LOCUS       NM_053200               1966 bp    mRNA    linear   ROD 14-MAY-2024
DEFINITION  Mus musculus carboxylesterase 1D (Ces1d), mRNA.
ACCESSION   NM_053200
VERSION     NM_053200.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1966)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1966)
  AUTHORS   Gan,C., Wang,J., Wang,Y., Martinez-Chavez,A., Hillebrand,M., de
            Vries,N., Beukers,J., Lebre,M.C., Wagenaar,E., Rosing,H.,
            Klarenbeek,S., Bleijerveld,O.B., Song,J.Y., Altelaar,M.,
            Beijnen,J.H. and Schinkel,A.H.
  TITLE     Natural deletion of mouse carboxylesterases Ces1c/d/e impacts drug
            metabolism and metabolic syndrome development
  JOURNAL   Biomed Pharmacother 164, 114956 (2023)
   PUBMED   37267638
  REMARK    GeneRIF: Natural deletion of mouse carboxylesterases Ces1c/d/e
            impacts drug metabolism and metabolic syndrome development.
REFERENCE   3  (bases 1 to 1966)
  AUTHORS   Datta,R., Gholampour,M.A., Yang,C.D., Volk,R., Lin,S.,
            Podolsky,M.J., Arnold,T., Rieder,F., Zaro,B.W., Verzi,M.,
            Lehner,R., Abumrad,N., Lizama,C.O. and Atabai,K.
  TITLE     MFGE8 links absorption of dietary fatty acids with catabolism of
            enterocyte lipid stores through HNF4gamma-dependent transcription
            of CES enzymes
  JOURNAL   Cell Rep 42 (3), 112249 (2023)
   PUBMED   36924494
REFERENCE   4  (bases 1 to 1966)
  AUTHORS   Li,G., Li,X., Yang,L., Wang,S., Dai,Y., Fekry,B., Veillon,L.,
            Tan,L., Berdeaux,R., Eckel-Mahan,K., Lorenzi,P.L., Zhao,Z.,
            Lehner,R. and Sun,K.
  TITLE     Adipose tissue-specific ablation of Ces1d causes metabolic
            dysregulation in mice
  JOURNAL   Life Sci Alliance 5 (8), e202101209 (2022)
   PUBMED   35459739
  REMARK    GeneRIF: Adipose tissue-specific ablation of Ces1d causes metabolic
            dysregulation in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1966)
  AUTHORS   Lian,J., van der Veen,J.N., Watts,R., Jacobs,R.L. and Lehner,R.
  TITLE     Carboxylesterase 1d (Ces1d) does not contribute to cholesteryl
            ester hydrolysis in the liver
  JOURNAL   J Lipid Res 62, 100093 (2021)
   PUBMED   34153284
  REMARK    GeneRIF: Carboxylesterase 1d (Ces1d) does not contribute to
            cholesteryl ester hydrolysis in the liver.
REFERENCE   6  (bases 1 to 1966)
  AUTHORS   Wei,E., Lehner,R. and Vance,D.E.
  TITLE     C/EBPalpha activates the transcription of triacylglycerol hydrolase
            in 3T3-L1 adipocytes
  JOURNAL   Biochem J 388 (Pt 3), 959-966 (2005)
   PUBMED   15752068
  REMARK    GeneRIF: C/EBPalpha participates directly in the regulation of TGH,
            an enzyme associated with lipolysis
REFERENCE   7  (bases 1 to 1966)
  AUTHORS   Furihata,T., Hosokawa,M., Koyano,N., Nakamura,T., Satoh,T. and
            Chiba,K.
  TITLE     Identification of di-(2-ethylhexyl) phthalate-induced
            carboxylesterase 1 in C57BL/6 mouse liver microsomes: purification,
            cDNA cloning, and baculovirus-mediated expression
  JOURNAL   Drug Metab Dispos 32 (10), 1170-1177 (2004)
   PUBMED   15269189
REFERENCE   8  (bases 1 to 1966)
  AUTHORS   Soni,K.G., Lehner,R., Metalnikov,P., O'Donnell,P., Semache,M.,
            Gao,W., Ashman,K., Pshezhetsky,A.V. and Mitchell,G.A.
  TITLE     Carboxylesterase 3 (EC 3.1.1.1) is a major adipocyte lipase
  JOURNAL   J Biol Chem 279 (39), 40683-40689 (2004)
   PUBMED   15220344
  REMARK    GeneRIF: Carboxylesterase 3 is an adipocyte lyase
REFERENCE   9  (bases 1 to 1966)
  AUTHORS   Dolinsky,V.W., Sipione,S., Lehner,R. and Vance,D.E.
  TITLE     The cloning and expression of a murine triacylglycerol hydrolase
            cDNA and the structure of its corresponding gene
  JOURNAL   Biochim Biophys Acta 1532 (3), 162-172 (2001)
   PUBMED   11470237
REFERENCE   10 (bases 1 to 1966)
  AUTHORS   Mori,M., Hosokawa,M., Ogasawara,Y., Tsukada,E. and Chiba,K.
  TITLE     cDNA cloning, characterization and stable expression of novel human
            brain carboxylesterase
  JOURNAL   FEBS Lett 458 (1), 17-22 (1999)
   PUBMED   10518925
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ133999.1, AK078879.1 and AA522194.1.
            
            On Nov 3, 2006 this sequence version replaced NM_053200.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF378751.1, AK078879.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                CJ133999.1         2-24
            24-1964             AK078879.1         2-1942
            1965-1966           AA522194.1         581-582
FEATURES             Location/Qualifiers
     source          1..1966
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 45.05 cM"
     gene            1..1966
                     /gene="Ces1d"
                     /gene_synonym="Ces3; TGH"
                     /note="carboxylesterase 1D"
                     /db_xref="GeneID:104158"
                     /db_xref="MGI:MGI:2148202"
     exon            1..137
                     /gene="Ces1d"
                     /gene_synonym="Ces3; TGH"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1783
                     /gene="Ces1d"
                     /gene_synonym="Ces3; TGH"
                     /EC_number="3.1.1.1"
                     /EC_number="3.1.1.67"
                     /note="FAEE synthase; triacylglycerol hydrolase; fatty
                     acid ethyl ester synthase; carboxylesterase 3"
                     /codon_start=1
                     /product="carboxylesterase 1D precursor"
                     /protein_id="NP_444430.2"
                     /db_xref="CCDS:CCDS22528.1"
                     /db_xref="GeneID:104158"
                     /db_xref="MGI:MGI:2148202"
                     /translation="MGLYPLIWLSLAACTAWGYPSSPPVVNTVKGKVLGKYVNLEGFT
                     QPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDAVGGQVLSELFT
                     NRKENIPLQFSEDCLYLNIYTPADLTKNSRLPVMVWIHGGGLVVGGASTYDGLALSAH
                     ENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIANFGGNPGSVTIF
                     GESAGGFSVSVLVLSPLAKNLFHRAISESGVSLTAALITTDVKPIAGLVATLSGCKTT
                     TSAVMVHCLRQKTEDELLETSLKLNLFKLDLLGNPKESYPFLPTVIDGVVLPKAPEEI
                     LAEKSFSTVPYIVGINKQEFGWIIPTLMGYPLAEGKLDQKTANSLLWKSYPTLKISEN
                     MIPVVAEKYLGGTDDLTKKKDLFQDLMADVVFGVPSVIVSRSHRDAGASTYMYEFEYR
                     PSFVSAMRPKAVIGDHGDEIFSVFGSPFLKDGASEEETNLSKMVMKFWANFARNGNPN
                     GGGLPHWPEYDQKEGYLKIGASTQAAQRLKDKEVSFWAELRAKESAQRPSHREHVEL"
     exon            138..342
                     /gene="Ces1d"
                     /gene_synonym="Ces3; TGH"
                     /inference="alignment:Splign:2.1.0"
     exon            343..487
                     /gene="Ces1d"
                     /gene_synonym="Ces3; TGH"
                     /inference="alignment:Splign:2.1.0"
     exon            488..621
                     /gene="Ces1d"
                     /gene_synonym="Ces3; TGH"
                     /inference="alignment:Splign:2.1.0"
     exon            622..775
                     /gene="Ces1d"
                     /gene_synonym="Ces3; TGH"
                     /inference="alignment:Splign:2.1.0"
     exon            776..880
                     /gene="Ces1d"
                     /gene_synonym="Ces3; TGH"
                     /inference="alignment:Splign:2.1.0"
     exon            881..985
                     /gene="Ces1d"
                     /gene_synonym="Ces3; TGH"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1024
                     /gene="Ces1d"
                     /gene_synonym="Ces3; TGH"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1165
                     /gene="Ces1d"
                     /gene_synonym="Ces3; TGH"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1246
                     /gene="Ces1d"
                     /gene_synonym="Ces3; TGH"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1394
                     /gene="Ces1d"
                     /gene_synonym="Ces3; TGH"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1526
                     /gene="Ces1d"
                     /gene_synonym="Ces3; TGH"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1599
                     /gene="Ces1d"
                     /gene_synonym="Ces3; TGH"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1966
                     /gene="Ces1d"
                     /gene_synonym="Ces3; TGH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1944..1949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ces1d"
                     /gene_synonym="Ces3; TGH"
                     /note="putative"
ORIGIN      
        1 aggaggcggg tcccctggtc cacaacagaa gcattgctaa agcagcagat agctcagaga
       61 cccacagagc ccttgtcctt ccacaatggg cctctaccct ctgatatggc tttctcttgc
      121 tgcgtgcaca gcttgggggt acccatcctc accacctgtg gtgaacactg ttaaaggcaa
      181 agtcctgggg aagtatgtca atttggaagg attcacacag cctgtggctg ttttcctggg
      241 agtccccttt gccaagcccc ctcttggctc cttgagattt gctccaccac agcctgcaga
      301 gccctggagc ttcgtgaaga acaccacctc ctacccgcct atgtgctctc aggatgctgt
      361 tggagggcag gtgctctcag agctcttcac caacaggaag gagaacattc ctttacagtt
      421 ttctgaagac tgcctctacc tgaatattta cactcctgct gacttgacaa agaacagcag
      481 actaccagtg atggtgtgga tccatggagg tggactggtg gtgggcggag catccaccta
      541 tgatggactg gccctctctg cccatgaaaa tgtggtggtg gtgaccattc agtatcgcct
      601 tggcatctgg ggattcttca gcactgggga tgaacacagt cggggaaact ggggtcactt
      661 ggaccaggtg gctgcactac gctgggtcca ggacaacatt gccaactttg ggggcaaccc
      721 aggctcggtg accatctttg gagagtcagc aggaggtttc agtgtctctg ttcttgtctt
      781 gtctcctttg gccaagaacc tcttccacag ggccatttct gagagtggtg tgtccctcac
      841 tgctgctctg attacaacag atgtaaagcc cattgctggt ctggttgcta ctctttctgg
      901 gtgtaaaact accacatcag ctgttatggt tcattgcctg cgccagaaga cagaggatga
      961 actactggag acctcactaa aattgaatct ttttaaactg gacttacttg gaaatccaaa
     1021 agagagctat cccttcctcc ctactgtgat tgatggagta gttctgccaa aggcaccaga
     1081 agagatcctg gctgagaaga gtttcagcac tgtcccctac atagtgggca tcaacaagca
     1141 agagtttggc tggatcattc caacgcttat gggctatcca ctcgctgaag gcaaactgga
     1201 ccagaagaca gccaattctc tcttgtggaa gtcctaccca acacttaaaa tctctgagaa
     1261 tatgattcca gtggtcgctg agaagtattt aggagggaca gatgacctca ccaaaaagaa
     1321 agacctgttc caggacttga tggctgatgt ggtatttggt gtcccatcag tgattgtgtc
     1381 tcgaagtcac agagatgctg gagcctccac ctatatgtat gagtttgagt atcgcccaag
     1441 ctttgtatcg gccatgagac ccaaggcagt aataggagac catggtgatg agatcttctc
     1501 agtatttgga tctccatttt taaaagatgg tgcctcagaa gaggagacca acctcagcaa
     1561 gatggtgatg aaattctggg ccaactttgc tcggaatggg aaccccaatg gtggagggct
     1621 gccccactgg ccagaatatg accagaagga agggtatctg aagattggtg cctcaactca
     1681 ggcagcccag aggctgaagg acaaagaagt gagtttttgg gctgagctca gggccaagga
     1741 gtcagcccag aggccatccc acagggaaca tgttgagctc tgatcaggag ggtcagctgt
     1801 gcttaagaac ctggagtcaa aggagtatta ttccacagaa gatttttgta gaaaaataac
     1861 acttatcttt gaagctataa cattatatgg tattttatac aaatgcatta aaaaggaaat
     1921 atttatctcc ttcaacttgt aaaaataaaa taatgttttg aaaatc
//
