LOCUS       NP_001258974             558 aa            linear   ROD 06-AUG-2023
DEFINITION  cocaine esterase precursor [Mus musculus].
ACCESSION   NP_001258974 XP_003085419 XP_003086744 XP_488149 XP_920139
VERSION     NP_001258974.1
DBSOURCE    REFSEQ: accession NM_001272045.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 558)
  AUTHORS   Chalhoub G, Jamnik A, Pajed L, Kolleritsch S, Hois V, Bagaric A,
            Prem D, Tilp A, Kolb D, Wolinski H, Taschler U, Zullig T,
            Rechberger GN, Fuchs C, Trauner M, Schoiswohl G and Haemmerle G.
  TITLE     Carboxylesterase 2a deletion provokes hepatic steatosis and insulin
            resistance in mice involving impaired diacylglycerol and
            lysophosphatidylcholine catabolism
  JOURNAL   Mol Metab 72, 101725 (2023)
   PUBMED   37059417
  REMARK    GeneRIF: Carboxylesterase 2a deletion provokes hepatic steatosis
            and insulin resistance in mice involving impaired diacylglycerol
            and lysophosphatidylcholine catabolism.
REFERENCE   2  (residues 1 to 558)
  AUTHORS   Holmes RS, Wright MW, Laulederkind SJ, Cox LA, Hosokawa M, Imai T,
            Ishibashi S, Lehner R, Miyazaki M, Perkins EJ, Potter PM, Redinbo
            MR, Robert J, Satoh T, Yamashita T, Yan B, Yokoi T, Zechner R and
            Maltais LJ.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from AC166833.4.
            
            On or before Jan 5, 2013 this sequence version replaced
            XP_003085419.1, XP_920139.1, XP_488149.1, XP_003086744.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849377, SAMN00849378
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..558
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     Protein         1..558
                     /product="cocaine esterase precursor"
                     /EC_number="3.1.1.1"
                     /note="carboxylesterase 2"
                     /calculated_mol_wt=59970
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2807
     Region          30..537
                     /region_name="COesterase"
                     /note="Carboxylesterase family; pfam00135"
                     /db_xref="CDD:395084"
     Site            order(147..149,226..228,231,366,370..371,410,457,460)
                     /site_type="other"
                     /note="substrate binding pocket [chemical binding]"
                     /db_xref="CDD:238191"
     Site            order(227,344,456)
                     /site_type="active"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:238191"
     CDS             1..558
                     /gene="Ces2h"
                     /gene_synonym="Ces2; Gm5744"
                     /coded_by="NM_001272045.2:24..1700"
                     /db_xref="CCDS:CCDS59742.1"
                     /db_xref="GeneID:436059"
                     /db_xref="MGI:MGI:3648740"
ORIGIN      
        1 mrleqiharl ttatcgllll lrvqgqdsts pirtthtgqi lgslihmkdl dvgvhsflgi
       61 pfakppvgpl rfappeppep wggvrdgtsh pamclqdita mnmqafkllk ltlppfpmse
      121 dclylniyap dhahegsnlp vmvwihggsl vigmasmydg smlaamenvv vvtiqyrlgv
      181 lgffstgder argnwgyldq vaalrwlqqn iayfggnpdr vtifgtsagg tsvsslvvsp
      241 msqglfrgai mesgvaliss lisvssdvvy qtvanlsgce qvdsealvnc lrgkseeeim
      301 ainkafkiip givdgiflpr hpqelmasad fhpvpsiigv nndeygwiip ssmsmidskk
      361 gmdrqmvqai lqrratqmmw ppevsdllme eymgdnedpq flqvqfkemm kdftfvipal
      421 qvaqfqrsha pvffyefqhr psffkdskps hvkadhgdei lfifrsfwgg tqvdfteeee
      481 llsrrmmkyw anfarqrnpn seglpywpmf dqdeqylqld tqpavgralk trrlqfwtkt
      541 lpekiqelkd iedrhkel
//
