LOCUS       NM_144511               2065 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus carboxylesterase 3B (Ces3b), transcript variant 1,
            mRNA.
ACCESSION   NM_144511
VERSION     NM_144511.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2065)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2065)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
REFERENCE   3  (bases 1 to 2065)
  AUTHORS   Holmes,R.S., Cox,L.A. and VandeBerg,J.L.
  TITLE     Mammalian carboxylesterase 3: comparative genomics and proteomics
  JOURNAL   Genetica 138 (7), 695-708 (2010)
   PUBMED   20422440
REFERENCE   4  (bases 1 to 2065)
  AUTHORS   Aida,K., Moore,R. and Negishi,M.
  TITLE     Cloning and nucleotide sequence of a novel, male-predominant
            carboxylesterase in mouse liver
  JOURNAL   Biochim Biophys Acta 1174 (1), 72-74 (1993)
   PUBMED   7916639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA455872.1, AI048193.1, AC164311.4, CB946634.1, CB947075.1 and
            AI173514.1.
            
            On Apr 16, 2009 this sequence version replaced NM_144511.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            CCDS Note: The coding region has been updated to start at an
            alternate in-frame start codon which appears to be rodent-specific,
            and results in a protein that is 3 aa longer at the N-terminal.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019147.1, SRR5189682.65980.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               CA455872.1         38-199
            163-508             AI048193.1         72-417
            509-674             CA455872.1         546-711
            675-743             AC164311.4         103165-103233
            744-826             AC164311.4         103344-103426
            827-1237            CB946634.1         3-413
            1238-1435           CB947075.1         414-611
            1436-2029           AI173514.1         20-613              c
            2030-2065           AC164311.4         110078-110113
FEATURES             Location/Qualifiers
     source          1..2065
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..2065
                     /gene="Ces3b"
                     /gene_synonym="Ces31L; Ces3L; EG13909; Es31; ES31L;
                     Gm4738"
                     /note="carboxylesterase 3B"
                     /db_xref="GeneID:13909"
                     /db_xref="MGI:MGI:3644960"
     exon            1..111
                     /gene="Ces3b"
                     /gene_synonym="Ces31L; Ces3L; EG13909; Es31; ES31L;
                     Gm4738"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1736
                     /gene="Ces3b"
                     /gene_synonym="Ces31L; Ces3L; EG13909; Es31; ES31L;
                     Gm4738"
                     /EC_number="3.1.1.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="carboxylesterase 3B isoform 1 precursor"
                     /protein_id="NP_653094.2"
                     /db_xref="CCDS:CCDS22590.2"
                     /db_xref="GeneID:13909"
                     /db_xref="MGI:MGI:3644960"
                     /translation="MTNMRTMIPAGSSVLVWVTCLLLAFVTTVTGPKVIQPEVDTPLG
                     RVRGRQVGVKDTDRMVNVFLGIPFAQAPVGPLRFSAPLPPQPWEGVRDASINPPMCLQ
                     DVEKMINSRFGLNEKIKIFPISEDCLTLNIYSPTEITAGDKRPVMVWIHGGSLLVGSS
                     TSQDGSALAAYGDVVVVTVQYRLGIFGFLSTGDKHMPGNRGFLDVVAALRWVQGNIAP
                     FGGDPNCVTIFGNSAGGMIVSSLFLSPISAGLFHRAISQSGIVTTIMMEDMKPWPEAQ
                     NFANSVACGSASPAELVQCLLQKEGKDLIKQKNVNISYIVNDSFFPQRPEKLLADQQF
                     PTVPYLLGVTNHEFGWLLLKSLNILDKLEHLSREDLLEISRPFLAIMEVPPEIMPTVI
                     DEYLDNGSDQSATRYAFQELLGDISFIIPTLNFSKYLRDAGCPVFLYEFQHTPSSFAK
                     FKPAWVKADHASENSFVFGGPFLTDESSLLAFPEATEEEKQLSLTMMAQWSQFARTGN
                     PNGKGLPPWPQLNQLEQYLEIGLESRTGVKLKKGRLQFWTETLPRKIQEWHREQRSRK
                     VPEEL"
     exon            112..316
                     /gene="Ces3b"
                     /gene_synonym="Ces31L; Ces3L; EG13909; Es31; ES31L;
                     Gm4738"
                     /inference="alignment:Splign:2.1.0"
     exon            317..455
                     /gene="Ces3b"
                     /gene_synonym="Ces31L; Ces3L; EG13909; Es31; ES31L;
                     Gm4738"
                     /inference="alignment:Splign:2.1.0"
     exon            456..589
                     /gene="Ces3b"
                     /gene_synonym="Ces31L; Ces3L; EG13909; Es31; ES31L;
                     Gm4738"
                     /inference="alignment:Splign:2.1.0"
     exon            590..743
                     /gene="Ces3b"
                     /gene_synonym="Ces31L; Ces3L; EG13909; Es31; ES31L;
                     Gm4738"
                     /inference="alignment:Splign:2.1.0"
     exon            744..848
                     /gene="Ces3b"
                     /gene_synonym="Ces31L; Ces3L; EG13909; Es31; ES31L;
                     Gm4738"
                     /inference="alignment:Splign:2.1.0"
     exon            849..941
                     /gene="Ces3b"
                     /gene_synonym="Ces31L; Ces3L; EG13909; Es31; ES31L;
                     Gm4738"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1082
                     /gene="Ces3b"
                     /gene_synonym="Ces31L; Ces3L; EG13909; Es31; ES31L;
                     Gm4738"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1163
                     /gene="Ces3b"
                     /gene_synonym="Ces31L; Ces3L; EG13909; Es31; ES31L;
                     Gm4738"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1311
                     /gene="Ces3b"
                     /gene_synonym="Ces31L; Ces3L; EG13909; Es31; ES31L;
                     Gm4738"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1461
                     /gene="Ces3b"
                     /gene_synonym="Ces31L; Ces3L; EG13909; Es31; ES31L;
                     Gm4738"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1540
                     /gene="Ces3b"
                     /gene_synonym="Ces31L; Ces3L; EG13909; Es31; ES31L;
                     Gm4738"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..2065
                     /gene="Ces3b"
                     /gene_synonym="Ces31L; Ces3L; EG13909; Es31; ES31L;
                     Gm4738"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2011..2016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ces3b"
                     /gene_synonym="Ces31L; Ces3L; EG13909; Es31; ES31L;
                     Gm4738"
                     /note="hexamer: AATAAA"
     polyA_site      2029
                     /gene="Ces3b"
                     /gene_synonym="Ces31L; Ces3L; EG13909; Es31; ES31L;
                     Gm4738"
                     /note="major polyA site"
ORIGIN      
        1 agcttcgtcc acagtccgtt atgacaaata tgaggacaat gataccagct gggtccagtg
       61 tcctagtctg ggtgacctgt ctgctcctgg catttgttac cacagtcact ggacccaaag
      121 tcattcagcc tgaagtggat acccccctgg gtcgtgttcg aggccggcag gtgggtgtga
      181 aggacacaga ccgcatggta aatgtcttcc tgggcatccc ctttgctcaa gcaccagtgg
      241 gacctcttcg gttctcagct ccactcccac cacagccctg ggaaggtgtg agagatgcca
      301 gcatcaatcc cccaatgtgc cttcaggatg tagagaaaat gatcaacagc agatttggcc
      361 tcaatgaaaa gattaaaatc ttccccattt ctgaggactg cctgaccctc aacatctaca
      421 gccccactga gatcactgca ggggacaaaa ggccggtcat ggtatggatc cacggaggct
      481 ctctgctggt tggctcctcc acatctcagg atggatcagc actggccgcg tacggggatg
      541 tggtagttgt cactgtccag tatcgccttg ggatctttgg cttcctcagc actggagaca
      601 agcacatgcc aggcaacagg ggattcctgg atgtggtggc tgctcttcgc tgggtccagg
      661 ggaacatagc cccctttggg ggtgatccca actgtgtcac tatcttcggt aactctgctg
      721 gaggcatgat tgtctcatcc ctgttcctgt ctccaatatc tgctgggctc ttccacagag
      781 ccatatccca gagtgggatt gtcacgacca ttatgatgga agacatgaaa ccatggcctg
      841 aagctcagaa ctttgccaat tctgtggcct gtggctctgc atccccagct gagctggtcc
      901 agtgtttgct gcagaaggaa ggaaaggacc ttatcaagca gaaaaacgtg aacatttcct
      961 acatagtcaa tgactccttc ttcccacaaa ggccagagaa gctcctagca gaccagcaat
     1021 tccccactgt gccctacctt ttgggagtca ccaaccatga atttggctgg cttctactca
     1081 aatccttgaa tatcctggat aagttggaac atctgagccg ggaagacctg ttggagattt
     1141 cacggccctt cttggccatt atggaagtgc cccctgagat catgcccact gtcatcgatg
     1201 aatacctaga caatggctca gatcaatcag ctacaaggta tgccttccag gaattgctgg
     1261 gtgatatctc gttcatcatt cctaccttga acttctcaaa ataccttcga gatgctgggt
     1321 gccctgtttt cttgtacgag ttccagcata cacccagttc ttttgcaaag ttcaagccag
     1381 cctgggtgaa ggctgaccat gcgtctgaga attcctttgt ttttggaggt cctttcctca
     1441 ctgatgagag ttcccttctg gccttcccag aggccacaga ggaagagaag cagctgagcc
     1501 tgaccatgat ggcccaatgg agccagtttg cacgcacagg aaaccccaat ggcaaggggc
     1561 tgcctccttg gccccaatta aaccagttag aacaatactt ggagattggt ctagaatcac
     1621 ggactggggt gaagctaaag aagggtcggc tacagttctg gacagagaca ctgccaagaa
     1681 aaattcaaga atggcaccga gagcagagaa gcaggaaagt tccagaggag ctctgaggcc
     1741 agacctacct agaccttact gactgggcca acccaagaat agtggcaccc aagcagggca
     1801 actacaactt ctttttgttt ctgttcagag actttagcct ggaccacgct gctgtgagcc
     1861 catgtttctt aaatcatcgg cccctgcaag accagtatgg tgaaccacta aatgttatca
     1921 atctggtttc tacttcttga tcattgaaca tactgctgtt tcttcctaaa gtgacttgaa
     1981 cccttgctgt atggcaaggt ccagcacatt aataaagctc ttcagaggat ctgttctctt
     2041 gagaaacctc ctctgccttc tctaa
//
