LOCUS       NM_145603               1978 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus carboxylesterase 2C (Ces2c), mRNA.
ACCESSION   NM_145603
VERSION     NM_145603.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1978)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1978)
  AUTHORS   Chen,S., Lu,W., Yueh,M.F., Rettenmeier,E., Liu,M., Paszek,M.,
            Auwerx,J., Yu,R.T., Evans,R.M., Wang,K., Karin,M. and Tukey,R.H.
  TITLE     Intestinal NCoR1, a regulator of epithelial cell maturation,
            controls neonatal hyperbilirubinemia
  JOURNAL   Proc Natl Acad Sci U S A 114 (8), E1432-E1440 (2017)
   PUBMED   28167773
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4115. doi:
            10.1073/pnas.1705671114.. Paszek, Miles [added]. PMID: 28484028]
REFERENCE   3  (bases 1 to 1978)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
REFERENCE   4  (bases 1 to 1978)
  AUTHORS   Ahowesso,C., Piccolo,E., Li,X.M., Dulong,S., Hossard,V., La
            Sorda,R., Filipski,E., Tinari,N., Delaunay,F., Iacobelli,S. and
            Levi,F.
  TITLE     Relations between strain and gender dependencies of irinotecan
            toxicity and UGT1A1, CES2 and TOP1 expressions in mice
  JOURNAL   Toxicol Lett 192 (3), 395-401 (2010)
   PUBMED   19931604
REFERENCE   5  (bases 1 to 1978)
  AUTHORS   Holmes,R.S., Cox,L.A. and Vandeberg,J.L.
  TITLE     A new class of mammalian carboxylesterase CES6
  JOURNAL   Comp Biochem Physiol Part D Genomics Proteomics 4 (3), 209-217
            (2009)
   PUBMED   20161041
REFERENCE   6  (bases 1 to 1978)
  AUTHORS   Zhu,H.J., Appel,D.I., Jiang,Y. and Markowitz,J.S.
  TITLE     Age- and sex-related expression and activity of carboxylesterase 1
            and 2 in mouse and human liver
  JOURNAL   Drug Metab Dispos 37 (9), 1819-1825 (2009)
   PUBMED   19487248
REFERENCE   7  (bases 1 to 1978)
  AUTHORS   Furihata,T., Hosokawa,M., Masuda,M., Satoh,T. and Chiba,K.
  TITLE     Hepatocyte nuclear factor-4alpha plays pivotal roles in the
            regulation of mouse carboxylesterase 2 gene transcription in mouse
            liver
  JOURNAL   Arch Biochem Biophys 447 (2), 107-117 (2006)
   PUBMED   16527247
  REMARK    GeneRIF: These findings show that HNF-4alpha plays an important
            role in the regulation of mCES2 gene transcription.
REFERENCE   8  (bases 1 to 1978)
  AUTHORS   Furihata,T., Hosokawa,M., Satoh,T. and Chiba,K.
  TITLE     Synergistic role of specificity proteins and upstream stimulatory
            factor 1 in transactivation of the mouse carboxylesterase
            2/microsomal acylcarnitine hydrolase gene promoter
  JOURNAL   Biochem J 384 (Pt 1), 101-110 (2004)
   PUBMED   15283701
REFERENCE   9  (bases 1 to 1978)
  AUTHORS   Furihata,T., Hosokawa,M., Nakata,F., Satoh,T. and Chiba,K.
  TITLE     Purification, molecular cloning, and functional expression of
            inducible liver acylcarnitine hydrolase in C57BL/6 mouse, belonging
            to the carboxylesterase multigene family
  JOURNAL   Arch Biochem Biophys 416 (1), 101-109 (2003)
   PUBMED   12859986
  REMARK    GeneRIF: purified and characterized an acylcarnitine hydrolase (ACH
            M1) from liver microsomes, cloned the cDNA named mCES2, expressed
            it in Sf9 cells and characterized it
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB110073.1 and AI255649.1.
            
            On Jun 13, 2010 this sequence version replaced NM_145603.1.
            
            Summary: This gene encodes a member of the carboxylesterase large
            family. The family members are responsible for the hydrolysis or
            transesterification of various xenobiotics, such as cocaine and
            heroin, and endogenous substrates with ester, thioester, or amide
            bonds. They may participate in fatty acyl and cholesterol ester
            metabolism, and may play a role in the blood-brain barrier system.
            The protein encoded by this gene is the major intestinal enzyme and
            functions in intestine drug clearance. The transcription of this
            gene is regulated by several factors including HNF-4alpha
            (hepatocyte nuclear factor-4alpha), Sp1 (specificity protein 1),
            Sp3 and USF1 (upstream stimulatory factor 1). The expression and
            activity of this gene is age-related but independent of growth
            hormone level. This gene is clustered with several family members
            including a few of pseudogenes and Ces5 on chromosome 8.[provided
            by RefSeq, Jun 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB110073.1, AK136411.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1776              AB110073.1         1-1776
            1777-1978           AI255649.1         1-202               c
FEATURES             Location/Qualifiers
     source          1..1978
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..1978
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; CES 2; Ces2; ces2A3"
                     /note="carboxylesterase 2C"
                     /db_xref="GeneID:234671"
                     /db_xref="MGI:MGI:2385905"
     exon            1..141
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; CES 2; Ces2; ces2A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1751
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; CES 2; Ces2; ces2A3"
                     /EC_number="3.1.1.28"
                     /note="carboxylesterase 2; carboxylesterase ML3;
                     acylcarnitine hydrolase M1; peroxisome
                     proliferator-inducible acylcarnitine hydrolase; carboxylic
                     ester hydrolase"
                     /codon_start=1
                     /product="acylcarnitine hydrolase precursor"
                     /protein_id="NP_663578.1"
                     /db_xref="CCDS:CCDS22587.1"
                     /db_xref="GeneID:234671"
                     /db_xref="MGI:MGI:2385905"
                     /translation="MTRNQLHNWLNAGFFGLLLLLIHVQGQDSPEANPIRNTHTGQIQ
                     GSLIHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTAHPAMCLQNLD
                     MLNEAGLPDMKMMLSSFPMSEDCLYLNIYTPAHAHEGSNLPVMVWIHGGALVIGMASM
                     FDGSLLTVNEDLVVVTIQYRLGVLGFFSTGDQHARGNWGYLDQAAALRWVQQNIAHFG
                     GNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVALLPDLISETSEMVSTTV
                     AKLSGCEAMDSQALVRCLRGKSEAEILAINKVFKMIPAVVDGEFFPRHPKELLASEDF
                     HPVPSIIGVNNDEFGWSIPVVMGSAQMIKGITRENLQAVLKDTAVQMMLPPECSDLLM
                     EEYMGDTEDAQTLQIQFTEMMGDFMFVIPALQVAHFQRSHAPVYFYEFQHPPSYFKDV
                     RPPHVKADHADEIPFVFASFFWGMKLDFTEEEELLSRRMMKYWANFARHGNPNSEGLP
                     YWPVMDHDEQYLQLDIQPAVGRALKAGRLQFWTKTLPQKIQELKASQDKHREL"
     exon            142..352
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; CES 2; Ces2; ces2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            353..494
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; CES 2; Ces2; ces2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            495..628
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; CES 2; Ces2; ces2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            629..887
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; CES 2; Ces2; ces2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            888..986
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; CES 2; Ces2; ces2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1127
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; CES 2; Ces2; ces2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1208
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; CES 2; Ces2; ces2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1353
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; CES 2; Ces2; ces2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1491
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; CES 2; Ces2; ces2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1564
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; CES 2; Ces2; ces2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1970
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; CES 2; Ces2; ces2A3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1930..1935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; CES 2; Ces2; ces2A3"
     polyA_site      1970
                     /gene="Ces2c"
                     /gene_synonym="ACH M1; CES 2; Ces2; ces2A3"
ORIGIN      
        1 cttatgcttc ctgtttgtga aacttggtca tcttagcagc acagacttag gactgagagc
       61 tgatcatgac acggaaccaa ctacataact ggctgaatgc tgggttcttc gggctgctgc
      121 ttcttcttat ccatgtgcag ggtcaggact caccagaggc caaccccatc agaaacacac
      181 atacaggaca gatccaaggc agccttatcc acgtgaagga cactaaagct ggtgtccaca
      241 ccttcctggg aatccccttt gccaaacctc ctgtaggacc actgcgattt gcacctcctg
      301 aggcccctga accatggagt ggtgtgagag atggaactgc acatccggcc atgtgtctgc
      361 aaaatcttga catgctgaat gaagcaggcc tgccagatat gaaaatgatg ctgtcttcct
      421 tccctatgtc tgaggactgc ctgtatctca acatctacac cccagcccat gcccatgagg
      481 gctctaacct gcctgtgatg gtgtggatcc atggaggtgc actggttata ggaatggctt
      541 ccatgtttga tggatctcta ttgacagtca atgaggactt ggtggttgtt actatccagt
      601 atcgtctggg tgtcctgggc tttttcagca ctggagacca gcatgccaga ggcaactggg
      661 gatacctgga ccaagcagct gccctacgct gggtccagca gaacatcgct cactttggag
      721 gcaaccctga ccgggtcact atttttggcg agtctgcagg tggcacaagt gtgtcttcac
      781 atgttgtgtc ccccatgtcc caagggctct tccatggtgc catcatggag agtggggtgg
      841 ccctgcttcc tgaccttatc tctgaaacct ctgagatggt ttccactacg gtggccaagc
      901 tttctggatg tgaggctatg gattcccagg ccctggtgcg ctgtctgaga ggcaaaagtg
      961 aagcagagat tctggctatt aacaaggtct tcaagatgat ccctgctgtg gtggatgggg
     1021 agttcttccc caggcatccc aaagagttgt tggcatctga ggattttcac cctgtcccca
     1081 gcatcattgg tgtcaacaat gatgagtttg gctggtccat tcctgtggtc atgggctctg
     1141 ctcagatgat aaaaggaata accagagaga acctgcaggc tgttctgaag gatacagcag
     1201 tacaaatgat gctgcctcct gagtgtagtg acctgctaat ggaagagtac atgggggaca
     1261 ctgaggatgc ccagaccctc caaatacagt tcacagagat gatgggagat ttcatgtttg
     1321 tgatccctgc actccaagta gcacattttc aacgctccca tgcccctgtc tacttctatg
     1381 agttccaaca tccacccagc tacttcaagg atgtcagacc accccacgtg aaggctgacc
     1441 atgctgatga gattcctttt gtctttgcgt ccttcttctg gggcatgaaa cttgacttca
     1501 ctgaggagga ggagctgctg agcaggagga tgatgaagta ctgggccaac tttgcacgac
     1561 atgggaaccc caacagtgag ggtctaccct actggcctgt gatggaccat gatgagcagt
     1621 acctgcaact ggacatccag cctgctgtgg gtcgagccct gaaggctgga aggctgcagt
     1681 tctggaccaa gactctgccc cagaagatcc aggagctaaa ggcttctcag gacaagcaca
     1741 gggagcttta gtaccctgta tcaaaaaaaa tgtgtttggg gtttaaagtc aatagcgcta
     1801 caaattccat ttatttattt ttatttgttc caacacttac ataagcatct gtcacctcag
     1861 tctttgagct ttcatgtatg aaaaatactc tgtattactt atcattctgg ccaaactttc
     1921 attaaattca ataaattctc aaataacact gtggatgtgt gagcctcaaa aaaaaaaa
//
