg tgtgatatac tccttcatca tcaaggattc
     1081 aaagtaccaa gtgaagacct ttctcgagtt tgatgggccg gtgacacatc tggtgttctc
     1141 ccccagttac aaaatgttac tgattcaaac agacaagggg tctgtttata tctatacgtt
     1201 tggtgcagag atgcctcttg ataaactcct cgatgcctgc gatgggaaag tgcaggctgt
     1261 cagctttatc acacctggaa ccaaatactt cctgacactc actagttctg gggaagtttc
     1321 cactgtatca ctagaagact gcaattgtac aagcaggatt ttcctgaaga ctcaagcaac
     1381 agctctggcg tgctcccctt cctcgccgac agctgccgtg gggacggtgg atggctatgt
     1441 ctactttctg aacatccttg atgtggagtc ccctcagatg atccaccagg ccttcctctc
     1501 ccagtcacca gtgaagatag tgacgtatga ccagcgagga atctttctgt tagttggtac
     1561 agaggaagga aacatctttg tcatcgatgc cagaccctca aagtcatttc aaatttttgg
     1621 attcactgag acgggcaagg acatcctgca gatatccacg gtgtctgtca tggagtcaga
     1681 tgtggtcgaa gtgctggtgt tgtacccgct tccagatatg ggcagaagca ggctggaata
     1741 cttcaccctg ccagtcatgt taccagaagt ggttcctgaa aacttttctg atgaacgagg
     1801 aaggctgaaa gacgatttaa cccacaagta cctgtacgag gtggagcaca ctctgtcctc
     1861 tgcagtgctg ggcttcacag gcagcaaaat ctttggcttc tgcagccagg tgccctacat
     1921 ctgcagctat gtaatgcccg taaaggaaca cactggtgtc cttgttctta agcctcacca
     1981 aaaagtacag agcaaacagt acggatctgg aacaatctat ctgtcttctc acggattatg
     2041 gcttatgaca atagctaaat gtggaattct ctgtatccga gatatgttca gtatggaaac
     2101 ctttgttcga tgtcggagtc attctcacca ggggcgaggg atccagaaca tgaaaatgtc
     2161 attggacgga cagcacatcc tggtgaatgg aaaagatgac aacacccttg tctgcctcaa
     2221 atggaagcgg cttggagcaa acatagcaag tgagatcttt gaacacagcc gtccgctagt
     2281 gctccatctg tcccagacag tggaatcgga gagtgtatac ttagctttat cgagagagtc
     2341 cacgaatgag cagcaagaag agacaactga atcccaaaaa cacctgaact cagactcatc
     2401 agaagaggaa gcagtcatcg atcacaagat gattccctgg atccaacaaa aaatggaaga
     2461 ggccatcaaa aaggaggtga ggattttttc ccctagaaga aaggagatca aaagaggaat
     2521 taaggagctc gctcaggtta ttgcaatgat gatggaagag aatgaaaagg tggacatcat
     2581 tgcaaaacta gatgaacagg agttttgcct ggacgccgat gagctggaaa ggcttcatga
     2641 tgaatgtgag gaggaagtag cgaagataag gaaagatgtg gagatgcaca acttggccca
     2701 gagctactta actgagctca tcaaggagga gtgctggaac tccatggctg tgaagggccg
     2761 ggctctaaag tgttttcata taccctatgt ggttgacaac tttcccatga aagagcgcac
     2821 ggaagaggag ctacaggagt tgagtaaagt tatgcagcaa aagaagactg agattgagtg
     2881 tcttaagctc cggaaagaga ttgtggaggt ccaggcgaca accactatag ctaagaaaca
     2941 ccacgaggag gaggaggagg aggaagagga tgaagaaagg acaataaaaa ctaccagtct
     3001 gcccaattac ctgcttggta gtttgagcac tgattttggg gcggacacat ctttgttgac
     3061 aagccaactg gaccttcatt ccagagagga gaaaatcaac caaattatat tgctaaagga
     3121 tatcatttac aatataaaaa ggaatttcaa tagtgaattt gatgctgcct ataagcaaaa
     3181 agagattgaa attgcacgtg taaaagaaaa gaatgttaga attgcagaaa ttatttcaga
     3241 cttggaattg gaagaaacag tgtggcagcc agtgtttgaa gacagtgaga aaccagaaag
     3301 agcccttgtc gtggaagatg atgagatctc atttaaaaaa tacattgctc catggcaaag
     3361 agccaaaata aaagaagtgg tctcaaccta tgaaatggaa cggttgcagc aagcacggat
     3421 ctctgatgaa cggcagagag gcctgatgga tatgatggga ggtgttctgg aagtcaagaa
     3481 ggaagacatc ttaaggatgg tgatccctca accacctttc atggcgaaag ctgatgctct
     3541 gtggagtgaa gatgaaagga agcaattcaa agagtacgag aaaaaagtca aggagctgaa
     3601 tgaagagaga gacaagtaca gaaagtcttt agaagcggag ctgaagaaac ttcaaaattc
     3661 tattcaagag agcacgcaga actttgacga ccatctgaag agactctttg aaaggagagt
     3721 gaaggcagaa atggtcatca accaggagga actgaaaata aacaacatta tattttcgtt
     3781 gctgctggat gaagaactca gctccaggga acagttcctg aacaactacc ttttgaagaa
     3841 acaggaggag aaaaccaaga ctgcagaagc catccagaag gcgagagaag atctggacgt
     3901 attcaaggag caccatgaca tgttagtggc agaggacaaa attctggatc gaagcttcaa
     3961 aaaggaattt tctgacattt tgggtcacca ggtggatgtc ctctacaaac tttttaaacg
     4021 ccggccaagg gttcacaaac agaaaacaca ggcagatgtg accagtcttg ttccttatgg
     4081 agagcgacca ggatctgcca agttaaataa ggaaaactta gcccagctaa tgaaatccat
     4141 ggatgagttg gacaatatca ataacatgcc agaaggcttg gacccctctg tctgggaaca
     4201 tttctgctca actagacggg caaaagtgga aaatgaatac aaagtgaagc agaaggcagc
     4261 ctgcctcctg gaaatgacga cttttctccg gaagcggatg gaagaggatg acgtagtgca
     4321 tcatgagatc gaaaaagtgt tccatgagct catccgatta caggatgaga aagtgagatt
     4381 ccaggtgaat ttgacagtac aaatccttct taagcaagga caagtagagc tggagaattt
     4441 ccagttgatg ctggaatatt ctgacgcaat tctcatcaat aagaatataa ttgaagactt
     4501 gaattctgtg attcggactc aaggacaaaa gaaagttgct agcatgatgg aaagtaaaga
     4561 ggtccacaaa ggaatctatc agattgagtg ggagcacaag aagatggaga tggagatgga
     4621 ggacctaaac cagagggcct gggacatcga gatgctcttc ttctcacgag accggcagaa
     4681 gtacctaaac gaaccaaact acgagaatgt gattgccatt cagattggaa taatggagca
     4741 aacgattagt gttatagata agactcataa gaagaatgta gaaaactgca aaaagctact
     4801 caagaaactg ggaaaataca gcaatcagaa agatgttgca aattacaccc taagctgtaa
     4861 tctacgggaa gaactggtgg ccgtctcaga gagacaagac atttgcaatg agatagggtc
     4921 taagctgacc tgtgagaaga ttgctagaga acgctacgac aaccagctga agcagcagaa
     4981 gctgttgaac atctccaagc agcaagctga gcagatctca atcctgcagg ctgaagttga
     5041 aagactcagg atgaagacat tccctgctct catcccaatg tagagcagaa agcacacaat
     5101 gcccaactaa tgtcccttga atagaatcac ttggacagaa acttctctct ctcctgatca
     5161 ggaaatttaa gtaggtcacc tcttagctgc acgtttttaa tagtacagtt acctgtcctc
     5221 caggaataaa tgagtaaaat atcataaagt gtcgcttgta tttattaaag aacagtggtt
     5281 ttcagccaag aaacactgga ttgtaaatta tattttgcaa acagtcttcc ttccttccct
     5341 actgtaacag aactgttttg ttttgttttt ttaaccctca aagggtccag taaacaagtg
     5401 ctcattccct tgaaaccttt attctacttg tgtagaacat tctaattctg taagacaact
     5461 ccctggcaaa cataatccca cccaccctcc cagagctgtg gtttgctgat tccaagaggc
     5521 atcttcaaga tcacttatca ttgtctccac gtgatagcaa tgtcccaatt ttctgcaact
     5581 tataatctaa atttaggttt aatgtacatc accatatata atatatactt gaatgggtaa
     5641 aagtaatcaa aacaaatctt tcacttggaa gcatactcct gcaatttcac aatcattaga
     5701 actggctgcc attctgggtt acatgagact acctcaaaaa aataaaaatt tccacttaag
     5761 tttgtttcgc ctattctggt gtattagttt ttatcttatt ttactttact cttatcccta
     5821 gaagcctgtt ttagtttttt aatgagacag aaagagggtg gatctggatg agaggggaag
     5881 gaagaactag gagtagaggg aagggaaact aatcagaatg taagagaaaa aaaaagctat
     5941 ttccaat
//
