LOCUS       NM_026005               2133 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus cilia and flagella associated protein 418 (Cfap418),
            mRNA.
ACCESSION   NM_026005
VERSION     NM_026005.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2133)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2133)
  AUTHORS   Clark,A.M., Yu,D., Neiswanger,G., Zhu,D., Zou,J., Maschek,J.A.,
            Burgoyne,T. and Yang,J.
  TITLE     Disruption of CFAP418 interaction with lipids causes widespread
            abnormal membrane-associated cellular processes in retinal
            degenerations
  JOURNAL   JCI Insight 9 (1), e162621 (2024)
   PUBMED   37971880
  REMARK    GeneRIF: Disruption of CFAP418 interaction with lipids causes
            widespread abnormal membrane-associated cellular processes in
            retinal degenerations.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2133)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2133)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2133)
  AUTHORS   Sharif,A.S., Yu,D., Loertscher,S., Austin,R., Nguyen,K.,
            Mathur,P.D., Clark,A.M., Zou,J., Lobanova,E.S., Arshavsky,V.Y. and
            Yang,J.
  TITLE     C8ORF37 Is Required for Photoreceptor Outer Segment Disc
            Morphogenesis by Maintaining Outer Segment Membrane Protein
            Homeostasis
  JOURNAL   J Neurosci 38 (13), 3160-3176 (2018)
   PUBMED   29440555
REFERENCE   6  (bases 1 to 2133)
  AUTHORS   Alavizadeh,A., Kiernan,A.E., Nolan,P., Lo,C., Steel,K.P. and
            Bucan,M.
  TITLE     The Wheels mutation in the mouse causes vascular, hindbrain, and
            inner ear defects
  JOURNAL   Dev Biol 234 (1), 244-260 (2001)
   PUBMED   11356033
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX220600.1, BM948390.1, AK003887.1 and AI840411.1.
            
            On Jan 17, 2008 this sequence version replaced NM_026005.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058777.1, SRR1660817.249442.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               CX220600.1         1-128
            129-870             BM948390.1         1-742
            871-1741            AK003887.1         286-1156
            1742-2133           AI840411.1         1-392               c
FEATURES             Location/Qualifiers
     source          1..2133
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 4.85 cM"
     gene            1..2133
                     /gene="Cfap418"
                     /gene_synonym="2610301B20Rik"
                     /note="cilia and flagella associated protein 418"
                     /db_xref="GeneID:67157"
                     /db_xref="MGI:MGI:1914407"
     exon            1..275
                     /gene="Cfap418"
                     /gene_synonym="2610301B20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..747
                     /gene="Cfap418"
                     /gene_synonym="2610301B20Rik"
                     /note="protein C8orf37 homolog"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 418"
                     /protein_id="NP_080281.3"
                     /db_xref="CCDS:CCDS17961.1"
                     /db_xref="GeneID:67157"
                     /db_xref="MGI:MGI:1914407"
                     /translation="MAKDLDELLDEVETKFCRLDPLRLDLGERPKGDGGGGSHSGDRN
                     GAQEKETLRSTETFKKEDDLDSLINEIFEEPDFDRKSFQKFKSKSSSNTCVRAPMQGV
                     SKSCSPVYLSGSAIPCGIGTNTSQRACDRLRCVACDFRIVSYNDYMWDKSCDYLFFRN
                     NMPEFHKLKTKLIEKKGARAYACQCSWRTVEELTDLQTDHQLRWVCGKH"
     exon            276..363
                     /gene="Cfap418"
                     /gene_synonym="2610301B20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            364..431
                     /gene="Cfap418"
                     /gene_synonym="2610301B20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            432..497
                     /gene="Cfap418"
                     /gene_synonym="2610301B20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            498..593
                     /gene="Cfap418"
                     /gene_synonym="2610301B20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            594..2120
                     /gene="Cfap418"
                     /gene_synonym="2610301B20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2097..2102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfap418"
                     /gene_synonym="2610301B20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2120
                     /gene="Cfap418"
                     /gene_synonym="2610301B20Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggtttgcgca ggcgcggaag gttgtgggga acccgctccc gggcgcgtcg gtttctcgcg
       61 ttgccgtgga aaccaccggc cagcgaggct cgggagagaa agacgcgtct gttcaagatg
      121 gcgaaggacc tggacgaact tctggatgaa gtcgagacca agttctgcag actcgacccc
      181 ttgaggctgg acctgggtga gcggcccaaa ggcgacggcg gcggcggctc gcacagcggc
      241 gaccggaacg gagcccagga gaaagaaact ctcagatcaa cagaaacatt taaaaaagaa
      301 gatgatcttg acagtcttat taatgaaata ttcgaggagc ctgactttga cagaaaatct
      361 tttcaaaaat ttaaatctaa atcttcaagt aacacatgtg tcagagctcc catgcaaggc
      421 gtcagtaaaa gttgcagtcc agtgtatctc agtggaagcg ccattccatg tgggattgga
      481 acaaatactt cacagagagc atgtgaccga ctgcgttgtg tagcctgtga tttccggata
      541 gtgagctaca atgactatat gtgggacaag tcatgtgact acctgttctt cagaaacaac
      601 atgccagaat tccacaaact caaaacaaaa ttgatcgaga agaaaggagc acgggcatat
      661 gcctgccagt gtagctggag aactgttgaa gaactcactg acctgcagac agatcatcag
      721 cttcgctggg tgtgtggtaa acactgagag tgcagacagc ggcacctgtg agaacaagtt
      781 ccgggtacca gcttgggtac cagtgcacag cagtattgtg cgcgctggga aaaggcaaca
      841 aatgctgtgt aaccacacat gtctgaagac caaatggact ggaaaaggca tgcgtactgt
      901 gacaccttgg cattcttcct ttcgacgtgg acattttact taggttaaaa tatctgcgtt
      961 tgccagcata tcacctttta gggactgaaa tagtgacatc ccgtgcagat ttacagcttt
     1021 tttatagcaa ctgccatact gactgctaat gcactctaaa atgttcctca tgtgtcatcg
     1081 ttgttaaaga atacccactg gcatggcaga gaggtcattg tatatgagtg ttcatggctc
     1141 ttcctattct gatccatcat tgtctgagac tataagttga acatgacaga aaagcagatg
     1201 accattggtt aactgaggag ttggcaagaa tacaggaaca ttgtaaccct gccttttatg
     1261 tatctcatct tgcctcacca actcaattca gtattatgca taatagtaat aatgatgtta
     1321 ccagttttag tgtatttcct cctttgctca ctgaaatagc aaaagttgtt agttttctat
     1381 tagcaaacat atatatatac atatatatgt tttgatgcaa ctaaagttac taaaatccta
     1441 aaaataagtc gttgttagac ttttcaagta tactccataa ctctaaatga gcagcagtaa
     1501 gatgactttc agacaacctg tatactttct aatagtatca ggttggccca ttctttattg
     1561 aagcataaag aaccaatggg tagctcgtgg gctcctgtga tatcactgag atgggaggaa
     1621 ctgtatcata catagtaacg ttcaagaaat gcattgcctc agttttacct cccagcccca
     1681 tagacatttc agggcttttc tagtctgcta gagttctttt ctgtgtgacc atttcctgtg
     1741 tgtgtattac ttaagtgtgt gacactgggc actctgaaag gaagtacatt ttagcccaga
     1801 tatgatctgc ttgcttttca gttaactcca ttcttgccac caagcaaatc ctctgagtgc
     1861 taaaagcttt ttcctaggct agggtctagc ttggcaatag agtacttgca ttgcatgtac
     1921 aagaccctaa atttattccc agtggtacaa aagaaaaaag aaagacagag aggcaagctt
     1981 ttcctcacca tgacacattt atgtacttaa aaaaaacttt aattgcagca aaagagatct
     2041 caaagtggct gatgctcaag tttttgtatt aagattattt gcaaatttta tctttcaata
     2101 aaccaattta ctcctcaaaa aaaaaaaaaa aaa
//
