LOCUS       NM_001048176            1759 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ceramide kinase-like (Cerkl), mRNA.
ACCESSION   NM_001048176
VERSION     NM_001048176.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1759)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1759)
  AUTHORS   Garcia-Arroyo,R., Domenech,E.B., Herrera-Ubeda,C., Asensi,M.A.,
            Nunez de Arenas,C., Cuezva,J.M., Garcia-Fernandez,J.,
            Pallardo,F.V., Mirra,S. and Marfany,G.
  TITLE     Exacerbated response to oxidative stress in the Retinitis
            Pigmentosa CerklKD/KO mouse model triggers retinal degeneration
            pathways upon acute light stress
  JOURNAL   Redox Biol 66, 102862 (2023)
   PUBMED   37660443
  REMARK    GeneRIF: Exacerbated response to oxidative stress in the Retinitis
            Pigmentosa Cerkl[KD/KO] mouse model triggers retinal degeneration
            pathways upon acute light stress.
REFERENCE   3  (bases 1 to 1759)
  AUTHORS   Garcia-Arroyo,R., Marfany,G. and Mirra,S.
  TITLE     CERKL, a Retinal Dystrophy Gene, Regulates Mitochondrial Transport
            and Dynamics in Hippocampal Neurons
  JOURNAL   Int J Mol Sci 23 (19), 11593 (2022)
   PUBMED   36232896
  REMARK    GeneRIF: CERKL, a Retinal Dystrophy Gene, Regulates Mitochondrial
            Transport and Dynamics in Hippocampal Neurons.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1759)
  AUTHORS   Huang,S., Hong,Z., Zhang,L., Guo,J., Li,Y. and Li,K.
  TITLE     CERKL alleviates ischemia reperfusion-induced nervous system injury
            through modulating the SIRT1/PINK1/Parkin pathway and mitophagy
            induction
  JOURNAL   Biol Chem 403 (7), 691-701 (2022)
   PUBMED   35238502
  REMARK    GeneRIF: CERKL alleviates ischemia reperfusion-induced nervous
            system injury through modulating the SIRT1/PINK1/Parkin pathway and
            mitophagy induction.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1759)
  AUTHORS   Mirra,S., Garcia-Arroyo,R., B Domenech,E., Gavalda-Navarro,A.,
            Herrera-Ubeda,C., Oliva,C., Garcia-Fernandez,J., Artuch,R.,
            Villarroya,F. and Marfany,G.
  TITLE     CERKL, a retinal dystrophy gene, regulates mitochondrial function
            and dynamics in the mammalian retina
  JOURNAL   Neurobiol Dis 156, 105405 (2021)
   PUBMED   34048907
  REMARK    GeneRIF: CERKL, a retinal dystrophy gene, regulates mitochondrial
            function and dynamics in the mammalian retina.
REFERENCE   6  (bases 1 to 1759)
  AUTHORS   Garanto,A., Riera,M., Pomares,E., Permanyer,J., de Castro-Miro,M.,
            Sava,F., Abril,J.F., Marfany,G. and Gonzalez-Duarte,R.
  TITLE     High transcriptional complexity of the retinitis pigmentosa CERKL
            gene in human and mouse
  JOURNAL   Invest Ophthalmol Vis Sci 52 (8), 5202-5214 (2011)
   PUBMED   21508105
  REMARK    GeneRIF: An unexpected multiplicity of CERKL transcriptional start
            sites (four in each species) plus a high variety of alternative
            splicing events primarily affecting the 5' half of the gene
            generate >20 fully validated mRNA isoforms in human and 23 in
            mouse.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1759)
  AUTHORS   Vekslin,S. and Ben-Yosef,T.
  TITLE     Spatiotemporal expression pattern of ceramide kinase-like in the
            mouse retina
  JOURNAL   Mol Vis 16, 2539-2549 (2010)
   PUBMED   21151604
  REMARK    GeneRIF: The purpose of this work was to investigate alternative
            splicing, and the temporal and spatial expression pattern of CERKL
            in the mouse retina.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1759)
  AUTHORS   Graf,C., Niwa,S., Muller,M., Kinzel,B. and Bornancin,F.
  TITLE     Wild-type levels of ceramide and ceramide-1-phosphate in the retina
            of ceramide kinase-like-deficient mice
  JOURNAL   Biochem Biophys Res Commun 373 (1), 159-163 (2008)
   PUBMED   18555012
  REMARK    GeneRIF: This work shows that CerkL does not contribute to
            phosphorylation of Cer and has no impact on Cer and C16-C1P levels
            in the retina.
REFERENCE   9  (bases 1 to 1759)
  AUTHORS   Pritsker,M., Doniger,T.T., Kramer,L.C., Westcot,S.E. and
            Lemischka,I.R.
  TITLE     Diversification of stem cell molecular repertoire by alternative
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14290-14295 (2005)
   PUBMED   16183747
REFERENCE   10 (bases 1 to 1759)
  AUTHORS   Tuson,M., Marfany,G. and Gonzalez-Duarte,R.
  TITLE     Mutation of CERKL, a novel human ceramide kinase gene, causes
            autosomal recessive retinitis pigmentosa (RP26)
  JOURNAL   Am J Hum Genet 74 (1), 128-138 (2004)
   PUBMED   14681825
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY742285.1, CJ130836.1, DT912627.1 and CJ235603.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HQ426680.1, SRR17784644.1264050.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-639               BY742285.1         11-649
            640-880             CJ130836.1         219-459
            881-1289            DT912627.1         77-485
            1290-1759           CJ235603.1         221-690
FEATURES             Location/Qualifiers
     source          1..1759
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 47.43 cM"
     gene            1..1759
                     /gene="Cerkl"
                     /gene_synonym="Gm1958; Rp26"
                     /note="ceramide kinase-like"
                     /db_xref="GeneID:228094"
                     /db_xref="MGI:MGI:3037816"
     exon            1..287
                     /gene="Cerkl"
                     /gene_synonym="Gm1958; Rp26"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1675
                     /gene="Cerkl"
                     /gene_synonym="Gm1958; Rp26"
                     /note="retinitis pigmentosa 26 (autosomal recessive)"
                     /codon_start=1
                     /product="ceramide kinase-like protein"
                     /protein_id="NP_001041641.1"
                     /db_xref="CCDS:CCDS38157.1"
                     /db_xref="GeneID:228094"
                     /db_xref="MGI:MGI:3037816"
                     /translation="MFRGRRRSRVGALEEAPPENPKAAAEPERVLLRGIFEIRRESCD
                     VALGERALRWRRIQPELPAGGTRHDLLSKEESLELEDIFSVKLKRRCWAKHPGRDTLL
                     GITLFICLKEQRNKLKDSTLDLINFSEDHCDIWFRQFKKILDGFTSRPKALKILLNPQ
                     SHRKESVHVYYEKVEPLLKLAGIETDVTITEYEGHALSLLDECELRGFDGVVCVGGDG
                     SASEAARALLLRAQKNAGVEMDCIPTLVGAELPLGFIPAGSTNALAHSLFGTPHVVTA
                     TMHIILGHIRSVDVCTFSSAGKLLCFGFSAMFGFGGRTLALAEKYRWMSPSQRRDFAI
                     IKALAKLKPEDCKISFLLAGCSQNKQERKSQRSAESDCGGHWQTIQGQFLNISIMAMP
                     CPCSMAPRGFTPDTRLHNGSMALRVVRNTTRSEFVKHLKRHSSVKNQFNFPFVETYII
                     EEVKIHPKSNSNGYSPQEEGGNHTTASEHGFPWNVDGDLMEAASEVHIRLHPRLIRLY
                     GGSLEEMNDCKVACDCI"
     exon            288..530
                     /gene="Cerkl"
                     /gene_synonym="Gm1958; Rp26"
                     /inference="alignment:Splign:2.1.0"
     exon            531..662
                     /gene="Cerkl"
                     /gene_synonym="Gm1958; Rp26"
                     /inference="alignment:Splign:2.1.0"
     exon            663..726
                     /gene="Cerkl"
                     /gene_synonym="Gm1958; Rp26"
                     /inference="alignment:Splign:2.1.0"
     exon            727..869
                     /gene="Cerkl"
                     /gene_synonym="Gm1958; Rp26"
                     /inference="alignment:Splign:2.1.0"
     exon            870..944
                     /gene="Cerkl"
                     /gene_synonym="Gm1958; Rp26"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1122
                     /gene="Cerkl"
                     /gene_synonym="Gm1958; Rp26"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1182
                     /gene="Cerkl"
                     /gene_synonym="Gm1958; Rp26"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1208
                     /gene="Cerkl"
                     /gene_synonym="Gm1958; Rp26"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1317
                     /gene="Cerkl"
                     /gene_synonym="Gm1958; Rp26"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1414
                     /gene="Cerkl"
                     /gene_synonym="Gm1958; Rp26"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1593
                     /gene="Cerkl"
                     /gene_synonym="Gm1958; Rp26"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1759
                     /gene="Cerkl"
                     /gene_synonym="Gm1958; Rp26"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagcgtgg gacaaggccc aggcagtggc tgtagccaca cttccttccc acgaagattt
       61 ctggtggctc cccaattcgg cccagcaccg cgtcaccatg ttccggggga gacgcaggag
      121 ccgggtgggc gccctggagg aggcgcctcc ggagaaccca aaggcagctg ctgaacccga
      181 gcgggttttg ctgcgtggca tcttcgagat ccggagggaa agctgcgatg tggcgttggg
      241 cgagcgggcc ctgcggtggc gacgcatcca gcccgagctc ccggctggtg gcaccaggca
      301 tgatctgctg agcaaagaag agtccctaga acttgaagac atcttctcag tgaagctgaa
      361 gcggcgttgc tgggccaagc atccaggcag agacacactg ctgggcataa cgcttttcat
      421 ctgcttgaag gagcaacgga acaaactaaa ggactccacg ctggatctta ttaacttcag
      481 tgaagaccac tgtgacatat ggtttagaca gttcaagaaa atcttggatg gtttcacaag
      541 caggcccaag gctctcaaga tcctcctcaa cccccagagt cacagaaagg agtctgtcca
      601 cgtctattac gagaaggtgg agcctctgct gaagcttgcg ggcatagaga ctgatgtgac
      661 aataacagaa tatgaagggc atgccctgtc tctgcttgac gaatgtgaac tccgaggatt
      721 tgatggtgtt gtctgtgttg gtggagatgg atctgcgagt gaggccgccc gcgctttgct
      781 cctcagagct cagaagaacg cgggagtgga gatggactgc atcccgactc tcgttggagc
      841 agagcttcct cttggcttca ttccagcagg atctactaac gcactggcac attctctctt
      901 tggaactcct cacgtggtga ctgcaaccat gcatattata ctaggtcaca tacggtcagt
      961 ggatgtctgc acctttagct ctgctggcaa gcttctttgc tttgggttct cagccatgtt
     1021 tggctttggt ggaaggacct tggctctggc agagaaatac cgatggatgt cccccagtca
     1081 gcgaagagac tttgctataa tcaaagcact ggccaaactt aagccagagg actgcaaaat
     1141 atcattttta ctagcaggtt gttctcagaa taaacaagaa agaaaatcac agagatctgc
     1201 agaatctgac tgtggtggtc actggcaaac catccagggg cagttcttga acatcagcat
     1261 catggcaatg ccctgtccat gttcaatggc acccagaggc tttacacctg acaccagatt
     1321 acataatgga agcatggctc ttagggttgt ccggaacacc actcgatcag aatttgtaaa
     1381 gcacctgaaa agacactcca gtgtaaagaa tcagttcaat tttccctttg tggagactta
     1441 tatcattgaa gaagtaaaaa ttcacccaaa gagtaatagc aatggataca gcccacagga
     1501 ggagggtgga aaccatacaa ctgcttcaga acacgggttt ccgtggaatg tagatggtga
     1561 cttaatggaa gctgcatcag aggttcacat taggctgcac ccaagactga tcaggctcta
     1621 tggaggaagc ctggaagaaa tgaatgattg caaagtagca tgtgattgca tatgaaagaa
     1681 gtatgtaagc agaaatttat tatgaaggaa tctggcatgc aagatatata caaatagaaa
     1741 atgcattttt gttgtggat
//
