LOCUS       NM_007954               1850 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus carboxylesterase 1C (Ces1c), mRNA.
ACCESSION   NM_007954
VERSION     NM_007954.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1850)
  AUTHORS   Feng,Y., Lee,J., Yang,L., Hilton,M.B., Morris,K., Seaman,S.,
            Edupuganti,V.V.S.R., Hsu,K.S., Dower,C., Yu,G., So,D., Bajgain,P.,
            Zhu,Z., Dimitrov,D.S., Patel,N.L., Robinson,C.M.,
            Difilippantonio,S., Dyba,M., Corbel,A., Basuli,F., Swenson,R.E.,
            Kalen,J.D., Suthe,S.R., Hussain,M., Italia,J.S., Souders,C.A.,
            Gao,L., Schnermann,M.J. and St Croix,B.
  TITLE     Engineering CD276/B7-H3-targeted antibody-drug conjugates with
            enhanced cancer-eradicating capability
  JOURNAL   Cell Rep 42 (12), 113503 (2023)
   PUBMED   38019654
REFERENCE   2  (bases 1 to 1850)
  AUTHORS   Gan,C., Wang,J., Wang,Y., Martinez-Chavez,A., Hillebrand,M., de
            Vries,N., Beukers,J., Lebre,M.C., Wagenaar,E., Rosing,H.,
            Klarenbeek,S., Bleijerveld,O.B., Song,J.Y., Altelaar,M.,
            Beijnen,J.H. and Schinkel,A.H.
  TITLE     Natural deletion of mouse carboxylesterases Ces1c/d/e impacts drug
            metabolism and metabolic syndrome development
  JOURNAL   Biomed Pharmacother 164, 114956 (2023)
   PUBMED   37267638
  REMARK    GeneRIF: Natural deletion of mouse carboxylesterases Ces1c/d/e
            impacts drug metabolism and metabolic syndrome development.
REFERENCE   3  (bases 1 to 1850)
  AUTHORS   Rais,R., Lemberg,K.M., Tenora,L., Arwood,M.L., Pal,A., Alt,J.,
            Wu,Y., Lam,J., Aguilar,J.M.H., Zhao,L., Peters,D.E., Tallon,C.,
            Pandey,R., Thomas,A.G., Dash,R.P., Seiwert,T., Majer,P.,
            Leone,R.D., Powell,J.D. and Slusher,B.S.
  TITLE     Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug
  JOURNAL   Sci Adv 8 (46), eabq5925 (2022)
   PUBMED   36383674
REFERENCE   4  (bases 1 to 1850)
  AUTHORS   Li,H., Perino,A., Huang,Q., Von Alvensleben,G.V.G.,
            Banaei-Esfahani,A., Velazquez-Villegas,L.A., Gariani,K.,
            Korbelius,M., Bou Sleiman,M., Imbach,J., Sun,Y., Li,X.,
            Bachmann,A., Goeminne,L.J.E., Gallart-Ayala,H., Williams,E.G.,
            Ivanisevic,J., Auwerx,J. and Schoonjans,K.
  TITLE     Integrative systems analysis identifies genetic and dietary
            modulators of bile acid homeostasis
  JOURNAL   Cell Metab 34 (10), 1594-1610 (2022)
   PUBMED   36099916
REFERENCE   5  (bases 1 to 1850)
  AUTHORS   Zhu,C., Lee,J.Y., Woo,J.Z., Xu,L., Nguyenla,X., Yamashiro,L.H.,
            Ji,F., Biering,S.B., Van Dis,E., Gonzalez,F., Fox,D., Wehri,E.,
            Rustagi,A., Pinsky,B.A., Schaletzky,J., Blish,C.A., Chiu,C.,
            Harris,E., Sadreyev,R.I., Stanley,S., Kauppinen,S., Rouskin,S. and
            Naar,A.M.
  TITLE     An intranasal ASO therapeutic targeting SARS-CoV-2
  JOURNAL   Nat Commun 13 (1), 4503 (2022)
   PUBMED   35922434
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1850)
  AUTHORS   Genetta,T.L., D'Eustachio,P., Kadner,S.S. and Finlay,T.H.
  TITLE     cDNA cloning of esterase 1, the major esterase activity in mouse
            plasma
  JOURNAL   Biochem Biophys Res Commun 151 (3), 1364-1370 (1988)
   PUBMED   2895647
REFERENCE   7  (bases 1 to 1850)
  AUTHORS   Fox,R.R. and van Zutphen,L.F.
  TITLE     Chromosomal homology of rabbit (Oryctolagus cuniculus) linkage
            group VI with rodent species
  JOURNAL   Genetics 93 (1), 183-188 (1979)
   PUBMED   297012
REFERENCE   8  (bases 1 to 1850)
  AUTHORS   Soares,E.R.
  TITLE     Identification of a new allele of Es-I segregating in an inbred
            strain of mice
  JOURNAL   Biochem Genet 17 (7-8), 577-583 (1979)
   PUBMED   540008
REFERENCE   9  (bases 1 to 1850)
  AUTHORS   Peters,J. and Nash,H.R.
  TITLE     Esterases of Mus musculus: substrate and inhibition
            characteristics, new isozymes, and homologies with man
  JOURNAL   Biochem Genet 16 (5-6), 553-569 (1978)
   PUBMED   216346
REFERENCE   10 (bases 1 to 1850)
  AUTHORS   Womack,J.E.
  TITLE     Esterase-6 (Es-6) in laboratory mice: hormone-influenced expression
            and linkage relationship to oligosyndactylism (Os), esterase-1
            (Es-1), and esterase-2 (Es-2) in chromosome 8
  JOURNAL   Biochem Genet 13 (5-6), 311-322 (1975)
   PUBMED   170908
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI116924.1, AI527022.1, AC121985.3, AA286207.1 and AI047526.1.
            
            On Jul 2, 2009 this sequence version replaced NM_007954.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M57960.1, BC028907.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-758               AI116924.1         2-759
            759-1128            AI527022.1         122-491
            1129-1140           AC121985.3         127220-127231       c
            1141-1180           AI527022.1         503-542
            1181-1500           AA286207.1         9-328
            1501-1850           AI047526.1         1-350               c
FEATURES             Location/Qualifiers
     source          1..1850
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 44.99 cM"
     gene            1..1850
                     /gene="Ces1c"
                     /gene_synonym="Ces-N; Ee-1; Ee1; Es-4; Es-N; Es1; Es4;
                     EsN; PESN"
                     /note="carboxylesterase 1C"
                     /db_xref="GeneID:13884"
                     /db_xref="MGI:MGI:95420"
     exon            1..77
                     /gene="Ces1c"
                     /gene_synonym="Ces-N; Ee-1; Ee1; Es-4; Es-N; Es1; Es4;
                     EsN; PESN"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1690
                     /gene="Ces1c"
                     /gene_synonym="Ces-N; Ee-1; Ee1; Es-4; Es-N; Es1; Es4;
                     EsN; PESN"
                     /EC_number="3.1.1.1"
                     /note="liver carboxylesterase N; lung surfactant
                     convertase; PES-N; esterase 1"
                     /codon_start=1
                     /product="carboxylesterase 1C precursor"
                     /protein_id="NP_031980.2"
                     /db_xref="CCDS:CCDS22527.1"
                     /db_xref="GeneID:13884"
                     /db_xref="MGI:MGI:95420"
                     /translation="MWLHALVWASLAVCPILGHSLLPPVVDTTQGKVLGKYISLEGFE
                     QPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNATSYPPMCSQDAGWAKILSDMFS
                     TEKEILPLKISEDCLYLNIYSPADLTKSSQLPVMVWIHGGGLVIGGASPYNGLALSAH
                     ENVVVVTIQYRLGIWGLFSTGDEHSPGNWAHLDQLAALRWVQDNIANFGGNPDSVTIF
                     GESSGGISVSVLVLSPLGKDLFHRAISESGVVINTNVGKKNIQAVNEIIATLSQCNDT
                     SSAAMVQCLRQKTESELLEISGKLVQYNISLSTMIDGVVLPKAPEEILAEKSFNTVPY
                     IVGFNKQEFGWIIPMMLQNLLPEGKMNEETASLLLRRFHSELNISESMIPAVIEQYLR
                     GVDDPAKKSELILDMFGDIFFGIPAVLLSRSLRDAGVSTYMYEFRYRPSFVSDKRPQT
                     VEGDHGDEIFFVFGAPLLKEGASEEETNLSKMVMKFWANFARNGNPNGEGLPHWPEYD
                     EQEGYLQIGATTQQAQRLKAEEVAFWTELLAKNPPETDPTEHTEHK"
     exon            78..282
                     /gene="Ces1c"
                     /gene_synonym="Ces-N; Ee-1; Ee1; Es-4; Es-N; Es1; Es4;
                     EsN; PESN"
                     /inference="alignment:Splign:2.1.0"
     exon            283..427
                     /gene="Ces1c"
                     /gene_synonym="Ces-N; Ee-1; Ee1; Es-4; Es-N; Es1; Es4;
                     EsN; PESN"
                     /inference="alignment:Splign:2.1.0"
     exon            428..561
                     /gene="Ces1c"
                     /gene_synonym="Ces-N; Ee-1; Ee1; Es-4; Es-N; Es1; Es4;
                     EsN; PESN"
                     /inference="alignment:Splign:2.1.0"
     exon            562..715
                     /gene="Ces1c"
                     /gene_synonym="Ces-N; Ee-1; Ee1; Es-4; Es-N; Es1; Es4;
                     EsN; PESN"
                     /inference="alignment:Splign:2.1.0"
     exon            716..820
                     /gene="Ces1c"
                     /gene_synonym="Ces-N; Ee-1; Ee1; Es-4; Es-N; Es1; Es4;
                     EsN; PESN"
                     /inference="alignment:Splign:2.1.0"
     exon            821..931
                     /gene="Ces1c"
                     /gene_synonym="Ces-N; Ee-1; Ee1; Es-4; Es-N; Es1; Es4;
                     EsN; PESN"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1072
                     /gene="Ces1c"
                     /gene_synonym="Ces-N; Ee-1; Ee1; Es-4; Es-N; Es1; Es4;
                     EsN; PESN"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1153
                     /gene="Ces1c"
                     /gene_synonym="Ces-N; Ee-1; Ee1; Es-4; Es-N; Es1; Es4;
                     EsN; PESN"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1301
                     /gene="Ces1c"
                     /gene_synonym="Ces-N; Ee-1; Ee1; Es-4; Es-N; Es1; Es4;
                     EsN; PESN"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1433
                     /gene="Ces1c"
                     /gene_synonym="Ces-N; Ee-1; Ee1; Es-4; Es-N; Es1; Es4;
                     EsN; PESN"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1506
                     /gene="Ces1c"
                     /gene_synonym="Ces-N; Ee-1; Ee1; Es-4; Es-N; Es1; Es4;
                     EsN; PESN"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1840
                     /gene="Ces1c"
                     /gene_synonym="Ces-N; Ee-1; Ee1; Es-4; Es-N; Es1; Es4;
                     EsN; PESN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1816..1821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ces1c"
                     /gene_synonym="Ces-N; Ee-1; Ee1; Es-4; Es-N; Es1; Es4;
                     EsN; PESN"
                     /note="hexamer: AATAAA"
     polyA_site      1836
                     /gene="Ces1c"
                     /gene_synonym="Ces-N; Ee-1; Ee1; Es-4; Es-N; Es1; Es4;
                     EsN; PESN"
                     /note="major polyA site"
ORIGIN      
        1 aagagctcct ctccttcctt ccaacatgtg gctccatgct ctggtctggg cttctcttgc
       61 tgtttgccca attctgggac actcactctt accacctgtg gtggacacca cacaaggcaa
      121 agtcctgggg aagtatatca gcttagaagg atttgaacag cctgtggccg tcttcctggg
      181 agtccccttt gccaagcccc ctcttggatc tctgaggttt gctccaccac agcctgcaga
      241 gccctggagc ttcgtgaaga atgccacctc ctaccctcct atgtgctccc aagatgcagg
      301 ttgggcaaag atactctcag atatgttcag caccgaaaag gagatcctgc ctctcaagat
      361 ttcggaagac tgtctctacc tgaatattta cagtcctgcc gatttgacaa aaagcagcca
      421 attgcctgtg atggtgtgga tccatggagg tggactggtg ataggcggag catcacccta
      481 taatggacta gctctctctg cccatgagaa cgtggtggta gtaaccattc aataccgcct
      541 gggtatttgg ggattattta gcacaggtga tgaacacagc ccaggaaact gggctcacct
      601 ggaccaactg gctgcactac gctgggtcca agataacatt gcaaactttg gagggaaccc
      661 ggattccgtg accatctttg gagagtcatc agggggtatc agtgtctctg tccttgtctt
      721 atctcctctg ggcaaggacc tcttccacag agccatttct gagagtggtg tggtcataaa
      781 tacaaacgtg ggcaagaaga atatacaggc tgtgaatgaa ataatagcta ctctttccca
      841 gtgtaatgac acctcatcag ctgccatggt tcagtgcttg cgccagaaga cagagagtga
      901 gctcttggag atttcaggga aactggtaca gtacaatatc tccctgtcca ccatgattga
      961 cggagtggtg ctgccaaagg caccagaaga gatcctggct gagaagagtt tcaacactgt
     1021 cccctacata gtgggcttca acaagcaaga gtttggctgg ataattccaa tgatgttgca
     1081 aaatctactc cctgaaggca aaatgaatga ggaaacggcc agtcttctct tgaggaggtt
     1141 ccactctgaa cttaacatct ctgaaagtat gattccagca gtcattgagc agtacttaag
     1201 aggggtagat gaccctgcca aaaagagtga gcttatcctg gacatgtttg gagatatatt
     1261 ttttggtatc ccggctgtgc tcttgtcccg tagcctcaga gatgctggag tgtccaccta
     1321 catgtatgag tttcggtatc gcccaagctt cgtgtctgac aagagacccc agacggttga
     1381 gggtgatcat ggcgatgaaa tcttctttgt attcggggct ccactattaa aagagggtgc
     1441 ctcagaagag gaaaccaacc tcagcaagat ggtgatgaaa ttctgggcca actttgctcg
     1501 aaatgggaac cctaatgggg aggggctgcc tcactggcca gaatatgatg agcaggaagg
     1561 gtatctacag attggagcca ctacccagca agcccagaga ctgaaagcag aggaagtggc
     1621 tttctggact gagctcctgg ctaagaatcc acctgagaca gaccctactg aacacacaga
     1681 acacaaatga atgggaggct ctgccagtct caggaccagc ggagcgaaaa tggagctatt
     1741 ccacaaagga tgactattca ccaaagatgg atcttacaga ggaaactgca caatagtaca
     1801 gtatcacaat ttgaaaataa atttcctttt agaaatcaaa aaaaaaaaaa
//
