LOCUS       NM_001370840            4771 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus cilia and flagella associated protein 251 (Cfap251),
            mRNA.
ACCESSION   NM_001370840 XM_006530515
VERSION     NM_001370840.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4771)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Wdr66 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
REFERENCE   2  (bases 1 to 4771)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163337.2 and AC113504.10.
            
            On Jun 6, 2019 this sequence version replaced XM_006530515.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849383,
                              SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-971               AC163337.2         68376-69346         c
            972-1214            AC163337.2         66888-67130         c
            1215-1352           AC163337.2         60980-61117         c
            1353-1462           AC163337.2         58234-58343         c
            1463-1574           AC163337.2         49271-49382         c
            1575-1655           AC163337.2         48887-48967         c
            1656-1733           AC163337.2         44753-44830         c
            1734-1784           AC163337.2         43149-43199         c
            1785-2002           AC163337.2         39564-39781         c
            2003-2197           AC163337.2         36701-36895         c
            2198-2448           AC163337.2         35724-35974         c
            2449-2600           AC163337.2         35369-35520         c
            2601-2774           AC163337.2         34318-34491         c
            2775-2959           AC163337.2         33068-33252         c
            2960-3074           AC163337.2         25599-25713         c
            3075-3238           AC163337.2         24504-24667         c
            3239-3329           AC163337.2         20670-20760         c
            3330-3473           AC163337.2         20297-20440         c
            3474-3702           AC163337.2         473-701             c
            3703-3804           AC113504.10        78953-79054
            3805-4771           AC113504.10        81156-82122
FEATURES             Location/Qualifiers
     source          1..4771
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.86 cM"
     gene            1..4771
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /note="cilia and flagella associated protein 251"
                     /db_xref="GeneID:269701"
                     /db_xref="MGI:MGI:1918495"
     exon            1..971
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..3917
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /note="WD repeat-containing protein 66; WD repeat domain
                     66"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 251"
                     /protein_id="NP_001357769.1"
                     /db_xref="CCDS:CCDS89985.1"
                     /db_xref="GeneID:269701"
                     /db_xref="MGI:MGI:1918495"
                     /translation="MSDTEENPLEESRESGEMEEEKEEKKEEEEEEEEGEKEKEEEEE
                     EEKGKEEEKEEEKEEGKEEEKKEEEEEKGKKEEEEEEEEEGKGKEEEKEEEKEEEEKE
                     EEKEKEEEEEEEGKGKEEEEEGKEEEEEEKEEEEKEEEKEEEEEEEEEKEEYNPSFEE
                     DALQQSLTEGSLSWEESQEDGEGLEEWVEKEEQREGEEVRGEEESEVRGREEEEGWEE
                     EKSGEEEKSEESERSKERGGEEEGQEKEEAEHEGEREEGREEEEKEKSVEREEEEEEE
                     DTETTETKAGRAKEEKKEKQNKTALVDNIVISHEPPRSSSSLADSPEVSQIYKDNSMK
                     VDDTEEASQKPEDILAQGKDEARLSLEERRKLFQSKGLSAEESLVSVSTEDTLFQKEE
                     DSKVYPLSMTWSFGWNSSLPVYYMREDRRVILYTCAHTAIMYDVVRNTQYHLQGHPNI
                     ISCLCVSEDRRWIATADEGPDCLIIIWDSFTGIPVHTIFDSCPEGNGMRSIAITRDSK
                     FLATISDSATQKVCIWKWTLAVETPACTLELPKEYGFQDNLVFNPANNKELVSNSKTQ
                     AIYYCWFEDKGILAHSAPVLTEKTFNKLVGKFSQSVFHLKLPQVLSATKEGKLVVWDI
                     HYPSSTSSSAISAFPFIKPRKLVHLQKEAITVLMTIDSYIVTGDIKGNIKFYDHTLSV
                     VNWYSNFKLGAIRTLSFSKTIPSLPTEKSNLPTDCTLRGDLFVVRNFIIGTFDATVYH
                     MTVDGTKLEKLFVEPRDAVYAVSCHPYQPLIAVGSVCGMIKVWDFEKKVYLFSRTFEK
                     GLGVQCLTYNPEGALLGAGFTEGTVYILDAMSLENESPEPFKYSKSSVSHCCFSHDSN
                     YMATADVNFTVAVYMVVVKNGQRVWEYLARLRSHQNSIQSLLFGVHLDSNEPRLLSLG
                     KDRFLIEYNLVKSCKDHLDVLDVHRTDQGNYPTCMIWYPPLTKELFLLICNSGYKVKL
                     FNATTKMCRKTLLGPAYGSPIEHAQVLPVKSTLELQKRYLVFINKDKVGLQILPVDGN
                     PHKTCAIVCHPNGVAGMALSYDGRFAFTAGGQDRSVVQWKINLGALEAAVSLGGEDLT
                     PFYGLVSGGREGKFYRELEDYFYYSQIRSQGIDTMETRQVSEHICLSELPFVMRAIGF
                     YPSEEKIEDMFNEIKFSEYVETGKLIDKINLPDFLKVYLNHRPPFGNTMDGIQNSFNV
                     LGYTNSEGKKAIRREDFLNLLLTKGEHMTEEEMIDCFSTLFGLTPEGWKSEPAATCIN
                     GPEICLQKELPEEITAEIFTTEILGLTLSDSSEQLIQ"
     exon            972..1214
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1352
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1462
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1574
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1655
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1733
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1784
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..2002
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2197
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2448
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2600
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2774
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2959
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     exon            2960..3074
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3238
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..3329
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     exon            3330..3473
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     exon            3474..3702
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     exon            3703..3804
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     exon            3805..4771
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4054..4059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /note="hexamer: ATTAAA"
     polyA_site      4084
                     /gene="Cfap251"
                     /gene_synonym="4930415N18Rik; 4933428F06Rik; 5031404N07;
                     Wdr66"
                     /note="major polyA site"
ORIGIN      
        1 cggaaactac agaagaaatg tcagatacag aagaaaaccc cctagaagaa tcaagagaaa
       61 gtggagagat ggaggaggag aaggaggaga agaaggagga ggaagaggag gaagaggagg
      121 gggagaagga gaaggaggag gaggaagagg aggagaaggg gaaggaggag gagaaggagg
      181 aggagaagga ggaggggaag gaggaggaga agaaggagga agaggaggag aaggggaaga
      241 aggaggaaga ggaggaggag gaagaggagg ggaaggggaa ggaggaggag aaggaggagg
      301 agaaggagga ggaggagaag gaggaggaga aggagaagga ggaggaggag gaagaggagg
      361 ggaaggggaa ggaggaggag gaggagggga aggaggagga ggaggaggag aaggaggagg
      421 aggagaagga ggaggagaag gaggaggagg aggaggagga ggaggagaag gaggaatata
      481 atccaagttt tgaagaagat gctctgcagc agagcctaac tgagggctca ctgtcatggg
      541 aggagtctca ggaggatgga gaggggctgg aggagtgggt ggagaaggag gagcagagag
      601 agggagagga agtgagaggg gaggaagaaa gtgaagtgag aggaagggaa gaggaagagg
      661 gatgggagga agagaagagc ggtgaagagg aaaaaagtga ggagagcgag agaagtaagg
      721 aaaggggagg tgaggaagag ggccaggaga aggaagaggc ggaacatgag ggggaaaggg
      781 aggagggaag agaagaggaa gagaaagaga agagtgtgga gcgggaggag gaggaggagg
      841 aggaagatac tgagacaact gagacaaaag ctggacgagc caaggaggaa aagaaagaga
      901 agcaaaacaa aacagccctg gtggacaata ttgtcatcag ccatgagcca cccaggtcaa
      961 gctcctccct ggctgatagt ccagaagtaa gccagattta caaagataac agtatgaaag
     1021 tggatgatac cgaggaagcc agccagaagc ctgaagacat tttagcccaa ggaaaagatg
     1081 aagcaagact ctccctggaa gaaagacgaa aattattcca gtccaaagga ctgagtgcgg
     1141 aggagtcact ggtgtctgtc tccacagagg acaccttatt ccagaaggag gaggactcca
     1201 aggtgtaccc tttgagcatg acctggtcct ttggctggaa cagttcgctc cctgtctact
     1261 acatgcggga agacaggaga gtcatccttt acacctgtgc tcacaccgcc atcatgtacg
     1321 acgtcgtcag gaacacccag taccatctgc agggccaccc taacatcatc tcttgcctct
     1381 gtgttagcga agacagacga tggattgcca cagcagacga aggaccagac tgcctcataa
     1441 ttatttggga ttccttcacg ggaatccccg tgcacaccat atttgacagc tgtccagaag
     1501 gtaatggcat gaggtcaata gccatcaccc gtgactccaa gtttctggcc accatctcag
     1561 attctgcaac ccagaaagtt tgcatctgga agtggacttt ggcagtggag acgcccgcat
     1621 gcacacttga gcttcccaag gagtatggtt ttcaggataa cctcgtcttc aacccagcca
     1681 acaacaaaga gttggtgagc aacagcaaga ctcaggccat ctactactgc tggtttgaag
     1741 acaagggtat acttgctcac agtgccccgg ttttaacaga gaaaacgttc aacaaacttg
     1801 tggggaaatt tagccagtct gtctttcact tgaagttacc acaagtactg tcggcaacaa
     1861 aggaagggaa gctggttgtc tgggacatac actacccatc ttccacctcc tcctccgcca
     1921 tctcggcctt ccctttcatc aagcctcgta aactggtcca tttacagaag gaggccatca
     1981 cggtgctcat gacaatcgac agctacattg tcaccggtga cattaagggc aacattaagt
     2041 tctacgacca caccctctcc gtggtcaact ggtacagcaa cttcaaactg ggcgccataa
     2101 ggactctgtc cttttcaaaa accataccaa gcctgccaac cgagaagtcc aacctcccca
     2161 cagactgcac tctaagaggc gaccttttcg ttgtcaggaa ttttatcatt gggacgtttg
     2221 acgccaccgt gtaccacatg accgtggatg gcaccaaact tgagaagctc ttcgtggaac
     2281 ccagggacgc tgtctatgcc gtctcctgcc acccatacca acccctcatc gcagtcggga
     2341 gtgtctgcgg gatgatcaag gtgtgggact tcgagaagaa ggtctatctg ttcagcagga
     2401 ccttcgagaa ggggcttgga gtccagtgtc tgacctacaa tcccgaagga gccctgcttg
     2461 gagctggatt caccgagggg acagtttata ttcttgatgc gatgtcttta gaaaatgaaa
     2521 gcccggagcc cttcaaatat tccaaaagca gcgtgtccca ctgctgcttc tcacacgact
     2581 ccaattacat ggcgacagcc gacgtcaact tcactgtggc cgtctatatg gtggtggtca
     2641 aaaatggaca aagggtctgg gagtatttgg caagacttcg ctctcaccaa aacagcatcc
     2701 aaagcctcct gttcggcgtc cacctggaca gcaatgagcc caggctgctg agccttggga
     2761 aagacagatt cttgatcgag tacaatcttg tcaagagctg caaagaccac ctggatgtcc
     2821 tggacgttca ccggacagac cagggcaact acccgacctg catgatctgg tacccgccgc
     2881 tcaccaagga actcttcctg ctcatctgca acagcggcta caaagtgaag ctcttcaatg
     2941 ccaccacgaa gatgtgcaga aagacgctcc ttggaccggc gtatgggtcg cctattgagc
     3001 atgcgcaggt gctccccgta aaatccacgc tagagctgca gaagcgatac ttggtgttca
     3061 ttaacaagga caaggttgga ctccagatct taccagttga cggcaacccc cacaaaacat
     3121 gtgctatcgt ttgccaccca aacggggtgg ctgggatggc cctttcctat gatggccgct
     3181 ttgccttcac agccggaggc caagatcgct cagtggtgca gtggaaaatt aacttagggg
     3241 ccctggaggc tgccgtttcc cttgggggtg aagacttgac cccgttctat ggtctggtgt
     3301 ctggtggcag ggaaggaaaa ttctacaggg agttggagga ctatttttac tactctcaga
     3361 tccgcagtca aggtatcgat acaatggaga ccaggcaggt gtcggaacat atttgcctgt
     3421 cggagcttcc ttttgtcatg agagcgatcg gtttttaccc gtcagaggag aagattgagg
     3481 acatgtttaa tgagatcaag ttcagcgaat acgtggagac cgggaagctc atcgacaaga
     3541 tcaacctccc ggatttcctc aaagtttacc ttaaccatag gccacctttc ggcaacacta
     3601 tggacggcat ccagaacagc ttcaacgtgc tgggttacac caattcggaa gggaaaaagg
     3661 ccattcggag agaggatttc ctgaacttac tcctcaccaa aggggagcac atgacagaag
     3721 aagagatgat cgactgtttc tcgactctgt ttggcctgac tccggagggg tggaaatcgg
     3781 agcctgcagc cacctgcatc aacggtccag aaatctgcct ccagaaagag cttcccgagg
     3841 aaatcactgc agaaatattc accacggaaa ttcttggctt aaccctttcc gacagctcgg
     3901 aacagctcat tcagtgacgt cattggcgat gctggcagca caaagggctc cgtgtgtgct
     3961 tgcacatgtg tgtgcatgtt ccaagaggtg tccccttttc tgtccatgcc caccccccac
     4021 cacccccagc ctaatctttg gagcatttta gacattaaaa gcaaatttct cttaggcagt
     4081 ggaattcaca gagttggaca ttgcactgtc tgtgaaagag aagagtaggc ggaagcgaga
     4141 acaggcctga cagctggatc gccaggcctg aaggagcctc agccagcaga gtctgtgctg
     4201 catggacgtc atagccagcc gctcataccc cgaaactggg gtggggtggg gggaggtgtt
     4261 ctgggctcct gggagtgcca gactatttta cttcccagca aaacacccaa gcagttgtgt
     4321 gtggccatga cagcaagcat caccagtcat gcctaacccc ggtgacaact gccaaagaga
     4381 atgcagaagc aacctgggtc ccgcaaactg caggtggccc agaagccacg gggtcctgct
     4441 cctgaaggat gcaaatggca gatgctgctt caccccctca ctttctgcca ggcttcaatg
     4501 cacacagtgg tcaaaaccag tggacactag gggacacagc taagtttgca gtgatgtctt
     4561 attcctgcac tatggcataa caagtgaacg ctacggtcta cttttgtagg ttttctctca
     4621 gttctgagga ctctttcctg ccagtgtccc cagtgatacg tctctatcac actctgtcca
     4681 gtgtgcctgc ccacccccac cagggccttc tcagacaact gcgttaagga aacatttctt
     4741 taggggaagg gattaaactt tctcttctct t
//
