LOCUS       NM_021456               2289 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus carboxylesterase 1G (Ces1g), mRNA.
ACCESSION   NM_021456
VERSION     NM_021456.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2289)
  AUTHORS   Xu,J., Xu,Y., Xu,Y., Yin,L. and Zhang,Y.
  TITLE     Global inactivation of carboxylesterase 1 (Ces1/Ces1g) protects
            against atherosclerosis in Ldlr -/- mice
  JOURNAL   Sci Rep 7 (1), 17845 (2017)
   PUBMED   29259301
  REMARK    GeneRIF: Global loss of Ces1/Ces1g protects against the development
            of atherosclerosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2289)
  AUTHORS   Li,J., Wang,Y., Matye,D.J., Chavan,H., Krishnamurthy,P., Li,F. and
            Li,T.
  TITLE     Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via
            Functional Interaction with Liver Carboxylesterase 1
  JOURNAL   J Biol Chem 292 (1), 146-160 (2017)
   PUBMED   27881673
  REMARK    GeneRIF: Loss of CES1 is associated with the susceptibility to high
            cholesterol diet-induced liver injury.
REFERENCE   3  (bases 1 to 2289)
  AUTHORS   Bahitham,W., Watts,R., Nelson,R., Lian,J. and Lehner,R.
  TITLE     Liver-specific expression of carboxylesterase 1g/esterase-x reduces
            hepatic steatosis, counteracts dyslipidemia and improves insulin
            signaling
  JOURNAL   Biochim Biophys Acta 1861 (5), 482-490 (2016)
   PUBMED   26976727
  REMARK    GeneRIF: Hepatic Ces1g/Es-x plays a critical role in limiting
            hepatic steatosis, very low-density lipoprotein assembly and in
            augmenting insulin sensitivity.
REFERENCE   4  (bases 1 to 2289)
  AUTHORS   Hoffmann,A.D., Yang,X.H., Burnicka-Turek,O., Bosman,J.D., Ren,X.,
            Steimle,J.D., Vokes,S.A., McMahon,A.P., Kalinichenko,V.V. and
            Moskowitz,I.P.
  TITLE     Foxf genes integrate tbx5 and hedgehog pathways in the second heart
            field for cardiac septation
  JOURNAL   PLoS Genet 10 (10), e1004604 (2014)
   PUBMED   25356765
  REMARK    Erratum:[PLoS Genet. 2016 Dec 29;12(12):e1006533. doi:
            10.1371/journal.pgen.1006533.. PMID: 28033319]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2289)
  AUTHORS   Iusuf,D., Ludwig,M., Elbatsh,A., van Esch,A., van de Steeg,E.,
            Wagenaar,E., van der Valk,M., Lin,F., van Tellingen,O. and
            Schinkel,A.H.
  TITLE     OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics
            and carboxylesterase expression in knockout and humanized
            transgenic mice
  JOURNAL   Mol Cancer Ther 13 (2), 492-503 (2014)
   PUBMED   24194565
  REMARK    GeneRIF: Data indicate that organic anion-transporting polypeptides
            Oatp1a/1b-null mice had increased levels of carboxylesterase (Ces)
            enzymes, which caused higher conversion of irinotecan to SN-38 in
            plasma, potentially complicating pharmacokinetic analyses.
REFERENCE   6  (bases 1 to 2289)
  AUTHORS   Zhu,H.J., Appel,D.I., Jiang,Y. and Markowitz,J.S.
  TITLE     Age- and sex-related expression and activity of carboxylesterase 1
            and 2 in mouse and human liver
  JOURNAL   Drug Metab Dispos 37 (9), 1819-1825 (2009)
   PUBMED   19487248
REFERENCE   7  (bases 1 to 2289)
  AUTHORS   Holmes,R.S., Glenn,J.P., VandeBerg,J.L. and Cox,L.A.
  TITLE     Baboon carboxylesterases 1 and 2: sequences, structures and
            phylogenetic relationships with human and other primate
            carboxylesterases
  JOURNAL   J Med Primatol 38 (1), 27-38 (2009)
   PUBMED   19187434
REFERENCE   8  (bases 1 to 2289)
  AUTHORS   Feng,J.M., Wu,J.S., Campagnoni,A.T. and Chen,W.F.
  TITLE     Nonspecific esterase released from thymic macrophages accumulates
            in the apoptotic thymocytes: an indication for this enzyme
            participating in the clearance of apoptotic thymocytes
  JOURNAL   Eur J Immunol 32 (5), 1386-1392 (2002)
   PUBMED   11981826
REFERENCE   9  (bases 1 to 2289)
  AUTHORS   Ellinghaus,P., Seedorf,U. and Assmann,G.
  TITLE     Cloning and sequencing of a novel murine liver carboxylesterase
            cDNA
  JOURNAL   Biochim Biophys Acta 1397 (2), 175-179 (1998)
   PUBMED   9565681
REFERENCE   10 (bases 1 to 2289)
  AUTHORS   Becker-Follmann,J., Gaa,A., Bausch,E., Natt,E., Scherer,G. and von
            Deimling,O.
  TITLE     High-resolution mapping of a linkage group on mouse chromosome 8
            conserved on human chromosome 16Q
  JOURNAL   Mamm Genome 8 (3), 172-177 (1997)
   PUBMED   9069116
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AI316467.1 and AK136588.1.
            
            On Jun 13, 2010 this sequence version replaced NM_021456.3.
            
            Summary: This gene encodes a member of the carboxylesterase large
            family. The family members are responsible for the hydrolysis or
            transesterification of various xenobiotics, such as cocaine and
            heroin, and endogenous substrates with ester, thioester, or amide
            bonds. They may participate in fatty acyl and cholesterol ester
            metabolism, and may play a role in the blood-brain barrier system.
            This enzyme is the major liver enzyme and functions in liver drug
            clearance. The expression and activity of this gene is age-related
            but independent of growth hormone level. This gene is clustered
            with Ces7 and Ces3 on chromosome 8. [provided by RefSeq, Jun 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136588.1, Y12887.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AI316467.1         1-4
            5-2289              AK136588.1         2-2286
FEATURES             Location/Qualifiers
     source          1..2289
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 45.29 cM"
     gene            1..2289
                     /gene="Ces1g"
                     /gene_synonym="CEH; Ces-1; Ces1; Ses-1"
                     /note="carboxylesterase 1G"
                     /db_xref="GeneID:12623"
                     /db_xref="MGI:MGI:88378"
     exon            1..107
                     /gene="Ces1g"
                     /gene_synonym="CEH; Ces-1; Ces1; Ses-1"
                     /inference="alignment:Splign:2.1.0"
     exon            108..312
                     /gene="Ces1g"
                     /gene_synonym="CEH; Ces-1; Ces1; Ses-1"
                     /inference="alignment:Splign:2.1.0"
     exon            313..457
                     /gene="Ces1g"
                     /gene_synonym="CEH; Ces-1; Ces1; Ses-1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..591
                     /gene="Ces1g"
                     /gene_synonym="CEH; Ces-1; Ces1; Ses-1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..745
                     /gene="Ces1g"
                     /gene_synonym="CEH; Ces-1; Ces1; Ses-1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..850
                     /gene="Ces1g"
                     /gene_synonym="CEH; Ces-1; Ces1; Ses-1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..955
                     /gene="Ces1g"
                     /gene_synonym="CEH; Ces-1; Ces1; Ses-1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..994
                     /gene="Ces1g"
                     /gene_synonym="CEH; Ces-1; Ces1; Ses-1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1135
                     /gene="Ces1g"
                     /gene_synonym="CEH; Ces-1; Ces1; Ses-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1216
                     /gene="Ces1g"
                     /gene_synonym="CEH; Ces-1; Ces1; Ses-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1364
                     /gene="Ces1g"
                     /gene_synonym="CEH; Ces-1; Ces1; Ses-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1496
                     /gene="Ces1g"
                     /gene_synonym="CEH; Ces-1; Ces1; Ses-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1569
                     /gene="Ces1g"
                     /gene_synonym="CEH; Ces-1; Ces1; Ses-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..2289
                     /gene="Ces1g"
                     /gene_synonym="CEH; Ces-1; Ces1; Ses-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2157..2162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ces1g"
                     /gene_synonym="CEH; Ces-1; Ces1; Ses-1"
                     /note="hexamer: TATAAA"
     polyA_site      2184
                     /gene="Ces1g"
                     /gene_synonym="CEH; Ces-1; Ces1; Ses-1"
     regulatory      2243..2248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ces1g"
                     /gene_synonym="CEH; Ces-1; Ces1; Ses-1"
                     /note="hexamer: TATAAA"
     polyA_site      2263
                     /gene="Ces1g"
                     /gene_synonym="CEH; Ces-1; Ces1; Ses-1"
                     /note="major polyA site"
ORIGIN      
        1 cattatctcc accaccagac acctcactag accccagagc tgctattctt ccatgatgtg
       61 gctctgtgct ttgagtctga tctctctcac tgcttgcttg agtctgggac acccatcctt
      121 accgcctgtg gtacacaccg ttcatggcaa agtcctgggg aagtatgtca ccttagaagg
      181 attctcacag cctgtggccg tcttcctggg agtccccttt gccaagcccc ctcttggatc
      241 tctgaggttt gctccaccag agcctgcaga gccctggagc ttcgtgaagc acaccacttc
      301 ctaccctcct ttgtgctacc aaaacccaga ggcagcattg aggctcgctg agctcttcac
      361 caaccaaagg aagatcattc cccacaaatt ttctgaggac tgtctctacc tcaacattta
      421 tactcctgct gacttaacac agaacagcag gttgcccgtg atggtgtgga tacatggagg
      481 tggacttgtg atagatggag catcaaccta tgatggagtg cccctcgctg tccatgaaaa
      541 tgtggttgta gtggtcattc agtatcgcct gggcatctgg ggattcttca gcacagagga
      601 tgaacacagc cgggggaact ggggtcactt ggaccaggtg gctgcactac attgggtcca
      661 agacaacatt gccaactttg ggggcaaccc aggatctgtg actatcttcg gcgagtcagc
      721 aggaggtgaa agtgtctctg ttcttgtgtt aagcccactg gccaagaacc tcttccacag
      781 ggccatcgct cagagtagtg tcattttcaa tccttgcctt tttgggagag ctgccagacc
      841 cttggctaag aaaattgctg ctcttgctgg ctgtaaaacc accacctccg ctgccatggt
      901 tcactgcctg cgccagaaga ctgaagatga gctcttggag gtctcactga aaatgaaatt
      961 tgggactgtt gattttcttg gagaccccag agagagctat cccttcctcc ctactgtgat
     1021 tgatggagtg ttgctgccaa aggcaccaga agagattctg gctgagaaga gtttcaacac
     1081 tgtcccctac atggtgggca tcaacaagca tgagtttggc tggatcattc caatgttttt
     1141 ggacttccca ctctctgaaa gaaaactgga ccagaagaca gctgcatcca tcctgtggca
     1201 ggcctaccca attcttaaca tctctgaaaa gctgattcca gcagctattg aaaagtattt
     1261 aggagggaca gaagaccctg ccacaatgac agacctgttc ctggacttga ttggagacat
     1321 tatgttcggt gtcccatctg taatcgtgtc ccgtagtcac agagatgctg gagccccaac
     1381 ctacatgtat gaatatcagt atcgcccaag ttttgtatca gacgatagac cccaggaatt
     1441 gttaggagac cacgctgatg aactcttttc tgtatgggga gccccgtttt taaaagaggg
     1501 tgcttcagaa gaagagatca acctcagcaa gatggtgatg aaattctggg ccaactttgc
     1561 tcggaatggg aaccctaatg gtgaagggct gcctcattgg ccagaatatg accagaagga
     1621 aggatacctt cagattggag tcccagcaca ggcagcccat aggctgaaag acaaggaagt
     1681 ggacttttgg actgagctca gagccaagga aacagcagag aggtcatccc atagggaaca
     1741 tgttgaactg tgatcaggag gcccagtcat gtttgagagt ctggagctaa gaaaagggtg
     1801 actttttgtc agatattgtt tccaaaatca atcgtctgac accagtggga cacaataggg
     1861 agaaacattt gattttatgc tttcaaattt ttggtttttg ttatttggtt acctgtgtag
     1921 tcctggcttt cctggaactc actctgtaga ccaggctagg attgaaatca gagacccacc
     1981 tgcctctgcc tcccaagttc tgggattaaa gacatgtgac acaactgact ggccatatgc
     2041 tttcaatttt taatgacatc acaaatacat tcccttagaa atcaaaccag agtctctgtc
     2101 tttggctcaa aatggatcta tatacattag tgtactaata atgtttttgt acactgtata
     2161 aagtttaccc ttgtgttatt caaatgctca tttctcttct tttgtgtctt gtttcattct
     2221 gaacatggca ttgtaatgct tatataaagt atctcctgtc tcacatctgt gtaaacattt
     2281 cttgccact
//
