LOCUS       NP_653094                571 aa            linear   ROD 30-APR-2024
DEFINITION  carboxylesterase 3B isoform 1 precursor [Mus musculus].
ACCESSION   NP_653094
VERSION     NP_653094.2
DBSOURCE    REFSEQ: accession NM_144511.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 571)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 571)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
REFERENCE   3  (residues 1 to 571)
  AUTHORS   Holmes,R.S., Cox,L.A. and VandeBerg,J.L.
  TITLE     Mammalian carboxylesterase 3: comparative genomics and proteomics
  JOURNAL   Genetica 138 (7), 695-708 (2010)
   PUBMED   20422440
REFERENCE   4  (residues 1 to 571)
  AUTHORS   Aida,K., Moore,R. and Negishi,M.
  TITLE     Cloning and nucleotide sequence of a novel, male-predominant
            carboxylesterase in mouse liver
  JOURNAL   Biochim Biophys Acta 1174 (1), 72-74 (1993)
   PUBMED   7916639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA455872.1, AI048193.1, AC164311.4, CB946634.1, CB947075.1 and
            AI173514.1.
            
            On Apr 16, 2009 this sequence version replaced NP_653094.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            CCDS Note: The coding region has been updated to start at an
            alternate in-frame start codon which appears to be rodent-specific,
            and results in a protein that is 3 aa longer at the N-terminal.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019147.1, SRR5189682.65980.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..571
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     Protein         1..571
                     /product="carboxylesterase 3B isoform 1 precursor"
                     /EC_number="3.1.1.1"
                     /calculated_mol_wt=60057
     sig_peptide     1..31
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3314
     mat_peptide     32..571
                     /product="Carboxylesterase 3B. /id=PRO_0000305195"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCU1.2)"
                     /calculated_mol_wt=60057
     Region          36..547
                     /region_name="COesterase"
                     /note="Carboxylesterase family; pfam00135"
                     /db_xref="CDD:395084"
     Site            order(152..154,231..233,236,373,377..378,413,461,464)
                     /site_type="other"
                     /note="substrate binding pocket [chemical binding]"
                     /db_xref="CDD:238191"
     Site            order(232,347,460)
                     /site_type="active"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:238191"
     Site            311
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VCU1.2)"
     Region          568..571
                     /region_name="Prevents secretion from ER.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCU1.2)"
     CDS             1..571
                     /gene="Ces3b"
                     /gene_synonym="Ces31L; Ces3L; EG13909; Es31; ES31L;
                     Gm4738"
                     /coded_by="NM_144511.2:21..1736"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS22590.2"
                     /db_xref="GeneID:13909"
                     /db_xref="MGI:MGI:3644960"
ORIGIN      
        1 mtnmrtmipa gssvlvwvtc lllafvttvt gpkviqpevd tplgrvrgrq vgvkdtdrmv
       61 nvflgipfaq apvgplrfsa plppqpwegv rdasinppmc lqdvekmins rfglnekiki
      121 fpisedcltl niyspteita gdkrpvmvwi hggsllvgss tsqdgsalaa ygdvvvvtvq
      181 yrlgifgfls tgdkhmpgnr gfldvvaalr wvqgniapfg gdpncvtifg nsaggmivss
      241 lflspisagl fhraisqsgi vttimmedmk pwpeaqnfan svacgsaspa elvqcllqke
      301 gkdlikqknv nisyivndsf fpqrpeklla dqqfptvpyl lgvtnhefgw lllkslnild
      361 klehlsredl leisrpflai mevppeimpt videyldngs dqsatryafq ellgdisfii
      421 ptlnfskylr dagcpvflye fqhtpssfak fkpawvkadh asensfvfgg pfltdessll
      481 afpeateeek qlsltmmaqw sqfartgnpn gkglppwpql nqleqyleig lesrtgvklk
      541 kgrlqfwtet lprkiqewhr eqrsrkvpee l
//
