LOCUS       NM_198019               2576 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus centrosomal protein 78 (Cep78), mRNA.
ACCESSION   NM_198019
VERSION     NM_198019.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2576)
  AUTHORS   Liu,M., Wen,Z., Zhao,D., Tian,W., Lv,Q., Zhang,C., Zhang,X.,
            Meng,F., Liu,H., Gao,J. and Yao,Z.
  TITLE     Cep78 knockout causes sterility and oligoasthenoteratozoospermia in
            male mice
  JOURNAL   Sci Rep 15 (1), 63 (2025)
   PUBMED   39747485
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2576)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2576)
  AUTHORS   Zhu,T., Zhang,Y., Sheng,X., Zhang,X., Chen,Y., Zhu,H., Guo,Y.,
            Qi,Y., Zhao,Y., Zhou,Q., Chen,X., Guo,X. and Zhao,C.
  TITLE     Absence of CEP78 causes photoreceptor and sperm flagella
            impairments in mice and a human individual
  JOURNAL   Elife 12, e76157 (2023)
   PUBMED   36756949
  REMARK    GeneRIF: Absence of CEP78 causes photoreceptor and sperm flagella
            impairments in mice and a human individual.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2576)
  AUTHORS   Zhang,X., Zheng,R., Liang,C., Liu,H., Zhang,X., Ma,Y., Liu,M.,
            Zhang,W., Yang,Y., Liu,M., Jiang,C., Ren,Q., Wang,Y., Chen,S.,
            Yang,Y. and Shen,Y.
  TITLE     Loss-of-function mutations in CEP78 cause male infertility in
            humans and mice
  JOURNAL   Sci Adv 8 (40), eabn0968 (2022)
   PUBMED   36206347
  REMARK    GeneRIF: Loss-of-function mutations in CEP78 cause male infertility
            in humans and mice.
REFERENCE   5  (bases 1 to 2576)
  AUTHORS   Nikopoulos,K., Farinelli,P., Giangreco,B., Tsika,C.,
            Royer-Bertrand,B., Mbefo,M.K., Bedoni,N., Kjellstrom,U., El
            Zaoui,I., Di Gioia,S.A., Balzano,S., Cisarova,K., Messina,A.,
            Decembrini,S., Plainis,S., Blazaki,S.V., Khan,M.I., Micheal,S.,
            Boldt,K., Ueffing,M., Moulin,A.P., Cremers,F.P.M., Roepman,R.,
            Arsenijevic,Y., Tsilimbaris,M.K., Andreasson,S. and Rivolta,C.
  TITLE     Mutations in CEP78 Cause Cone-Rod Dystrophy and Hearing Loss
            Associated with Primary-Cilia Defects
  JOURNAL   Am J Hum Genet 99 (3), 770-776 (2016)
   PUBMED   27588451
REFERENCE   6  (bases 1 to 2576)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC070400.1.
            
            On Jun 20, 2004 this sequence version replaced NM_198019.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070400.1, SRR7345562.943940.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2576
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 10.89 cM"
     gene            1..2576
                     /gene="Cep78"
                     /gene_synonym="5730599I05Rik; D030027P05"
                     /note="centrosomal protein 78"
                     /db_xref="GeneID:208518"
                     /db_xref="MGI:MGI:1924386"
     exon            1..377
                     /gene="Cep78"
                     /gene_synonym="5730599I05Rik; D030027P05"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2482
                     /gene="Cep78"
                     /gene_synonym="5730599I05Rik; D030027P05"
                     /codon_start=1
                     /product="centrosomal protein of 78 kDa"
                     /protein_id="NP_932136.2"
                     /db_xref="CCDS:CCDS29682.1"
                     /db_xref="GeneID:208518"
                     /db_xref="MGI:MGI:1924386"
                     /translation="MIDSVKLRRDCAADFFSHYEYLCALQDSVPLPAVRACLRDGVLD
                     FNADRLRAVDWAPLLSTLRVNRDLPLVAIKSSFQPWLGETVLRSGGADTHRICRNRVP
                     AVRSKDISFQLCKALRGCLSVSGVLRNLELNGLILRERDLTSLTKGLSKSTSLVHLSL
                     ANCPIGDGGLEIICQGIKNSVTLKTVNFTGCNLTWQGACHMAKILKYQTMRRHEETWA
                     ESLRYRRPDLDCMAGLRRITLNCNTLIGDQGASAFADSLSEDLWLRALDLQQCGLTSE
                     GAKALLEALETNRTLVVLDIRKNPLIDHSMMKAVIKKVLQNGRSADSEYQWVTSPSSK
                     EPSKTAKQRKKTIVLGSSRKGKATIRIGLATKKPSSNGRKQGLGKDCYAPNPLPPGAS
                     GFLPWRTAERAKRSRSSSLIKTRDLSNHLKKSDFPVTVTVESPSSSETDETEDSSESV
                     QEAPQKTSIKEETLQEKLEECLRQLKEERVIRLKADKRVSELEHENAQLRNINFSLSE
                     ALHAQSLTNMILDDEGVLGSIENSFQKFHAFLDLLKDAGLGQLATMAGIDQSDFHLLG
                     RPQMNSTVNTPIQEQKALEDETLHPKQTATGQMQDIRFQKITSDALIPLPLNTVQDPA
                     SAQEAVGASRDHLGVVGLEQQEGSAAGFIAKTGSPLAGGIPGGRSQREEEVLSKHSRS
                     SSEKGSTASEPSRRPSAERHPRKDLLSDADPPGNSESKGPGDRRSLLNEPIKSESLKK
                     CISIKKENRIVTVSSKTIKSKPNLLEHSESDTLGSDFELQERVHSSAHLT"
     exon            378..550
                     /gene="Cep78"
                     /gene_synonym="5730599I05Rik; D030027P05"
                     /inference="alignment:Splign:2.1.0"
     exon            551..623
                     /gene="Cep78"
                     /gene_synonym="5730599I05Rik; D030027P05"
                     /inference="alignment:Splign:2.1.0"
     exon            624..727
                     /gene="Cep78"
                     /gene_synonym="5730599I05Rik; D030027P05"
                     /inference="alignment:Splign:2.1.0"
     exon            728..902
                     /gene="Cep78"
                     /gene_synonym="5730599I05Rik; D030027P05"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1016
                     /gene="Cep78"
                     /gene_synonym="5730599I05Rik; D030027P05"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1081
                     /gene="Cep78"
                     /gene_synonym="5730599I05Rik; D030027P05"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1193
                     /gene="Cep78"
                     /gene_synonym="5730599I05Rik; D030027P05"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1329
                     /gene="Cep78"
                     /gene_synonym="5730599I05Rik; D030027P05"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1375
                     /gene="Cep78"
                     /gene_synonym="5730599I05Rik; D030027P05"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1504
                     /gene="Cep78"
                     /gene_synonym="5730599I05Rik; D030027P05"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1582
                     /gene="Cep78"
                     /gene_synonym="5730599I05Rik; D030027P05"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1749
                     /gene="Cep78"
                     /gene_synonym="5730599I05Rik; D030027P05"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1918
                     /gene="Cep78"
                     /gene_synonym="5730599I05Rik; D030027P05"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2549
                     /gene="Cep78"
                     /gene_synonym="5730599I05Rik; D030027P05"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2528..2533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep78"
                     /gene_synonym="5730599I05Rik; D030027P05"
                     /note="hexamer: AATAAA"
     polyA_site      2549
                     /gene="Cep78"
                     /gene_synonym="5730599I05Rik; D030027P05"
                     /note="major polyA site"
ORIGIN      
        1 cgccggtgac tagaacggcg gcggcggctc ccagagcggg cgctaaccgc ccgaggcgtg
       61 gcgggaggcg gcgcggggcg gctggtggag gtccccgggg ttgccggtca tgatcgactc
      121 ggtgaagctc cggcgcgact gcgcggccga cttcttctcg cactacgagt acctgtgcgc
      181 gctgcaggac tccgtgccgc tgcccgccgt gcgcgcctgc ctgcgggacg gcgtgctgga
      241 cttcaatgcc gaccggctgc gcgcggtgga ctgggcaccg ctgctcagca cgctcagggt
      301 gaaccgcgac ctgccgctgg tggccatcaa gagctccttc cagccgtggc tcggggaaac
      361 agttctgcgg tccggaggtg ctgatacaca ccgaatttgt aggaatcgag ttcctgcagt
      421 gagatccaaa gacataagct tccagttatg taaggctctt agaggctgct taagtgtatc
      481 aggggtgcta agaaatctgg agctaaatgg gctgattctg agagagagag atttgactag
      541 tctaacaaag ggactgagta aatcaacctc tttggtgcac ttgtctcttg caaattgtcc
      601 aattggagat ggaggtttag aaattatttg tcaaggtata aagaactctg tcactctcaa
      661 gaccgtcaac tttacagggt gtaatctgac atggcaagga gcctgtcata tggccaagat
      721 cttaaagtat caaaccatga gaaggcatga agaaacctgg gcggagagcc tccgctacag
      781 gagacccgat ctggactgca tggctggctt acggcgcatc acactgaact gcaacacact
      841 cattggtgac cagggtgcaa gtgcctttgc agactctctt agtgaggacc tgtggcttcg
      901 agcactcgac ctgcagcagt gcggcctcac cagtgaaggg gccaaggctt tactggaggc
      961 cctggaaacc aacagaaccc tggtcgttct ggatataagg aaaaacccac ttattgatca
     1021 ttctatgatg aaagcagtta tcaaaaaggt cctccagaac ggaaggagtg cagactcaga
     1081 gtaccagtgg gttacatccc catcatcaaa ggaaccgtct aaaaccgcta agcagagaaa
     1141 gaaaacaatt gtcttaggaa gcagccggaa gggaaaagca accattagaa ttggtttagc
     1201 tacaaagaag ccttcgagta atgggagaaa acaggggctc ggtaaagact gctatgctcc
     1261 caaccctctg cctccaggcg catctggttt cttgccttgg cgaacagcag aacgtgcaaa
     1321 aagaagcagg agttcttcat taatcaaaac tcgtgatcta tcaaatcacc tgaagaaatc
     1381 agatttcccg gtgactgtga cagtagaaag tccttcatcc tcagaaactg acgagactga
     1441 agattcttca gaaagtgtcc aggaagcgcc tcagaaaacc agcataaaag aagaaacatt
     1501 acaggagaag ctggaggagt gcctaaggca gctgaaggag gagagagtga tccgcctcaa
     1561 ggccgacaag cgcgtcagtg agctggaaca tgaaaatgcc cagctaagaa atataaattt
     1621 ctccctgtct gaagcccttc atgcacagtc cttgacaaac atgatcctgg acgatgaagg
     1681 agtcttgggc agcatcgaga attcttttca gaagtttcac gcttttttgg acctccttaa
     1741 agacgctggg cttggacagc ttgccactat ggctggcata gatcagtcag atttccacct
     1801 gttaggtcgt ccgcagatga attccacggt taatacacct atacaagaac agaaggcact
     1861 tgaagatgaa actctgcatc cgaaacagac tgccaccgga caaatgcagg atatccgatt
     1921 tcagaagatt accagcgatg ctctgattcc tttacctctg aacaccgtcc aggatccggc
     1981 ttctgcacaa gaggcagtgg gagcgtctag agaccatctg ggagttgtag gcctggagca
     2041 gcaggaggga tctgcagcag gattcattgc taaaacaggc tctcctttag caggtggcat
     2101 tcctggaggc aggagtcaaa gagaagagga ggtgttgtct aaacacagca ggtcttcttc
     2161 agagaagggg agcacggcaa gtgagccctc cagaaggccg tctgctgaga gacaccccag
     2221 gaaggacctg ctgtccgatg ctgaccctcc tgggaactct gaaagcaaag gacctgggga
     2281 tagaaggtct ctgcttaatg agccaattaa aagtgaatct ttgaaaaaat gcatttctat
     2341 caagaaagaa aacagaatag tgactgtctc atctaagact atcaaaagta aacccaacct
     2401 tctagaacat tctgaaagtg atactcttgg atctgatttt gaacttcagg aacgtgtcca
     2461 ttcgtcagca cacctaacct gacataggtc taaccttttg aaattatgat ttttgccttc
     2521 aaattttaat aaattttctt atgtttttaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
