LOCUS       NM_001347161            7034 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus ceramide synthase 6 (Cers6), transcript variant 1,
            mRNA.
ACCESSION   NM_001347161 XM_006499452
VERSION     NM_001347161.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7034)
  AUTHORS   Zhang,J., Ruiz,M., Bergh,P.O., Henricsson,M., Stojanovic,N.,
            Devkota,R., Henn,M., Bohlooly-Y,M., Hernandez-Hernandez,A.,
            Alsheimer,M., Boren,J., Pilon,M. and Shibuya,H.
  TITLE     Regulation of meiotic telomere dynamics through membrane fluidity
            promoted by AdipoR2-ELOVL2
  JOURNAL   Nat Commun 15 (1), 2315 (2024)
   PUBMED   38485951
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7034)
  AUTHORS   Jeon,S., Scorletti,E., Dempsey,J., Buyco,D., Lin,C., Saiman,Y.,
            Bayen,S., Harkin,J., Martin,J., Hooks,R., Ogretmen,B., Argemi,J.,
            Melo,L., Bataller,R. and Carr,R.M.
  TITLE     Ceramide synthase 6 (CerS6) is upregulated in alcohol-associated
            liver disease and exhibits sex-based differences in the regulation
            of energy homeostasis and lipid droplet accumulation
  JOURNAL   Mol Metab 78, 101804 (2023)
   PUBMED   37714377
  REMARK    GeneRIF: Ceramide synthase 6 (CerS6) is upregulated in
            alcohol-associated liver disease and exhibits sex-based differences
            in the regulation of energy homeostasis and lipid droplet
            accumulation.
REFERENCE   3  (bases 1 to 7034)
  AUTHORS   Hammerschmidt,P., Steculorum,S.M., Bandet,C.L., Del Rio-Martin,A.,
            Steuernagel,L., Kohlhaas,V., Feldmann,M., Varela,L., Majcher,A.,
            Quatorze Correia,M., Klar,R.F.U., Bauder,C.A., Kaya,E.,
            Porniece,M., Biglari,N., Sieben,A., Horvath,T.L., Hornemann,T.,
            Brodesser,S. and Bruning,J.C.
  TITLE     CerS6-dependent ceramide synthesis in hypothalamic neurons promotes
            ER/mitochondrial stress and impairs glucose homeostasis in obese
            mice
  JOURNAL   Nat Commun 14 (1), 7824 (2023)
   PUBMED   38016943
  REMARK    GeneRIF: CerS6-dependent ceramide synthesis in hypothalamic neurons
            promotes ER/mitochondrial stress and impairs glucose homeostasis in
            obese mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7034)
  AUTHORS   Wang,X., Song,M., Li,X., Su,C., Yang,Y., Wang,K., Liu,C., Zheng,Z.,
            Jia,Y., Ren,S., Dong,W., Chen,J., Wang,T., Liu,L., Guan,M.,
            Zhang,C. and Xue,Y.
  TITLE     CERS6-derived ceramides aggravate kidney fibrosis by inhibiting
            PINK1-mediated mitophagy in diabetic kidney disease
  JOURNAL   Am J Physiol Cell Physiol 325 (2), C538-C549 (2023)
   PUBMED   37458434
  REMARK    GeneRIF: CERS6-derived ceramides aggravate kidney fibrosis by
            inhibiting PINK1-mediated mitophagy in diabetic kidney disease.
REFERENCE   5  (bases 1 to 7034)
  AUTHORS   Griess,K., Rieck,M., Muller,N., Karsai,G., Hartwig,S., Pelligra,A.,
            Hardt,R., Schlegel,C., Kuboth,J., Uhlemeyer,C., Trenkamp,S.,
            Jeruschke,K., Weiss,J., Peifer-Weiss,L., Xu,W., Cames,S., Yi,X.,
            Cnop,M., Beller,M., Stark,H., Kondadi,A.K., Reichert,A.S.,
            Markgraf,D., Wammers,M., Haussinger,D., Kuss,O., Lehr,S.,
            Eizirik,D., Lickert,H., Lammert,E., Roden,M., Winter,D.,
            Al-Hasani,H., Hoglinger,D., Hornemann,T., Bruning,J.C. and
            Belgardt,B.F.
  TITLE     Sphingolipid subtypes differentially control proinsulin processing
            and systemic glucose homeostasis
  JOURNAL   Nat Cell Biol 25 (1), 20-29 (2023)
   PUBMED   36543979
REFERENCE   6  (bases 1 to 7034)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 7034)
  AUTHORS   Li,X., Madison,B.B., Zacharias,W., Kolterud,A., States,D. and
            Gumucio,D.L.
  TITLE     Deconvoluting the intestine: molecular evidence for a major role of
            the mesenchyme in the modulation of signaling cross talk
  JOURNAL   Physiol Genomics 29 (3), 290-301 (2007)
   PUBMED   17299133
REFERENCE   8  (bases 1 to 7034)
  AUTHORS   Mizutani,Y., Kihara,A. and Igarashi,Y.
  TITLE     Mammalian Lass6 and its related family members regulate synthesis
            of specific ceramides
  JOURNAL   Biochem J 390 (Pt 1), 263-271 (2005)
   PUBMED   15823095
REFERENCE   9  (bases 1 to 7034)
  AUTHORS   Riebeling,C., Allegood,J.C., Wang,E., Merrill,A.H. Jr. and
            Futerman,A.H.
  TITLE     Two mammalian longevity assurance gene (LAG1) family members, trh1
            and trh4, regulate dihydroceramide synthesis using different fatty
            acyl-CoA donors
  JOURNAL   J Biol Chem 278 (44), 43452-43459 (2003)
   PUBMED   12912983
REFERENCE   10 (bases 1 to 7034)
  AUTHORS   Venkataraman,K. and Futerman,A.H.
  TITLE     Do longevity assurance genes containing Hox domains regulate cell
            development via ceramide synthesis?
  JOURNAL   FEBS Lett 528 (1-3), 3-4 (2002)
   PUBMED   12297269
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929137.5 and AL929221.6.
            
            On Jan 6, 2022 this sequence version replaced NM_001347161.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR6116558.122760.1,
                                           SRR7345562.3498551.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               AL929137.5         34883-35219
            338-443             AL929137.5         107929-108034
            444-574             AL929137.5         120641-120771
            575-632             AL929137.5         176161-176218
            633-683             AL929137.5         220559-220609
            684-776             AL929221.6         4660-4752
            777-905             AL929221.6         22509-22637
            906-1012            AL929221.6         25212-25318
            1013-1169           AL929221.6         58883-59039
            1170-1193           AL929221.6         59623-59646
            1194-7034           AL929221.6         62322-68162
FEATURES             Location/Qualifiers
     source          1..7034
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 39.53 cM"
     gene            1..7034
                     /gene="Cers6"
                     /gene_synonym="4732462C07Rik; Lass6; T1L"
                     /note="ceramide synthase 6"
                     /db_xref="GeneID:241447"
                     /db_xref="MGI:MGI:2442564"
     exon            1..337
                     /gene="Cers6"
                     /gene_synonym="4732462C07Rik; Lass6; T1L"
                     /inference="alignment:Splign:2.1.0"
     exon            338..443
                     /gene="Cers6"
                     /gene_synonym="4732462C07Rik; Lass6; T1L"
                     /inference="alignment:Splign:2.1.0"
     exon            444..574
                     /gene="Cers6"
                     /gene_synonym="4732462C07Rik; Lass6; T1L"
                     /inference="alignment:Splign:2.1.0"
     exon            575..632
                     /gene="Cers6"
                     /gene_synonym="4732462C07Rik; Lass6; T1L"
                     /inference="alignment:Splign:2.1.0"
     exon            633..683
                     /gene="Cers6"
                     /gene_synonym="4732462C07Rik; Lass6; T1L"
                     /inference="alignment:Splign:2.1.0"
     exon            684..776
                     /gene="Cers6"
                     /gene_synonym="4732462C07Rik; Lass6; T1L"
                     /inference="alignment:Splign:2.1.0"
     exon            777..905
                     /gene="Cers6"
                     /gene_synonym="4732462C07Rik; Lass6; T1L"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1012
                     /gene="Cers6"
                     /gene_synonym="4732462C07Rik; Lass6; T1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1169
                     /gene="Cers6"
                     /gene_synonym="4732462C07Rik; Lass6; T1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1193
                     /gene="Cers6"
                     /gene_synonym="4732462C07Rik; Lass6; T1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..7034
                     /gene="Cers6"
                     /gene_synonym="4732462C07Rik; Lass6; T1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7012..7017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cers6"
                     /gene_synonym="4732462C07Rik; Lass6; T1L"
                     /note="hexamer: AATAAA"
     polyA_site      7034
                     /gene="Cers6"
                     /gene_synonym="4732462C07Rik; Lass6; T1L"
                     /note="major polyA site"
ORIGIN      
        1 ggagcggatc gcggagcctg agagtgcagc ggccacagag gaggcggcgg caggcggagc
       61 ggcagcggca aaggctcccg gccaacccag cgcgcatccc cagtgccctg agctgcagag
      121 agctcggagg agcgcgggag cagcgacacc ggagtggaca aagcaagatg gcagggatct
      181 tagcctggtt ctggaacgag cggttttggc ttccgcacaa tgtcacctgg gcagacctga
      241 agaacacgga ggaagccacc tttccgcagg cggaggacct ctaccttgcc ttccccttgg
      301 ccttctgcat cttcatggtg cggctcatct tcgagagatt catagccaaa ccatgtgcca
      361 tagccctcaa catccaagcc aatggaccac aaactgccca gccaaatgcc attctggaaa
      421 aggttttcac tgctataaca aagcatcctg atgaaaagag attagaaggg ctctccaagc
      481 agctggactg ggatgttcgg agcattcaac gctggtttcg acaaagacgc aaccaggaga
      541 aacccagcac tctgaccagg ttctgtgaga gcatgtggag attttccttt tacctctatg
      601 tatttagcta cggagtccgg ttcttgaaac agaccccttg gttgtggaat acaagacact
      661 gctggtataa ctacccttac cagccactca cagctgacct tcactactat tacatcctgg
      721 agctgtcatt ttattggtct ttaatggttt cccagttcac agatatcaaa aggaaggact
      781 tcggcattat gttcctgcac caccttgcaa caattttctt aataaccttt tcatatgtca
      841 acaacatggc ccgagtagga accctggtcc tctgtcttca cgactcagcc gatgctctgc
      901 tagaggctgc caaaatggca aattacgcca aatttcagaa aatgtgtgat ctcctgtttg
      961 tcatgtttgc cgtggttttt atcaccacac ggctgggcat atttcctctc tgggtgttga
     1021 ataccacatt atttgaaagt tgggagatcg tcggacccta cccttcctgg tgggttttta
     1081 acctgctgct cttgttacta caagggttga actgcttctg gtcttacctg attgtaaaaa
     1141 tagcttgcaa aactgtttca aaaggcaagg ctgggaagtg gaaccctttg catgtatcca
     1201 aggatgaccg gagtgacatt gaatctagct cagatgatga ggactcagag cctccaggga
     1261 agaaaccaca ctcttcaaca accaccaacg gaaccagcgg taccaatggg tacctcctca
     1321 ctggtccttg ttccgtggat gattaactac ccaaaactat aagttctgaa caaagggaac
     1381 tgtttgttcc tggaagtatt taataagttg caaatgcagt tcctttcatg atatctcatc
     1441 accagagaca aaaaattagg attcttggag cattctgaat agtgtactgc catgtgtcct
     1501 gtctgtgaat gaagaaatcc attatttcta tgtaggcatg ctgtatgtaa ctgacacagg
     1561 gaacagtatt tgcatttgtc ttaggatatt atttattttt ttatttgttt gtaaatctgt
     1621 ggacaaacga ggattccttc actcctttca ttctctgggc tcgtgattga cagtaaggat
     1681 gtcctgtctg tgtgtgcccc ttttccacgt tgtggtccag tgtgccgtga gcatcagctt
     1741 tctttacccc ttagagcaag gaacatccca tgccagatcc tcacacagtt cccagtaggt
     1801 tggctttcct tctgttctgc acccattttc tatttgccca tacagttggt gaccattgcc
     1861 ccacgtgagt ctaaacaggg tgaaccaggt gttttccttg ccactcttgg tgatcagatg
     1921 aaagagagtg gctatggggg gactttagaa ttttacagga aaccgccttg gtttgtctct
     1981 tgtgcacaga catgagactt cttttctgtg gtaggttgtc gggggttgac tatgttggta
     2041 acaaagctat tttgccctcc agtgaagtca gtgttctgag tatgaaacag tatctcttgc
     2101 ataagttccc agatacaagg gccccacata ctgggttctg ggagtctcgt aaggatagcc
     2161 actgccctca accaggtctt gccatgactt ctaccctatt agtccagtct tctgtcctga
     2221 cgtataaaaa agaggaagcc ccgaatattc tgaggcagga aaagaaaaag tcttgtggga
     2281 gttggcaaag acttccttcc ctgcaaagca ctttattgca accagctttc aagagaaagc
     2341 cctatctggt attagacttt gtattttgct gagtaaaata aatcgaatga gagaaagaca
     2401 attaacccct tgccttcctc ctcaaatgca tcccataatg actttcttgt tgctagaaac
     2461 atccacccca caggacaagt ctgttccatt tactgctctg acgacttgtg agggctcctg
     2521 tgaatttctc ttcaagtgga gctatttcca gaaaaacagt aaaaaattct actggagaat
     2581 agcagcaaca gctgtgggga aaattgccaa agaatacgtc atgagccctc acccaccccc
     2641 accccctgca gccagtgtta cttttgttcg gctacagaaa ccacacagat gagccgagga
     2701 ctagacccat ctcatcctca gtaaaaagga aactgaatgg gattacaagt actcgtgagt
     2761 caaacatctc ctaaaacagg actccaaacc agtcagcgct gagtaaccaa tagcaaaaca
     2821 ttacagtgca tgacggtcct gctcagaacc acccccactc catttggttc ttttaaatta
     2881 aatctgcata cccatacctt gaagcctgtg agttaattgt taagagaaga ctcccgaaga
     2941 actcactgca atattaaatc ctcctccacc taattacaaa acagtatttt ctggtatggt
     3001 ccagacaata attttcaaag cttggaagca tgtctagttg ttaccacaga agacagtgca
     3061 agtgactgtg tgatttgagc cttgctgata tattagccaa aacagttata tgtctaggag
     3121 tgaaacttga ttgagtgttt gggtttgtga gaccagtgat aagacacggg aggtactgtt
     3181 agtaatcaga gcatttgctc aaatacaaat ggatgaaaac caagagcagt gttgagacag
     3241 tgaaagtttg tcatcagcta agctaaggaa cctacccatc tctagttaat gtctgggctc
     3301 atcctcccag gtatgagatg gttttgacaa ccactgtgta cttgtatttg aaccatgtga
     3361 cactctttag cacagaagaa ttttaagatc aatctgtaaa ttcagaagag gtatataaaa
     3421 atgaagtaag ttgatcctgt ccatatcaaa ggcagctcta actcatcttc tccacggaag
     3481 ttactgtgga agactagggg cacgctttct gactgacacc tttaggttgg ctcagtctgc
     3541 aacgtgtctg ttgatttttc tgtttcgtat tacctttgtg agaaaataat tctgcttggc
     3601 taattgaaat ggagtttgta ggctttttct ggaatagaat attaatatct ctgtctaatg
     3661 ttctcccaaa aatggacgga taagactgag aacagacact gtccgcggaa tcgtatccac
     3721 atatggcagg ccatagctct cagaaagtct gacttgtaaa tccagcttta ggttagttct
     3781 aagtggtgat tttggtaatt agcatagctt gtggtgatgt ctcctccttc ctggttgcat
     3841 ccaaactccc cagggtacca aagtgtgtgt agaaaggact ctagaaaaag taactctcat
     3901 agcttaccta gatttagtgg gggggaaagt aggaaatcaa gtagactttg gcctagagtc
     3961 agtaattgat atagccgtgt ctgatttatg tgtgcatatg tatgtttctc caaaaactgg
     4021 taaaactaaa tgattactga ttcatcatcg tcctccatat tcctttcctt agaaaaaaaa
     4081 cgaacgcatt caaccatgtc ctaaacagac tttccttctc tttagttttg ctttgcacca
     4141 gctgagagta gcaaagccct ctcagcctct cagtcacaga gctccctgag atagactcag
     4201 gtcctggagc atctgctgcc acacatagga cacacccact tcactatcgc agactcggcc
     4261 ccgtggatgt tgagagcaga ggagcaactg caaggatcag tattgtgggt cattcgagta
     4321 ttcattgtaa aagtgcaagt gattgccatt taaccccatg gttctaatgt ctgctgaact
     4381 gccagacaga gcatatccca aattatcatt agattgtgtc attggcgtcc aatgctgatg
     4441 aacaaggcag caaaggcacg gaccaagaaa gaccagtcat ctttagtcca tatggtaggt
     4501 gagtctcaaa ctggtaaact cctgtctgag tcatacactt agcaaaagca ctgcgtgcta
     4561 ccatggtccc aaaaggtgat gacatagcct aggtacagag gcggtactgt ctgctgtgtg
     4621 taagtacact tattgatgtt cgcagagtga caaaaatgtg tccctgctgt gacatgacat
     4681 aggcctatac tttttgagca aatgtattgc ctttccttca ctttagatag aaaggtctga
     4741 atcttccacc ttgcatttaa atctcattgt tacttgggct aaggaaaaat gagacttcgt
     4801 tgttataaag gacattggag ctcccctgag tctgtgttga ccagttcttc tgagagaacg
     4861 aatgggtgcc tttcattgcc tccaacccag tttacattac taatcatttt ggggtaaatc
     4921 aatgtcagag ttgcctggat atttgagtat tttccttaat ttgaagaaga aaaatagtgt
     4981 gtagaattag cccaaaggta cggatgtggg ccatttatca gtatgggaga tgatgtcatt
     5041 aacccagaga ggccgcaaca cctttggaaa taagaagtta agtgctggcc ctttgtgtaa
     5101 tgtttgtggt actaaggctc ctacctgcct ttcactttcc ttgtcttcgg cttatttctg
     5161 cttagtcaat aagtcgtcat agccctgcaa tggttctaac acccaaagga gaaaaacatc
     5221 aaacaagacc agagtcgccc tgaggggata gtgatcacct ggctcttgtg tagcaagaaa
     5281 gaaatgtgga gggctctaac tactgcaggt gccttcaagt atgctgcccc tgtcaggaat
     5341 gatcataaac gttcttaaag tgaaacaaga ctgtttcctt acatgtatgc ttcccactat
     5401 cagcttctct tccagaggtg agattgtgcc attctccaaa tgctgtgagc taattagcaa
     5461 tagtctacca atcacatttt agttccatga actgatgggc taaaggaggg ccctcctttc
     5521 acctatgtgt acatagcacc cacccacccc taggaggcgc caagcagatg tgggggagcc
     5581 ctagccaaag ctcttgaaac tcctgtaacc accaatactc aaaagcagcc acttttcatg
     5641 gagaaaatca tgttgaagaa cgtaagtcac cataagtaat gagatacgta gacacccgaa
     5701 taagaaggtt cgcctcctgc aggcttttgt gacttgatgc atcccaaagc ctttgacagg
     5761 aagcatcggc aggtgcgtgc attgagactc ccaccaatgc caagtgacag gaatgcatcg
     5821 gcaggtgcgt gcattgagac tcccaccaat gccaagtgac aggaatgcat cggcaggtgc
     5881 gtgcattgag actcccacca atgccaagtg acaggaatgc atgggcaggt gcgtgcattg
     5941 agactcccac caatgccaag tgacaggaat gcatgggcag gtgcgtgcat tgagactccc
     6001 accaatgccg agaagttgca aaagcctggg ccacagggtg agttactgtg tctgcatgga
     6061 atcgggcact ctcggattgc tgggaagcga tgaggaggcg ctgttagcct ggagctggtc
     6121 tcctttagct cattcactca cggcctttta ggcttctgga actctggtaa aagaaagcca
     6181 gatgctaaca tttttctgct ttcagtttac taatgactgt tagatcagct cttcccatcc
     6241 cttcttctct gtctggtgcc attttcagga ggtgggagag ggtgtgccca tgtacacctg
     6301 tctccttaac acaggtccac gaatacttag cttcctgggt tgtgtgtctt ctgagaacca
     6361 tggtacagcg tcagtcacca tagtttctgt gctcagtgga aaattttgat ttcattcata
     6421 tttttattct ctttacctat gataaatgtc ataaactgta aaactctcct taatgtgaaa
     6481 ctttttttgg ttttttgttt tgtttgtttg ggtttttttt gttttttgtt ttttgttttt
     6541 tgttttttgt ttttttttag tgttagctgc aaagctacaa agctctggaa tggttacatt
     6601 atgattctgg aacgttcgct caaagcttaa ttagcataag tgtggaccac actccagctt
     6661 aattcccctg tgcacacagt tctcatcact cctgtgccca agtcccagtc atttcccttc
     6721 atggcctgta gctgtcagag aaaggaatgg tggttaattt ggaggtttgt ttctcttttc
     6781 cagctttccc tggggactag aataagtgac agaacctcat ttgttttcta aagatagttc
     6841 ggtgcgtgag catctgtcag aagtggaatg gtgtgccatt agccaattag aatcactctg
     6901 tactgtcact gtgtttttgc tgatttttta tatgggaata taattactcg ttcttgatct
     6961 ttggaagtaa ttgttattat gaggatcatt ttactttgga aacactttca taataaagat
     7021 aaacattaag agta
//
