LOCUS       NM_144930               1925 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus carboxylesterase 1F (Ces1f), mRNA.
ACCESSION   NM_144930
VERSION     NM_144930.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1925)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1925)
  AUTHORS   Zhao,S., Yang,X., Yu,Q. and Liu,L.M.
  TITLE     [Effects of in vivo targeted carboxylesterase 1f gene knockdown on
            the Kupffer cells polarization activity in mice with acute liver
            failure]
  JOURNAL   Zhonghua Gan Zang Bing Za Zhi 31 (6), 582-588 (2023)
   PUBMED   37400381
  REMARK    GeneRIF: [Effects of in vivo targeted carboxylesterase 1f gene
            knockdown on the Kupffer cells polarization activity in mice with
            acute liver failure].
REFERENCE   3  (bases 1 to 1925)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
REFERENCE   4  (bases 1 to 1925)
  AUTHORS   Okazaki,H., Igarashi,M., Nishi,M., Tajima,M., Sekiya,M.,
            Okazaki,S., Yahagi,N., Ohashi,K., Tsukamoto,K., Amemiya-Kudo,M.,
            Matsuzaka,T., Shimano,H., Yamada,N., Aoki,J., Morikawa,R.,
            Takanezawa,Y., Arai,H., Nagai,R., Kadowaki,T., Osuga,J. and
            Ishibashi,S.
  TITLE     Identification of a novel member of the carboxylesterase family
            that hydrolyzes triacylglycerol: a potential role in adipocyte
            lipolysis
  JOURNAL   Diabetes 55 (7), 2091-2097 (2006)
   PUBMED   16804080
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB583655.1, AK136491.1, AI786051.1, EH107325.1 and AI174063.1.
            
            On Jun 16, 2010 this sequence version replaced NM_144930.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013479.1, AK136491.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BB583655.1         2-10
            10-661              AK136491.1         2-653
            662-993             AI786051.1         58-389
            994-1239            EH107325.1         242-487
            1240-1909           AK136491.1         1232-1901
            1910-1925           AI174063.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..1925
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 45.21 cM"
     gene            1..1925
                     /gene="Ces1f"
                     /gene_synonym="CesML1; TGH-2"
                     /note="carboxylesterase 1F"
                     /db_xref="GeneID:234564"
                     /db_xref="MGI:MGI:2142687"
     exon            1..88
                     /gene="Ces1f"
                     /gene_synonym="CesML1; TGH-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1722
                     /gene="Ces1f"
                     /gene_synonym="CesML1; TGH-2"
                     /EC_number="3.1.1.1"
                     /note="carboxylic ester hydrolase; triacylglycerol
                     hydrolase 2; liver carboxylesterase B-1"
                     /codon_start=1
                     /product="carboxylesterase 1F precursor"
                     /protein_id="NP_659179.1"
                     /db_xref="CCDS:CCDS22530.1"
                     /db_xref="GeneID:234564"
                     /db_xref="MGI:MGI:2142687"
                     /translation="MFLSTLFLVSLATCVICGNPSSPPVVDTAHGKVLGKHVNVEGFS
                     QPVAVFLGIPFAKPPLGSLRFAPPQPAEPWSSVKNATTYPPMCSQDAARGQAVNDLIT
                     NRKEKIHLEFSEDCLYLNIYTPADFSKNSRLPVMVWIHGGGLKLGGASSFDGRALSAY
                     ENVVVVAIQYRLSIWGFFSTGDEHSRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIF
                     GESAGGYSVSILILSPLSKNLFHRAISESGVAFIPGMFTKDVRPITEQIAVTAGCKTT
                     TSAVIVHCMRQKTEEELLEIMHKLNLYKLSLQGDTKNSDQFVTSVLDGVVLPKDPKEI
                     LAEKNFNTVPYIVGINKQECGWLLPTMTGFLPADVKLDKKKAIALLEQFASMTGIPED
                     IIPVAVEKYTKGSDDPDQIREGVLDAMGDVAFGVPSVIVSRGHRDTGAPTYMYEYQYY
                     PSFSSPQRPKNVVGDHADDVYSVFGAPILREGASEEEINLSKMVMKFWANFARNGNPN
                     GKGLPHWPKYDQKEGYLHIGGTTQQAQRLKEEEVTFWTQSLAKKQPQPYHNEL"
     exon            89..293
                     /gene="Ces1f"
                     /gene_synonym="CesML1; TGH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            294..438
                     /gene="Ces1f"
                     /gene_synonym="CesML1; TGH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            439..572
                     /gene="Ces1f"
                     /gene_synonym="CesML1; TGH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            573..726
                     /gene="Ces1f"
                     /gene_synonym="CesML1; TGH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            727..831
                     /gene="Ces1f"
                     /gene_synonym="CesML1; TGH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            832..936
                     /gene="Ces1f"
                     /gene_synonym="CesML1; TGH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..975
                     /gene="Ces1f"
                     /gene_synonym="CesML1; TGH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1116
                     /gene="Ces1f"
                     /gene_synonym="CesML1; TGH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1197
                     /gene="Ces1f"
                     /gene_synonym="CesML1; TGH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1345
                     /gene="Ces1f"
                     /gene_synonym="CesML1; TGH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1477
                     /gene="Ces1f"
                     /gene_synonym="CesML1; TGH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1550
                     /gene="Ces1f"
                     /gene_synonym="CesML1; TGH-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1915
                     /gene="Ces1f"
                     /gene_synonym="CesML1; TGH-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1888..1893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ces1f"
                     /gene_synonym="CesML1; TGH-2"
                     /note="hexamer: AATAAA"
     polyA_site      1912
                     /gene="Ces1f"
                     /gene_synonym="CesML1; TGH-2"
                     /note="major polyA site"
ORIGIN      
        1 agaaggtcca ttgacttggg agcctgtcca tgcaagatgt tccttagcac tctgttcctg
       61 gtgtctctag caacctgtgt gatttgcgga aatccctctt caccacctgt ggtagacact
      121 gctcatggta aagtcctggg gaaacacgtg aacgtagaag gattttcaca gcctgtggcc
      181 gtcttcctgg gaatcccctt tgccaagccc cctcttggat ccctgaggtt tgctccacca
      241 cagcctgcag agccctggag ctcagtgaag aatgccacca cctacccacc tatgtgctcc
      301 caagatgcag ctagaggaca ggcggtcaat gacctcataa ccaatagaaa ggagaaaatc
      361 catcttgaat tttctgaaga ttgcctgtac ctaaatattt acactcctgc ggacttttca
      421 aagaacagta ggctaccggt gatggtgtgg atccatggag gtggactgaa gctgggtggg
      481 gcatcaagct ttgatggacg ggctctctct gcatacgaaa atgtggtggt ggtggccatt
      541 caatatcgcc tgagtatctg gggattcttc agcacagggg atgaacacag tcggggaaac
      601 tggggtcatt tggaccaagt ggctgctctg cattgggtcc aggacaacat tgccaacttt
      661 ggcggggacc caggctctgt gaccatcttt ggagagtcag caggaggtta cagtgtctca
      721 attcttatat tgtccccatt gtccaagaac ctcttccaca gggccatttc tgagagtggt
      781 gtggccttca ttcctggaat gtttaccaaa gatgtgaggc caattactga gcaaattgct
      841 gttactgctg gctgtaagac caccacgtct gccgtcattg ttcactgcat gcgccagaag
      901 acggaggagg agctattaga gatcatgcat aaattgaatc tgtataaact gagtttacaa
      961 ggagatacca aaaatagcga ccagttcgtg acaagtgtgc ttgatggagt ggtgctacca
     1021 aaggacccca aagagatcct ggctgagaag aacttcaaca ctgtgcctta cattgtggga
     1081 atcaacaagc aagaatgtgg ctggcttctg ccaacaatga cgggatttct accagctgat
     1141 gtaaaattgg acaagaagaa agccattgca ctcctggagc aatttgcttc catgactggc
     1201 ataccagagg atattattcc agttgctgtt gagaagtaca caaaaggtag tgatgaccct
     1261 gatcagatca gagagggagt tctcgacgca atgggggatg tggcatttgg tgttccatcg
     1321 gtgattgtgt cccgtggcca cagagacact ggagctccca cctacatgta tgagtatcaa
     1381 tactacccaa gcttctcatc accccaaaga cccaagaatg tagtaggaga ccatgcagat
     1441 gatgtctact ctgtcttcgg tgctccaatt ttaagagagg gtgcctccga agaggagatc
     1501 aatctcagca agatggtgat gaaattctgg gccaactttg ctcggaatgg gaaccctaat
     1561 ggcaaagggc tgcctcattg gccaaagtat gatcagaaag aaggatatct tcatattggt
     1621 ggcaccaccc agcaagccca gagactgaag gaagaggaag tgactttctg gacacagtcc
     1681 cttgccaaga aacaacccca gccataccac aatgagctgt gaatgcaaag ctctgccagg
     1741 cttataccag agaagccaag atatggttct tccactaaca gtgtatgtaa atccaagatg
     1801 gatcttggag gatcctgaag aactttgtca tagatatagg cagagcccag ggaagggaaa
     1861 tgttgtattt atgtctttaa tttagagaat aaatgttctt tatatggtca aataaaaaaa
     1921 aaaaa
//
