LOCUS       NM_172759               2699 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus carboxylesterase 2E (Ces2e), transcript variant 1,
            mRNA.
ACCESSION   NM_172759
VERSION     NM_172759.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2699)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
REFERENCE   2  (bases 1 to 2699)
  AUTHORS   Stok,J.E., Huang,H., Jones,P.D., Wheelock,C.E., Morisseau,C. and
            Hammock,B.D.
  TITLE     Identification, expression, and purification of a
            pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes
  JOURNAL   J Biol Chem 279 (28), 29863-29869 (2004)
   PUBMED   15123619
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166833.4 and AK077248.1.
            
            On Jul 31, 2009 this sequence version replaced NM_172759.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033563.1, AK077248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC166833.4         96170-96179
            11-2157             AK077248.1         2-2148
            2158-2694           AK077248.1         2150-2686
            2695-2699           AC166833.4         104578-104582
FEATURES             Location/Qualifiers
     source          1..2699
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..2699
                     /gene="Ces2e"
                     /gene_synonym="9030624L02Rik; Ces5"
                     /note="carboxylesterase 2E"
                     /db_xref="GeneID:234673"
                     /db_xref="MGI:MGI:2443170"
     exon            1..137
                     /gene="Ces2e"
                     /gene_synonym="9030624L02Rik; Ces5"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1741
                     /gene="Ces2e"
                     /gene_synonym="9030624L02Rik; Ces5"
                     /EC_number="3.1.1.88"
                     /note="carboxylesterase 5; pyrethroid hydrolase Ces2e;
                     carboxylic ester hydrolase"
                     /codon_start=1
                     /product="pyrethroid hydrolase Ces2e precursor"
                     /protein_id="NP_766347.1"
                     /db_xref="CCDS:CCDS22588.1"
                     /db_xref="GeneID:234673"
                     /db_xref="MGI:MGI:2443170"
                     /translation="MPLYKLLGWLNAVACGVLLLVLHVQGQDSASPIRNTHTGQVRGS
                     LVHVKDTDIAVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSHPNMCLQNDNLM
                     GSEDLKMMNLILPPISMSEDCLYLNIYVPAHAHEGSNLPVMVWIHGGALTVGMASMYD
                     GSMLAATEDVVVVAIQYRLGVLGFFSTGDQHAKGNWGYLDQVAALRWVQQNIVHFGGN
                     PDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVAVLPDLISSSSEMVHRIVAN
                     LSGCAAVNSETLMCCLRGKNEAEMLAINKVFKIIPGVVDGEFLPKHPQELMASKDFHP
                     VPSIIGINNDEYGWILPTIMDPAQKIEEITRKTLPAVLKSTALKMMLPPECGDLLMEE
                     YMGDTEDPETLQAQFREMKGDFMFVIPALQVAHFQRSHAPVYFYEFQHRPSFFKDFRP
                     PYVKADHGDEIFLVFGYQFGNIKLPYTEEEEQLSRRIMKYWANFARHGNPNSEGLPYW
                     PVMDHDEQYLQLDIQPSVGRALKARRLQFWTKTLPQKIQELKGSQERHKEL"
     exon            138..342
                     /gene="Ces2e"
                     /gene_synonym="9030624L02Rik; Ces5"
                     /inference="alignment:Splign:2.1.0"
     exon            343..484
                     /gene="Ces2e"
                     /gene_synonym="9030624L02Rik; Ces5"
                     /inference="alignment:Splign:2.1.0"
     exon            485..618
                     /gene="Ces2e"
                     /gene_synonym="9030624L02Rik; Ces5"
                     /inference="alignment:Splign:2.1.0"
     exon            619..877
                     /gene="Ces2e"
                     /gene_synonym="9030624L02Rik; Ces5"
                     /inference="alignment:Splign:2.1.0"
     exon            878..976
                     /gene="Ces2e"
                     /gene_synonym="9030624L02Rik; Ces5"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1117
                     /gene="Ces2e"
                     /gene_synonym="9030624L02Rik; Ces5"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1198
                     /gene="Ces2e"
                     /gene_synonym="9030624L02Rik; Ces5"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1343
                     /gene="Ces2e"
                     /gene_synonym="9030624L02Rik; Ces5"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1481
                     /gene="Ces2e"
                     /gene_synonym="9030624L02Rik; Ces5"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1554
                     /gene="Ces2e"
                     /gene_synonym="9030624L02Rik; Ces5"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..2699
                     /gene="Ces2e"
                     /gene_synonym="9030624L02Rik; Ces5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2672..2677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ces2e"
                     /gene_synonym="9030624L02Rik; Ces5"
                     /note="hexamer: AATAAA"
     polyA_site      2695
                     /gene="Ces2e"
                     /gene_synonym="9030624L02Rik; Ces5"
                     /note="major polyA site"
ORIGIN      
        1 tttcctgtcc atagcacaca gatatcctgg agcaacacag actcagatct aagagctgac
       61 tatgccacta tacaaacttc ttggatggct gaatgctgtg gcctgtgggg tcctgcttct
      121 cgttctgcat gtgcaaggtc aggactcagc cagccccatc aggaacacac acacaggcca
      181 ggtgagaggc agccttgtcc acgtgaagga cactgacatc gctgttcata ccttcctggg
      241 aatccccttt gccaagcctc ctgtaggacc actgcgcttt gcacctcctg aggcccctga
      301 gccatggagt ggggtgaggg atgggacctc acatccaaac atgtgtctac aaaatgacaa
      361 tttgatgggt tcagaggatc tgaagatgat gaacttgatc ctgcctccca tctctatgtc
      421 tgaggactgc ctgtatctca acatctatgt accagcccat gcccatgagg gttctaacct
      481 acctgtgatg gtatggatcc atggtggtgc actcactgtt ggcatggctt ccatgtatga
      541 tggatccatg ctggcagcaa ctgaggatgt ggtggtggtc gctatccagt accgcctggg
      601 tgttctggga ttcttcagca ctggagacca gcatgccaaa ggcaactggg gatacctgga
      661 ccaagtggct gcccttcgtt gggtccagca aaacattgtc cactttggag gcaaccctga
      721 ccgagtcacc atttttggag agtcagcagg tggcacaagt gtgtcttcac atgttgtgtc
      781 ccccatgtcc cagggactct tccatggtgc catcatggag agtggagtag ctgtgctccc
      841 tgatcttatc tccagctcct ctgagatggt tcacagaata gtggccaatc tatctggctg
      901 tgcagctgtg aactcagaga ccctgatgtg ctgcctaaga ggcaagaatg aagcagagat
      961 gctggctatt aataaggtct tcaaaatcat ccctggtgtg gtggatggag agttcctacc
     1021 caagcatcct caggagctga tggcctctaa ggattttcac cctgtcccca gcatcattgg
     1081 tatcaacaat gatgaatatg gttggattct tcctacgatc atggacccag ctcagaaaat
     1141 agaggaaata accagaaaga ccctgccagc tgttctaaaa agcacagccc taaaaatgat
     1201 gctgcctcct gagtgtggtg acctgctaat ggaggagtac atgggggaca ctgaggaccc
     1261 agagactctg caagcacagt tcagagagat gaagggggac ttcatgttcg tgatccctgc
     1321 actacaagta gcacattttc aacgttccca tgctcctgtc tacttctatg agttccaaca
     1381 tcgacccagc ttcttcaagg atttcaggcc accctatgtg aaggctgacc atggtgatga
     1441 aattttcctt gtctttggct accagttcgg taacataaaa cttccttaca ctgaggaaga
     1501 ggagcaacta agcagaagga taatgaagta ctgggccaac tttgcacggc acgggaaccc
     1561 caacagtgag ggtctaccct actggcctgt gatggaccat gatgagcagt acctgcagct
     1621 ggacatccag ccttctgtgg gtcgagccct gaaggccaga aggctgcagt tctggaccaa
     1681 gactctgccc cagaagatcc aggagctaaa ggggtctcag gagaggcaca aagagttgta
     1741 gtgccctgtg tgaagaaagg catgtgggct tcatgtctga ggtttggaaa gctttttgac
     1801 cctaccattc acacaaccat tcctaacaca tacagttatc cattttacca atttatatga
     1861 caaacccttt acatgtcact ccttcacaaa atgctgacaa tctcttgtta gagccactca
     1921 ataaaagctt ctgtaacaat gtggaatatg gatgtaggag ccccaagttc ccatagtctc
     1981 cacaagttct gaatgctgtt ccaagtagat ctcaaactac cagcaggtct tgggatctag
     2041 tggacctgaa tatttagaaa ctaagtcagg gatgttgcat gagcctagta gttccatacc
     2101 accatggaca acatagcaag acctgtaact caataacaga aataatcact agctgggtaa
     2161 cttgcaaaca acagaaatgt atgtaaagtt ctgtggtatg agaaatagag ggtgagaaaa
     2221 tgaacttgag ccatacagtc tttcagggct cagctactag acctctgatg tcagccactg
     2281 aacattccag ctactaaaaa ctgtgtccat tgtccctata gaggaaatcg catcctttcc
     2341 aaattgccat tatctacttt tgtgaaaagc ttgacttggt atgtttatag acacctcaag
     2401 caaggccaag aatgggggtt gaccagcagg cccaagtagg ctttctctaa taacaaattg
     2461 cttttacgca cagggattct gcagacactg tgaagcccac atttatgtga acataacaca
     2521 tctgcaaaga tctttggcta tgattgtgtt ctagagatga tatagaagag aaaagaatcc
     2581 ccggatatgt atagcagaag agatttctgt ccttggcacc ctgatggctt ctccatgtat
     2641 ggaagtgact tcttgccttt cataaaatcc taataaaacc catcttttca tggcatttc
//
