LOCUS       NM_001272045            1700 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus carboxylesterase 2H (Ces2h), mRNA.
ACCESSION   NM_001272045 XM_003085371 XM_003086696 XM_488149 XM_915046
VERSION     NM_001272045.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1700)
  AUTHORS   Chalhoub G, Jamnik A, Pajed L, Kolleritsch S, Hois V, Bagaric A,
            Prem D, Tilp A, Kolb D, Wolinski H, Taschler U, Zullig T,
            Rechberger GN, Fuchs C, Trauner M, Schoiswohl G and Haemmerle G.
  TITLE     Carboxylesterase 2a deletion provokes hepatic steatosis and insulin
            resistance in mice involving impaired diacylglycerol and
            lysophosphatidylcholine catabolism
  JOURNAL   Mol Metab 72, 101725 (2023)
   PUBMED   37059417
  REMARK    GeneRIF: Carboxylesterase 2a deletion provokes hepatic steatosis
            and insulin resistance in mice involving impaired diacylglycerol
            and lysophosphatidylcholine catabolism.
REFERENCE   2  (bases 1 to 1700)
  AUTHORS   Holmes RS, Wright MW, Laulederkind SJ, Cox LA, Hosokawa M, Imai T,
            Ishibashi S, Lehner R, Miyazaki M, Perkins EJ, Potter PM, Redinbo
            MR, Robert J, Satoh T, Yamashita T, Yan B, Yokoi T, Zechner R and
            Maltais LJ.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from AC166833.4.
            
            On Feb 13, 2019 this sequence version replaced NM_001272045.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849377, SAMN00849378
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC166833.4         170740-170835
            97-301              AC166833.4         184361-184565
            302-443             AC166833.4         185846-185987
            444-577             AC166833.4         186465-186598
            578-836             AC166833.4         186680-186938
            837-935             AC166833.4         187345-187443
            936-1076            AC166833.4         187717-187857
            1077-1157           AC166833.4         187955-188035
            1158-1302           AC166833.4         188280-188424
            1303-1440           AC166833.4         188836-188973
            1441-1513           AC166833.4         189844-189916
            1514-1700           AC166833.4         190134-190320
FEATURES             Location/Qualifiers
     source          1..1700
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..1700
                     /gene="Ces2h"
                     /gene_synonym="Ces2; Gm5744"
                     /note="carboxylesterase 2H"
                     /db_xref="GeneID:436059"
                     /db_xref="MGI:MGI:3648740"
     exon            1..96
                     /gene="Ces2h"
                     /gene_synonym="Ces2; Gm5744"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1700
                     /gene="Ces2h"
                     /gene_synonym="Ces2; Gm5744"
                     /EC_number="3.1.1.1"
                     /note="carboxylesterase 2"
                     /codon_start=1
                     /product="cocaine esterase precursor"
                     /protein_id="NP_001258974.1"
                     /db_xref="CCDS:CCDS59742.1"
                     /db_xref="GeneID:436059"
                     /db_xref="MGI:MGI:3648740"
                     /translation="MRLEQIHARLTTATCGLLLLLRVQGQDSTSPIRTTHTGQILGSL
                     IHMKDLDVGVHSFLGIPFAKPPVGPLRFAPPEPPEPWGGVRDGTSHPAMCLQDITAMN
                     MQAFKLLKLTLPPFPMSEDCLYLNIYAPDHAHEGSNLPVMVWIHGGSLVIGMASMYDG
                     SMLAAMENVVVVTIQYRLGVLGFFSTGDERARGNWGYLDQVAALRWLQQNIAYFGGNP
                     DRVTIFGTSAGGTSVSSLVVSPMSQGLFRGAIMESGVALISSLISVSSDVVYQTVANL
                     SGCEQVDSEALVNCLRGKSEEEIMAINKAFKIIPGIVDGIFLPRHPQELMASADFHPV
                     PSIIGVNNDEYGWIIPSSMSMIDSKKGMDRQMVQAILQRRATQMMWPPEVSDLLMEEY
                     MGDNEDPQFLQVQFKEMMKDFTFVIPALQVAQFQRSHAPVFFYEFQHRPSFFKDSKPS
                     HVKADHGDEILFIFRSFWGGTQVDFTEEEELLSRRMMKYWANFARQRNPNSEGLPYWP
                     MFDQDEQYLQLDTQPAVGRALKTRRLQFWTKTLPEKIQELKDIEDRHKEL"
     exon            97..301
                     /gene="Ces2h"
                     /gene_synonym="Ces2; Gm5744"
                     /inference="alignment:Splign:2.1.0"
     exon            302..443
                     /gene="Ces2h"
                     /gene_synonym="Ces2; Gm5744"
                     /inference="alignment:Splign:2.1.0"
     exon            444..577
                     /gene="Ces2h"
                     /gene_synonym="Ces2; Gm5744"
                     /inference="alignment:Splign:2.1.0"
     exon            578..836
                     /gene="Ces2h"
                     /gene_synonym="Ces2; Gm5744"
                     /inference="alignment:Splign:2.1.0"
     exon            837..935
                     /gene="Ces2h"
                     /gene_synonym="Ces2; Gm5744"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1076
                     /gene="Ces2h"
                     /gene_synonym="Ces2; Gm5744"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1157
                     /gene="Ces2h"
                     /gene_synonym="Ces2; Gm5744"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1302
                     /gene="Ces2h"
                     /gene_synonym="Ces2; Gm5744"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1440
                     /gene="Ces2h"
                     /gene_synonym="Ces2; Gm5744"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1513
                     /gene="Ces2h"
                     /gene_synonym="Ces2; Gm5744"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1700
                     /gene="Ces2h"
                     /gene_synonym="Ces2; Gm5744"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaacacgc ctgtgtacca accatgagac tggaacaaat tcatgctcgg ctaaccaccg
       61 cgacctgtgg gctcctgctt ctcctccggg tccagggcca ggactcaacc agtcccatca
      121 ggaccacaca cacaggccag atactgggca gccttatcca tatgaaggac cttgatgtgg
      181 gtgtccactc tttcctggga atcccctttg ccaagcctcc tgtaggacca ctgcgctttg
      241 caccccctga gccacctgaa ccatggggtg gtgtgagaga tgggacatca catccggcca
      301 tgtgtctgca ggacatcact gcaatgaata tgcaggcttt taagctgttg aagctgacct
      361 tgcctccctt ccctatgtct gaggactgcc tataccttaa catctatgca ccagatcatg
      421 cccatgaggg ttccaacctg cctgtgatgg tgtggatcca cggtggctca ctggttatag
      481 gcatggcttc catgtatgat ggatccatgc tagcagccat ggagaatgta gtagtggtca
      541 ctatccagta ccgcctaggt gttctgggct tctttagcac tggagatgag cgcgccagag
      601 gcaactgggg atacctggac caagtggccg ccctacgctg gctccaacag aacatcgcct
      661 actttggagg caaccctgac cgggtcacta tttttggcac atcagcaggt ggcacaagtg
      721 tctcttcact tgtggtatcc cctatgtccc aaggactttt ccgtggtgcc ataatggaga
      781 gtggggtggc cctgatatca agcctcatct cagtatcctc tgatgtagtc tatcaaacgg
      841 tggccaacct ctctggatgt gaacaggtgg actctgaggc cctggtgaac tgtctacgag
      901 gcaaaagcga ggaagagatt atggctatta ataaggcctt caagatcatc cctggcatag
      961 tggatggtat cttcctgccc agacatcctc aggagctgat ggcctctgct gactttcacc
     1021 ctgttcccag tattatcggt gtcaacaatg atgagtatgg ttggatcatc ccctcaagca
     1081 tgagcatgat tgactccaag aaggggatgg acagacaaat ggtgcaagct atcctgcaga
     1141 gaagggcaac ccagatgatg tggcctcctg aagtaagtga cctgctgatg gaggagtaca
     1201 tgggggacaa tgaggaccct cagtttctcc aagtgcagtt caaggagatg atgaaagatt
     1261 tcacctttgt gatccctgca ctgcaagtcg cacagtttca acgttcccat gcccctgtct
     1321 tcttctatga gttccagcat cggcccagct tcttcaagga ctccaagcca tcccatgtaa
     1381 aggctgacca tggtgatgaa attctcttta tcttcagatc attttgggga ggcacccaag
     1441 ttgacttcac tgaggaggaa gagctgctga gcaggaggat gatgaagtac tgggccaact
     1501 tcgcacgaca gaggaacccc aacagtgagg gtctacccta ctggcccatg tttgaccaag
     1561 atgagcagta cctgcagctg gacacccagc ctgctgtggg tcgagctctg aagacccgaa
     1621 ggctgcagtt ctggaccaag actcttcctg aaaagataca ggaactaaaa gatattgagg
     1681 acagacataa agagttgtag
//
