LOCUS       NM_001381850            2188 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus carboxylesterase 5A (Ces5a), transcript variant 1,
            mRNA.
ACCESSION   NM_001381850 XM_006531320
VERSION     NM_001381850.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2188)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2188)
  AUTHORS   Robertson,M.J., Kent,K., Tharp,N., Nozawa,K., Dean,L., Mathew,M.,
            Grimm,S.L., Yu,Z., Legare,C., Fujihara,Y., Ikawa,M., Sullivan,R.,
            Coarfa,C., Matzuk,M.M. and Garcia,T.X.
  TITLE     Large-scale discovery of male reproductive tract-specific genes
            through analysis of RNA-seq datasets
  JOURNAL   BMC Biol 18 (1), 103 (2020)
   PUBMED   32814578
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2188)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
REFERENCE   4  (bases 1 to 2188)
  AUTHORS   Miyazaki,M., Yamashita,T., Hosokawa,M., Taira,H. and Suzuki,A.
  TITLE     Species-, sex-, and age-dependent urinary excretion of cauxin, a
            mammalian carboxylesterase
  JOURNAL   Comp Biochem Physiol B Biochem Mol Biol 145 (3-4), 270-277 (2006)
   PUBMED   17045831
REFERENCE   5  (bases 1 to 2188)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124591.5 and AC162945.6.
            
            On Apr 15, 2020 this sequence version replaced XM_006531320.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.133462.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               AC124591.5         143523-143740       c
            219-423             AC124591.5         142408-142612       c
            424-562             AC124591.5         138659-138797       c
            563-696             AC124591.5         136401-136534       c
            697-850             AC124591.5         133446-133599       c
            851-955             AC124591.5         131024-131128       c
            956-1060            AC124591.5         128870-128974       c
            1061-1201           AC124591.5         127404-127544       c
            1202-1270           AC124591.5         124805-124873       c
            1271-1418           AC162945.6         220100-220247       c
            1419-1568           AC162945.6         208083-208232       c
            1569-1641           AC162945.6         205593-205665       c
            1642-2188           AC162945.6         204968-205514       c
FEATURES             Location/Qualifiers
     source          1..2188
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 45.67 cM"
     gene            1..2188
                     /gene="Ces5a"
                     /gene_synonym="1700081L16Rik; 1700122C07Rik; cauxin; Ces7;
                     Gm503"
                     /note="carboxylesterase 5A"
                     /db_xref="GeneID:67935"
                     /db_xref="MGI:MGI:1915185"
     exon            1..218
                     /gene="Ces5a"
                     /gene_synonym="1700081L16Rik; 1700122C07Rik; cauxin; Ces7;
                     Gm503"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1873
                     /gene="Ces5a"
                     /gene_synonym="1700081L16Rik; 1700122C07Rik; cauxin; Ces7;
                     Gm503"
                     /EC_number="3.1.1.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; carboxylesterase-like urinary excreted protein
                     homolog; carboxylesterase 7"
                     /codon_start=1
                     /product="carboxylesterase 5A isoform 1 precursor"
                     /protein_id="NP_001368779.1"
                     /db_xref="GeneID:67935"
                     /db_xref="MGI:MGI:1915185"
                     /translation="MSGDWVRPGQALIWVIWIFGAIIEGAMAGSVTEEPHRYTKLGWV
                     QGKQATVLGRLEPVNVFLGIPFAAPPLGPLRFSKPQPPIPWDNLREATAYPNLCFQNL
                     EWLFIYQNLLKVSYPILGMSEDCLYLNIYAPCHANNGSSLPVMVWIPGGGFETGSASI
                     FDGSALAVYEDVLVVTIQYRLGIFGFFTTQNQHAPGNWAFWDQLAALLWVRENIKYFG
                     GNPDSVTIFGNSAGAISISSLILSPLSADLFHRAIMQSGVAIIPSLKSSDNDLKHDLQ
                     VVANVCDCNVSDSKALLKCLREKSSLELMSLSQKAKSFTRVVDGSFFSEEPLELLSQK
                     TLKIVPSIIGVNNQECGYILPVRDTPEILLGSNESTALTLIHTLLHIPTQHLYIVTKE
                     YFHGKHSPTDIRDTLLDLFGDVFFVVPGLVTARYHRDSGGPVYFYEFQHRPHCFQNSR
                     PAFVKADHTDEIRFVFGGPFLKGDVVMFEEATEEEKLLSRKMMKYWANFARSGDPNGA
                     DLPPWPVYDENEQYLELDVNISTGRRLKDQRVEFWTDTLPLILSASKALLSPTFSLIL
                     LSLLSPVLLSAAS"
     exon            219..423
                     /gene="Ces5a"
                     /gene_synonym="1700081L16Rik; 1700122C07Rik; cauxin; Ces7;
                     Gm503"
                     /inference="alignment:Splign:2.1.0"
     exon            424..562
                     /gene="Ces5a"
                     /gene_synonym="1700081L16Rik; 1700122C07Rik; cauxin; Ces7;
                     Gm503"
                     /inference="alignment:Splign:2.1.0"
     exon            563..696
                     /gene="Ces5a"
                     /gene_synonym="1700081L16Rik; 1700122C07Rik; cauxin; Ces7;
                     Gm503"
                     /inference="alignment:Splign:2.1.0"
     exon            697..850
                     /gene="Ces5a"
                     /gene_synonym="1700081L16Rik; 1700122C07Rik; cauxin; Ces7;
                     Gm503"
                     /inference="alignment:Splign:2.1.0"
     exon            851..955
                     /gene="Ces5a"
                     /gene_synonym="1700081L16Rik; 1700122C07Rik; cauxin; Ces7;
                     Gm503"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1060
                     /gene="Ces5a"
                     /gene_synonym="1700081L16Rik; 1700122C07Rik; cauxin; Ces7;
                     Gm503"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1201
                     /gene="Ces5a"
                     /gene_synonym="1700081L16Rik; 1700122C07Rik; cauxin; Ces7;
                     Gm503"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1270
                     /gene="Ces5a"
                     /gene_synonym="1700081L16Rik; 1700122C07Rik; cauxin; Ces7;
                     Gm503"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1418
                     /gene="Ces5a"
                     /gene_synonym="1700081L16Rik; 1700122C07Rik; cauxin; Ces7;
                     Gm503"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1568
                     /gene="Ces5a"
                     /gene_synonym="1700081L16Rik; 1700122C07Rik; cauxin; Ces7;
                     Gm503"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1641
                     /gene="Ces5a"
                     /gene_synonym="1700081L16Rik; 1700122C07Rik; cauxin; Ces7;
                     Gm503"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..2188
                     /gene="Ces5a"
                     /gene_synonym="1700081L16Rik; 1700122C07Rik; cauxin; Ces7;
                     Gm503"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2165..2170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ces5a"
                     /gene_synonym="1700081L16Rik; 1700122C07Rik; cauxin; Ces7;
                     Gm503"
                     /note="hexamer: AATAAA"
     polyA_site      2188
                     /gene="Ces5a"
                     /gene_synonym="1700081L16Rik; 1700122C07Rik; cauxin; Ces7;
                     Gm503"
                     /note="major polyA site"
ORIGIN      
        1 atttcttctg cgtcctgtgt cttgcctgtt cagcccctgt ctactcacag acaatacttt
       61 ctggtccctg attgaagttc tctgaggtca ggaagaactg tggatatcca gacagttcag
      121 gcaggccaac cagatgagcg gggactgggt gcgtccagga caagccctaa tctgggttat
      181 ttggatcttt ggagccatca tcgagggtgc aatggcaggg tctgtgactg aagagccaca
      241 taggtacacc aagctgggat gggtgcaggg gaagcaagcc accgtgctgg gaagactgga
      301 acccgtgaac gtgtttcttg ggatcccctt tgctgcaccc cctcttggac ctctgcggtt
      361 ttccaagcca cagcctccga tcccctggga taatttgcga gaagccactg cctatcccaa
      421 tttgtgcttt cagaacttag agtggttatt catatatcaa aacctgctca aagtaagtta
      481 ccctatactt ggaatgtcag aggactgctt atacctcaac atttatgcac catgccatgc
      541 caataacggc tccagtctcc cggtcatggt gtggatacca ggtggtggct ttgagactgg
      601 ctcagcctcc atctttgatg gctctgccct ggctgtctat gaggatgtgt tggttgtcac
      661 catccagtac cgcctaggaa tatttggctt cttcaccaca cagaaccagc atgcccctgg
      721 gaattgggcc ttctgggacc agctggctgc cttgctgtgg gtcagggaga acatcaagta
      781 cttcggtgga aaccctgact ccgtgaccat cttcggtaac tcagcgggag ccataagcat
      841 ttctagcctc attctgtctc ctttgagtgc ggacttattc cacagagcca tcatgcagag
      901 tggagtggcc atcatcccca gcctgaagag ctctgataat gatctgaaac atgatttgca
      961 ggtggttgca aatgtttgtg attgcaatgt atcagactcc aaggctttgc tgaagtgcct
     1021 gagggaaaag tcttctttgg agttgatgag ccttagccag aaagcaaaat cattcactcg
     1081 agtggtcgac ggttctttct tctccgaaga accactagaa ctgttgtctc aaaagacatt
     1141 gaaaatagta ccttctatca ttggagtcaa taaccaggag tgtggctaca tattgcccgt
     1201 gagagacact cctgagattc tcctcggctc caatgagtct actgctctca ccttgataca
     1261 tactttgctg catatcccca cccagcattt gtacattgtg actaaagagt acttccatgg
     1321 caagcattct ccgaccgaca tccgagacac tttactggac ttgtttggag atgtgttctt
     1381 tgtggttccc gggctggtta cagctcgata tcacagagat tctggtggac ctgtctattt
     1441 ttatgagttt cagcacagac cccattgctt tcaaaactca aggccagcct tcgtgaaggc
     1501 tgaccacaca gacgaaatcc gcttcgtttt tggaggccct ttcctgaagg gcgacgtggt
     1561 catgtttgag gaagccaccg aggaagagaa gttgctaagc aggaagatga tgaaatactg
     1621 ggctaacttt gccaggagcg gggatcctaa cggtgccgac ctgcctccgt ggccagtcta
     1681 tgatgagaat gaacagtacc tggaactgga tgtgaacatc agcactgggc ggagactgaa
     1741 agaccagagg gtggagtttt ggacagacac cctccccctg atcctgtctg cttccaaagc
     1801 gctgctcagt cccacgttct ccttaatcct cctatcacta ctgtcgcctg tccttctctc
     1861 cgctgcttct tagaagtcat cagtatttgg ttctgatttt cttctgtcga agtttctccc
     1921 tcagccatta tccctgttcc cagctgagct gctttcctgg ggatttctgt gcgctaatct
     1981 gctttagctg gtgttttatg ggcttaggga tgaacctcat aaaattcttt tcaacatcaa
     2041 aaaaaaaaaa aaagaaaaga aaagaaaaat tcaatttgtc ttggaaggta atgaaatttt
     2101 ctcaatgagt ctggaggagg gctggcccat tacttgtcac agaatgatcc cattactcat
     2161 atgaaataaa accagaatgc aaaatgta
//
