LOCUS       NM_001081073            4431 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus centrosomal protein 76 (Cep76), transcript variant 1,
            mRNA.
ACCESSION   NM_001081073 XM_129027
VERSION     NM_001081073.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4431)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4431)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4431)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 4431)
  AUTHORS   Kobayashi,T., Kim,S., Lin,Y.C., Inoue,T. and Dynlacht,B.D.
  TITLE     The CP110-interacting proteins Talpid3 and Cep290 play overlapping
            and distinct roles in cilia assembly
  JOURNAL   J Cell Biol 204 (2), 215-229 (2014)
   PUBMED   24421332
REFERENCE   5  (bases 1 to 4431)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 4431)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120410.11.
            
            On Nov 4, 2017 this sequence version replaced NM_001081073.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC119218.1, SRR1660817.138155.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               AC120410.11        3569-3812
            245-400             AC120410.11        4761-4916
            401-476             AC120410.11        6583-6658
            477-701             AC120410.11        7561-7785
            702-887             AC120410.11        9984-10169
            888-985             AC120410.11        11376-11473
            986-1114            AC120410.11        14977-15105
            1115-1303           AC120410.11        18216-18404
            1304-1470           AC120410.11        19828-19994
            1471-1804           AC120410.11        21454-21787
            1805-2022           AC120410.11        25171-25388
            2023-4431           AC120410.11        25552-27960
FEATURES             Location/Qualifiers
     source          1..4431
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 40.04 cM"
     gene            1..4431
                     /gene="Cep76"
                     /gene_synonym="6230425F05Rik; 9630013E05"
                     /note="centrosomal protein 76"
                     /db_xref="GeneID:225659"
                     /db_xref="MGI:MGI:1923401"
     exon            1..244
                     /gene="Cep76"
                     /gene_synonym="6230425F05Rik; 9630013E05"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..2161
                     /gene="Cep76"
                     /gene_synonym="6230425F05Rik; 9630013E05"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centrosomal protein of 76 kDa"
                     /codon_start=1
                     /product="centrosomal protein of 76 kDa isoform 1"
                     /protein_id="NP_001074542.1"
                     /db_xref="CCDS:CCDS37850.1"
                     /db_xref="GeneID:225659"
                     /db_xref="MGI:MGI:1923401"
                     /translation="MSLPPEKASELKQLIHQQLSKMDVHGRIREILAETIREELAPDQ
                     QHLSTEDLIKALRRRGIIDDVMKELNFVTDSVDQELPSSPKQTVGFDKQSTLKKTNVD
                     PTRRYLYLQVLGGKAFLEHLQEPEPLPGQICSTFTLCLHYRNQRFRSKPVPCACEPDF
                     HDGFLLEVHRESLGDGTRMADSTTMLSISDPIHMVLIKTDIFGETTLVASYFLEWRSV
                     LGSENGVTNLTVELMGVGTESKVSVGILNIKLEMYPPLSQTLSQEVVNTQLALERQKT
                     AEKERLFLVYAKQWWREYLQIRPSHNSRLVKIFAQDENGINRPVCSYVKPLRAGRLLD
                     TPRQAARFVNVLGYERAPVIGGGGKQEQWCTLLAFLCRNKGDCEDHANLLCSLLLGYG
                     LEAFVCVGTKAKGAPHAWVMTCGTDGTIMFWESLTGHRYIHKPTNPDGPPLAEQPKPL
                     YPYRTIGCVFNHQMFLGNCQPSDAVETCIFDLNDESKWKPMSEEAIKSVCAPGATTSL
                     PPFPPLCASTIDASVTSNEIEMQLRLLVSEHRKDLGLTTVWEDQLSYLLSPALASYEF
                     ERTTSISAGNEEFQDAIRRAVPDGHTFKGFPIHFVYRNARRAFATCLRSPFCEEIICC
                     RGDQVRLAVRVRVFTYPESACAVWIMFACKYRSVL"
     exon            245..400
                     /gene="Cep76"
                     /gene_synonym="6230425F05Rik; 9630013E05"
                     /inference="alignment:Splign:2.1.0"
     exon            401..476
                     /gene="Cep76"
                     /gene_synonym="6230425F05Rik; 9630013E05"
                     /inference="alignment:Splign:2.1.0"
     exon            477..701
                     /gene="Cep76"
                     /gene_synonym="6230425F05Rik; 9630013E05"
                     /inference="alignment:Splign:2.1.0"
     exon            702..887
                     /gene="Cep76"
                     /gene_synonym="6230425F05Rik; 9630013E05"
                     /inference="alignment:Splign:2.1.0"
     exon            888..985
                     /gene="Cep76"
                     /gene_synonym="6230425F05Rik; 9630013E05"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1114
                     /gene="Cep76"
                     /gene_synonym="6230425F05Rik; 9630013E05"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1303
                     /gene="Cep76"
                     /gene_synonym="6230425F05Rik; 9630013E05"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1470
                     /gene="Cep76"
                     /gene_synonym="6230425F05Rik; 9630013E05"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1804
                     /gene="Cep76"
                     /gene_synonym="6230425F05Rik; 9630013E05"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..2022
                     /gene="Cep76"
                     /gene_synonym="6230425F05Rik; 9630013E05"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..4431
                     /gene="Cep76"
                     /gene_synonym="6230425F05Rik; 9630013E05"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2366..2371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep76"
                     /gene_synonym="6230425F05Rik; 9630013E05"
                     /note="hexamer: AATAAA"
     polyA_site      2391
                     /gene="Cep76"
                     /gene_synonym="6230425F05Rik; 9630013E05"
                     /note="major polyA site"
     regulatory      3573..3578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep76"
                     /gene_synonym="6230425F05Rik; 9630013E05"
                     /note="hexamer: AATAAA"
     polyA_site      3595
                     /gene="Cep76"
                     /gene_synonym="6230425F05Rik; 9630013E05"
                     /note="major polyA site"
ORIGIN      
        1 gtttgaagac agttaagtta gttggggcgc cgcggctgcc ggattcccgc cctgccaggt
       61 ctgacgcggc cgcggcgctt tgtgctccgc ccgccgctga tgctgcgcgc ccgggacgac
      121 gggctccgcc gctgcaccgt gtgaggtggg cgactagcgg ccgcgaggcg ccagcgccgg
      181 catgtcgctg cctccggaga aagcctcgga gctgaagcag ctcatccacc agcagctgag
      241 caagatggat gtccatggca gaataagaga aattcttgca gagactatac gagaagaatt
      301 agcaccggat caacaacatt tatcaacaga agatctgatc aaagctctaa gacgtcgagg
      361 aatcattgat gatgtaatga aagaacttaa ttttgtgact gatagtgttg atcaagaact
      421 cccttcttct ccaaagcaaa ccgttggttt tgataagcag tcaacattaa aaaaaactaa
      481 tgttgatcca acacggaggt atctttacct tcaggttctg ggtggaaaag ctttcttgga
      541 acatctgcaa gaacctgagc ctttgcctgg acagatttgc tcgactttca ctttatgttt
      601 gcactatcgg aaccaacgat ttcgctccaa acctgtaccc tgcgcttgtg agccagattt
      661 ccatgacggc tttttgcttg aagttcacag agaaagttta ggtgatggaa ctagaatggc
      721 tgattcaaca acaatgttat caataagtga tccaattcac atggtactaa tcaaaacaga
      781 catatttggt gagaccactt tagttgcgtc ctatttcctg gaatggagat cagttttggg
      841 ctcagaaaat ggagtgacca atctgactgt ggagctcatg ggtgtaggca cagaatcaaa
      901 agtttccgtg ggaattttaa atataaaact tgaaatgtac ccaccgctca gccaaacgct
      961 gtctcaggag gtagtgaaca cacagcttgc cttggaacgt cagaaaactg cagagaaaga
     1021 gcgattattt ctcgtctatg ctaagcagtg gtggagggag tatttgcaaa ttcgaccttc
     1081 tcacaactca aggctggtca agatttttgc ccaggatgag aatgggataa atagaccagt
     1141 ctgttcctac gttaagccac ttcgagctgg acgacttctg gatactccga ggcaagcggc
     1201 tcgatttgtt aatgtccttg gttatgaacg agcccctgtt attggaggag gtggcaagca
     1261 ggaacagtgg tgcactctgc tggcttttct ctgtagaaac aagggtgatt gtgaggacca
     1321 cgctaacctg ctgtgcagcc ttcttcttgg ctatggactg gaggcctttg tctgtgtggg
     1381 gactaaggcc aagggggcgc cgcatgcctg ggtgatgacc tgtgggactg atggcaccat
     1441 catgttttgg gagagtttaa cagggcacag gtacatccac aagcctacca atcctgacgg
     1501 acctccactt gctgagcagc ccaaaccact gtacccatat cgaacaattg gttgtgtttt
     1561 caatcatcag atgttcctgg gaaactgtca gccctcagat gcagtagaga cctgcatatt
     1621 tgatttgaat gatgagtcca agtggaaacc catgagcgaa gaagcaatta agtctgtgtg
     1681 tgctccaggt gctactacct ccctccctcc cttcccacct ctgtgtgcgt ccacgattga
     1741 cgcctcggtc accagcaatg aaatcgaaat gcagctgagg cttctggtgt cggagcacag
     1801 aaaggacctt ggcctcacca ctgtctggga agaccagctc tcctatcttt tgtcaccagc
     1861 tctggcctcg tatgagtttg agcgaacaac aagcatatct gcaggcaatg aagaatttca
     1921 ggatgccatc aggagggctg tacctgacgg gcacacattt aaaggcttcc ccatacattt
     1981 tgtgtataga aatgcaaggc gtgcatttgc cacttgtctt cggtctcctt tttgtgaaga
     2041 aataatctgt tgtcgtggag accaggtgcg actggcagtt cgcgttcgag tgtttaccta
     2101 ccctgagtct gcatgtgctg tttggatcat gtttgcttgt aaatatcgct cagtattata
     2161 ggactaacat ttcctaagaa ttattcctgt gttttattag aattgtatat gagcagctgt
     2221 gtgtaggttt cttaatttaa aatcagcctt ttggatgtca ttgttttaca tagatctgac
     2281 tggtaatatt ttaaaatatc atgtatgtgc ttaaaaatta aggataaaaa tttgtattga
     2341 atttagtatg aattaagtgt ataataataa atgacactgt gttctgaggg actcggtgtt
     2401 taaatgtgaa tgtaagatct gttactttac atcagtaagt aaagagattt gtctactggc
     2461 ttaagccata gttaattcaa aatgatccct atttttcata aaggaaagat tattttacac
     2521 aaattaggaa aaattagcct cataatagtt tatttattac atagatgaaa atatattttg
     2581 ctaaattata atttttgtgt gatactaggg gtatatgagg ctttccagaa gtctgtgtga
     2641 agactttgat gtaagaatag aaaaaagctg gtgtggtggc acacactttt aattccacaa
     2701 caggtctaca tagcaaactc caggccagtc agggccacac agtgagaacc tgactccaaa
     2761 acacaaacaa caacaacaaa aggaatgtaa taaccaaaaa gcataagtgt taataatgaa
     2821 tctcacatga atatgcagaa tgtgagtaat ttatggatat tattaaaatt aattgagcac
     2881 tttagaaaat acttattata cttccttgtt acaatgctgg ttgttcttta tttttttgtt
     2941 gtgataaaat caccagccta ctggcaggcc atggtggtgc acacttttaa ttccagcact
     3001 agggaggcag aaacacgcgg atctcaactt cgagagcagc ctggtctaca gagctagttc
     3061 caggatagcc agggttatac ggagaaactc tgcctcaaaa aacccaataa agaaacggat
     3121 cagcctataa gtgactaatg tcattgacaa aaatcataag aggccattga gaaagcatgt
     3181 gagtttatat atttatctta aattgagcaa atttaaatgt tttaagagag caaagataag
     3241 cattaaaaag taattcaact tactctaagt aacgaatgat gaatattttg actgcccatt
     3301 ctgtgtttct gtgcagaggg ttttattgtc ttattttggt gatactagga attagatcaa
     3361 gggcttccta catgctaggc aaacattacc actgagctat acccacagtg tctcagttat
     3421 gtagccctgg ctggcctaga actcccagaa ggttgcttgc ctctgtgtac agtttcttag
     3481 tttagctgct ttatccactg gtcttcttaa gaaataagtg tatgccagcc cactatccaa
     3541 attatttatt cttttcatca cttgctgttg caaataaaat gattttattt atttatttag
     3601 ttttggatgt cttgactttt tttatagtgt gtgtatgtgt gtgtgtgctt gtacatatga
     3661 gcgagtataa gccttagagt ttgtagcaat caggccaact ttgaggagca ggctctgtct
     3721 gtcacactgt gggctctgga gattgacctc aggtcagcag tcttgccagc aaggaagtaa
     3781 ggaagtgcct ttaccccctg agccagctcg ctggcctaaa aatggttttt tgaaattaaa
     3841 atctaaagat accatgccta gttatggttg cacaggcctt taatcccagt agttgggagg
     3901 cagaggcagg catatctctg agtttgaggc cagcctggac tatagaaggg gagttccagg
     3961 acagctagag ctacacagag aaaacattgt ctaccattaa aaaaaaaaaa ccaaaaaacc
     4021 aacaacccaa aacaaaacaa aaacaataat ctaaccaacc aagccccccc ccccaaaaaa
     4081 caaaaaccct aaagatagct agatactgta aaacttaaaa aaaattacaa tatttataat
     4141 ttaatgtttt ttagaagtca aaatattact ccttcttcat tttcatctct tgtaagactg
     4201 acatgacttt agagaattaa tctattacta gaattatacg taaatccacc aacagagaat
     4261 ctcttgtagt tttcaacttt tgagataaac tgaggcatat acaaagaagc tggatatatt
     4321 gagatcgaag ctgttttgtt actaggttgg tcctcctgtc ttcctatata ggagcacatg
     4381 tatttcagta tggttttatt atcaattcta caataaattt gtttgttatg c
//
