LOCUS       NM_177088               2737 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus centrosomal protein 95 (Cep95), transcript variant 1,
            mRNA.
ACCESSION   NM_177088
VERSION     NM_177088.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2737)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2737)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   3  (bases 1 to 2737)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU695983.1, AK052705.1, BC090675.1 and BE852789.1.
            
            On Nov 3, 2009 this sequence version replaced NM_177088.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076400.1, BC090675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               BU695983.1         1-121
            122-1483            AK052705.1         50-1411
            1484-2722           BC090675.1         1440-2678
            2723-2737           BE852789.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..2737
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 70.02 cM"
     gene            1..2737
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /note="centrosomal protein 95"
                     /db_xref="GeneID:320162"
                     /db_xref="MGI:MGI:2443502"
     exon            1..126
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..2591
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centrosomal protein of 95 kDa; coiled-coil
                     domain-containing protein 45; coiled-coil domain
                     containing 45"
                     /codon_start=1
                     /product="centrosomal protein of 95 kDa isoform 1"
                     /protein_id="NP_796062.2"
                     /db_xref="CCDS:CCDS25563.1"
                     /db_xref="GeneID:320162"
                     /db_xref="MGI:MGI:2443502"
                     /translation="MASSEAEWVTIANNLLFKCHIHLRIHELQDCDANVFIALYQSIL
                     GEKVPDLIVLPRNQEDEAHNVQAVIDSLALDYLQVSLSHITGENIVKGDNESIRNLLE
                     IFDGLLDYLTEHISESSPNKSETEQYSKDSHGEEAGEDLERTEEAKWRNASFMRCSFS
                     SDTLGPTWDEDEAESTGEIIRLGDTAHTFSQRSNGAQNSKDLRSRKASASPGVEPPEE
                     MLNPGPLGFLSQNGPPCEAASETPPMSMVPSARKLGEPIRAAIPLHPPYHPSEPRAPC
                     PIGKEYLWSSRYLSTPTSGEHMAPSVEPDDAFLTSTLFKDDDQETYLPKPEATRTRKP
                     SKGERDENRAAIPSEHLPFSQKARKPLTEQELHAMSEKLSQRLSELDWMLKTALGDRG
                     TGETDGNDGDGGGEEVRSGNEEMLSQHSDSVMEYGPKKPRPGFSTCRKAPYRSHSLSP
                     SSVNKHRQLEKEKKRQHKSKGTDSCHFQAKALTEAFERELRKHKVQENVGLRGIREEE
                     EEEEETGKSYREVVPKGTSKRSQVQKTYSRKTAAPSPKGDGRLKSSKASPMKVSEHSL
                     LSLMLEQFPFLYVSDPTLTKMWKQQMAQVEQLKREAQRENRSKKKLQDEIEEALRRHD
                     LLTALVKKEYDHNKRLQDFRDRIQRQRLTQSKIKENRHQSVRARKYYDDYRVQLRAKM
                     MKMRTREEMIFKKLFEEGLQIQKQRLRDLRNYAKEKRNEEKRQHQNELDSMENHYKDQ
                     FSLLAEAISQERQELKVRQKFQAQTLHKVKRELRAKMEKEIQQLQHMITQNDDDAFFR
                     ELEAERFKARLQLASFQYSKNPFPRGQTS"
     exon            127..255
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            256..363
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            364..474
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            475..574
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            575..690
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            691..819
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1013
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1123
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1253
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1407
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1547
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1649
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1782
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1952
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2027
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2180
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2327
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2399
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2727
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2703..2708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2727
                     /gene="Cep95"
                     /gene_synonym="4732496G21Rik; AI118346; Ccdc45;
                     D330027A14Rik; F630025I20Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtgtctgcc ccctcctcct cccgtcggct cgaccgagtt cgacccttct gggacaccgt
       61 cgcccgcgct ctcgtcttgg agtccggccg cgacctctcc tggcagtatg gccagctcag
      121 aggctgaatg ggtaacaatt gccaataacc tcctttttaa atgtcacata cacctgagga
      181 tacacgaact tcaagactgt gatgctaatg tttttattgc cctttatcaa tccattttgg
      241 gagaaaaggt accagacctc atagttcttc ccaggaatca agaagacgag gcccacaatg
      301 tccaagcggt aattgattca ctcgctttgg attaccttca ggtcagcctg tctcacataa
      361 caggagaaaa catagtgaaa ggggataatg aatctatcag gaatctccta gaaatatttg
      421 atggattgct ggattatctg acagaacaca tcagtgaatc gtctcccaac aaaagtgaaa
      481 ctgagcagta ttctaaagat tctcatggag aagaagctgg ggaggaccta gaacgtaccg
      541 aggaggcgaa gtggagaaac gcttctttta tgaggtgttc cttctcatcg gacactttgg
      601 gccccacctg ggatgaagac gaagctgagt ccacaggtga aataattagg ctgggagaca
      661 ctgcacatac cttttcccaa agaagtaatg gtgctcaaaa ttctaaggac ttacggtcta
      721 gaaaagcctc ggcttcacca ggcgttgagc cacctgagga aatgttgaac cctggcccat
      781 tgggttttct ttcccagaat gggccacctt gtgaggcagc atcagaaact cctcctatga
      841 gcatggttcc aagtgccagg aagctaggcg agccgatccg agctgccatt cctttacatc
      901 ctccctacca tccttctgag cctagagcac catgtcccat aggcaaagaa tacctctggt
      961 caagtcgcta cttgtctacg ccgacttctg gagagcacat ggcaccttct gtggaaccag
     1021 atgatgcttt cttaacttct accttattta aagatgatga tcaggaaaca tatctaccta
     1081 aacctgaagc caccaggaca aggaagcctt ctaaaggaga aagagatgaa aacagagctg
     1141 cgatcccctc agagcatctg cctttctctc agaaggccag gaagccgtta acagaacaag
     1201 aactgcacgc catgtcagag aaactctctc agcggctctc tgaactagac tggatgttaa
     1261 aaactgccct gggtgatcga ggaacgggcg aaactgatgg taatgatggt gatggcggag
     1321 gtgaggaggt gcgcagtggg aacgaggaga tgctctcgca gcacagtgac agcgtcatgg
     1381 agtacggacc aaagaagccg aggccaggat tttctacgtg cagaaaggca ccttacaggt
     1441 cccattcact gtcgccatct tcagtgaaca aacacagaca attagagaaa gagaaaaaaa
     1501 ggcagcacaa atctaaaggg acagactcat gccatttcca agcaaaggca ctgactgaag
     1561 catttgaacg ggaactaaga aaacataaag ttcaagagaa cgttggactt cgagggataa
     1621 gggaggagga ggaagaggaa gaggaaacag ggaagtcata cagagaagtc gttcctaaag
     1681 gaacttccaa acggagtcag gtccagaaga cttactccag aaaaactgca gctccaagtc
     1741 caaaaggaga tggtcgcctg aagtcaagca aggcgtctcc gatgaaagta agtgaacaca
     1801 gtctgctatc cctgatgctg gaacagtttc catttctcta tgtttctgac ccaacactga
     1861 ccaaaatgtg gaagcagcag atggcccagg ttgaacaact caaaagggaa gcgcagagag
     1921 agaaccgatc caagaagaaa ctccaggatg aaatagaaga agccctgaga aggcatgacc
     1981 tcctcactgc tcttgtcaag aaagaatatg accataacaa gaggctgcaa gacttcaggg
     2041 accgaattca gagacaaagg ttgacccaat caaagataaa agaaaatcgt catcaaagtg
     2101 ttcgtgcccg gaaatattat gatgattaca gagttcagtt acgtgcaaaa atgatgaaga
     2161 tgagaacccg ggaagaaatg atctttaaga aactgtttga agaaggttta caaattcaga
     2221 aacaaagact acgagaccta agaaactacg ccaaagagaa acgcaacgaa gaaaagagac
     2281 agcaccagaa tgagctggac tcgatggaga accactataa ggaccagttt tcattgctag
     2341 cagaagccat ctcacaggaa cgtcaagaac tcaaagtgag acagaaattc caggctcaga
     2401 cattacataa ggtgaagagg gagctgagag ctaaaatgga gaaggagatt cagcaactgc
     2461 agcacatgat aacgcagaac gacgatgatg ctttcttccg ggagctagaa gctgagcgct
     2521 tcaaagctcg gctgcagttg gcttccttcc agtacagtaa aaatcctttc ccaagaggcc
     2581 aaacttcata ggtgaagttt ctagacacct taatatgaac agagctagac ctgagccagt
     2641 aaacagtcta aaccagaata tgccttattt atgtattcat gttaaaattt agaattattt
     2701 taaataaaaa ctttctctta aagcttaaaa aaaaaaa
//
