LOCUS       NM_028015               2050 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus ceramide synthase 5 (Cers5), mRNA.
ACCESSION   NM_028015
VERSION     NM_028015.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2050)
  AUTHORS   Liu,J., Koutalos,Y. and Fan,J.
  TITLE     Lack of ceramide synthase 5 protects retinal ganglion cells from
            ocular hypertensive injury
  JOURNAL   Exp Eye Res 247, 110061 (2024)
   PUBMED   39182597
  REMARK    GeneRIF: Lack of ceramide synthase 5 protects retinal ganglion
            cells from ocular hypertensive injury.
REFERENCE   2  (bases 1 to 2050)
  AUTHORS   Zhu,Q., Chen,S., Funcke,J.B., Straub,L.G., Lin,Q., Zhao,S.,
            Joung,C., Zhang,Z., Kim,D.S., Li,N., Gliniak,C.M., Lee,C.,
            Cebrian-Serrano,A., Pedersen,L., Halberg,N., Gordillo,R.,
            Kusminski,C.M. and Scherer,P.E.
  TITLE     PAQR4 regulates adipocyte function and systemic metabolic health by
            mediating ceramide levels
  JOURNAL   Nat Metab 6 (7), 1347-1366 (2024)
   PUBMED   38961186
REFERENCE   3  (bases 1 to 2050)
  AUTHORS   Zhang,J., Ruiz,M., Bergh,P.O., Henricsson,M., Stojanovic,N.,
            Devkota,R., Henn,M., Bohlooly-Y,M., Hernandez-Hernandez,A.,
            Alsheimer,M., Boren,J., Pilon,M. and Shibuya,H.
  TITLE     Regulation of meiotic telomere dynamics through membrane fluidity
            promoted by AdipoR2-ELOVL2
  JOURNAL   Nat Commun 15 (1), 2315 (2024)
   PUBMED   38485951
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2050)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2050)
  AUTHORS   Chen,J., Hao,Y., Xu,P., Bian,D., Han,L., Wu,X., Zhuang,Z., Wang,J.
            and Luo,Y.
  TITLE     CerS5 deficiency promotes liver fibrosis development in
            non-alcoholic fatty liver disease
  JOURNAL   Biochem Biophys Res Commun 667, 120-126 (2023)
   PUBMED   37216827
  REMARK    GeneRIF: CerS5 deficiency promotes liver fibrosis development in
            non-alcoholic fatty liver disease.
REFERENCE   6  (bases 1 to 2050)
  AUTHORS   Lahiri,S. and Futerman,A.H.
  TITLE     LASS5 is a bona fide dihydroceramide synthase that selectively
            utilizes palmitoyl-CoA as acyl donor
  JOURNAL   J Biol Chem 280 (40), 33735-33738 (2005)
   PUBMED   16100120
REFERENCE   7  (bases 1 to 2050)
  AUTHORS   Mizutani,Y., Kihara,A. and Igarashi,Y.
  TITLE     Mammalian Lass6 and its related family members regulate synthesis
            of specific ceramides
  JOURNAL   Biochem J 390 (Pt 1), 263-271 (2005)
   PUBMED   15823095
REFERENCE   8  (bases 1 to 2050)
  AUTHORS   Xu,Z., Zhou,J., McCoy,D.M. and Mallampalli,R.K.
  TITLE     LASS5 is the predominant ceramide synthase isoform involved in de
            novo sphingolipid synthesis in lung epithelia
  JOURNAL   J Lipid Res 46 (6), 1229-1238 (2005)
   PUBMED   15772421
  REMARK    GeneRIF: LASS5 is the major ceramide synthase gene product involved
            in sphingolipid production that may also regulate
            phosphatidylcholine metabolism in pulmonary epithelia
REFERENCE   9  (bases 1 to 2050)
  AUTHORS   Riebeling,C., Allegood,J.C., Wang,E., Merrill,A.H. Jr. and
            Futerman,A.H.
  TITLE     Two mammalian longevity assurance gene (LAG1) family members, trh1
            and trh4, regulate dihydroceramide synthesis using different fatty
            acyl-CoA donors
  JOURNAL   J Biol Chem 278 (44), 43452-43459 (2003)
   PUBMED   12912983
  REMARK    GeneRIF: Lag1p family members trh1 and trh4 regulate
            (dihydro)ceramide synthases responsible for production of
            sphingolipids containing different fatty acids
REFERENCE   10 (bases 1 to 2050)
  AUTHORS   Venkataraman,K. and Futerman,A.H.
  TITLE     Do longevity assurance genes containing Hox domains regulate cell
            development via ceramide synthesis?
  JOURNAL   FEBS Lett 528 (1-3), 3-4 (2002)
   PUBMED   12297269
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC046797.1.
            
            On Jun 19, 2003 this sequence version replaced NM_028015.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046797.1, AK010241.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2050
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.13 cM"
     gene            1..2050
                     /gene="Cers5"
                     /gene_synonym="2310081H14Rik; Lass5; Trh4"
                     /note="ceramide synthase 5"
                     /db_xref="GeneID:71949"
                     /db_xref="MGI:MGI:1919199"
     exon            1..333
                     /gene="Cers5"
                     /gene_synonym="2310081H14Rik; Lass5; Trh4"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1381
                     /gene="Cers5"
                     /gene_synonym="2310081H14Rik; Lass5; Trh4"
                     /EC_number="2.3.1.24"
                     /EC_number="2.3.1.291"
                     /note="LAG1 longevity assurance homolog 5; TRAM homolog 4;
                     translocating chain-associating membrane protein homolog
                     4; LAG1 homolog, ceramide synthase 5; sphingosine
                     N-acyltransferase CERS5; sphingoid base
                     N-palmitoyltransferase CERS5"
                     /codon_start=1
                     /product="ceramide synthase 5"
                     /protein_id="NP_082291.1"
                     /db_xref="CCDS:CCDS27830.1"
                     /db_xref="GeneID:71949"
                     /db_xref="MGI:MGI:1919199"
                     /translation="MATAAAETLGLLWGWLWSESFWLPQNVSWADLEGPGDGYGYPRA
                     QHVLSVFPLAVCIFSVRMLFERFIAKPCALRVGIKDSPVNKVEPNDTLEKVFVSVTKY
                     PDEKRLKGLSKQLDWSVRKIQCWFRHRRNQDKPPTLTKFCESMWRFTYYLCIFCYGIR
                     FLWSMPWFWDTRQCWYNYPYQPLSRELYYYYITQLAFYWSLMFSQFIDVKRKDFLMMF
                     IHHMIGIMLTTFSYVNNMVRVGALIFCLHDFADPLLEAAKMANYARRERLCTTLFVIF
                     GAAFIVSRLAIFPLWILNTTLFESWEIIGPYPSWWLFNALLLILQVLHAIWSYLIVQT
                     ASKALSRGKVSKDDRSDVESSSEEEDETTHKNNLSGSSSSNGANCMNGYMGGSHLAEE
                     QGTCKATGNLHFRASPHLHSCD"
     exon            334..439
                     /gene="Cers5"
                     /gene_synonym="2310081H14Rik; Lass5; Trh4"
                     /inference="alignment:Splign:2.1.0"
     exon            440..570
                     /gene="Cers5"
                     /gene_synonym="2310081H14Rik; Lass5; Trh4"
                     /inference="alignment:Splign:2.1.0"
     exon            571..628
                     /gene="Cers5"
                     /gene_synonym="2310081H14Rik; Lass5; Trh4"
                     /inference="alignment:Splign:2.1.0"
     exon            629..679
                     /gene="Cers5"
                     /gene_synonym="2310081H14Rik; Lass5; Trh4"
                     /inference="alignment:Splign:2.1.0"
     exon            680..772
                     /gene="Cers5"
                     /gene_synonym="2310081H14Rik; Lass5; Trh4"
                     /inference="alignment:Splign:2.1.0"
     exon            773..901
                     /gene="Cers5"
                     /gene_synonym="2310081H14Rik; Lass5; Trh4"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1008
                     /gene="Cers5"
                     /gene_synonym="2310081H14Rik; Lass5; Trh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1165
                     /gene="Cers5"
                     /gene_synonym="2310081H14Rik; Lass5; Trh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..2010
                     /gene="Cers5"
                     /gene_synonym="2310081H14Rik; Lass5; Trh4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcggctgg gaggacccag ggacggaaga gggtggccgt aggccgggcc ccgcctcggg
       61 gccgcctccc agcgggttcc ttttgccttg actgcctccg aggctgtggc ggcagtggcc
      121 gccgggcgcg cgtaagatgg cgactgcagc agcggaaacc ctgggcctcc tgtggggttg
      181 gctgtggagc gagagcttct ggctgcctca gaacgtgagc tgggcggacc tggagggccc
      241 gggcgacggc tacggctacc cgcgcgccca gcacgtgctg tcggtgttcc cgctggcagt
      301 gtgcatcttc tccgtgagga tgctgtttga gcgatttatt gccaagccct gtgcactccg
      361 tgttggcatt aaagacagtc ctgtcaataa ggtggaaccc aatgacaccc ttgagaaggt
      421 gttcgtatct gttactaagt atcctgatga gaaaaggttg aagggcctat caaagcaact
      481 ggactggagt gttcgaaaaa tccaatgctg gtttcgccat cggaggaatc aggacaagcc
      541 tccaacgctc acgaaattct gtgaaagcat gtggagattc acttattatt tatgtatctt
      601 ctgctacgga atcagatttc tctggtcgat gccttggttc tgggataccc gacagtgctg
      661 gtacaactat ccgtatcagc cactctcgag agagctgtat tactattaca tcacacaact
      721 ggctttctac tggtctctta tgttttctca gtttatagat gttaaaagaa aggacttcct
      781 gatgatgttt attcatcata tgattggcat tatgctcacc actttctcct acgtcaacaa
      841 catggtgcga gtgggagcac tcatcttctg tctgcatgac ttcgcagacc ccttactgga
      901 agctgccaag atggccaatt atgccagacg tgagcggctc tgtaccaccc tttttgtgat
      961 ctttggcgca gcttttatag tttctcgtct agcaatcttc ccattgtgga ttctgaacac
     1021 aaccctcttt gaaagctggg agattattgg gccctaccct tcctggtggc tcttcaatgc
     1081 ccttctcctg atcctgcagg tgctccatgc catctggtcc tacctaattg tccagactgc
     1141 ttccaaagcc ttgagccggg gaaaggtgtc taaggatgac cgcagtgatg tagagagcag
     1201 ctcagaggaa gaagatgaga caacccacaa aaacaacctc tctggcagca gctctagcaa
     1261 tggtgccaac tgcatgaacg gctacatggg aggcagccac ttggctgaag agcaggggac
     1321 ttgtaaagcc actggcaacc tacattttag ggcctcccca catctacact cctgtgacta
     1381 gagggactgc aaggcactga ggagaatcaa agaaatattt ttgtgtttta aagaaactct
     1441 gccgttttgt atttaatgcc ctctggtcct ttcagtaagg ttattggctc tgtgtttgtg
     1501 tggtttttgt gtgtgattat acatgtgtat tgtgcatata aatgagtttc attgactcgg
     1561 ttggggcaca attctggatt actagtcatt gtctggtcac ttctgagccc acctcaagtc
     1621 cagccctggc tgcatcttga attaagctgt ctccagacca tctgtgacct cgtcccatgg
     1681 ctcttgagac tctgggttcc tgatcactta aataagtgct gtcaccagac tcagctccag
     1741 gacttgaaaa ttgttctttt ggaggaggaa gtaatatttc acctgatgga acactaccca
     1801 ggatcaacat agctcctagc tacatgtccc cttcctatca cctgctagtg gcagggacaa
     1861 ctacataccc tgctgcttat ttaatggtat gcagggaggg ggagggtagg agaggatgag
     1921 ctgagatttg gagagcagca gccactggtt gcgctgttaa tgattttata ctattgctta
     1981 ttcttctgtg attaaattgt ttcaaccctc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2041 aaaaaaaaaa
//
