LOCUS       NM_133960               1964 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus carboxylesterase 2A (Ces2a), transcript variant 1,
            mRNA.
ACCESSION   NM_133960
VERSION     NM_133960.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1964)
  AUTHORS   Chalhoub,G., Jamnik,A., Pajed,L., Kolleritsch,S., Hois,V.,
            Bagaric,A., Prem,D., Tilp,A., Kolb,D., Wolinski,H., Taschler,U.,
            Zullig,T., Rechberger,G.N., Fuchs,C., Trauner,M., Schoiswohl,G. and
            Haemmerle,G.
  TITLE     Carboxylesterase 2a deletion provokes hepatic steatosis and insulin
            resistance in mice involving impaired diacylglycerol and
            lysophosphatidylcholine catabolism
  JOURNAL   Mol Metab 72, 101725 (2023)
   PUBMED   37059417
REFERENCE   2  (bases 1 to 1964)
  AUTHORS   Suzuki,T., Kikuguchi,C., Nishijima,S., Nagashima,T., Takahashi,A.,
            Okada,M. and Yamamoto,T.
  TITLE     Postnatal liver functional maturation requires Cnot
            complex-mediated decay of mRNAs encoding cell cycle and immature
            liver genes
  JOURNAL   Development 146 (4) (2019)
   PUBMED   30733279
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1964)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
REFERENCE   4  (bases 1 to 1964)
  AUTHORS   Theodorou,V., Boer,M., Weigelt,B., Jonkers,J., van der Valk,M. and
            Hilkens,J.
  TITLE     Fgf10 is an oncogene activated by MMTV insertional mutagenesis in
            mouse mammary tumors and overexpressed in a subset of human breast
            carcinomas
  JOURNAL   Oncogene 23 (36), 6047-6055 (2004)
   PUBMED   15208658
REFERENCE   5  (bases 1 to 1964)
  AUTHORS   Stok,J.E., Huang,H., Jones,P.D., Wheelock,C.E., Morisseau,C. and
            Hammock,B.D.
  TITLE     Identification, expression, and purification of a
            pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes
  JOURNAL   J Biol Chem 279 (28), 29863-29869 (2004)
   PUBMED   15123619
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY088529.1, AK078953.1 and BY458169.1.
            
            On Jun 16, 2010 this sequence version replaced NM_133960.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078953.1, BC025537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BY088529.1         1-5
            6-1960              AK078953.1         2-1956
            1961-1964           BY458169.1         406-409
FEATURES             Location/Qualifiers
     source          1..1964
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..1964
                     /gene="Ces2a"
                     /gene_synonym="9130231C15Rik; Ces6"
                     /note="carboxylesterase 2A"
                     /db_xref="GeneID:102022"
                     /db_xref="MGI:MGI:2142491"
     exon            1..145
                     /gene="Ces2a"
                     /gene_synonym="9130231C15Rik; Ces6"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1746
                     /gene="Ces2a"
                     /gene_synonym="9130231C15Rik; Ces6"
                     /EC_number="3.1.1.88"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; carboxylesterase 6; pyrethroid hydrolase Ces2a;
                     carboxylic ester hydrolase 2A"
                     /codon_start=1
                     /product="pyrethroid hydrolase Ces2a isoform 1 precursor"
                     /protein_id="NP_598721.1"
                     /db_xref="CCDS:CCDS22585.1"
                     /db_xref="GeneID:102022"
                     /db_xref="MGI:MGI:2142491"
                     /translation="MPLARLPGWLCVVACGLLLLLQHVHGQDSASPIRNTHRGQVRGS
                     FVHVKDTKSGVHAFLGIPFAKPPVGLLRFAPPEDPEPWSGVRDGTSQPAMCLQPDIMN
                     LEDAKEMNLILPPISMSEDCLYLNIYTPTHAQEGSNLPVMVWIHGGGLVVGSASMNDV
                     SKLAATEEIVIVAIQYRLGVLGFFSTGDQHARGNWGYLDQVAALRWVQKNIAYFGGNR
                     DRVTIFGVSAGGTSVSSHILSPMSKGLFHGAIMQSGVALLPDLISDTSEVVYKTVANL
                     SGCEATDSEALIHCLRAKSKQEILAINQVFKMIPAVVDGEFLPKHPQELLTSMDFHPV
                     PSIIGVNTDECGWGVPMFMGLDHIIKNITRETLPAVLKNTAARMMLPPECSHLLVEEY
                     MGDTEDPETLQAQFREMLGDFMFVIPALQVAHFQRSQAPVYFYEFQHLSSFIKHVRPS
                     HVKADHGDDVAFVFGSYLWDMNLDLTEEEELLKRMMMKYWANFARNGNPNSEGLPSWP
                     VLDHDEQYLQLDTQPAVGRALKARRLQFWTKTLPQKIQELKGSQDKHAEL"
     exon            146..350
                     /gene="Ces2a"
                     /gene_synonym="9130231C15Rik; Ces6"
                     /inference="alignment:Splign:2.1.0"
     exon            351..489
                     /gene="Ces2a"
                     /gene_synonym="9130231C15Rik; Ces6"
                     /inference="alignment:Splign:2.1.0"
     exon            490..623
                     /gene="Ces2a"
                     /gene_synonym="9130231C15Rik; Ces6"
                     /inference="alignment:Splign:2.1.0"
     exon            624..882
                     /gene="Ces2a"
                     /gene_synonym="9130231C15Rik; Ces6"
                     /inference="alignment:Splign:2.1.0"
     exon            883..981
                     /gene="Ces2a"
                     /gene_synonym="9130231C15Rik; Ces6"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1122
                     /gene="Ces2a"
                     /gene_synonym="9130231C15Rik; Ces6"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1203
                     /gene="Ces2a"
                     /gene_synonym="9130231C15Rik; Ces6"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1348
                     /gene="Ces2a"
                     /gene_synonym="9130231C15Rik; Ces6"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1486
                     /gene="Ces2a"
                     /gene_synonym="9130231C15Rik; Ces6"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1559
                     /gene="Ces2a"
                     /gene_synonym="9130231C15Rik; Ces6"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1964
                     /gene="Ces2a"
                     /gene_synonym="9130231C15Rik; Ces6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1774..1779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ces2a"
                     /gene_synonym="9130231C15Rik; Ces6"
                     /note="hexamer: ATTAAA"
     polyA_site      1793
                     /gene="Ces2a"
                     /gene_synonym="9130231C15Rik; Ces6"
     regulatory      1941..1946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ces2a"
                     /gene_synonym="9130231C15Rik; Ces6"
                     /note="hexamer: AATAAA"
     polyA_site      1962
                     /gene="Ces2a"
                     /gene_synonym="9130231C15Rik; Ces6"
                     /note="major polyA site"
ORIGIN      
        1 gatctgtttt tgtttcctgc tgtgacactc tcatgtgcag cagcacaggt ttaggcctga
       61 gattcaacca tgccattggc tagacttcct ggttggctgt gtgttgttgc ctgtgggctc
      121 ctgcttctcc tccagcatgt gcatggccag gactcagcca gccccatcag gaacacccac
      181 aggggtcagg tgagaggcag ctttgtccac gtgaaggaca ctaaatctgg tgtccatgcc
      241 ttcctgggaa tcccctttgc caagcctcct gtaggactac tgcgctttgc acctcctgag
      301 gaccctgagc catggagtgg tgtgagagat gggacctcac agccggccat gtgtctgcag
      361 cctgatataa tgaatttaga ggatgcgaag gaaatgaatc tgatcctgcc tcccatctct
      421 atgtccgagg actgcctgta tctcaacatc tacacaccaa cccacgccca ggagggctct
      481 aacctgcctg tgatggtatg gatccacggt ggtggactgg ttgtaggatc agcttccatg
      541 aatgatgtat ctaaactggc agccactgag gaaatagtaa ttgtcgccat ccagtatcgc
      601 ttgggggtcc ttggcttctt cagcactgga gaccagcatg ccagaggcaa ctggggatac
      661 ctggaccaag tggctgcctt acgctgggtg cagaagaata ttgcttactt tggaggcaac
      721 cgtgacaggg tcactatatt tggagtctca gcaggaggta caagtgtgtc ttctcatatt
      781 ctgtccccaa tgtccaaagg actctttcat ggagccatta tgcagagtgg agtggccctg
      841 ctgcctgacc tcatctctga cacttctgag gtggtctaca agacagtagc caacctatct
      901 ggttgtgaag ccacagactc agaagccctg atccactgcc tgagagcaaa gagtaaacaa
      961 gagatcctgg ctattaacca ggtcttcaag atgatccctg ctgtggtgga tggggagttc
     1021 ctacccaagc atcctcagga gctgctgacc tctatggatt ttcaccctgt ccccagcatc
     1081 attggtgtca acacagatga atgtggctgg ggagtcccca tgttcatggg ccttgaccat
     1141 atcataaaga acataaccag agagaccctg ccagctgttc tgaagaacac agcagcacgg
     1201 atgatgttgc ctccagaatg tagtcacctg ctagtggagg agtatatggg ggacactgag
     1261 gacccagaga ccctgcaagc acagttcaga gagatgctgg gggacttcat gtttgtgatc
     1321 cctgctctcc aagtggcaca tttccagcgt tcccaggctc ctgtctactt ctatgagttc
     1381 cagcatctgt ccagcttcat caagcatgtc aggccatcac atgtgaaggc agaccatggt
     1441 gatgacgttg cctttgtctt tggctcctat ttgtgggaca tgaatttgga cctcactgag
     1501 gaggaggagc tgctaaagag gatgatgatg aagtactggg ccaatttcgc aagaaatggg
     1561 aaccccaaca gtgagggtct accctcctgg cctgtgttgg accatgatga gcagtacctg
     1621 cagctggaca cccagcctgc tgtgggtcga gccctgaagg ccagaaggct gcagttctgg
     1681 accaagactc tgccccagaa gatccaggag ctcaagggtt ctcaggacaa gcatgcagag
     1741 ctgtagcgtc ctgtgtcagg gaaggtgtgt gagattaaaa gcagatggtg taattctgag
     1801 gttacaaagt ccatttattc atttttattt gttctaatac ttatggaagc atttctaata
     1861 tcagcatttg cccttccaga catgtatgaa gagcagtcag tgttatttct tatcattctg
     1921 ggcaaacatt cattagaatc aataaaagct ctcataacag tgtg
//
