LOCUS       NM_028567               3085 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus cilia and flagella associated protein 141 (Cfap141),
            mRNA.
ACCESSION   NM_028567 XM_892960 XM_910384
VERSION     NM_028567.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3085)
  AUTHORS   Tai,L., Yin,G., Huang,X., Sun,F. and Zhu,Y.
  TITLE     In-cell structural insight into the stability of sperm microtubule
            doublet
  JOURNAL   Cell Discov 9 (1), 116 (2023)
   PUBMED   37989994
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3085)
  AUTHORS   Chen,Z., Shiozaki,M., Haas,K.M., Skinner,W.M., Zhao,S., Guo,C.,
            Polacco,B.J., Yu,Z., Krogan,N.J., Lishko,P.V., Kaake,R.M.,
            Vale,R.D. and Agard,D.A.
  TITLE     De novo protein identification in mammalian sperm using in situ
            cryoelectron tomography and AlphaFold2 docking
  JOURNAL   Cell 186 (23), 5041-5053 (2023)
   PUBMED   37865089
REFERENCE   3  (bases 1 to 3085)
  AUTHORS   Zhou,L., Liu,H., Liu,S., Yang,X., Dong,Y., Pan,Y., Xiao,Z.,
            Zheng,B., Sun,Y., Huang,P., Zhang,X., Hu,J., Sun,R., Feng,S.,
            Zhu,Y., Liu,M., Gui,M. and Wu,J.
  TITLE     Structures of sperm flagellar doublet microtubules expand the
            genetic spectrum of male infertility
  JOURNAL   Cell 186 (13), 2897-2910 (2023)
   PUBMED   37295417
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163616.3.
            
            On May 2, 2019 this sequence version replaced NM_028567.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.325630.1,
                                           SRR7345562.633744.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC163616.3         170744-170819
            77-117              AC163616.3         171145-171185
            118-247             AC163616.3         172361-172490
            248-3085            AC163616.3         173446-176283
FEATURES             Location/Qualifiers
     source          1..3085
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.2 cM"
     gene            1..3085
                     /gene="Cfap141"
                     /gene_synonym="1700094D03Rik"
                     /note="cilia and flagella associated protein 141"
                     /db_xref="GeneID:73545"
                     /db_xref="MGI:MGI:1920795"
     exon            1..76
                     /gene="Cfap141"
                     /gene_synonym="1700094D03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..349
                     /gene="Cfap141"
                     /gene_synonym="1700094D03Rik"
                     /note="uncharacterized protein C1orf189 homolog; protein
                     CFAP141"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 141"
                     /protein_id="NP_082843.2"
                     /db_xref="CCDS:CCDS50968.2"
                     /db_xref="GeneID:73545"
                     /db_xref="MGI:MGI:1920795"
                     /translation="MSAEKMTKLEENLQRAVALKKTVDRWRNFHIHCMWQTTLDQRRN
                     LFAALRMKDTKEQELALSNKQLLVVRQAALHELFEKEYQQYQQELNQMGKAFYEERL"
     exon            77..117
                     /gene="Cfap141"
                     /gene_synonym="1700094D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            118..247
                     /gene="Cfap141"
                     /gene_synonym="1700094D03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            248..3085
                     /gene="Cfap141"
                     /gene_synonym="1700094D03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      590..595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfap141"
                     /gene_synonym="1700094D03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      614
                     /gene="Cfap141"
                     /gene_synonym="1700094D03Rik"
                     /note="major polyA site"
     regulatory      783..788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfap141"
                     /gene_synonym="1700094D03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      808
                     /gene="Cfap141"
                     /gene_synonym="1700094D03Rik"
     regulatory      3059..3064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfap141"
                     /gene_synonym="1700094D03Rik"
                     /note="hexamer: AATAAA"
     regulatory      3065..3070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfap141"
                     /gene_synonym="1700094D03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3076
                     /gene="Cfap141"
                     /gene_synonym="1700094D03Rik"
     polyA_site      3085
                     /gene="Cfap141"
                     /gene_synonym="1700094D03Rik"
ORIGIN      
        1 cttcccagtg tccccaaact tagcaagcat gtctgtagta gatatgtctg cagaaaaaat
       61 gacaaaacta gaagagaatt tgcaaagagc tgtggcactt aagaagactg tcgacaggtg
      121 gcggaatttt catattcact gtatgtggca gacaacattg gaccaacgga gaaacctatt
      181 tgctgcccta aggatgaagg atactaagga acaggaatta gcactgtcta acaaacagct
      241 actagtggtc cgtcaagctg ccttacacga gctgtttgaa aaggagtatc agcagtacca
      301 gcaggaactc aatcagatgg gcaaagcttt ttatgaggaa agactctgac agctgccaag
      361 acactgttct tccacctcgt cacgcctgct aagcaagcct tcatgcttta ccctgagctt
      421 cccaaaacac acctggacct ggaacttaaa tctttttcac tattttgtca acctaaatgt
      481 tgcctctgga cacaagagtg acaccttgtg gtcagtgtgg gatatgcact gtggcgggaa
      541 gagagattat gtacattgtc tggttttaaa aatctgattt ggtttaacaa ataaagctag
      601 ctcttaaagg ttcagatttg ggctggcagg atggctcagc aggtaagagc actgactgct
      661 tttccaaagg tcctgagttc aaatcccagc aaccacatgg tagctcacaa ccacccataa
      721 tgaaatctga tgccctcttc tagtgtctga agtcagctac agtgtactta catataataa
      781 taaataaatc ttttttttaa aaagttcaga tttaggccac agggcttatt ctcagccttg
      841 agtcttgatt tgttcttggc tgccataatt ttacttccta gattgtgggc actgcctcag
      901 acttcagttt cactgatctt tcctaaattc gtggacaaaa accatgttta atgtctatta
      961 atctgtaggc actgtggtgc ttgagtgtca ggaggcccca gttgtatgtt tagaagtcac
     1021 ctcattgtga aaccatggat tagcctgaat tcccactcct actttacaaa actgaagcct
     1081 ccaaactcta atccctctag gcatttggct tgcagtggag caagtgtcaa gtatcaagca
     1141 gtaggtttga ggagctggaa agatcatgtc tattctcaag gtgtttgaca ctgaaaatcc
     1201 tggaaagtat acacctgtag gtcacaaaga tgcaaatgag tagccttggc tgtcctgaaa
     1261 ctcactctgt agaccaggct gacctcgaac tcagaaatct gcctaactct gcctcccaag
     1321 tgctgggatt aaaggcgtgc gccaccaccc ggcaatggct aatattttaa atttggcttc
     1381 catcgatagt gctgctgttc aggcatgtgt gccaagggat cttttcctac cctcagtttt
     1441 gtgtggctgt ctccactgca aagttcacat tctcgtcctt tttccttcca gcctgtctct
     1501 agcctgcatc ccttactaaa gcctgtaatt ttcattagct gtcgggagct actacttctt
     1561 gtccctccat atcccaccca tggaaagcac aagctttagg gtcaggtata agttcacagt
     1621 atcagaacat cgttcctctt ctggaaatga cagactctcc taggattttc ctcgggatta
     1681 aataggtaga gagcacaagc ccagtgattg acctaaaata ccctcattat atttctctgt
     1741 aacccagggc ccttttctgt ggtcctgcag ttaacgcaca tccagttaaa tgtcatcttt
     1801 cttcttttga tcacattcct tcctctttgc cttcaatgcc actgcttcct aatcccttgt
     1861 cattcgtagc tggtcatgga tactttcatt aaatgagttg gagctacagg ctggtgggga
     1921 aagcaggctt tgaacaggag ttacaagtgt agcatgtgtt ttgtagatga agccacaaaa
     1981 tgccacctgg attttgattg acaagactga ctgaatcctt ctgtctgtcc ctgccctgtg
     2041 ttagtctggt ctgtaccctc ttagcctctt taatcttcct tctgtctcct ggaccacctg
     2101 ctgattacca gatagtatgg cctagagtta atagaatgga cagatctggt tttcagggtt
     2161 ggccttttcg cttagtttgg tctagtccaa tttttaatct gagaagcggg taactgggga
     2221 aacggctcag tgattgggag cactagctac tcttgcaaag aacccagatt caattcctaa
     2281 catctatatg gttactcaac agttccagag tatccctttc ccggccttgg cagggaccag
     2341 gcaaacgcat ggtacacaga catgcagata aaacacccat gcatataaaa catttttaaa
     2401 taattttaag tctgagtttt ggttgctaat ttatgaaatg aaaacaattc caaccttact
     2461 gggttactgt gggaattaaa taagacacct agaagaaatc acacataata agtaatacaa
     2521 acaggaagcc ataatgctgt cttcctactc catggtactt tcttccctaa tttctactcc
     2581 cactacactt tataaccaac ctcttcagtt ctctcttcct ttgttcattt agactcactg
     2641 gatgccccat cctgtctgcc tggatctctg accttggcct gttgcctcag ggctcatcag
     2701 tgccaggccg actcctttat tggcaggttg gctcactaca gcgctcatct tccctgaccc
     2761 tccctgccaa tactgtgtgc actcatcaca tcgctcaatt gtaccccacc agtccatgct
     2821 gctgctggag ctgatgtcac accctggcct tgtgacttgg gacttaaacc tatttgaaat
     2881 agctgcctaa aaaccactgg cagagctctg tgagatggtg cagtggataa agacacttcc
     2941 tactaggccc gatgacctga gttaatcaac cctcataaag gagagaacag attcctggaa
     3001 attgtcctct gaccttcaca tgggcaccat gacacaacca cacaaaatat gaaagtgtaa
     3061 taaaaataaa aggaaagata aagta
//
