LOCUS       NM_197999               2859 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus carboxylesterase 2G (Ces2g), mRNA.
ACCESSION   NM_197999
VERSION     NM_197999.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2859)
  AUTHORS   Szafran B, Borazjani A, Lee JH, Ross MK and Kaplan BL.
  TITLE     Lipopolysaccharide suppresses carboxylesterase 2g activity and
            2-arachidonoylglycerol hydrolysis: A possible mechanism to regulate
            inflammation
  JOURNAL   Prostaglandins Other Lipid Mediat 121 (Pt B), 199-206 (2015)
   PUBMED   26403860
  REMARK    GeneRIF: Data suggest that down-regulation of hydrolysis of
            2-arachidonoylglycerol, an endocannabinoid, in spleen/splenocytes
            in endotoxemia (induced by lipopolysaccharide) is due to reduction
            in Ces2g activity/expression.
REFERENCE   2  (bases 1 to 2859)
  AUTHORS   Holmes RS, Wright MW, Laulederkind SJ, Cox LA, Hosokawa M, Imai T,
            Ishibashi S, Lehner R, Miyazaki M, Perkins EJ, Potter PM, Redinbo
            MR, Robert J, Satoh T, Yamashita T, Yan B, Yokoi T, Zechner R and
            Maltais LJ.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166833.4.
            
            On Nov 19, 2009 this sequence version replaced NM_197999.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027185.1, ERR3363658.957456.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               AC166833.4         131628-131773
            147-357             AC166833.4         132380-132590
            358-496             AC166833.4         133786-133924
            497-630             AC166833.4         134570-134703
            631-889             AC166833.4         134785-135043
            890-988             AC166833.4         135799-135897
            989-1129            AC166833.4         136160-136300
            1130-1210           AC166833.4         136422-136502
            1211-1355           AC166833.4         136739-136883
            1356-1493           AC166833.4         137229-137366
            1494-1566           AC166833.4         137670-137742
            1567-2859           AC166833.4         138155-139447
FEATURES             Location/Qualifiers
     source          1..2859
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..2859
                     /gene="Ces2g"
                     /gene_synonym="2210023G05Rik; Ces2l"
                     /note="carboxylesterase 2G"
                     /db_xref="GeneID:72361"
                     /db_xref="MGI:MGI:1919611"
     exon            1..146
                     /gene="Ces2g"
                     /gene_synonym="2210023G05Rik; Ces2l"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1753
                     /gene="Ces2g"
                     /gene_synonym="2210023G05Rik; Ces2l"
                     /EC_number="3.1.1.1"
                     /codon_start=1
                     /product="carboxylesterase 2-like precursor"
                     /protein_id="NP_932116.2"
                     /db_xref="CCDS:CCDS22589.1"
                     /db_xref="GeneID:72361"
                     /db_xref="MGI:MGI:1919611"
                     /translation="MPRNQMHSWLDAVFFGLLLLLGHVQGHDSPETSPIRSTHSGQVQ
                     GRLIHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSQPAICPQNVT
                     MNMEGLKELKLTLPPVSMSEDCLYLNIYTPAHAQEGSNLPVMVWIHGGALTVGMASMY
                     DGSVLAATEDVVVVAIQYRLGVLGFFSTGDEHARGNWGFLDQVAALRWVQQNIAHFGG
                     NPDRVTIFGESAGGISVSSHVVSPMSKGLFHRAIMESGVALLPGTIFSFSEVVYQTVA
                     KLSGCEAMDSEALVRCLRGKSEEEILAISKNFQMIPGVVDGEFLPKHPQELLASADFH
                     PVPSIIGFNNDEYGWIVPKVIGSTQTIKGITRENLQAVLKDTAPQMMLPPECSDLLME
                     EYMEDIEDPKTLQIQFTEMMEDFMFVIPSLQVAYFQRSHAPVYFYEFQHQSSFLKDVR
                     PPHVNADHGDEVPFVFGSFFWGMKLNLTEEEKLLNRRMMKYWANFARHGNPNSESLPY
                     WPVFDHDEQYLQLNIQPAVGQFQKARKLQFWTKTLPRKIEELKRSQNVHKEL"
     exon            147..357
                     /gene="Ces2g"
                     /gene_synonym="2210023G05Rik; Ces2l"
                     /inference="alignment:Splign:2.1.0"
     exon            358..496
                     /gene="Ces2g"
                     /gene_synonym="2210023G05Rik; Ces2l"
                     /inference="alignment:Splign:2.1.0"
     exon            497..630
                     /gene="Ces2g"
                     /gene_synonym="2210023G05Rik; Ces2l"
                     /inference="alignment:Splign:2.1.0"
     exon            631..889
                     /gene="Ces2g"
                     /gene_synonym="2210023G05Rik; Ces2l"
                     /inference="alignment:Splign:2.1.0"
     exon            890..988
                     /gene="Ces2g"
                     /gene_synonym="2210023G05Rik; Ces2l"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1129
                     /gene="Ces2g"
                     /gene_synonym="2210023G05Rik; Ces2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1210
                     /gene="Ces2g"
                     /gene_synonym="2210023G05Rik; Ces2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1355
                     /gene="Ces2g"
                     /gene_synonym="2210023G05Rik; Ces2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1493
                     /gene="Ces2g"
                     /gene_synonym="2210023G05Rik; Ces2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1566
                     /gene="Ces2g"
                     /gene_synonym="2210023G05Rik; Ces2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..2859
                     /gene="Ces2g"
                     /gene_synonym="2210023G05Rik; Ces2l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatattctg cttcctgttt gtgaaacgtg gtcctcctag cagcacagac tcagagcctg
       61 agagccggcc atgccacgga accaaatgca tagctggctg gatgctgtgt tctttggact
      121 cctgcttctc ctcggccatg tgcagggtca cgactcacca gagaccagcc ccatcagaag
      181 cacacactct ggccaggtcc aaggcaggct cattcacgtg aaggacacta aagctggtgt
      241 ccacaccttc ctgggaatcc cctttgccaa gcctcctgta ggaccactgc gctttgcacc
      301 tcctgaggcc cctgagccat ggagtggtgt gagagatgga acctcacagc cagccatttg
      361 tccacaaaat gttacgatga atatggaggg cctgaaggag ttgaaactga ccctgccacc
      421 tgtctctatg tccgaggact gcctgtatct caacatctac acaccagccc acgcccagga
      481 gggctctaac ctgcctgtga tggtgtggat ccacggtggt gcactcactg taggcatggc
      541 ttccatgtat gatggatccg tgctggcagc cactgaggat gtggtggtgg tcgctatcca
      601 gtaccgcctg ggtgtcttgg gattcttcag cactggagat gaacatgcca ggggaaactg
      661 ggggttcctg gaccaagtgg ctgccctacg ctgggtccag cagaacatcg cccactttgg
      721 tggcaaccct gaccgggtca ctatttttgg cgagtcagca ggaggcataa gcgtgtcttc
      781 gcatgttgtg tcccccatgt ccaaaggact ctttcacaga gccatcatgg agagtggagt
      841 agctctgttg cctggaacca tatttagctt ctctgaggtg gtttaccaaa cggtggccaa
      901 gctctctggt tgtgaggcca tggattcaga ggccctggtg cgctgtctga gaggcaagag
      961 tgaagaggag attctagcta ttagcaagaa cttccagatg atccctggtg tggtggatgg
     1021 agagttccta cccaagcatc ctcaggagct gctggcctct gctgattttc accctgtccc
     1081 cagcatcatt ggtttcaaca atgatgagta tggttggatc gtccccaaag tcataggctc
     1141 tactcagaca ataaagggaa taaccagaga gaacctgcag gctgtcctga aggatacagc
     1201 accgcaaatg atgctgcctc ctgagtgtag tgatctgttg atggaagagt acatggagga
     1261 cattgaggac cccaagactc ttcaaataca gttcaccgaa atgatggaag acttcatgtt
     1321 tgtgatccct tctctccaag tagcatattt tcagcgttcc catgcccctg tctacttcta
     1381 tgaattccaa catcaatcca gcttcctcaa ggatgtcagg ccaccccacg tgaacgctga
     1441 ccatggagat gaggttcctt ttgtttttgg ttccttcttc tggggcatga aacttaacct
     1501 cactgaagag gaaaagctgc taaacaggag aatgatgaag tactgggcca actttgcaag
     1561 acatgggaac cccaacagtg agagtctacc ctactggccc gtgtttgacc atgatgaaca
     1621 gtatctacag ctgaacatcc agcctgctgt gggacaattc cagaaggcca gaaagctgca
     1681 gttctggacc aagactctgc cccggaagat tgaggagtta aagagatctc aaaacgtgca
     1741 caaagagcta tagtgccttg tgtgaggaat ggtatatggt gtcagctgct gatggagtca
     1801 gcttcaggtt cccaaaacat tctaacattc atataaactc tgtgcttgtc tgttcttcat
     1861 ttatcacaaa tcctctgcat gtgactcctt ctcctgctgg gtcatctttt gttagaccca
     1921 ttaaaaaagc agcctattga ttgggttaga cctatccaaa ctcccctccc agtggatttg
     1981 tgaaccccat aattccccat ctccttttac actccactgg gactaggatc tttgctttct
     2041 tctttcctca cctcacctct catcctcact gtcctcttct ctatgaccaa aacagtcttc
     2101 aagtaggact ttggaaaaca ttgatattgt tctccaaaca gtccctatca caggggtggg
     2161 ctgtgtcaga accacatgct ccctctcatc agcttcacac ttttggagac catagatccc
     2221 aagattaaga tactaacagg tttgctgtac atgctctcta gcccaaagat gatacctgtg
     2281 atttcactga gcatatgaga tagttaacaa tcctcatggc ccgggcctcc aataggcctc
     2341 ttttttttta attggatatt ttctttattt acatttcaaa tgttatcacc tttctcaccc
     2401 cacccccaaa accctttatt atatcccccc ttcccctgct tctatgaggg tgttccctca
     2461 cccatcccac ccatccccac ttccccgccc tctcattcct ctatactggg gcattgatcc
     2521 ttcacaggac caagggcctc tcctccgatt gatgcctgac aaggtcattc tctgctatat
     2581 aggtggctga agccatgatt ccctccatgt ttactctccg gttggtggtt tagtccctgg
     2641 gagctctggg gggaggtctg gttgtttgat attgttgttc ttcctatggg tttatcacat
     2701 tggagttatt cagtatagaa atatgattca tagatatttt caaaacacag cacacagagg
     2761 ttcccaactt gatcactaga tttgaaaaca tctaaaagtg tctctatcta ctgtgtttat
     2821 aaattaaaat ttgccaacaa tttgttttaa gataatcta
//
