LOCUS       NM_001379426            1076 bp    mRNA    linear   ROD 21-SEP-2024
DEFINITION  Mus musculus cilia and flagella associated protein 126 (Cfap126),
            transcript variant 2, mRNA.
ACCESSION   NM_001379426 XM_006497018
VERSION     NM_001379426.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1076)
  AUTHORS   Tai,L., Yin,G., Huang,X., Sun,F. and Zhu,Y.
  TITLE     In-cell structural insight into the stability of sperm microtubule
            doublet
  JOURNAL   Cell Discov 9 (1), 116 (2023)
   PUBMED   37989994
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1076)
  AUTHORS   Chen,Z., Shiozaki,M., Haas,K.M., Skinner,W.M., Zhao,S., Guo,C.,
            Polacco,B.J., Yu,Z., Krogan,N.J., Lishko,P.V., Kaake,R.M.,
            Vale,R.D. and Agard,D.A.
  TITLE     De novo protein identification in mammalian sperm using in situ
            cryoelectron tomography and AlphaFold2 docking
  JOURNAL   Cell 186 (23), 5041-5053 (2023)
   PUBMED   37865089
REFERENCE   3  (bases 1 to 1076)
  AUTHORS   Ford,M.J., Harwalkar,K., Kazemdarvish,H., Yamanaka,N. and
            Yamanaka,Y.
  TITLE     CD133/Prom1 marks proximal mouse oviduct epithelial progenitors and
            adult epithelial cells with a low generative capacity
  JOURNAL   Biol Open 12 (9) (2023)
   PUBMED   37605939
REFERENCE   4  (bases 1 to 1076)
  AUTHORS   Zhou,L., Liu,H., Liu,S., Yang,X., Dong,Y., Pan,Y., Xiao,Z.,
            Zheng,B., Sun,Y., Huang,P., Zhang,X., Hu,J., Sun,R., Feng,S.,
            Zhu,Y., Liu,M., Gui,M. and Wu,J.
  TITLE     Structures of sperm flagellar doublet microtubules expand the
            genetic spectrum of male infertility
  JOURNAL   Cell 186 (13), 2897-2910 (2023)
   PUBMED   37295417
REFERENCE   5  (bases 1 to 1076)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1076)
  AUTHORS   Bader,E., Migliorini,A., Gegg,M., Moruzzi,N., Gerdes,J.,
            Roscioni,S.S., Bakhti,M., Brandl,E., Irmler,M., Beckers,J.,
            Aichler,M., Feuchtinger,A., Leitzinger,C., Zischka,H.,
            Wang-Sattler,R., Jastroch,M., Tschop,M., Machicao,F., Staiger,H.,
            Haring,H.U., Chmelova,H., Chouinard,J.A., Oskolkov,N., Korsgren,O.,
            Speier,S. and Lickert,H.
  TITLE     Identification of proliferative and mature beta-cells in the islets
            of Langerhans
  JOURNAL   Nature 535 (7612), 430-434 (2016)
   PUBMED   27398620
REFERENCE   7  (bases 1 to 1076)
  AUTHORS   Gegg,M., Bottcher,A., Burtscher,I., Hasenoeder,S., Van
            Campenhout,C., Aichler,M., Walch,A., Grant,S.G. and Lickert,H.
  TITLE     Flattop regulates basal body docking and positioning in mono- and
            multiciliated cells
  JOURNAL   Elife 3, e03842 (2014)
   PUBMED   25296022
  REMARK    GeneRIF: The uncharacterized gene Flattop (Fltp) is
            transcriptionally activated during planar cell polarity acquisition
            in ciliated tissues.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1076)
  AUTHORS   Lange,A., Gegg,M., Burtscher,I., Bengel,D., Kremmer,E. and
            Lickert,H.
  TITLE     Fltp(T2AiCre): a new knock-in mouse line for conditional gene
            targeting in distinct mono- and multiciliated tissues
  JOURNAL   Differentiation 83 (2), S105-S113 (2012)
   PUBMED   22153975
  REMARK    GeneRIF: Fltp(T2AiCre): a new knock-in mouse line for conditional
            gene targeting in distinct mono- and multiciliated tissues.
REFERENCE   9  (bases 1 to 1076)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1076)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: 1700009P17Rik is most abundantly expressed in tissues rich
            in highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163497.14.
            
            On or before Jul 30, 2020 this sequence version replaced
            XM_006497018.3, NM_001379426.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777535.2166567.1,
                                           SRR13422597.1210665.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               AC163497.14        106090-106309       c
            221-368             AC163497.14        97102-97249         c
            369-431             AC163497.14        95199-95261         c
            432-512             AC163497.14        94945-95025         c
            513-689             AC163497.14        94085-94261         c
            690-1076            AC163497.14        93345-93731         c
FEATURES             Location/Qualifiers
     source          1..1076
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 78.96 cM"
     gene            1..1076
                     /gene="Cfap126"
                     /gene_synonym="1700009P17Rik; Flattop; Fltp"
                     /note="cilia and flagella associated protein 126"
                     /db_xref="GeneID:75472"
                     /db_xref="MGI:MGI:1922722"
     exon            1..220
                     /gene="Cfap126"
                     /gene_synonym="1700009P17Rik; Flattop; Fltp"
                     /inference="alignment:Splign:2.1.0"
     exon            221..368
                     /gene="Cfap126"
                     /gene_synonym="1700009P17Rik; Flattop; Fltp"
                     /inference="alignment:Splign:2.1.0"
     CDS             342..911
                     /gene="Cfap126"
                     /gene_synonym="1700009P17Rik; Flattop; Fltp"
                     /note="isoform 1 is encoded by transcript variant 2;
                     UPF0740 protein C1orf192 homolog; protein Flattop"
                     /codon_start=1
                     /product="protein Flattop isoform 1"
                     /protein_id="NP_001366355.1"
                     /db_xref="GeneID:75472"
                     /db_xref="MGI:MGI:1922722"
                     /translation="MATNYSANQYEKAYLPTYLQNWSPARPTKEKIAAHEGYTQIIAN
                     DRGHLLPSVPRSKASPWGSFMGTWQMPLKIPPAKVTLTARTTTAADNLTKWIHKNPDL
                     LNACNGLRPEISGKPFDPDSQTKQKKSVTKTVQQAPNPTIIPSSPVIQGDNPDEPQSS
                     HPSAGHTPGPQTPVNSPNNPPPSPCKSTK"
     exon            369..431
                     /gene="Cfap126"
                     /gene_synonym="1700009P17Rik; Flattop; Fltp"
                     /inference="alignment:Splign:2.1.0"
     exon            432..512
                     /gene="Cfap126"
                     /gene_synonym="1700009P17Rik; Flattop; Fltp"
                     /inference="alignment:Splign:2.1.0"
     exon            513..689
                     /gene="Cfap126"
                     /gene_synonym="1700009P17Rik; Flattop; Fltp"
                     /inference="alignment:Splign:2.1.0"
     exon            690..1076
                     /gene="Cfap126"
                     /gene_synonym="1700009P17Rik; Flattop; Fltp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1052..1057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cfap126"
                     /gene_synonym="1700009P17Rik; Flattop; Fltp"
                     /note="hexamer: AATAAA"
     polyA_site      1076
                     /gene="Cfap126"
                     /gene_synonym="1700009P17Rik; Flattop; Fltp"
                     /note="major polyA site"
ORIGIN      
        1 ctcagcttcc ggttccttct cccggacgca gcctgtccct cctcgtctcc tggtcgcccc
       61 gccttcatgc ccggtctcac ggtcccagta gcgctttccc ggtactcagg cgtgagtcac
      121 ggaaaggggg gttgtgggtt gagctcattt ctggacagtg ggaccggatg tgactctccc
      181 gggccacgca cttgcgggag gagagcggag cagagaaagg agagaaagga agagggtagt
      241 gtaaaccaca gaatgtagcc caacccctgc tgaccgggag taactcccag aaggctggcc
      301 ttctgcagtt gccaggcaac aagtgtaaac agcactggat catggccact aactacagtg
      361 ccaaccagta tgaaaaagct tacttaccca cgtacctgca gaactggtct cctgccaggc
      421 caacgaaaga gaaaatcgct gcccatgaag gttacactca gatcatcgcc aacgatcgag
      481 ggcatctctt gccttcagtg ccccgttcca aggcaagtcc ttggggttcc ttcatgggca
      541 cctggcaaat gcccctgaag atcccacctg ctaaggtgac cttgaccgcc cgtacaacta
      601 cagctgccga caacctcacc aaatggatac acaagaatcc tgatctactc aacgcctgta
      661 atgggctgcg tcctgaaatc tcaggcaagc ccttcgatcc tgacagtcag acgaaacaga
      721 agaaatctgt caccaagact gtacaacaag caccaaatcc aaccataatt cccagctccc
      781 cggttatcca aggagacaac ccagatgaac cgcaaagctc gcacccctct gcaggtcaca
      841 ctccaggtcc ccaaactcca gtcaactctc ccaacaaccc acctccgagc ccttgtaaga
      901 gcaccaagta ggtcctagtc tagctgaggt ccagatctat gccatgctgg ggtgacattt
      961 tagagactga ccgaaatagg tgagaccctg cctgtattca gaaatgtgga acagagaaat
     1021 ggtgggccag gagtgaaggc agatttaggg aaataaacat tgtgtgttaa atcttt
//
