LOCUS       NM_001013764            1980 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus carboxylesterase 1A (Ces1a), mRNA.
ACCESSION   NM_001013764 XM_146438
VERSION     NM_001013764.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1980)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1980)
  AUTHORS   Jin,Q., Li,Z., Zhang,M.J., Liu,W.C., Zou,L.W., Sui,H., Wang,D.D.,
            Tang,Q.F. and Ge,G.B.
  TITLE     Deciphering the species differences in CES1A-mediated hydrolytic
            metabolism by using a bioluminescence substrate
  JOURNAL   Chem Biol Interact 368, 110197 (2022)
   PUBMED   36174736
  REMARK    GeneRIF: Deciphering the species differences in CES1A-mediated
            hydrolytic metabolism by using a bioluminescence substrate.
REFERENCE   3  (bases 1 to 1980)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1980)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC089371.1 and AC140217.3.
            
            On Jan 6, 2010 this sequence version replaced NM_001013764.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089371.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-766               BC089371.1         1-766
            767-767             AC140217.3         6622-6622
            768-1906            BC089371.1         768-1906
            1907-1980           AC140217.3         22294-22367
FEATURES             Location/Qualifiers
     source          1..1980
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 44.99 cM"
     gene            1..1980
                     /gene="Ces1a"
                     /gene_synonym="Ces1l; EG244595; Gm4976"
                     /note="carboxylesterase 1A"
                     /db_xref="GeneID:244595"
                     /db_xref="MGI:MGI:3648919"
     exon            1..136
                     /gene="Ces1a"
                     /gene_synonym="Ces1l; EG244595; Gm4976"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1776
                     /gene="Ces1a"
                     /gene_synonym="Ces1l; EG244595; Gm4976"
                     /codon_start=1
                     /product="carboxylesterase 1-like precursor"
                     /protein_id="NP_001013786.2"
                     /db_xref="CCDS:CCDS22526.1"
                     /db_xref="GeneID:244595"
                     /db_xref="MGI:MGI:3648919"
                     /translation="MWLFALALASLNTCMALGHLSSPPVVDTLQGKVMGKYISLEGSA
                     QPVAVFLGVPFAKPPLGPLRFAPPQPAETWSSVKNTTSYPPMCSQITGVGPVLSDVFT
                     NQLENVPLEYSEDCLYLNIYSPTDLTSKDRLPVMVWVHGGGLLSGGASTFDGLALSTH
                     ENVVIVVIQYRLGIWGFLSTGDEHSRGNWGHLDQVAALQWVQNNIANFGGDPSSVTLF
                     GESAGGESVSVLVLSPLTKNLFQRAISESGVALTPCLFRETTRRAAEQVAIATGCVAT
                     TSADIVHCLREKTEEELLATTLKMKFFALDLLGDPRESYPFLTTVIDGVVLPKAPEEI
                     LAEKSFNTVPYIVGINKQEFGWFIPMMMGYPLSEGKLDQKSATSLLWKSYPLTNISKE
                     LTPVATEKYLGGSDCPDKKKDLFLDMMGDVLFAVPSVIVARYHRDAGAPTYMYEFKYH
                     PSFVSDMRPKTVIADHGDEVYSVWGTPFLKEGASEEEINLSTMMMKFWGNFARNGNPN
                     GEGLPHWPEYGEKESYLQIGATTQQAQRLKDKEVAFWTSLRAMEVGEATKGDTQR"
     exon            137..341
                     /gene="Ces1a"
                     /gene_synonym="Ces1l; EG244595; Gm4976"
                     /inference="alignment:Splign:2.1.0"
     exon            342..486
                     /gene="Ces1a"
                     /gene_synonym="Ces1l; EG244595; Gm4976"
                     /inference="alignment:Splign:2.1.0"
     exon            487..620
                     /gene="Ces1a"
                     /gene_synonym="Ces1l; EG244595; Gm4976"
                     /inference="alignment:Splign:2.1.0"
     exon            621..774
                     /gene="Ces1a"
                     /gene_synonym="Ces1l; EG244595; Gm4976"
                     /inference="alignment:Splign:2.1.0"
     exon            775..879
                     /gene="Ces1a"
                     /gene_synonym="Ces1l; EG244595; Gm4976"
                     /inference="alignment:Splign:2.1.0"
     exon            880..984
                     /gene="Ces1a"
                     /gene_synonym="Ces1l; EG244595; Gm4976"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1023
                     /gene="Ces1a"
                     /gene_synonym="Ces1l; EG244595; Gm4976"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1164
                     /gene="Ces1a"
                     /gene_synonym="Ces1l; EG244595; Gm4976"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1245
                     /gene="Ces1a"
                     /gene_synonym="Ces1l; EG244595; Gm4976"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1393
                     /gene="Ces1a"
                     /gene_synonym="Ces1l; EG244595; Gm4976"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1525
                     /gene="Ces1a"
                     /gene_synonym="Ces1l; EG244595; Gm4976"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1598
                     /gene="Ces1a"
                     /gene_synonym="Ces1l; EG244595; Gm4976"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1980
                     /gene="Ces1a"
                     /gene_synonym="Ces1l; EG244595; Gm4976"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1950..1955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ces1a"
                     /gene_synonym="Ces1l; EG244595; Gm4976"
                     /note="hexamer: AATAAA"
     polyA_site      1980
                     /gene="Ces1a"
                     /gene_synonym="Ces1l; EG244595; Gm4976"
                     /note="major polyA site"
ORIGIN      
        1 caccatctaa gacaggttat acaaagccct tcagaagagc accaagatct cgtcacaggg
       61 ccccaaagca actggccttc cagcatgtgg ctctttgctc tggccctggc ttccctcaac
      121 acttgcatgg ctttggggca cctgtcctca ccacctgtgg tagacaccct gcaaggcaaa
      181 gtcatgggga agtacatcag cttagaagga tccgcacagc ctgtagccgt cttcctggga
      241 gtcccctttg ccaagccccc tcttgggccc ctgaggtttg ctccaccaca gcctgccgag
      301 acctggagct ccgtgaagaa caccacctcc taccctccta tgtgctcgca aattacagga
      361 gtggggccag tgctctccga tgtctttact aaccaactag aaaatgttcc tcttgagtat
      421 tctgaagact gcctttacct aaatatttac tcccctacag acctgacaag caaagacagg
      481 ctgccggtga tggtatgggt ccatggaggc ggtttactct ctggtggagc atcaactttt
      541 gatggactgg ccctgtctac ccatgaaaac gtagtgatag tagtcattca ataccgtctg
      601 ggcatctggg gtttcctcag cacaggagat gaacacagcc gagggaactg gggtcacttg
      661 gaccaggtgg ctgcactgca gtgggtccag aacaacattg ctaactttgg aggggaccca
      721 agctctgtga ccctctttgg cgagtcagca ggaggtgaaa gtgtctctgt ccttgtttta
      781 tctccgctga ccaagaacct cttccagagg gccatttctg agagtggtgt ggccctcacg
      841 ccatgtctgt tcagggagac tacaaggcgt gcggctgagc aagttgccat tgctacgggg
      901 tgtgtggcca ctacatcagc cgacatagtg cactgtctac gtgagaagac agaggaggaa
      961 ctcttggcaa cgaccctgaa gatgaaattc tttgctcttg atttgcttgg agaccccaga
     1021 gagagctacc ctttcctgac caccgtgatt gatggagtgg tgctgccaaa ggcacctgaa
     1081 gagatcctgg ctgagaagag tttcaacact gtcccctaca tagtgggcat caacaagcaa
     1141 gagtttggct ggtttattcc aatgatgatg ggctatccac tctctgaagg caaactggac
     1201 cagaagtcag ccacatctct cctgtggaag tcctacccac ttactaacat ctctaaggaa
     1261 ctgactccag tggccactga gaagtatttg ggaggatcag actgccctga caaaaagaaa
     1321 gacctctttt tagacatgat gggagatgtg ttatttgctg tgccatctgt gattgtggct
     1381 cgctatcaca gagatgctgg agcccccacc tacatgtatg agtttaagta tcacccaagc
     1441 tttgtgtccg acatgagacc caagacggta atagcagacc atggagatga agtttactcc
     1501 gtttggggga caccattttt aaaagagggt gcctcagagg aggagatcaa cctcagcacc
     1561 atgatgatga agttttgggg caattttgct cgaaatggga acccaaatgg ggaaggactg
     1621 ccacactggc cagagtatgg cgagaaggaa agttaccttc agatcggagc caccacccag
     1681 caagcccaga ggctcaaaga caaggaagta gctttctgga ccagcctccg ggccatggag
     1741 gtgggagaag caaccaaggg agacactcag agatgaagta gaagcagtac aaccctggaa
     1801 gccattagca gcctggtcaa tgctgttcca cagaaggtgt cctgtagccc agagagcttt
     1861 ctcatcccag agtctgaaga actgtgttga aagtaggcag aagccagtga agagaaatgt
     1921 ttgtagctgt ggtttgagtt tgcaaaatta ataaaatcat tgtttttgag gggtaccaaa
//
