LOCUS       NP_001013786             563 aa            linear   ROD 30-APR-2024
DEFINITION  carboxylesterase 1-like precursor [Mus musculus].
ACCESSION   NP_001013786 XP_146438
VERSION     NP_001013786.2
DBSOURCE    REFSEQ: accession NM_001013764.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 563)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 563)
  AUTHORS   Jin,Q., Li,Z., Zhang,M.J., Liu,W.C., Zou,L.W., Sui,H., Wang,D.D.,
            Tang,Q.F. and Ge,G.B.
  TITLE     Deciphering the species differences in CES1A-mediated hydrolytic
            metabolism by using a bioluminescence substrate
  JOURNAL   Chem Biol Interact 368, 110197 (2022)
   PUBMED   36174736
  REMARK    GeneRIF: Deciphering the species differences in CES1A-mediated
            hydrolytic metabolism by using a bioluminescence substrate.
REFERENCE   3  (residues 1 to 563)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (residues 1 to 563)
  AUTHORS   Holmes,R.S., Wright,M.W., Laulederkind,S.J., Cox,L.A., Hosokawa,M.,
            Imai,T., Ishibashi,S., Lehner,R., Miyazaki,M., Perkins,E.J.,
            Potter,P.M., Redinbo,M.R., Robert,J., Satoh,T., Yamashita,T.,
            Yan,B., Yokoi,T., Zechner,R. and Maltais,L.J.
  TITLE     Recommended nomenclature for five mammalian carboxylesterase gene
            families: human, mouse, and rat genes and proteins
  JOURNAL   Mamm Genome 21 (9-10), 427-441 (2010)
   PUBMED   20931200
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC089371.1 and AC140217.3.
            
            On Jan 6, 2010 this sequence version replaced NP_001013786.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089371.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..563
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 44.99 cM"
     Protein         1..563
                     /product="carboxylesterase 1-like precursor"
                     /calculated_mol_wt=60006
     sig_peptide     1..16
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1756
     Region          22..545
                     /region_name="COesterase"
                     /note="Carboxylesterase family; pfam00135"
                     /db_xref="CDD:395084"
     Site            order(141..143,220..222,225,382,386..387,419,467,470)
                     /site_type="other"
                     /note="substrate binding pocket [chemical binding]"
                     /db_xref="CDD:238191"
     Site            order(221,353,466)
                     /site_type="active"
                     /note="catalytic triad [active]"
                     /db_xref="CDD:238191"
     CDS             1..563
                     /gene="Ces1a"
                     /gene_synonym="Ces1l; EG244595; Gm4976"
                     /coded_by="NM_001013764.2:85..1776"
                     /db_xref="CCDS:CCDS22526.1"
                     /db_xref="GeneID:244595"
                     /db_xref="MGI:MGI:3648919"
ORIGIN      
        1 mwlfalalas lntcmalghl ssppvvdtlq gkvmgkyisl egsaqpvavf lgvpfakppl
       61 gplrfappqp aetwssvknt tsyppmcsqi tgvgpvlsdv ftnqlenvpl eysedclyln
      121 iysptdltsk drlpvmvwvh gggllsggas tfdglalsth envvivviqy rlgiwgflst
      181 gdehsrgnwg hldqvaalqw vqnnianfgg dpssvtlfge saggesvsvl vlspltknlf
      241 qraisesgva ltpclfrett rraaeqvaia tgcvattsad ivhclrekte eellattlkm
      301 kffaldllgd presypfltt vidgvvlpka peeilaeksf ntvpyivgin kqefgwfipm
      361 mmgyplsegk ldqksatsll wksypltnis keltpvatek ylggsdcpdk kkdlfldmmg
      421 dvlfavpsvi varyhrdaga ptymyefkyh psfvsdmrpk tviadhgdev ysvwgtpflk
      481 egaseeeinl stmmmkfwgn farngnpnge glphwpeyge kesylqigat tqqaqrlkdk
      541 evafwtslra mevgeatkgd tqr
//
