LOCUS       NM_023873               2735 bp    mRNA    linear   ROD 08-FEB-2024
DEFINITION  Mus musculus centrosomal protein 70 (Cep70), mRNA.
ACCESSION   NM_023873
VERSION     NM_023873.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2735)
  AUTHORS   Liu,Q., Guo,Q., Guo,W., Song,S., Wang,N., Chen,X., Sun,A., Yan,L.
            and Qiao,J.
  TITLE     Loss of CEP70 function affects acrosome biogenesis and flagella
            formation during spermiogenesis
  JOURNAL   Cell Death Dis 12 (5), 478 (2021)
   PUBMED   33980814
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2735)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   3  (bases 1 to 2735)
  AUTHORS   Alvarez-Dominguez,J.R., Hu,W., Yuan,B., Shi,J., Park,S.S.,
            Gromatzky,A.A., van Oudenaarden,A. and Lodish,H.F.
  TITLE     Global discovery of erythroid long noncoding RNAs reveals novel
            regulators of red cell maturation
  JOURNAL   Blood 123 (4), 570-581 (2014)
   PUBMED   24200680
REFERENCE   4  (bases 1 to 2735)
  AUTHORS   Shi,X., Liu,M., Li,D., Wang,J., Aneja,R. and Zhou,J.
  TITLE     Cep70 contributes to angiogenesis by modulating microtubule
            rearrangement and stimulating cell polarization and migration
  JOURNAL   Cell Cycle 11 (8), 1554-1563 (2012)
   PUBMED   22437770
  REMARK    GeneRIF: Cep70 is important for Cdc42 and Rac1 activation to
            promote angiogenesis.
REFERENCE   5  (bases 1 to 2735)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY728192.1 and BC071260.1.
            
            [WARNING] On Mar 31, 2024 this sequence was replaced by
            NM_023873.5.
            
            On Apr 11, 2018 this sequence version replaced NM_023873.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071260.1, SRR1660813.262373.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               BY728192.1         1-127
            128-2735            BC071260.1         1-2608
FEATURES             Location/Qualifiers
     source          1..2735
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 51.45 cM"
     gene            1..2735
                     /gene="Cep70"
                     /gene_synonym="6720484E09Rik; Bite; C030018L16Rik"
                     /note="centrosomal protein 70"
                     /db_xref="GeneID:68121"
                     /db_xref="MGI:MGI:1915371"
     exon            1..150
                     /gene="Cep70"
                     /gene_synonym="6720484E09Rik; Bite; C030018L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            151..250
                     /gene="Cep70"
                     /gene_synonym="6720484E09Rik; Bite; C030018L16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..2092
                     /gene="Cep70"
                     /gene_synonym="6720484E09Rik; Bite; C030018L16Rik"
                     /note="p10-binding protein"
                     /codon_start=1
                     /product="centrosomal protein of 70 kDa"
                     /protein_id="NP_076362.2"
                     /db_xref="CCDS:CCDS40738.1"
                     /db_xref="GeneID:68121"
                     /db_xref="MGI:MGI:1915371"
                     /translation="MTEGSQIFLLPISTSDSTKEPLSPVASKAQDPSLLSNRLMIEKQ
                     QEEAEWESINGLLMTHGFKPLCLVKGADLRDFIVFDKQSSQKMRQILKTLMEETTRQQ
                     SMIRELIETNQQLKSELQLEQNRAAHQEQRANDLQQIMDSVKSKIGELEDESLNRVCQ
                     QQNRIKDLQKEYKMLQMKCQQYKKNRMEQEGTIASLQKEIHRLAKEEEERILTQNRVF
                     AHLCRRVPHSVLDKQLLCLIDYYECKLRKLHIQRQFEEDSQSEEKDFTNLGASPNYKG
                     VLMSLQKQLKESKSRIDVLVGEKLSLQKDLENRPTEHELRLYKQQVKKLEKTLKKNIK
                     LQDLIGQKKSDDTEKKDEPSKDSHQQALIEQSYFQVLCSINSIVHNPRAPVIIYKQSK
                     GRAPNGNKDIGQDCGFEHLVPIIEMWVDELTSLKDLYKSLKILSAELVPWHSLKKLDE
                     KEGVKVGDLLFMVDTMLEEVENQKETSSTPNSQTLQAIVSHFQKLFDVQSLNGVFPRM
                     NEVYTRLGEMNNAVRNLQELLELDSSSSLCVVVSTVGKLCEIINKDVSEQVKQVLGPE
                     DLQSIIKKLEEHEEFFPAFQAFANDLLEILEIDDLDAIVPAVKKLKILSY"
     exon            251..373
                     /gene="Cep70"
                     /gene_synonym="6720484E09Rik; Bite; C030018L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            374..464
                     /gene="Cep70"
                     /gene_synonym="6720484E09Rik; Bite; C030018L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            465..588
                     /gene="Cep70"
                     /gene_synonym="6720484E09Rik; Bite; C030018L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            589..769
                     /gene="Cep70"
                     /gene_synonym="6720484E09Rik; Bite; C030018L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            770..939
                     /gene="Cep70"
                     /gene_synonym="6720484E09Rik; Bite; C030018L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            940..996
                     /gene="Cep70"
                     /gene_synonym="6720484E09Rik; Bite; C030018L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1078
                     /gene="Cep70"
                     /gene_synonym="6720484E09Rik; Bite; C030018L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1167
                     /gene="Cep70"
                     /gene_synonym="6720484E09Rik; Bite; C030018L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1242
                     /gene="Cep70"
                     /gene_synonym="6720484E09Rik; Bite; C030018L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1348
                     /gene="Cep70"
                     /gene_synonym="6720484E09Rik; Bite; C030018L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1519
                     /gene="Cep70"
                     /gene_synonym="6720484E09Rik; Bite; C030018L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1666
                     /gene="Cep70"
                     /gene_synonym="6720484E09Rik; Bite; C030018L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1835
                     /gene="Cep70"
                     /gene_synonym="6720484E09Rik; Bite; C030018L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1950
                     /gene="Cep70"
                     /gene_synonym="6720484E09Rik; Bite; C030018L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2030
                     /gene="Cep70"
                     /gene_synonym="6720484E09Rik; Bite; C030018L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2707
                     /gene="Cep70"
                     /gene_synonym="6720484E09Rik; Bite; C030018L16Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcccggcgc gccaggtggt gttgtcccgc cccgctggga ggccatcgac tgcgtcagtt
       61 cgattggtca gcctggctgc gctaacggtc gcgtaggcgg ggcttaggcc gcgggggcga
      121 gcgcggtgga agccacgggc tgtgaccgag atcaagatcc acttccggac atgagactca
      181 ttgggtgatc attttattga gattaacttg aacgacaggt gtaaacaaca aaggaatcac
      241 tatgactgag ggaagtcaaa tatttttatt gccgatctct acttcagatt ctacaaaaga
      301 accgctgtct ccagtagcct ctaaagccca ggatcctagc cttttatcaa acagactcat
      361 gattgaaaaa cagcaggagg aagcagaatg ggaaagcatc aatgggctat tgatgacaca
      421 tggcttcaaa cctttatgtc tagtcaaagg agcagatctc agagatttca ttgtttttga
      481 caaacaatca tcacaaaaaa tgaggcagat tttgaaaacg ttgatggaag aaacaacacg
      541 tcagcagagc atgatacggg agctcataga gaccaaccag caactgaaaa gtgaacttca
      601 gctagaacag aaccgagcgg cacaccagga acagcgagcc aatgacctgc agcagattat
      661 ggacagtgtg aaatccaaaa ttggtgaatt ggaagatgaa tccctaaaca gggtttgcca
      721 gcaacaaaat agaataaaag accttcaaaa ggaatataaa atgttacaga tgaaatgcca
      781 gcaatataag aaaaaccgaa tggagcaaga ggggaccatt gcttctttgc aaaaggagat
      841 ccacagactt gccaaagagg aggaagagcg catcctcact cagaacagag tgtttgccca
      901 tctctgcaga agagtccctc actcagtctt ggataaacaa ttgctgtgtc taattgatta
      961 ctatgaatgt aaacttagaa aacttcatat acaaaggcag tttgaggaag acagtcagtc
     1021 agaagaaaaa gacttcacaa acctgggtgc ctcaccaaat tataaaggcg ttctgatgtc
     1081 gttacagaag caactcaagg aatccaaatc caggatcgac gtgctggtag gtgagaagct
     1141 gagcctccag aaagatctgg aaaacaggcc cacagaacat gaattaagac tttataaaca
     1201 acaagtgaag aaactggaaa aaaccctgaa gaaaaacata aaattacaag atcttattgg
     1261 tcaaaaaaag tctgatgaca cggagaaaaa agatgagccc agcaaagaca gccatcagca
     1321 ggctctcatt gagcagagct actttcaggt gctgtgcagc atcaattcaa ttgttcacaa
     1381 cccacgagct ccagtgatta tttataaaca gagcaaagga agagccccaa acggcaataa
     1441 agatattggt caagattgtg gatttgaaca tcttgttcct ataatagaaa tgtgggtaga
     1501 tgaactgaca tccttaaagg atttgtataa gtccttgaaa atactgtctg cagaactggt
     1561 gccttggcat agcttaaaga aactggatga aaaggaaggt gtcaaagtcg gagatctgtt
     1621 gtttatggtg gataccatgt tggaagaagt tgaaaaccag aaagagacca gcagcacgcc
     1681 gaactctcaa actttgcaag ctatcgtttc tcacttccaa aagctatttg atgtgcagtc
     1741 tttaaatgga gtctttcccc ggatgaatga agtgtacacc aggcttggag aaatgaacaa
     1801 cgctgtaagg aaccttcagg agctcttaga attagacagt tcatcatcat tgtgtgtggt
     1861 ggtcagcaca gttggtaaac tgtgtgagat aattaacaag gatgtgagtg agcaggttaa
     1921 acaagtgtta ggacctgagg atctacaaag tattatcaag aaattggaag agcatgagga
     1981 atttttccca gcgtttcaag cttttgctaa tgatcttctt gaaatcttag agattgatga
     2041 cctggatgcc atcgtacctg cagtaaagaa attaaagatc ctttcatact gaaaacaaac
     2101 caggtcaact tcactgtgta aactgcattc gtaacattct aagcatttgt aaaggtctga
     2161 tcctgagaca aggctgtaca caatcagctc tcagaattca tcctctcacc ccgggtctgc
     2221 tcaacccata taatttttat ttttgattat ttaataaaat gtagctgtta agttattaaa
     2281 atagtgagtt aactttagat tccttaatcg tttcctaagc aatgcttgag tgctgtaaaa
     2341 tgtaaggaag agattgtggg taacaaaaga gacattgcaa agtacagaaa gtcgcagtta
     2401 acttcaaggt ttaatgaccc tttggtcaga gaaaaaagaa tgccagttgc tttctaagcc
     2461 caacggatag gaagcctctg ttctccaggc aaggattagt gggcatattc tataagaaaa
     2521 cttacagcta ttgccctgtc aaagcaagaa ggaaaggttt tgtctttgta ttaagatagg
     2581 aagttagtca tggagtgaaa tagatgatta ggtagaagtg tttctgtgtc tttatttgca
     2641 atactatgta atgtactttt ataaagaaat aagatcacaa ataaagtttt cgtaaagagt
     2701 ttccaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
