LOCUS       NM_026431               1696 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus cilia and flagella associated protein 410 (Cfap410),
            mRNA.
ACCESSION   NM_026431 XM_489736
VERSION     NM_026431.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1696)
  AUTHORS   Zelina,P., de Ruiter,A.A., Kolsteeg,C., van Ginneken,I., Vos,H.R.,
            Supiot,L.F., Burgering,B.M.T., Meye,F.J., Veldink,J.H., van den
            Berg,L.H. and Pasterkamp,R.J.
  TITLE     ALS-associated C21ORF2 variant disrupts DNA damage repair,
            mitochondrial metabolism, neuronal excitability and NEK1 levels in
            human motor neurons
  JOURNAL   Acta Neuropathol Commun 12 (1), 144 (2024)
   PUBMED   39227882
  REMARK    GeneRIF: ALS-associated C21ORF2 variant disrupts DNA damage repair,
            mitochondrial metabolism, neuronal excitability and NEK1 levels in
            human motor neurons.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1696)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1696)
  AUTHORS   Dharmat,R., Eblimit,A., Robichaux,M.A., Zhang,Z., Nguyen,T.T.,
            Jung,S.Y., He,F., Jain,A., Li,Y., Qin,J., Overbeek,P., Roepman,R.,
            Mardon,G., Wensel,T.G. and Chen,R.
  TITLE     SPATA7 maintains a novel photoreceptor-specific zone in the distal
            connecting cilium
  JOURNAL   J Cell Biol 217 (8), 2851-2865 (2018)
   PUBMED   29899041
REFERENCE   4  (bases 1 to 1696)
  AUTHORS   Wang,Z., Iida,A., Miyake,N., Nishiguchi,K.M., Fujita,K.,
            Nakazawa,T., Alswaid,A., Albalwi,M.A., Kim,O.H., Cho,T.J.,
            Lim,G.Y., Isidor,B., David,A., Rustad,C.F., Merckoll,E.,
            Westvik,J., Stattin,E.L., Grigelioniene,G., Kou,I., Nakajima,M.,
            Ohashi,H., Smithson,S., Matsumoto,N., Nishimura,G. and Ikegawa,S.
  TITLE     Axial Spondylometaphyseal Dysplasia Is Caused by C21orf2 Mutations
  JOURNAL   PLoS One 11 (3), e0150555 (2016)
   PUBMED   26974433
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1696)
  AUTHORS   Wheway,G., Schmidts,M., Mans,D.A., Szymanska,K., Nguyen,T.T.,
            Racher,H., Phelps,I.G., Toedt,G., Kennedy,J., Wunderlich,K.A.,
            Sorusch,N., Abdelhamed,Z.A., Natarajan,S., Herridge,W., van
            Reeuwijk,J., Horn,N., Boldt,K., Parry,D.A., Letteboer,S.J.F.,
            Roosing,S., Adams,M., Bell,S.M., Bond,J., Higgins,J.,
            Morrison,E.E., Tomlinson,D.C., Slaats,G.G., van Dam,T.J.P.,
            Huang,L., Kessler,K., Giessl,A., Logan,C.V., Boyle,E.A.,
            Shendure,J., Anazi,S., Aldahmesh,M., Al Hazzaa,S., Hegele,R.A.,
            Ober,C., Frosk,P., Mhanni,A.A., Chodirker,B.N., Chudley,A.E.,
            Lamont,R., Bernier,F.P., Beaulieu,C.L., Gordon,P., Pon,R.T.,
            Donahue,C., Barkovich,A.J., Wolf,L., Toomes,C., Thiel,C.T.,
            Boycott,K.M., McKibbin,M., Inglehearn,C.F., Stewart,F., Omran,H.,
            Huynen,M.A., Sergouniotis,P.I., Alkuraya,F.S., Parboosingh,J.S.,
            Innes,A.M., Willoughby,C.E., Giles,R.H., Webster,A.R., Ueffing,M.,
            Blacque,O., Gleeson,J.G., Wolfrum,U., Beales,P.L., Gibson,T.,
            Doherty,D., Mitchison,H.M., Roepman,R. and Johnson,C.A.
  CONSRTM   UK10K Consortium; University of Washington Center for Mendelian
            Genomics
  TITLE     An siRNA-based functional genomics screen for the identification of
            regulators of ciliogenesis and ciliopathy genes
  JOURNAL   Nat Cell Biol 17 (8), 1074-1087 (2015)
   PUBMED   26167768
REFERENCE   6  (bases 1 to 1696)
  AUTHORS   Lai,C.K., Gupta,N., Wen,X., Rangell,L., Chih,B., Peterson,A.S.,
            Bazan,J.F., Li,L. and Scales,S.J.
  TITLE     Functional characterization of putative cilia genes by high-content
            analysis
  JOURNAL   Mol Biol Cell 22 (7), 1104-1119 (2011)
   PUBMED   21289087
REFERENCE   7  (bases 1 to 1696)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   8  (bases 1 to 1696)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   9  (bases 1 to 1696)
  AUTHORS   Wiltshire,T., Pletcher,M., Cole,S.E., Villanueva,M., Birren,B.,
            Lehoczky,J., Dewar,K. and Reeves,R.H.
  TITLE     Perfect conserved linkage across the entire mouse chromosome 10
            region homologous to human chromosome 21
  JOURNAL   Genome Res 9 (12), 1214-1222 (1999)
   PUBMED   10613844
REFERENCE   10 (bases 1 to 1696)
  AUTHORS   Cole,S.E., Wiltshire,T., Rue,E.E., Morrow,D., Hieter,P., Brahe,C.,
            Fisher,E.M., Katsanis,N. and Reeves,R.H.
  TITLE     High-resolution comparative physical mapping of mouse chromosome 10
            in the region of homology with human chromosome 21
  JOURNAL   Mamm Genome 10 (3), 229-234 (1999)
   PUBMED   10051316
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004032.1, AK075794.1 and AK153233.1.
            
            On Mar 20, 2007 this sequence version replaced NM_026431.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075794.1, AK003097.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AK004032.1         3-16
            15-27               AK075794.1         2-14
            28-676              AK153233.1         8-656
            677-1696            AK075794.1         664-1683
FEATURES             Location/Qualifiers
     source          1..1696
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1696
                     /gene="Cfap410"
                     /gene_synonym="1810043G02Rik; D10Jhu13e"
                     /note="cilia and flagella associated protein 410"
                     /db_xref="GeneID:67884"
                     /db_xref="MGI:MGI:1915134"
     exon            1..132
                     /gene="Cfap410"
                     /gene_synonym="1810043G02Rik; D10Jhu13e"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..805
                     /gene="Cfap410"
                     /gene_synonym="1810043G02Rik; D10Jhu13e"
                     /note="protein C21orf2 homolog"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 410"
                     /protein_id="NP_080707.2"
                     /db_xref="CCDS:CCDS35954.1"
                     /db_xref="GeneID:67884"
                     /db_xref="MGI:MGI:1915134"
                     /translation="MKLTRKMVLSRAKASELHNVRKLNCWGSQLTDISICREMPSLEV
                     ITLSVNSVSTLEPVRSCRRLSELYLRRNRIPSLNELFYLKDLPHLRVLWLAENPCCGT
                     SPHLYRMTVLRNLPHLQKLDNQAVTEEELTRALMEGDEITAAPHREGAGNGCPKPPYA
                     LNSVSSATETSQHLLSYTEETEVQGQTTTDQSPSFSPRDTMRSHKNRNILTAILLLLR
                     ELDTEGLETVQQTVGSRLQALHRPEPQEDME"
     exon            133..151
                     /gene="Cfap410"
                     /gene_synonym="1810043G02Rik; D10Jhu13e"
                     /inference="alignment:Splign:2.1.0"
     exon            152..198
                     /gene="Cfap410"
                     /gene_synonym="1810043G02Rik; D10Jhu13e"
                     /inference="alignment:Splign:2.1.0"
     exon            199..428
                     /gene="Cfap410"
                     /gene_synonym="1810043G02Rik; D10Jhu13e"
                     /inference="alignment:Splign:2.1.0"
     exon            429..600
                     /gene="Cfap410"
                     /gene_synonym="1810043G02Rik; D10Jhu13e"
                     /inference="alignment:Splign:2.1.0"
     exon            601..676
                     /gene="Cfap410"
                     /gene_synonym="1810043G02Rik; D10Jhu13e"
                     /inference="alignment:Splign:2.1.0"
     exon            677..1696
                     /gene="Cfap410"
                     /gene_synonym="1810043G02Rik; D10Jhu13e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1039..1044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfap410"
                     /gene_synonym="1810043G02Rik; D10Jhu13e"
                     /note="hexamer: AATAAA"
     polyA_site      1066
                     /gene="Cfap410"
                     /gene_synonym="1810043G02Rik; D10Jhu13e"
                     /note="major polyA site"
     regulatory      1676..1681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfap410"
                     /gene_synonym="1810043G02Rik; D10Jhu13e"
                     /note="hexamer: AATAAA"
     polyA_site      1696
                     /gene="Cfap410"
                     /gene_synonym="1810043G02Rik; D10Jhu13e"
                     /note="major polyA site"
ORIGIN      
        1 cccgctagcc gagtgtacag cggagggcgg ccgggcccgc ggccctgtgg ccaccatgaa
       61 gctgacacga aagatggtcc tgtcccgagc caaggcttcg gagctgcaca acgtgcggaa
      121 gctcaactgc tggggcagcc agctcacaga tatttccata tgccgggaga tgcccagcct
      181 agaggtaatc acactcagtg tcaacagtgt ctccaccctg gaaccggtgc gcagctgcag
      241 gcgcctgagc gagctgtacc tgaggaggaa ccgcatcccc agtctgaacg agctgttcta
      301 cctgaaagac ctgccacacc tcagggtgct ctggctggcc gagaacccgt gctgtggcac
      361 cagcccgcac ctttaccgca tgaccgtgct gcgcaacctg ccccacctgc agaagctaga
      421 caaccaagct gtgaccgagg aagagctgac ccgcgcgctg atggagggag atgagatcac
      481 tgccgccccg cacagagaag gtgcaggcaa tggctgtccc aagcccccct acgccctcaa
      541 ctctgtcagc tctgcaactg agaccagcca gcacctgctg agctacacag aggagacaga
      601 agtccagggc cagactacca cagaccagtc tccttccttc tcaccaaggg acacgatgag
      661 gagtcacaag aataggaaca tcctgactgc catattgcta ctgctgcggg agctggatac
      721 ggaggggctg gagactgtcc agcagaccgt gggcagccgg ctacaggcgc tgcacaggcc
      781 ggagccccag gaagacatgg agtgatttca gacgccccag tatctggacc cttttatatc
      841 ctgaggaaac acagccctac ctggaaagcc ttcaaagcag gcccagtggc tgccagcaaa
      901 gcagacccct ctcctgtgct gagggctggc agaaatgctg cccaccagca tggtccctgg
      961 gacttacctg ctgaggccca aagctctggg cactgtctga cccttcctca agggaggcct
     1021 gaaggagcca taccctccaa taaagcactt tctgtttgag ctggaaggtc tgggacagga
     1081 agcatctcgg ggccttgacg ttgaggttca tgttgtttct cagccgctag ggggagccct
     1141 agtatcactg tatcaagcct acccttggag atgcctagaa tatctttacg gggcactgtg
     1201 tcccagctgt ccttagacat agcctgggag aatggaattt tttgtttttt caggacaagg
     1261 ctggtcagga cactgtcctt tttctttctt cttcaggaga gggatgtcac ctgagtgact
     1321 gttgctcgtc attctgaggc gccagatgcc attggtaaag ttgtcttcgt tagagccatt
     1381 aattggggga ggccctgtag cttacctagg cagggccacc ttggtgcctt ggggtgacct
     1441 tacacctgcc ataagagaac gagccaggaa aggccccaag attagcatat gtaaagcaac
     1501 ctaagcaaaa aaagtctaga agggccctta gagggacagg tagaacatgc caaagaagcc
     1561 tgctggctct gtagatgacc tgtaagggtc ttaatgctga aggttcaggg cagctgggcc
     1621 cttggctttg ctccaccgct ggcccacttc gaaacctggg agtgctttct ctcttaataa
     1681 actgttttta ccagtg
//
