LOCUS       NM_001347062            2231 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cilia and flagella associated protein 206 (Cfap206),
            transcript variant 1, mRNA.
ACCESSION   NM_001347062 XM_011250100
VERSION     NM_001347062.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2231)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2231)
  AUTHORS   Shen,Q., Martinez,G., Liu,H., Beurois,J., Wu,H., Amiri-Yekta,A.,
            Liang,D., Kherraf,Z.E., Bidart,M., Cazin,C., Celse,T., Satre,V.,
            Thierry-Mieg,N., Whitfield,M., Toure,A., Song,B., Lv,M., Li,K.,
            Liu,C., Tao,F., He,X., Zhang,F., Arnoult,C., Ray,P.F., Cao,Y. and
            Coutton,C.
  TITLE     Bi-allelic truncating variants in CFAP206 cause male infertility in
            human and mouse
  JOURNAL   Hum Genet 140 (9), 1367-1377 (2021)
   PUBMED   34255152
  REMARK    GeneRIF: Bi-allelic truncating variants in CFAP206 cause male
            infertility in human and mouse.
REFERENCE   3  (bases 1 to 2231)
  AUTHORS   Beckers,A., Adis,C., Schuster-Gossler,K., Tveriakhina,L., Ott,T.,
            Fuhl,F., Hegermann,J., Boldt,K., Serth,K., Rachev,E., Alten,L.,
            Kremmer,E., Ueffing,M., Blum,M. and Gossler,A.
  TITLE     The FOXJ1 target Cfap206 is required for sperm motility,
            mucociliary clearance of the airways and brain development
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32376681
  REMARK    GeneRIF: The FOXJ1 target Cfap206 is required for sperm motility,
            mucociliary clearance of the airways and brain development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2231)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: 1700003M02Rik is most abundantly expressed in tissues rich
            in highly ciliated cells, such as olfactory sensory neurons and
            testis, and is predicted to be important to cilia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928738.8.
            
            On Nov 15, 2016 this sequence version replaced XM_011250100.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.133168.1,
                                           SRR7345562.159346.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AL928738.8         125562-125708       c
            148-260             AL928738.8         124298-124410       c
            261-344             AL928738.8         123407-123490       c
            345-435             AL928738.8         120317-120407       c
            436-624             AL928738.8         118110-118298       c
            625-783             AL928738.8         116918-117076       c
            784-992             AL928738.8         115075-115283       c
            993-1112            AL928738.8         114547-114666       c
            1113-1311           AL928738.8         111807-112005       c
            1312-1452           AL928738.8         109897-110037       c
            1453-1646           AL928738.8         106904-107097       c
            1647-1790           AL928738.8         87889-88032         c
            1791-2231           AL928738.8         84076-84516         c
FEATURES             Location/Qualifiers
     source          1..2231
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 16.86 cM"
     gene            1..2231
                     /gene="Cfap206"
                     /gene_synonym="1700003M02Rik"
                     /note="cilia and flagella associated protein 206"
                     /db_xref="GeneID:69329"
                     /db_xref="MGI:MGI:1916579"
     exon            1..147
                     /gene="Cfap206"
                     /gene_synonym="1700003M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            148..260
                     /gene="Cfap206"
                     /gene_synonym="1700003M02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..2021
                     /gene="Cfap206"
                     /gene_synonym="1700003M02Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0704 protein C6orf165 homolog"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 206
                     isoform 1"
                     /protein_id="NP_001333991.1"
                     /db_xref="CCDS:CCDS84713.1"
                     /db_xref="GeneID:69329"
                     /db_xref="MGI:MGI:1916579"
                     /translation="MPPTQAESVIKNIIREIGQECAAHGEIASETVVAFMVKAVVLDP
                     SNGFNMDRTLIKTDVQKLVKLCVARLLDNKNPSLDTIKMQVYFDMNYTSREDFLEEHH
                     RVLESRLGIVSREITDNRASAREELENLYRKIVSYVLLRSGLGSPTDIKIVREATAAL
                     QSVFPQAELATFLTLSKKDKERQLKELTMIVTGIRLFNRDCGKGGEGIDDLPAILHEA
                     IPTTTQHIDSQLQIAQDQAFRYTAILEKVTNNPLMAKELQPYMLKEALYNVRQYEIFL
                     QTVLSDIITCAEEVEMMIKQLAAQLEQLKMAVKSKTAVPTSQVFPIFVALASLWMSFQ
                     DETVLISVLSNLTTNLELFLGTHELLFPEKVMLGLLDGVVVKSDLTRIEEHMEERVEL
                     ADFRTQEWLFPETTANFNKLLIQYRGFCGYTFAVTDGLLLPGNPAIGILKYKEKYYTF
                     STRDAAYTFAENPDHYIHLIKEKAKKNAELIQLLELHQQFETLIPYSQMRDVDKHYIK
                     PITKCDNGTQTDTHILPPTTMRTYEWNEWELRRKAIKLANLRQKITHSVQTDLSHMRR
                     DNTSQVYPLKEASTQSKREGSSRVPRPQIFIAGLRGGQSKTTYGVKVNLTRAVDET"
     exon            261..344
                     /gene="Cfap206"
                     /gene_synonym="1700003M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            345..435
                     /gene="Cfap206"
                     /gene_synonym="1700003M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            436..624
                     /gene="Cfap206"
                     /gene_synonym="1700003M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            625..783
                     /gene="Cfap206"
                     /gene_synonym="1700003M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            784..992
                     /gene="Cfap206"
                     /gene_synonym="1700003M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1112
                     /gene="Cfap206"
                     /gene_synonym="1700003M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1311
                     /gene="Cfap206"
                     /gene_synonym="1700003M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1452
                     /gene="Cfap206"
                     /gene_synonym="1700003M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1646
                     /gene="Cfap206"
                     /gene_synonym="1700003M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1790
                     /gene="Cfap206"
                     /gene_synonym="1700003M02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..2231
                     /gene="Cfap206"
                     /gene_synonym="1700003M02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2208..2213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfap206"
                     /gene_synonym="1700003M02Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2230
                     /gene="Cfap206"
                     /gene_synonym="1700003M02Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcttaggatc tggggctggc cgggagagcc gcggccggtt ggcgttccgg ccaagcccag
       61 cgcccaggga gctccaggcc gttaagtcgc gggtgtaccg gcgagaagac ggacgtcgga
      121 cggctacaga actagtgctg gtagtagcca caatgcctcc cactcaagca gaaagtgtga
      181 taaagaatat catacgagaa ataggacaag aatgtgcagc ccacggagag atcgcttcag
      241 agacggtggt tgcttttatg gtgaaagctg tcgtcctaga tcccagcaat ggctttaaca
      301 tggataggac cctcatcaag actgacgtgc agaaacttgt taagctttgt gtggcacggc
      361 tactggacaa taaaaatcca tccctggaca ccattaagat gcaggtctac tttgatatga
      421 actatacaag tcgagaggac tttcttgaag aacatcaccg ggtcttagaa tccaggttag
      481 gcattgttag cagagaaatc acagacaaca gagcaagtgc tagggaagag ctggaaaatc
      541 tctacagaaa gatcgtcagc tacgtgctcc tgcgctctgg gcttggatcc cccacagaca
      601 tcaagattgt cagagaggca acagccgctc tgcagagcgt tttccctcag gctgagctcg
      661 ccacgtttct gaccctcagt aagaaggaca aagagcgcca gttgaaagag ctcaccatga
      721 ttgttaccgg aattcgctta tttaacagag actgtggaaa aggaggagaa ggcattgatg
      781 atttgccggc cattctccac gaagcgatcc caaccaccac acagcacata gactcccagc
      841 ttcagattgc ccaggaccag gcgtttcgct acacggccat ccttgagaaa gtaaccaaca
      901 accccctcat ggccaaagaa ctccagccgt atatgttaaa ggaagcactg tacaatgttc
      961 ggcagtatga gatcttcctg cagactgttt tgtcagatat aattacttgt gctgaggaag
     1021 tagagatgat gataaaacaa ttagcagccc aactggaaca actgaaaatg gcagtaaaat
     1081 ctaagacggc ggtcccaaca tcccaagtct tccccatctt cgttgcgctg gcgagtctgt
     1141 ggatgagctt ccaggacgag acggttctga tcagcgttct cagtaacttg accaccaacc
     1201 tggagctctt cctgggcacc cacgagctcc tctttcccga gaaagtgatg ctagggcttc
     1261 tcgatggcgt cgtcgtgaaa agcgatttga cgaggataga ggaacacatg gaagaaagag
     1321 tggagttggc agatttcaga acacaggaat ggctttttcc agaaacaaca gcaaacttta
     1381 acaaactgtt aattcagtat cgtggatttt gtggctacac atttgctgtg actgatggcc
     1441 ttctcctccc aggaaatcca gccattggaa ttttgaaata caaagaaaaa tattatactt
     1501 tcagtaccag agatgctgca tacacattcg cagaaaatcc agaccattac atccatttga
     1561 ttaaggagaa agccaagaag aatgcagagt taattcagct actagaactt catcagcagt
     1621 ttgaaactct cataccctat tctcagatga gagatgttga caagcattat ataaagccaa
     1681 ttacaaagtg tgacaacggc acacagacag atacacacat attgccaccc acgaccatga
     1741 gaacatatga gtggaacgaa tgggaactaa gaagaaaagc cataaaactg gctaatttgc
     1801 gccagaaaat tactcactcc gtccagactg accttagcca catgagaaga gataacacct
     1861 cacaggtgta ccctttgaaa gaggctagca cccagtccaa gagagaaggc agcagccgag
     1921 tgcccaggcc ccagattttc atagctggcc ttcgtggggg acaaagcaaa acaacctatg
     1981 gggtgaaggt gaacttaacc agagcggtgg acgaaaccta gagatggacg tttacaggaa
     2041 gctgctcctt agtggcacgg atggagggtt taaagtgctg tgcgtgtata aagctcattt
     2101 gcggggctgg cacagtcact ggttgtgtga ctgtgcacta gggcaccgta tcctgcctga
     2161 ctgttatgca aatctaaaag cagtttctgt agtacatttt tcgttttatt aaaattgaca
     2221 agtaaaactc t
//
