LOCUS       NM_023420               5363 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ceramide transporter 1 (Cert1), transcript variant 1,
            mRNA.
ACCESSION   NM_023420
VERSION     NM_023420.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5363)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5363)
  AUTHORS   Zhang,X., Wang,Z., Xu,Q., Chen,Y., Liu,W., Zhong,T., Li,H.,
            Quan,C., Zhang,L. and Cui,C.P.
  TITLE     Splicing factor Srsf5 deletion disrupts alternative splicing and
            causes noncompaction of ventricular myocardium
  JOURNAL   iScience 24 (10), 103097 (2021)
   PUBMED   34622152
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5363)
  AUTHORS   Zhou,C., Chen,D., Ren,J., Huang,D., Li,R., Luo,H., Guan,C., Cao,Y.
            and Wang,W.
  TITLE     FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme
            proliferation and differentiation via Lhx8/Suv39h1 complex
  JOURNAL   J Cell Mol Med 25 (6), 3051-3062 (2021)
   PUBMED   33580754
REFERENCE   4  (bases 1 to 5363)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5363)
  AUTHORS   Fukushima,M., Dasgupta,D., Mauer,A.S., Kakazu,E., Nakao,K. and
            Malhi,H.
  TITLE     StAR-related lipid transfer domain 11 (STARD11)-mediated ceramide
            transport mediates extracellular vesicle biogenesis
  JOURNAL   J Biol Chem 293 (39), 15277-15289 (2018)
   PUBMED   30139741
  REMARK    GeneRIF: the size and number of multivesicular bodies were
            comparable in WT and STARD11-knockout cells. In conclusion, we
            propose a model of how STARD11 mediates ceramide trafficking in
            palmitate-treated cells and stimulates exosome biogenesis.
REFERENCE   6  (bases 1 to 5363)
  AUTHORS   Desai,J., Shannon,M.E., Johnson,M.D., Ruff,D.W., Hughes,L.A.,
            Kerley,M.K., Carpenter,D.A., Johnson,D.K., Rinchik,E.M. and
            Culiat,C.T.
  TITLE     Nell1-deficient mice have reduced expression of extracellular
            matrix proteins causing cranial and vertebral defects
  JOURNAL   Hum Mol Genet 15 (8), 1329-1341 (2006)
   PUBMED   16537572
REFERENCE   7  (bases 1 to 5363)
  AUTHORS   Chen,S., Kasama,Y., Lee,J.S., Jim,B., Marin,M. and Ziyadeh,F.N.
  TITLE     Podocyte-derived vascular endothelial growth factor mediates the
            stimulation of alpha3(IV) collagen production by transforming
            growth factor-beta1 in mouse podocytes
  JOURNAL   Diabetes 53 (11), 2939-2949 (2004)
   PUBMED   15504975
  REMARK    GeneRIF: VEGF inhibitor also partially prevented the stimulation of
            alpha3(IV) collagen by transforming growth factor (TGF)-beta1.
REFERENCE   8  (bases 1 to 5363)
  AUTHORS   Hanada,K., Kumagai,K., Yasuda,S., Miura,Y., Kawano,M., Fukasawa,M.
            and Nishijima,M.
  TITLE     Molecular machinery for non-vesicular trafficking of ceramide
  JOURNAL   Nature 426 (6968), 803-809 (2003)
   PUBMED   14685229
REFERENCE   9  (bases 1 to 5363)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 5363)
  AUTHORS   Raya,A., Revert-Ros,F., Martinez-Martinez,P., Navarro,S.,
            Rosello,E., Vieites,B., Granero,F., Forteza,J. and Saus,J.
  TITLE     Goodpasture antigen-binding protein, the kinase that phosphorylates
            the goodpasture antigen, is an alternatively spliced variant
            implicated in autoimmune pathogenesis
  JOURNAL   J Biol Chem 275 (51), 40392-40399 (2000)
   PUBMED   11007769
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB654693.1, AK080958.1, AK012989.1, AC122828.3 and AC154851.3.
            
            On Aug 15, 2009 this sequence version replaced NM_023420.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF232932.1, SRR10223971.13782.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BB654693.1         2-5
            5-1703              AK080958.1         3-1701
            1704-2359           AK012989.1         1607-2262
            2360-2854           AC122828.3         198110-198604
            2855-5363           AC154851.3         56449-58957
FEATURES             Location/Qualifiers
     source          1..5363
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 50.58 cM"
     gene            1..5363
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /note="ceramide transporter 1"
                     /db_xref="GeneID:68018"
                     /db_xref="MGI:MGI:1915268"
     exon            1..525
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             430..2304
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     procollagen, type IV, alpha 3 (Goodpasture antigen)
                     binding protein; collagen type IV alpha-3-binding protein;
                     stARD11; collagen, type IV, alpha 3 (Goodpasture antigen)
                     binding protein; ceramide transfer protein; START
                     domain-containing protein 11; goodpasture antigen-binding
                     protein; stAR-related lipid transfer protein 11; ceramide
                     transport protein"
                     /codon_start=1
                     /product="ceramide transfer protein isoform 1"
                     /protein_id="NP_075909.1"
                     /db_xref="CCDS:CCDS26705.1"
                     /db_xref="GeneID:68018"
                     /db_xref="MGI:MGI:1915268"
                     /translation="MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRW
                     VVLKNNTLSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDP
                     EHRQQWVDAIEQHKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREK
                     LAEMETFRDILCRQVDTLQKYFDVCADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLH
                     NTNGNKEKLFPHVTPKGINGIDFKGEAITFKATTAGILATLSHCIELMVKREESWQKR
                     HDREVEKRRRVEEAYKNVMEELKKKPRFGGPDYEEGPNSLINEEEFFDAVEAALDRQD
                     KIEEQSQSEKVRLHWPTSLPSGDTFSSVGTHRFVQKPYSRSSSMSSIDLVSASDDVHR
                     FSSQVEEMVQNHMNYSLQDVGGDANWQLVVEEGEMKVYRREVEENGIVLDPLKATHAV
                     KGVTGHEVCNYFWNVDVRNDWETTIENFHVVETLADNAIIVYQTHKRVWPASQRDVLY
                     LSAIRKIPALTENDPETWIVCNFSVDHDSAPLNNRCVRAKINIAMICQTLVSPPEGDQ
                     EISRDNILCKITYVANVNPGGWAPASVLRAVAKREYPKFLKRFTSYVQEKTAGKPILF
                     "
     exon            526..660
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            661..777
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            778..885
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1024
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1108
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1266
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1359
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1446
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1539
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1617
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1713
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1846
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1917
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2046
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2176
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2313
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..5363
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4078..4083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /note="hexamer: AAGAAA"
     polyA_site      4098
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
     regulatory      5310..5315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /note="hexamer: ATTAAA"
     polyA_site      5360
                     /gene="Cert1"
                     /gene_synonym="2810404O15Rik; 9230101K08Rik; CERT;
                     Col4a3bp; GPBP"
                     /note="major polyA site"
ORIGIN      
        1 gggtaaatag tggacccggc aggaagatgg cggctgtagc ggaggtgtga gtgagtggat
       61 ctgggtctct gccgttggct tggctcttcc cgtcttcctc ccctcctccc tccctgactg
      121 aggttggcat ctagggggcc gagttcaggt ggcggcgccg ggcgcagcgc aggggtcacg
      181 gccacggcgg ctgacggctg gaagggcagg ctttcttcgc cgctcgtcct ccttccccgg
      241 tccgctcggt gtcaggcgcg gcggcggcgg cgcggcgggc gcgcttcgtc cctcttcctg
      301 ttccctcact ccccggagcg ggctctcttg gcggtgccat cccccgaccc ttcaccccag
      361 ggactaggcg cctgcactgg cgcagctcgc ggagcggggg ccggtctcct gctcggctgt
      421 cgcgtctcca tgtcggataa ccagagctgg aactcgtcgg gctcggagga ggatccggag
      481 acggagtccg ggccgcctgt ggagcgctgc ggggtcctca gcaagtggac aaactatatt
      541 catggatggc aggatcgttg ggtagttttg aaaaataata ctttgagtta ctacaaatct
      601 gaagatgaaa cagaatatgg ctgtagggga tccatctgtc ttagcaaggc tgtgatcacg
      661 cctcacgatt ttgatgaatg ccggtttgat atcagtgtaa atgatagtgt ttggtacctt
      721 cgagctcagg acccggagca cagacagcaa tgggtagacg ccattgaaca gcacaagact
      781 gaatcgggat atggatctga gtccagcttg cgtagacatg gctcaatggt gtcactggtg
      841 tctggagcga gtggctattc tgctacgtcc acctcttctt tcaagaaagg ccacagttta
      901 cgtgagaaac tggctgaaat ggagacattt cgggacatcc tgtgccggca ggttgatact
      961 ctccagaagt actttgatgt ctgtgctgac gctgtctcca aggatgagct tcagagggat
     1021 aaagtcgtag aagatgatga agatgacttc cctacaactc gttctgatgg agactttttg
     1081 cacaatacca atggtaataa agaaaaatta tttccacatg taacaccaaa aggaattaat
     1141 ggcatagact ttaaagggga agcaataact tttaaagcaa ctactgctgg aatccttgct
     1201 acactttctc attgtattga attaatggta aaacgggaag agagctggca aaaaagacac
     1261 gatagggaag tggaaaagag gagacgagtg gaggaagcgt acaagaatgt gatggaagaa
     1321 cttaagaaga aaccccgttt cggagggccg gattatgaag aaggtccaaa cagtctgatt
     1381 aatgaggaag agttctttga tgctgttgaa gctgctcttg acagacaaga taaaatagag
     1441 gaacagtcac agagtgaaaa ggtcaggtta cactggccca catcattgcc atctggagac
     1501 accttttctt ctgtcgggac gcatagattt gtacaaaagc cctatagtcg ctcttcctcc
     1561 atgtcttcca ttgatctagt cagtgcctct gacgatgttc acagattcag ctcccaggtt
     1621 gaagaaatgg tacagaacca catgaactat tcattacagg atgtaggtgg tgatgcaaat
     1681 tggcaactgg ttgttgaaga aggagaaatg aaggtataca gaagagaagt ggaagaaaat
     1741 ggaattgttc tggatccttt gaaagctact catgcagtta aaggtgttac aggacatgag
     1801 gtctgcaatt acttttggaa tgttgatgtt cgcaatgact gggaaactac tatagaaaac
     1861 tttcatgtgg tggaaacatt agctgataat gcaatcatcg tttatcaaac gcacaagaga
     1921 gtatggcccg cttctcagag agacgtactg tatctttctg ctattcgaaa gatcccagcc
     1981 ttgactgaaa atgatcctga aacttggata gtttgtaatt tttctgtgga tcatgatagt
     2041 gctcctctga acaatcgatg tgtccgtgcc aaaatcaata ttgctatgat ttgtcaaact
     2101 ttagtaagcc caccagaggg agaccaggag ataagcagag acaacattct gtgcaagatc
     2161 acgtatgtag ctaatgtgaa cccaggagga tgggcgccag cctcggtctt aagagcagtg
     2221 gcaaagcgag aataccctaa gtttctaaaa cgttttactt cttatgtcca agaaaaaact
     2281 gcaggaaaac caattttgtt ttagtattaa cagtgactga agcaaggctg cgtgacgttc
     2341 catgttggag aaaggaggga aaaaataaaa agaatcctct aagctggaac gtaggatcta
     2401 cagccttgtc tgtggcccaa gaagaaacat tgcaatcgta aagctgggta tccagcacta
     2461 gccatctcct gctaggcctc ctcgctgagc gtgtaactat aaatacatgt agaatcacat
     2521 ggatatggct atatttttat ttgcttgctc cttggagtga aaacaaataa ctttgaatta
     2581 caactagaat taaccgatgc tttaattttg aggaactttt ttcagaattt tttatttacc
     2641 atggtccagc ctaagatcct cagttgtatc aggttttgtg cacaaaagaa aagcacaaaa
     2701 gttgaacgca cctgaggcat gtgctctctg tgcaccaaat actcagatgg gcttcttttt
     2761 acaggcctac agtctgtgtc tgtgtccaga agtttttgac ttttttgctt tgtataatca
     2821 tagaatctat tgctgctgat ttctataaga attcatcttg tgtgtctctt cataactgag
     2881 gactgtcaat aacctgtgat tttgcctttt ctatagtctt actcccatga agaacattgg
     2941 ttctgatgga gaaagaatga aaagctttat tcccccagat atctttatat ttttattata
     3001 tattttagtt gtgtactatg tgctaccaac ttttttcagt ttgttacaaa cacaatttgg
     3061 taatttttaa attggttctg cctgcctcca gtcagagaca actgtacatc tcttatgggt
     3121 atagagtact ttatatacag aggtcaggac aaagtgggtt catattttcc ctgaaatttg
     3181 taagagaata tatggtatta cttgttaaac caaatcagac tgtttgaatt tgacatttga
     3241 tttaatattt ctagtattct gtaacaaata tggtagtttt tctagcttgg attactttaa
     3301 atgatatatc gaaggtatac atagaaaatc tgaacaatgc tccaatttgc ctcttgatca
     3361 taaatttcag cagagcagta caatttcaca gtattcaaac tgaaaactgt ctttagttgc
     3421 tatgagaagc taacatgtaa aatacctgat ttagttgtag tcctctatga aaaacttgga
     3481 agcatggagt tgaggcaagg aatggtactc acttcagttg agatgactgc ccacttcaaa
     3541 ctcttgattg tgtttacaag cagatgtatt tatgtaaatc aggcatttcg tagatgcttt
     3601 gctgacttgt tcctctcctt agaaacacaa aaactcagac ccttttgtaa agcagagagt
     3661 catgtcatgt aaaacatgac ctgtatatat tccatacatc gaaatggagt ctaaagatga
     3721 atgcaaggtg tgataactta atgatgggat tagtctgatc acttaatatg cacaatcctg
     3781 gaagtgaatt acttgcatca gatagaatat ttattactct gtatagagag aaaagtgcgt
     3841 ataaaacata gagcttacat tacatgcacg cagtttcatg tcccataaat cttttatatt
     3901 ttttaattta cctttctcta aatgatgtgc atggaatatg ccttattaca gaaatgctat
     3961 tcataatttg actctgtgga aaagtgccta tgtggtggta gtgctaggaa ggcaaggaac
     4021 agattatcat accagtttac atcaccagtt aacattttat attgtgatgt ttaaaaaaag
     4081 aaaagtttat acctcaaatg tgtattttat tttgcaatca gctatggggt tgggatggga
     4141 gaacggggag ggttgggagg gaaagtttat ttgctatagg cactggtggg aatcttgggg
     4201 ggggggacaa aaaacaacaa aaacaaaact ctctacaccc actataaatg ttcttctgtt
     4261 tgcatttctg gtaactatga tgaaccagac aaataactct caaaacgaaa ttggatagct
     4321 ttattttaca aacgtgcaaa gtttatgaag cagggtctgc atctaattat taccagtggc
     4381 atttgcacta aatgtggtga taatctttta caatttattc tgtaaataaa atgttacact
     4441 aaaaatactt gtagtaaaaa gataagcaat gatcatttta gtaatgatct tcagtaaaag
     4501 actggtactt tattggagat aaccctgccc agtcagattt agaattgagt tcagaaatac
     4561 tgaaagtatt caaacagtca aagttaggag gagcactggc gacgttataa tattcagacc
     4621 gtcaagaatt actttcattt ggctaatccc tacatagtga atatttattg tttcttcata
     4681 acctgggtat ctatcttagc ctaagccccc atcccacaca cccccaaaac aagccccttt
     4741 actcaattct gctggattat tctgtgatgt tagacacctg aaaaatactg gtgatgtggg
     4801 gatttgtccc tgcgtgtgag tgagcataag gagggagcag agtgctcctc ctggggttga
     4861 ggactccata ttggaggtag agaaacttga cttggtgttg ctacaggagg agcgagggag
     4921 gaacctgact aagagagatg tgtggaggcc aagtgaggta caggaggcat ggctctcaac
     4981 tgtccgtttc catgactacc tatacaccta tccaatatca gtgtcagtcg ctacagaatt
     5041 ttaactgggc tgagctggct ctcttgtgaa attgtgccgg ttatcttcag acgtctcagt
     5101 tgtttgtccg atcagacgcg tgaccagtat gtggtccagg ctgtacaggt gatgtatttg
     5161 gattgtcgtc gttgttcatc tacagactca aaacataatc attttaaagt accttgggag
     5221 tgtgtagagt gtaactataa tagctttatg attctgatga tgttttttta aaaatataaa
     5281 agatggatct tccatgttac aatcacaaaa ttaaaaccag tatttaaaag tggagaagta
     5341 ttaaaatatt acaaatatgc tca
//
