LOCUS       NM_009887               1742 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus cerberus 1, DAN family BMP antagonist (Cer1), mRNA.
ACCESSION   NM_009887
VERSION     NM_009887.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1742)
  AUTHORS   Weberling,A., Siriwardena,D., Penfold,C., Christodoulou,N.,
            Boroviak,T.E. and Zernicka-Goetz,M.
  TITLE     Primitive to visceral endoderm maturation is essential for mouse
            epiblast survival beyond implantation
  JOURNAL   iScience 28 (1), 111671 (2024)
   PUBMED   39868030
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1742)
  AUTHORS   Thowfeequ,S., Fiorentino,J., Hu,D., Solovey,M., Ruane,S.,
            Whitehead,M., Zhou,F., Godwin,J., Mateo-Otero,Y.,
            Vanhaesebroeck,B., Scialdone,A. and Srinivas,S.
  TITLE     An integrated approach identifies the molecular underpinnings of
            murine anterior visceral endoderm migration
  JOURNAL   Dev Cell 59 (17), 2347-2363 (2024)
   PUBMED   38843837
REFERENCE   3  (bases 1 to 1742)
  AUTHORS   Chen,R., Fan,R., Chen,F., Govindasamy,N., Brinkmann,H.,
            Stehling,M., Adams,R.H., Jeong,H.W. and Bedzhov,I.
  TITLE     Analyzing embryo dormancy at single-cell resolution reveals dynamic
            transcriptional responses and activation of integrin-Yap/Taz
            prosurvival signaling
  JOURNAL   Cell Stem Cell 31 (9), 1262-1279 (2024)
   PUBMED   39047740
REFERENCE   4  (bases 1 to 1742)
  AUTHORS   Despin-Guitard,E., Rosa,V.S., Plunder,S., Mathiah,N., Van
            Schoor,K., Nehme,E., Merino-Aceituno,S., Egea,J., Shahbazi,M.N.,
            Theveneau,E. and Migeotte,I.
  TITLE     Non-apical mitoses contribute to cell delamination during mouse
            gastrulation
  JOURNAL   Nat Commun 15 (1), 7364 (2024)
   PUBMED   39198421
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1742)
  AUTHORS   Schumacher,S., Fernkorn,M., Marten,M., Chen,R., Kim,Y.S.,
            Bedzhov,I. and Schroter,C.
  TITLE     Tissue-intrinsic beta-catenin signals antagonize Nodal-driven
            anterior visceral endoderm differentiation
  JOURNAL   Nat Commun 15 (1), 5055 (2024)
   PUBMED   38871742
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1742)
  AUTHORS   Stanley,E., Gilbert,D.G., Jenkins,N.A., Copeland,N.G. and
            Harvey,R.P.
  TITLE     Murine cerberus homologue Cer1 maps to chromosome 4
  JOURNAL   Genomics 49 (2), 337-338 (1998)
   PUBMED   9598328
REFERENCE   7  (bases 1 to 1742)
  AUTHORS   Waldrip,W.R., Bikoff,E.K., Hoodless,P.A., Wrana,J.L. and
            Robertson,E.J.
  TITLE     Smad2 signaling in extraembryonic tissues determines
            anterior-posterior polarity of the early mouse embryo
  JOURNAL   Cell 92 (6), 797-808 (1998)
   PUBMED   9529255
REFERENCE   8  (bases 1 to 1742)
  AUTHORS   Biben,C., Stanley,E., Fabri,L., Kotecha,S., Rhinn,M.,
            Drinkwater,C., Lah,M., Wang,C.C., Nash,A., Hilton,D., Ang,S.L.,
            Mohun,T. and Harvey,R.P.
  TITLE     Murine cerberus homologue mCer-1: a candidate anterior patterning
            molecule
  JOURNAL   Dev Biol 194 (2), 135-151 (1998)
   PUBMED   9501024
REFERENCE   9  (bases 1 to 1742)
  AUTHORS   Belo,J.A., Bouwmeester,T., Leyns,L., Kertesz,N., Gallo,M.,
            Follettie,M. and De Robertis,E.M.
  TITLE     Cerberus-like is a secreted factor with neutralizing activity
            expressed in the anterior primitive endoderm of the mouse gastrula
  JOURNAL   Mech Dev 68 (1-2), 45-57 (1997)
   PUBMED   9431803
REFERENCE   10 (bases 1 to 1742)
  AUTHORS   Thomas,P., Brickman,J.M., Popperl,H., Krumlauf,R. and
            Beddington,R.S.
  TITLE     Axis duplication and anterior identity in the mouse embryo
  JOURNAL   Cold Spring Harb Symp Quant Biol 62, 115-125 (1997)
   PUBMED   9598343
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670958.4, BC132431.1 and AF031896.1.
            
            On Dec 1, 2007 this sequence version replaced NM_009887.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF031896.1, BC132431.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AL670958.4         13944-13960         c
            18-1311             BC132431.1         1-1294
            1312-1485           AL670958.4         10817-10990         c
            1486-1742           AF031896.1         1496-1752
FEATURES             Location/Qualifiers
     source          1..1742
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 39.4 cM"
     gene            1..1742
                     /gene="Cer1"
                     /gene_synonym="cer-1; Cerl; Cerl1; Cerr1"
                     /note="cerberus 1, DAN family BMP antagonist"
                     /db_xref="GeneID:12622"
                     /db_xref="MGI:MGI:1201414"
     exon            1..575
                     /gene="Cer1"
                     /gene_synonym="cer-1; Cerl; Cerl1; Cerr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..887
                     /gene="Cer1"
                     /gene_synonym="cer-1; Cerl; Cerl1; Cerr1"
                     /note="cer-l; cerberus-like protein; cerberus-related
                     protein; cerberus homolog; cerberus 1 homolog"
                     /codon_start=1
                     /product="cerberus precursor"
                     /protein_id="NP_034017.1"
                     /db_xref="CCDS:CCDS18295.1"
                     /db_xref="GeneID:12622"
                     /db_xref="MGI:MGI:1201414"
                     /translation="MHLLLVQLLVLLPLGKADLCVDGCQSQGSLSFPLLERGRRDLHV
                     ANHEEAEDKPDLFVAVPHLMGTSLAGEGQRQRGKMLSRLGRFWKKPETEFYPPRDVES
                     DHVSSGMQAVTQPADGRKVERSPLQEEAKRFWHRFMFRKGPAFQGVILPIKSHEVHWE
                     TCRTVPFNQTIAHEDCQKVVVQNNLCFGKCSSIRFPGEGADAHSFCSHCSPTKFTTVH
                     LMLNCTSPTPVVKMVMQVEECQCMVKTERGEERLLLAGSQGSFIPGLPASKTNP"
     exon            576..1742
                     /gene="Cer1"
                     /gene_synonym="cer-1; Cerl; Cerl1; Cerr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagagggagc ctctctttta ggcccgtcca tctgtgaatc taacctcagt ctctgggaat
       61 caggaagcat gcatctcctc ttagttcagc tgcttgttct cttgcctctg gggaaggcag
      121 acctatgtgt ggatggctgc cagagtcagg gctctttatc ctttcctctc ctagaaaggg
      181 gtcgcagaga tctccacgtg gccaaccacg aggaggcaga agacaagccg gatctgtttg
      241 tggccgtgcc acacctcatg ggcaccagcc tggctgggga aggccagagg cagagaggga
      301 agatgctgtc caggcttgga agattctgga agaaacctga gaccgaattt taccccccaa
      361 gggatgtgga aagcgatcat gtctcatcgg ggatgcaggc cgtgactcag ccagcagatg
      421 ggaggaaagt ggagagatca cctctacagg aggaagccaa gaggttctgg catcggttca
      481 tgttcagaaa gggcccggcg ttccagggag tcatcctgcc catcaaaagc cacgaagtac
      541 actgggagac ctgcaggact gtgcccttca accagaccat tgcccatgaa gactgtcaaa
      601 aagtcgttgt ccagaacaac ctttgctttg gcaaatgcag ttccattcgt tttcccggag
      661 aaggggcaga tgcccacagc ttctgctccc actgctcgcc caccaaattc accaccgtgc
      721 acttgatgct gaactgcacc agcccaaccc ccgtggtcaa gatggtgatg caagtagaag
      781 agtgtcagtg catggtgaag acggaacgtg gagaggagcg cctcctactg gctggttccc
      841 agggttcctt catccctgga cttccagctt caaaaacaaa cccatgaatt acctcaacag
      901 aaagcaaaac ctcaacagaa taagtgaggg ttattcaatc tggaaatgtt atgtgagtta
      961 tataaagatc agtggaaaat atctttctct ctccctctct ccccctctct cttctctcta
     1021 ttttctctct ctctctctct ctctctctct ctctctctct ctctcacaca cacacacaca
     1081 cacacacaca cacacacatg tttgtgttta gacagggtct tatgtattct cagctggcct
     1141 caaactcaca atgtggctgg ggatgatttt aaactcctga tccaattcct gagtgctggg
     1201 attacagaca tgctccataa tacatagctc ccagaaggat ttttaaaaga gattttgcat
     1261 gtttcaaagt tgcctttgag actcagaaaa tattttgatt ctattgaatg ggccttgcca
     1321 cagatgtggg acgcagcttg cttggtggcc catgtatttt tttttttttc tttctgtatt
     1381 ctccacatga agtttttact gttggttatc tggcgttgaa gaaggaatag tgaaggtact
     1441 cttaacagtt tacacgtgga aggggctcag gcactaggaa ccaaaccttt tcccggaata
     1501 tgaggaaaat acatgaacag tattagagtc acttgaggaa gttactagga aacgccataa
     1561 gtctccaagt acattgtgag tcattttgaa ggacaatcgt gtatatagac gaaatcttct
     1621 actcgtatgc ttttgaatct tctagcaagt taggtttcta tgtttgggct tcttcctatt
     1681 gtctaagagt atgtgtgaca aattcaacct gacaaatacc tcaatggcaa attctgaccc
     1741 tg
//
