LOCUS       NP_598721                558 aa            linear   ROD 03-JUN-2024
DEFINITION  pyrethroid hydrolase Ces2a isoform 1 precursor [Mus musculus].
ACCESSION   NP_598721
VERSION     NP_598721.1
DBSOURCE    REFSEQ: accession NM_133960.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 558)
  AUTHORS   Chalhoub,G., Jamnik,A., Pajed,L., Kolleritsch,S., Hois,V.,
            Bagaric,A., Prem,D., Tilp,A., Kolb,D., Wolinski,H., Taschler,U.,
            Zullig,T., Rechberger,G.N., Fuchs,C., Trauner,M., Schoiswohl,G. and
            Haemmerle,G.
  TITLE     Carboxylesterase 2a deletion provokes hepatic steatosis and insulin
            resistance in mice involving impaired diacylglycerol and
            lysophosphatidylcholine catabolism
  JOURNAL   Mol Metab 72, 101725 (2023)
   PUBMED   37059417
REFERENCE   2  (residues 1 to 558)
  AUTHORS   Suzuki,T., Kikuguchi,C., Nishijima,S., Nagashima,T., Takahashi,A.,
            Okada,M. and Yamamoto,T.
  TITLE     Postnatal liver functional maturation requires Cnot
            complex-mediated decay of mRNAs encoding cell cycle and immature
            liver genes
  JOURNAL   Development 146 (4) (2019)
   PUBMED   30733279
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 558)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
REFERENCE   4  (residues 1 to 558)
  AUTHORS   Theodorou,V., Boer,M., Weigelt,B., Jonkers,J., van der Valk,M. and
            Hilkens,J.
  TITLE     Fgf10 is an oncogene activated by MMTV insertional mutagenesis in
            mouse mammary tumors and overexpressed in a subset of human breast
            carcinomas
  JOURNAL   Oncogene 23 (36), 6047-6055 (2004)
   PUBMED   15208658
REFERENCE   5  (residues 1 to 558)
  AUTHORS   Stok,J.E., Huang,H., Jones,P.D., Wheelock,C.E., Morisseau,C. and
            Hammock,B.D.
  TITLE     Identification, expression, and purification of a
            pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes
  JOURNAL   J Biol Chem 279 (28), 29863-29869 (2004)
   PUBMED   15123619
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY088529.1, AK078953.1 and BY458169.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078953.1, BC025537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..558
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     Protein         1..558
                     /product="pyrethroid hydrolase Ces2a isoform 1 precursor"
                     /EC_number="3.1.1.88"
                     /note="carboxylesterase 6; pyrethroid hydrolase Ces2a;
                     carboxylic ester hydrolase 2A"
                     /calculated_mol_wt=59148
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2811
     mat_peptide     27..558
                     /product="Pyrethroid hydrolase Ces2a. /id=PRO_0000424210"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8QZR3.1)"
                     /calculated_mol_wt=59148
     Region          30..537
                     /region_name="COesterase"
                     /note="Carboxylesterase family; pfam00135"
                     /db_xref="CDD:395084"
     Site            order(147..149,226..228,231,370,376..377,410,457,460)
                     /site_type="other"
                     /note="substrate binding pocket [chemical binding]"
                     /db_xref="CDD:238191"
     Site            order(227,344,456)
                     /site_type="active"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:238191"
     Site            275
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8QZR3.1)"
     Site            361
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8QZR3.1)"
     CDS             1..558
                     /gene="Ces2a"
                     /gene_synonym="9130231C15Rik; Ces6"
                     /coded_by="NM_133960.5:70..1746"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS22585.1"
                     /db_xref="GeneID:102022"
                     /db_xref="MGI:MGI:2142491"
ORIGIN      
        1 mplarlpgwl cvvacgllll lqhvhgqdsa spirnthrgq vrgsfvhvkd tksgvhaflg
       61 ipfakppvgl lrfappedpe pwsgvrdgts qpamclqpdi mnledakemn lilppismse
      121 dclylniytp thaqegsnlp vmvwihgggl vvgsasmndv sklaateeiv ivaiqyrlgv
      181 lgffstgdqh argnwgyldq vaalrwvqkn iayfggnrdr vtifgvsagg tsvsshilsp
      241 mskglfhgai mqsgvallpd lisdtsevvy ktvanlsgce atdsealihc lrakskqeil
      301 ainqvfkmip avvdgeflpk hpqelltsmd fhpvpsiigv ntdecgwgvp mfmgldhiik
      361 nitretlpav lkntaarmml ppecshllve eymgdtedpe tlqaqfreml gdfmfvipal
      421 qvahfqrsqa pvyfyefqhl ssfikhvrps hvkadhgddv afvfgsylwd mnldlteeee
      481 llkrmmmkyw anfarngnpn seglpswpvl dhdeqylqld tqpavgralk arrlqfwtkt
      541 lpqkiqelkg sqdkhael
//
