LOCUS       NM_007593               1051 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus centrin 1 (Cetn1), mRNA.
ACCESSION   NM_007593
VERSION     NM_007593.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1051)
  AUTHORS   Langner,E., Cheng,T., Kefaloyianni,E., Gluck,C., Wang,B. and
            Mahjoub,M.R.
  TITLE     Cep120 is essential for kidney stromal progenitor cell growth and
            differentiation
  JOURNAL   EMBO Rep 25 (1), 428-454 (2024)
   PUBMED   38177914
REFERENCE   2  (bases 1 to 1051)
  AUTHORS   de Bruijn,S.E., Verbakel,S.K., de Vrieze,E., Kremer,H.,
            Cremers,F.P.M., Hoyng,C.B., van den Born,L.I. and Roosing,S.
  TITLE     Homozygous variants in KIAA1549, encoding a ciliary protein, are
            associated with autosomal recessive retinitis pigmentosa
  JOURNAL   J Med Genet 55 (10), 705-712 (2018)
   PUBMED   30120214
REFERENCE   3  (bases 1 to 1051)
  AUTHORS   Serjanov,D., Bachay,G., Hunter,D.D. and Brunken,W.J.
  TITLE     Laminin beta2 Chain Regulates Retinal Progenitor Cell Mitotic
            Spindle Orientation via Dystroglycan
  JOURNAL   J Neurosci 38 (26), 5996-6010 (2018)
   PUBMED   29853630
REFERENCE   4  (bases 1 to 1051)
  AUTHORS   Kim,S.Y., Kim,D.S., Hong,J.E. and Park,J.H.
  TITLE     Crystal Structure of Wild-Type Centrin 1 from Mus musculus Occupied
            by Ca2
  JOURNAL   Biochemistry (Mosc) 82 (10), 1129-1139 (2017)
   PUBMED   29037133
  REMARK    GeneRIF: The crystal structure exhibits three structural features,
            i.e. four Ca2+ equally occupied at each EF-hand motif, structural
            changes accompanying helix motion at the N- and C-lobes, and
            adoption of N-C type dimerization when Ca2+ binds to EF-hand I and
            II in the N-lobe.
REFERENCE   5  (bases 1 to 1051)
  AUTHORS   Levine,M.S., Bakker,B., Boeckx,B., Moyett,J., Lu,J., Vitre,B.,
            Spierings,D.C., Lansdorp,P.M., Cleveland,D.W., Lambrechts,D.,
            Foijer,F. and Holland,A.J.
  TITLE     Centrosome Amplification Is Sufficient to Promote Spontaneous
            Tumorigenesis in Mammals
  JOURNAL   Dev Cell 40 (3), 313-322 (2017)
   PUBMED   28132847
REFERENCE   6  (bases 1 to 1051)
  AUTHORS   Pulvermuller,A., Giessl,A., Heck,M., Wottrich,R., Schmitt,A.,
            Ernst,O.P., Choe,H.W., Hofmann,K.P. and Wolfrum,U.
  TITLE     Calcium-dependent assembly of centrin-G-protein complex in
            photoreceptor cells
  JOURNAL   Mol Cell Biol 22 (7), 2194-2203 (2002)
   PUBMED   11884606
  REMARK    GeneRIF: Calcium-dependent assembly of centrin-G-protein complex in
            photoreceptor cells
REFERENCE   7  (bases 1 to 1051)
  AUTHORS   Hart,P.E., Poynter,G.M., Whitehead,C.M., Orth,J.D., Glantz,J.N.,
            Busby,R.C., Barrett,S.L. and Salisbury,J.L.
  TITLE     Characterization of the X-linked murine centrin Cetn2 gene
  JOURNAL   Gene 264 (2), 205-213 (2001)
   PUBMED   11250075
REFERENCE   8  (bases 1 to 1051)
  AUTHORS   Hart,P.E., Glantz,J.N., Orth,J.D., Poynter,G.M. and Salisbury,J.L.
  TITLE     Testis-specific murine centrin, Cetn1: genomic characterization and
            evidence for retroposition of a gene encoding a centrosome protein
  JOURNAL   Genomics 60 (2), 111-120 (1999)
   PUBMED   10486202
REFERENCE   9  (bases 1 to 1051)
  AUTHORS   Wolfrum,U. and Salisbury,J.L.
  TITLE     Expression of centrin isoforms in the mammalian retina
  JOURNAL   Exp Cell Res 242 (1), 10-17 (1998)
   PUBMED   9665797
REFERENCE   10 (bases 1 to 1051)
  AUTHORS   Ogawa,K. and Shimizu,T.
  TITLE     cDNA sequence for mouse caltractin
  JOURNAL   Biochim Biophys Acta 1216 (1), 126-128 (1993)
   PUBMED   8218402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK006940.1 and AK015808.1.
            
            On Jun 15, 2006 this sequence version replaced NM_007593.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK006940.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-483               AK006940.1         2-484
            484-914             AK015808.1         483-913
            915-1051            AK006940.1         916-1052
FEATURES             Location/Qualifiers
     source          1..1051
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 4.91 cM"
     gene            1..1051
                     /gene="Cetn1"
                     /gene_synonym="caltractin"
                     /note="centrin 1"
                     /db_xref="GeneID:26369"
                     /db_xref="MGI:MGI:1347086"
     exon            1..1051
                     /gene="Cetn1"
                     /gene_synonym="caltractin"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..569
                     /gene="Cetn1"
                     /gene_synonym="caltractin"
                     /note="testis-specific murine centrin"
                     /codon_start=1
                     /product="centrin-1"
                     /protein_id="NP_031619.3"
                     /db_xref="CCDS:CCDS37731.1"
                     /db_xref="GeneID:26369"
                     /db_xref="MGI:MGI:1347086"
                     /translation="MASTFRKSNVASTSYKRKVGPKPELTEDQKQEVREAFDLFDSDG
                     SGTIDVKELKVAMRALGFEPRKEEMKKMISEVDKEATGKISFNDFLAVMTQKMAEKDT
                     KEEILKAFRLFDDDETGKISFKNLKRVANELGESLTDEELQEMIDEADRDGDGEVNEE
                     EFLKIMKKTNLY"
     regulatory      791..796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cetn1"
                     /gene_synonym="caltractin"
                     /note="hexamer: ATTAAA"
     regulatory      824..829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cetn1"
                     /gene_synonym="caltractin"
                     /note="hexamer: AATAAA"
     polyA_site      830
                     /gene="Cetn1"
                     /gene_synonym="caltractin"
                     /note="major polyA site"
     polyA_site      866
                     /gene="Cetn1"
                     /gene_synonym="caltractin"
     polyA_site      872
                     /gene="Cetn1"
                     /gene_synonym="caltractin"
                     /note="major polyA site"
ORIGIN      
        1 cacacacgtg cgatgtcagg gcaccgttaa gatcccaact gttgtggagg atggcgtcca
       61 ccttcaggaa gtcaaacgtt gcctctacca gctacaagag aaaggtgggt cctaagcctg
      121 aactcaccga agatcaaaag caagaagttc gggaagcctt tgacctcttc gattctgatg
      181 ggagcgggac catcgatgtg aaggagctga aggtggccat gagagcactt ggctttgaac
      241 ccaggaagga agagatgaag aaaatgattt cagaagtaga caaagaggcc acaggaaaga
      301 tcagcttcaa tgacttcttg gctgtgatga ctcagaagat ggccgagaaa gataccaaag
      361 aggaaatcct gaaggctttc aggttgtttg atgacgacga aactgggaaa atttcattca
      421 aaaacctcaa gcgtgtggcc aatgagctgg gggaaagcct cacagacgag gagctgcagg
      481 aaatgattga tgaagctgat cgtgatggcg acggagaagt gaacgaggaa gagtttctta
      541 agatcatgaa aaagaccaac ctttattaag tgactggctg aggtccctgc ttctgctttt
      601 gtgaaagtat gacagaacag ctgtggtctg ttccttcttc ctgcctcctt tgtcttggtt
      661 ggcttctaag cctctagatc aattataaat tttgaagata cttactatat gagtttctgt
      721 tgtttaattc tcaagaacac atctcaatta aggatctttg aggctggagt ccactcagtg
      781 cttgccattc attaaactga agagaggaca gcttcctcgg tcaaataaaa tcgtggttct
      841 ctggtcactt tagtgattct aaataacacg aatattctgg tgattccttc atttcaagtc
      901 agtgacctag catggtgagt tagaatttac cagaaagttc attctagctt tccacttaag
      961 tgcatactgc tctgaaggat actaatgtgg ttatttaaga actatttaaa ttaaggaaag
     1021 atattcctca ataaaccctt gcttgccctt c
//
