LOCUS       NM_133660               2059 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus carboxylesterase 1E (Ces1e), transcript variant 1,
            mRNA.
ACCESSION   NM_133660
VERSION     NM_133660.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2059)
  AUTHORS   Gan,C., Wang,J., Wang,Y., Martinez-Chavez,A., Hillebrand,M., de
            Vries,N., Beukers,J., Lebre,M.C., Wagenaar,E., Rosing,H.,
            Klarenbeek,S., Bleijerveld,O.B., Song,J.Y., Altelaar,M.,
            Beijnen,J.H. and Schinkel,A.H.
  TITLE     Natural deletion of mouse carboxylesterases Ces1c/d/e impacts drug
            metabolism and metabolic syndrome development
  JOURNAL   Biomed Pharmacother 164, 114956 (2023)
   PUBMED   37267638
  REMARK    GeneRIF: Natural deletion of mouse carboxylesterases Ces1c/d/e
            impacts drug metabolism and metabolic syndrome development.
REFERENCE   2  (bases 1 to 2059)
  AUTHORS   Chen,R., Wang,Y., Ning,R., Hu,J., Liu,W., Xiong,J., Wu,L., Liu,J.,
            Hu,G. and Yang,J.
  TITLE     Decreased carboxylesterases expression and hydrolytic activity in
            type 2 diabetic mice through Akt/mTOR/HIF-1alpha/Stra13 pathway
  JOURNAL   Xenobiotica 45 (9), 782-793 (2015)
   PUBMED   25801056
  REMARK    GeneRIF: the carboxylesterase 1d (Ces1d) and carboxylesterase 1e
            (Ces1e) expression and the capacity of hydrolytic activity of liver
            and intestine decreased, whereas the Akt/mTOR/HIF-1alpha/ Stra13
            (DEC1) signaling was activated in type 2 diabetes mice.
REFERENCE   3  (bases 1 to 2059)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
REFERENCE   4  (bases 1 to 2059)
  AUTHORS   Schreiber,R., Taschler,U., Wolinski,H., Seper,A., Tamegger,S.N.,
            Graf,M., Kohlwein,S.D., Haemmerle,G., Zimmermann,R., Zechner,R. and
            Lass,A.
  TITLE     Esterase 22 and beta-glucuronidase hydrolyze retinoids in mouse
            liver
  JOURNAL   J Lipid Res 50 (12), 2514-2523 (2009)
   PUBMED   19723663
  REMARK    GeneRIF: The Es22 plays a role in liver retinoid metabolism.
REFERENCE   5  (bases 1 to 2059)
  AUTHORS   Kaput,J., Klein,K.G., Reyes,E.J., Kibbe,W.A., Cooney,C.A.,
            Jovanovic,B., Visek,W.J. and Wolff,G.L.
  TITLE     Identification of genes contributing to the obese yellow Avy
            phenotype: caloric restriction, genotype, diet x genotype
            interactions
  JOURNAL   Physiol Genomics 18 (3), 316-324 (2004)
   PUBMED   15306695
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2059)
  AUTHORS   Ovnic,M., Swank,R.T., Fletcher,C., Zhen,L., Novak,E.K., Baumann,H.,
            Heintz,N. and Ganschow,R.E.
  TITLE     Characterization and functional expression of a cDNA encoding
            egasyn (esterase-22): the endoplasmic reticulum-targeting protein
            of beta-glucuronidase
  JOURNAL   Genomics 11 (4), 956-967 (1991)
   PUBMED   1783403
REFERENCE   7  (bases 1 to 2059)
  AUTHORS   Moen,C.J., van der Valk,M.A., Snoek,M., van Zutphen,B.F., von
            Deimling,O., Hart,A.A. and Demant,P.
  TITLE     The recombinant congenic strains--a novel genetic tool applied to
            the study of colon tumor development in the mouse
  JOURNAL   Mamm Genome 1 (4), 217-227 (1991)
   PUBMED   1686571
REFERENCE   8  (bases 1 to 2059)
  AUTHORS   Lusis,A.J. and Paigen,K.
  TITLE     Relationships between levels of membrane-bound glucuronidase and
            the associated protein egasyn in mouse tissues
  JOURNAL   J Cell Biol 73 (3), 728-735 (1977)
   PUBMED   873997
REFERENCE   9  (bases 1 to 2059)
  AUTHORS   Lusis,A.J., Tomino,S. and Paigen,K.
  TITLE     Inheritance in mice of the membrane anchor protein egasyn: the Eg
            locus determines egasyn levels
  JOURNAL   Biochem Genet 15 (1-2), 115-122 (1977)
   PUBMED   849245
REFERENCE   10 (bases 1 to 2059)
  AUTHORS   Lusis,A.J., Tomino,S. and Paigen,K.
  TITLE     Isolation, characterization, and radioimmunoassay of murine egasyn,
            a protein stabilizing glucuronidase membrane binding
  JOURNAL   J Biol Chem 251 (24), 7753-7760 (1976)
   PUBMED   826534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162949.7.
            
            On Apr 4, 2022 this sequence version replaced NM_133660.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019208.1, AK144549.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               AC162949.7         101068-101303       c
            237-444             AC162949.7         95593-95800         c
            445-589             AC162949.7         93286-93430         c
            590-723             AC162949.7         91073-91206         c
            724-877             AC162949.7         89197-89350         c
            878-982             AC162949.7         86744-86848         c
            983-1087            AC162949.7         85841-85945         c
            1088-1126           AC162949.7         84000-84038         c
            1127-1267           AC162949.7         82060-82200         c
            1268-1348           AC162949.7         80600-80680         c
            1349-1496           AC162949.7         80212-80359         c
            1497-1628           AC162949.7         74908-75039         c
            1629-1701           AC162949.7         73539-73611         c
            1702-2059           AC162949.7         72916-73273         c
FEATURES             Location/Qualifiers
     source          1..2059
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 45.11 cM"
     gene            1..2059
                     /gene="Ces1e"
                     /gene_synonym="Eg; egasyn; Es-22; Es22"
                     /note="carboxylesterase 1E"
                     /db_xref="GeneID:13897"
                     /db_xref="MGI:MGI:95432"
     exon            1..236
                     /gene="Ces1e"
                     /gene_synonym="Eg; egasyn; Es-22; Es22"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1873
                     /gene="Ces1e"
                     /gene_synonym="Eg; egasyn; Es-22; Es22"
                     /EC_number="3.1.1.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; liver carboxylesterase 22; esterase-22"
                     /codon_start=1
                     /product="carboxylesterase 1E isoform 1 precursor"
                     /protein_id="NP_598421.1"
                     /db_xref="CCDS:CCDS22529.1"
                     /db_xref="GeneID:13897"
                     /db_xref="MGI:MGI:95432"
                     /translation="MCLSALILVSLAAFTAGAGHPSSPPMVDTVQGKVLGKYISLEGF
                     TQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSSVKNATSYPPMCFQDPVTGQIVNDLL
                     TNRKEKIPLQFSEDCLYLNIYTPADLTKSDRLPVMVWIHGGGLVLGGASTYDGLVLST
                     HENVVVVVIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALHWVQDNIAKFGGDPGSVTI
                     FGESAGGESVSVLVLSPLAKNLFQRAISESGVALTAGLVKKNTRPLAEKIAVISGCKN
                     TTSAAMVHCLRQKTEEELLGTTLKLNLFKLDLHGDSRQSHPFVPTVLDGVLLPKMPEE
                     ILAEKNFNTVPYIVGINKQEFGWILPTMMNYPPSDVKLDQMTAMSLLKKSSFLLNLPE
                     DAIAVAIEKYLRDKDYTGRNKDQLLELIGDVVFGVPSVIVSRGHRDAGAPTYMYEFQY
                     SPSFSSEMKPDTVVGDHGDEIYSVFGAPILRGGTSEEEINLSKMMMKFWANFARNGNP
                     NGQGLPHWPEYDQKEGYLQIGATTQQAQKLKEKEVAFWTELLAKKQLPTEHTEL"
     exon            237..444
                     /gene="Ces1e"
                     /gene_synonym="Eg; egasyn; Es-22; Es22"
                     /inference="alignment:Splign:2.1.0"
     exon            445..589
                     /gene="Ces1e"
                     /gene_synonym="Eg; egasyn; Es-22; Es22"
                     /inference="alignment:Splign:2.1.0"
     exon            590..723
                     /gene="Ces1e"
                     /gene_synonym="Eg; egasyn; Es-22; Es22"
                     /inference="alignment:Splign:2.1.0"
     exon            724..877
                     /gene="Ces1e"
                     /gene_synonym="Eg; egasyn; Es-22; Es22"
                     /inference="alignment:Splign:2.1.0"
     exon            878..982
                     /gene="Ces1e"
                     /gene_synonym="Eg; egasyn; Es-22; Es22"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1087
                     /gene="Ces1e"
                     /gene_synonym="Eg; egasyn; Es-22; Es22"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1126
                     /gene="Ces1e"
                     /gene_synonym="Eg; egasyn; Es-22; Es22"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1267
                     /gene="Ces1e"
                     /gene_synonym="Eg; egasyn; Es-22; Es22"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1348
                     /gene="Ces1e"
                     /gene_synonym="Eg; egasyn; Es-22; Es22"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1496
                     /gene="Ces1e"
                     /gene_synonym="Eg; egasyn; Es-22; Es22"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1628
                     /gene="Ces1e"
                     /gene_synonym="Eg; egasyn; Es-22; Es22"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1701
                     /gene="Ces1e"
                     /gene_synonym="Eg; egasyn; Es-22; Es22"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..2059
                     /gene="Ces1e"
                     /gene_synonym="Eg; egasyn; Es-22; Es22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2035..2040
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ces1e"
                     /gene_synonym="Eg; egasyn; Es-22; Es22"
                     /note="hexamer: AATAAA"
     polyA_site      2059
                     /gene="Ces1e"
                     /gene_synonym="Eg; egasyn; Es-22; Es22"
                     /note="major polyA site"
ORIGIN      
        1 gtggcttagt gatctcttga gaaacctgca gagctctttg gaatagaaag attgttcttt
       61 tgtggtatca tacaattgat tgagagaaat ttgctggtac cctccaggag tggggcagga
      121 tcagtgtgcc ccctttgtca caggctggag acctccctgt cctgcaaacc tgtagcctcc
      181 taccatgtgc ctctctgctc tgatcctggt gtcacttgca gcattcacag caggggcagg
      241 acatccatcc tcaccaccca tggtggacac cgtgcaaggc aaagtcctgg ggaagtacat
      301 cagcttagaa ggattcacac agcctgtggc cgtcttcctg ggagtcccct ttgccaagcc
      361 ccctcttgga tctctgaggt ttgctccacc acagcctgca gagccctgga gctccgtgaa
      421 gaatgccacc tcctaccctc ctatgtgctt ccaagaccca gtgacagggc aaatagtcaa
      481 tgacctccta actaacagaa aggagaaaat tcctctccag ttttctgaag actgtctcta
      541 cctgaatatt tacactccag ctgacttgac aaagagtgac agattgccag tgatggtgtg
      601 gatccatgga ggtggactag tgttaggtgg ggcatcaacc tatgatggac tggtcctgtc
      661 tacgcatgaa aatgtcgtgg tggtggtcat ccaataccgt ttgggcatct ggggattctt
      721 cagcacaggg gatgaacaca gcagggggaa ctggggtcac ttggaccagg tggctgcact
      781 acactgggtc caggacaaca ttgctaaatt tggaggtgac ccaggctctg tgaccatctt
      841 tggagagtca gcaggaggtg aaagtgtctc tgttcttgtg ttgtctccct tggccaagaa
      901 tctcttccag agggctattt ctgaaagtgg tgtggccctc actgcaggcc tggtcaagaa
      961 gaacaccagg cctttggctg agaaaattgc tgtcatatct ggttgtaaaa acaccacttc
     1021 cgctgccatg gttcactgcc ttcgccagaa gacagaggaa gagctcttgg ggaccacact
     1081 aaaattgaat ctttttaagc tggatttgca tggagactcc agacagagcc atccctttgt
     1141 tcccactgtg cttgatggag tgttgctgcc aaagatgcct gaggagatcc tggctgagaa
     1201 gaacttcaac acagtgccct acatcgtggg aatcaacaag caagagtttg gctggattct
     1261 gccaactatg atgaactacc caccctctga tgtgaaattg gaccagatga cggccatgtc
     1321 tctcttgaag aagtcctctt ttcttcttaa cctccctgag gatgcaattg cagtggccat
     1381 tgagaagtat ttaagagata aagattacac aggcagaaat aaagaccaac ttctggaatt
     1441 gattggggat gtggtattcg gtgtaccatc tgtgattgtg tcccgtggac atagagatgc
     1501 cggagccccc acatacatgt atgagtttca atatagtcca agcttctcgt cagaaatgaa
     1561 accagatacg gtggtaggag accatggaga tgaaatctac tctgtctttg gggccccaat
     1621 tttaagaggt ggtacctcag aagaggagat caacctcagc aagatgatga tgaaattctg
     1681 ggccaacttt gctaggaatg ggaatcccaa tggacaaggg ctgccccatt ggccagagta
     1741 tgaccaaaag gaaggttatc tgcagattgg agccaccacc caacaagccc agaagctgaa
     1801 agaaaaagaa gtggctttct ggactgaact tctggctaag aagcaactgc cgacagaaca
     1861 cactgagctg tgaatgggag actctgtcag cctcaccctc aggggagccc aaatgagact
     1921 actttacatg gaagatgatt gtggccaagg ctttggggag actgcagaat tgtgtggtgg
     1981 gagtggacag aggccagaga gagaatattt gcacatgtgg actcaatttg aaaaaataaa
     2041 ttttgttcca taagtcaaa
//
