LOCUS       NM_198672               2049 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus carboxylesterase 3A (Ces3a), transcript variant 1,
            mRNA.
ACCESSION   NM_198672 XM_356125 XM_915050
VERSION     NM_198672.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2049)
  AUTHORS   Mukherjee,S., Choi,M. and Yun,J.W.
  TITLE     Novel regulatory roles of carboxylesterase 3 in lipid metabolism
            and browning in 3T3-L1 white adipocytes
  JOURNAL   Appl Physiol Nutr Metab 44 (10), 1089-1098 (2019)
   PUBMED   30807212
  REMARK    GeneRIF: activation of Ces3 contributes in the browning of white
            adipocytes, and maintains a balance in lipid metabolism, which
            could be a potential strategy in fighting against obesity
REFERENCE   2  (bases 1 to 2049)
  AUTHORS   Labialle,S., Marty,V., Bortolin-Cavaille,M.L., Hoareau-Osman,M.,
            Pradere,J.P., Valet,P., Martin,P.G. and Cavaille,J.
  TITLE     The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain
            controls neonatal metabolic adaptation
  JOURNAL   EMBO J 33 (19), 2216-2230 (2014)
   PUBMED   25124681
REFERENCE   3  (bases 1 to 2049)
  AUTHORS   Dominguez,E., Galmozzi,A., Chang,J.W., Hsu,K.L., Pawlak,J., Li,W.,
            Godio,C., Thomas,J., Partida,D., Niessen,S., O'Brien,P.E.,
            Russell,A.P., Watt,M.J., Nomura,D.K., Cravatt,B.F. and Saez,E.
  TITLE     Integrated phenotypic and activity-based profiling links Ces3 to
            obesity and diabetes
  JOURNAL   Nat Chem Biol 10 (2), 113-121 (2014)
   PUBMED   24362705
  REMARK    GeneRIF: This carboxylesterase proetin is linked to obesity and
            diabetes in mice
REFERENCE   4  (bases 1 to 2049)
  AUTHORS   Bie,J., Wang,J., Marqueen,K.E., Osborne,R., Kakiyama,G., Korzun,W.,
            Ghosh,S.S. and Ghosh,S.
  TITLE     Liver-specific cholesteryl ester hydrolase deficiency attenuates
            sterol elimination in the feces and increases atherosclerosis in
            ldlr-/- mice
  JOURNAL   Arterioscler Thromb Vasc Biol 33 (8), 1795-1802 (2013)
   PUBMED   23744992
  REMARK    GeneRIF: Hepatic Ces3 modulates the hydrolysis of
            lipoprotein-delivered cholesterol esters and thereby regulates free
            cholesterol and bile acid secretion into the feces.
REFERENCE   5  (bases 1 to 2049)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
REFERENCE   6  (bases 1 to 2049)
  AUTHORS   Holmes,R.S., Cox,L.A. and VandeBerg,J.L.
  TITLE     Mammalian carboxylesterase 3: comparative genomics and proteomics
  JOURNAL   Genetica 138 (7), 695-708 (2010)
   PUBMED   20422440
REFERENCE   7  (bases 1 to 2049)
  AUTHORS   Aida,K., Moore,R. and Negishi,M.
  TITLE     Cloning and nucleotide sequence of a novel, male-predominant
            carboxylesterase in mouse liver
  JOURNAL   Biochim Biophys Acta 1174 (1), 72-74 (1993)
   PUBMED   7916639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB952677.1, AK138932.1 and AC164311.4.
            
            On or before Sep 10, 2009 this sequence version replaced
            XM_356125.5, XM_915050.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057188.1, AK138932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 CB952677.1         4-5
            3-2030              AK138932.1         2-2029
            2031-2049           AC164311.4         74918-74936
FEATURES             Location/Qualifiers
     source          1..2049
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..2049
                     /gene="Ces3a"
                     /gene_synonym="Ces3; Ces31; Es31"
                     /note="carboxylesterase 3A"
                     /db_xref="GeneID:382053"
                     /db_xref="MGI:MGI:102773"
     exon            1..113
                     /gene="Ces3a"
                     /gene_synonym="Ces3; Ces31; Es31"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1738
                     /gene="Ces3a"
                     /gene_synonym="Ces3; Ces31; Es31"
                     /EC_number="3.1.1.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; liver carboxylesterase 31; Es-male
                     carboxylesterase; esterase 31"
                     /codon_start=1
                     /product="carboxylesterase 3A isoform 1 precursor"
                     /protein_id="NP_941074.1"
                     /db_xref="CCDS:CCDS52651.1"
                     /db_xref="GeneID:382053"
                     /db_xref="MGI:MGI:102773"
                     /translation="MTNMETTAQAGSSVRVWMACLLLIFPTTVIGPKVTQPEVDTPLG
                     RVRGRQVGVKDTDRMVNVFLGIPFAQAPLGPLRFSAPLPPQPWEGVRDASINPPMCLQ
                     DVERMSNSRFTLNEKMKIFPISEDCLTLNIYSPTEITAGDKRPVMVWIHGGSLLVGSS
                     TSHDGSALAAYGDVVVVTVQYRLGIFGFLSTGDKHMPGNRGFLDVVAALRWVQGNIAP
                     FGGDPNCVTIFGNSAGGIIVSSLLLSPMSAGLFHRAISQSGVVISKILEDLNAWSEAQ
                     NFANSVACGSASPAELVQCLLQKEGKDLITKKNVNISYTVNDSFFPQRPQKLLANKQF
                     PTVPYLLGVTNHEFGWLLLKFWNILDKMEHLSQEDLLENSRPLLAHMQLPPEIMPTVI
                     DEYLDNGSDESATRYALQELLGDITLVIPTLIFSKYLQDAGCPVFLYEFQHTPSSFAK
                     FKPAWVKADHSSENAFVFGGPFLTDESSLLAFPEATEEEKQLSLTMMAQWSQFARTGN
                     PNGKGLPPWPQLNQLEQYLEIGLEPRTGVKLKKGRLQFWTETLPRKIQEWHREQRSRK
                     VPEEL"
     exon            114..318
                     /gene="Ces3a"
                     /gene_synonym="Ces3; Ces31; Es31"
                     /inference="alignment:Splign:2.1.0"
     exon            319..457
                     /gene="Ces3a"
                     /gene_synonym="Ces3; Ces31; Es31"
                     /inference="alignment:Splign:2.1.0"
     exon            458..591
                     /gene="Ces3a"
                     /gene_synonym="Ces3; Ces31; Es31"
                     /inference="alignment:Splign:2.1.0"
     exon            592..745
                     /gene="Ces3a"
                     /gene_synonym="Ces3; Ces31; Es31"
                     /inference="alignment:Splign:2.1.0"
     exon            746..850
                     /gene="Ces3a"
                     /gene_synonym="Ces3; Ces31; Es31"
                     /inference="alignment:Splign:2.1.0"
     exon            851..943
                     /gene="Ces3a"
                     /gene_synonym="Ces3; Ces31; Es31"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1084
                     /gene="Ces3a"
                     /gene_synonym="Ces3; Ces31; Es31"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1165
                     /gene="Ces3a"
                     /gene_synonym="Ces3; Ces31; Es31"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1313
                     /gene="Ces3a"
                     /gene_synonym="Ces3; Ces31; Es31"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1463
                     /gene="Ces3a"
                     /gene_synonym="Ces3; Ces31; Es31"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1542
                     /gene="Ces3a"
                     /gene_synonym="Ces3; Ces31; Es31"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..2049
                     /gene="Ces3a"
                     /gene_synonym="Ces3; Ces31; Es31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2013..2018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ces3a"
                     /gene_synonym="Ces3; Ces31; Es31"
                     /note="hexamer: AATAAA"
     polyA_site      2031
                     /gene="Ces3a"
                     /gene_synonym="Ces3; Ces31; Es31"
                     /note="major polyA site"
ORIGIN      
        1 acagctttgt ccacagtcca ttatgacaaa tatggagaca acggcacaag ctgggtccag
       61 tgtccgagtc tggatggcct gtctgctcct gatatttcct accactgtca ttggacccaa
      121 agtcactcag cctgaagtgg atacccccct gggtcgtgtt cgaggccggc aggtgggtgt
      181 gaaggacaca gaccgcatgg taaatgtctt cctgggcatc ccctttgctc aagcaccact
      241 gggacctctt cggttctcag ctccactccc accacagccc tgggaaggtg tgagagatgc
      301 cagcatcaat cccccaatgt gccttcagga tgtagagaga atgagcaaca gcagattcac
      361 cctcaatgaa aagatgaaaa tcttccccat ttctgaggac tgcctgaccc tcaacatcta
      421 cagccccact gagatcactg caggggacaa aaggccggtc atggtatgga tccacggagg
      481 ctctctgctg gttggctcct ccacatctca tgatggatca gcactggctg cctatgggga
      541 tgtggtagtt gtcactgtcc agtatcgcct tgggatcttt ggcttcctca gcactggaga
      601 caagcacatg ccaggcaaca ggggattcct ggatgtggtg gctgctcttc gctgggtcca
      661 ggggaacata gccccctttg ggggtgatcc caactgtgtc actatcttcg gtaactctgc
      721 tggaggcatt attgtctcat ccctgctcct gtctccaatg tctgctgggc tcttccacag
      781 agccatatcg cagagtgggg ttgtcatcag caagattctg gaagacttga atgcatggtc
      841 tgaagctcag aactttgcca attctgtggc ctgtggctct gcatccccag ctgagctggt
      901 ccagtgtttg ctgcagaagg aaggaaagga ccttatcacg aagaaaaacg tgaacatttc
      961 ctacacagtc aatgactcct tcttcccaca aaggccccag aagctcctag caaacaagca
     1021 attccccact gtgccctacc tcttgggagt caccaaccat gagtttggct ggcttctact
     1081 caaattctgg aatatcctgg ataagatgga acatttgagc caggaagacc tgttggagaa
     1141 ttcaaggccc ttattagccc atatgcaact gccccctgag atcatgccca ccgtcataga
     1201 tgaataccta gacaatggct cagatgaatc agctacaagg tatgccctcc aggaattgct
     1261 gggtgatatc acattggtca ttcctacctt gatcttctca aaataccttc aagatgctgg
     1321 gtgccctgtt ttcttgtacg agttccagca tacacccagt tcttttgcaa agttcaagcc
     1381 agcctgggtg aaggctgacc attcctctga gaatgccttt gtttttggag gtcctttcct
     1441 cactgatgag agttccctcc tggccttccc agaggccaca gaggaagaga agcagctgag
     1501 cctgaccatg atggcccaat ggagccagtt tgcacgcaca ggaaatccca atggcaaggg
     1561 gctgcctcct tggccccaat taaaccagtt agaacaatac ttggagattg gtctagaacc
     1621 acggactggg gtgaagctaa agaagggtcg gctacagttc tggacagaga cactgccaag
     1681 aaaaattcaa gaatggcacc gagagcagag aagcaggaaa gttccagagg agctctgagg
     1741 ccagacctac ctggaccttc ctgactgggc caacccaaga atagtagcat ccaagcaggg
     1801 caactacaac ttctttttgt ttctgttcag agactttagc ctggaccatg ctgctgtgag
     1861 cccatgtttc ttaaatcatc agcccctaca agaccagtat ggtggaccac taaatgttac
     1921 caatctggtt tctacttctt gatcattgaa catactgctg tttcttccta aagtgacttg
     1981 aacccttgct gtatggtaca gtccagcaca ttaataaagc tcttcagagg atctgttctc
     2041 ttgagaaac
//
