LOCUS       NM_001407699            4745 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus centrosomal protein 63 (Cep63), transcript variant 3,
            mRNA.
ACCESSION   NM_001407699 XM_017313409
VERSION     NM_001407699.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4745)
  AUTHORS   Ho,U.Y., Feng,C.A., Yeap,Y.Y., Bain,A.L., Wei,Z., Shohayeb,B.,
            Reichelt,M.E., Homer,H., Khanna,K.K., Bowles,J. and Ng,D.C.H.
  TITLE     WDR62 is required for centriole duplication in spermatogenesis and
            manchette removal in spermiogenesis
  JOURNAL   Commun Biol 4 (1), 645 (2021)
   PUBMED   34059773
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4745)
  AUTHORS   Ha,H.L., Wang,H., Claudio,E., Tang,W. and Siebenlist,U.
  TITLE     IL-20-Receptor Signaling Delimits IL-17 Production in Psoriatic
            Inflammation
  JOURNAL   J Invest Dermatol 140 (1), 143-151 (2020)
   PUBMED   31252033
  REMARK    GeneRIF: this study shows that IL-20-receptor signaling delimits
            IL-17 production in psoriatic inflammation
REFERENCE   3  (bases 1 to 4745)
  AUTHORS   Mercey,O., Levine,M.S., LoMastro,G.M., Rostaing,P., Brotslaw,E.,
            Gomez,V., Kumar,A., Spassky,N., Mitchell,B.J., Meunier,A. and
            Holland,A.J.
  TITLE     Massive centriole production can occur in the absence of
            deuterosomes in multiciliated cells
  JOURNAL   Nat Cell Biol 21 (12), 1544-1552 (2019)
   PUBMED   31792378
REFERENCE   4  (bases 1 to 4745)
  AUTHORS   Jayaraman,D., Kodani,A., Gonzalez,D.M., Mancias,J.D., Mochida,G.H.,
            Vagnoni,C., Johnson,J., Krogan,N., Harper,J.W., Reiter,J.F.,
            Yu,T.W., Bae,B.I. and Walsh,C.A.
  TITLE     Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole
            Complex Regulating Centriole Biogenesis, Apical Complex, and Cell
            Fate
  JOURNAL   Neuron 92 (4), 813-828 (2016)
   PUBMED   27974163
  REMARK    GeneRIF: In brain development, Wdr62 and Aspm localize to the
            proximal end of the mother centriole and interact physically, with
            Wdr62 required for Aspm localization, and both proteins, as well as
            microcephaly protein Cep63, required to localize CENPJ/CPAP/Sas-4,
            a final common target.
REFERENCE   5  (bases 1 to 4745)
  AUTHORS   Marjanovic,M., Sanchez-Huertas,C., Terre,B., Gomez,R., Scheel,J.F.,
            Pacheco,S., Knobel,P.A., Martinez-Marchal,A., Aivio,S.,
            Palenzuela,L., Wolfrum,U., McKinnon,P.J., Suja,J.A., Roig,I.,
            Costanzo,V., Luders,J. and Stracker,T.H.
  TITLE     CEP63 deficiency promotes p53-dependent microcephaly and reveals a
            role for the centrosome in meiotic recombination
  JOURNAL   Nat Commun 6, 7676 (2015)
   PUBMED   26158450
  REMARK    GeneRIF: Cep63-deficient mice recapitulate Seckel syndrome
            pathology, microcephaly and dwarfism. Cep63 loss severely impairs
            meiotic recombination, leading to profound male infertility.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4745)
  AUTHORS   Zhao,H., Zhu,L., Zhu,Y., Cao,J., Li,S., Huang,Q., Xu,T., Huang,X.,
            Yan,X. and Zhu,X.
  TITLE     The Cep63 paralogue Deup1 enables massive de novo centriole
            biogenesis for vertebrate multiciliogenesis
  JOURNAL   Nat Cell Biol 15 (12), 1434-1444 (2013)
   PUBMED   24240477
  REMARK    GeneRIF: Cep63 regulates mother-centriole-dependent centriole
            duplication.
REFERENCE   7  (bases 1 to 4745)
  AUTHORS   Brown,N.J., Marjanovic,M., Luders,J., Stracker,T.H. and Costanzo,V.
  TITLE     Cep63 and cep152 cooperate to ensure centriole duplication
  JOURNAL   PLoS One 8 (7), e69986 (2013)
   PUBMED   23936128
  REMARK    GeneRIF: both mouse and human Cep63 and Cep152 cooperate to ensure
            efficient centriole duplication by promoting the accumulation of
            essential centriole duplication factors upstream of SAS-6
            recruitment and procentriole formation.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4745)
  AUTHORS   Zhao,Z., Oh,S., Li,D., Ni,D., Pirooz,S.D., Lee,J.H., Yang,S.,
            Lee,J.Y., Ghozalli,I., Costanzo,V., Stark,J.M. and Liang,C.
  TITLE     A dual role for UVRAG in maintaining chromosomal stability
            independent of autophagy
  JOURNAL   Dev Cell 22 (5), 1001-1016 (2012)
   PUBMED   22542840
REFERENCE   9  (bases 1 to 4745)
  AUTHORS   Sir,J.H., Barr,A.R., Nicholas,A.K., Carvalho,O.P., Khurshid,M.,
            Sossick,A., Reichelt,S., D'Santos,C., Woods,C.G. and Gergely,F.
  TITLE     A primary microcephaly protein complex forms a ring around parental
            centrioles
  JOURNAL   Nat Genet 43 (11), 1147-1153 (2011)
   PUBMED   21983783
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 4745)
  AUTHORS   Tabakoff,B., Saba,L., Kechris,K., Hu,W., Bhave,S.V., Finn,D.A.,
            Grahame,N.J. and Hoffman,P.L.
  TITLE     The genomic determinants of alcohol preference in mice
  JOURNAL   Mamm Genome 19 (5), 352-365 (2008)
   PUBMED   18563486
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CT573150.6 and AL450317.13.
            
            On Jun 6, 2022 this sequence version replaced XM_017313409.2.
            
            Summary: This gene encodes a subunit of the centrosome, the main
            microtubule-organizing center of the cell. The encoded protein
            associates with another centrosomal protein, CEP152, to regulate
            mother-centriole-dependent centriole duplication in dividing cells.
            Disruption of a similar gene in human has been associated with
            primary microcephaly (MCPH). Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.130952.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               CT573150.6         118633-118947
            316-348             CT573150.6         123123-123155
            349-417             CT573150.6         125091-125159
            418-595             CT573150.6         125863-126040
            596-691             CT573150.6         129481-129576
            692-814             CT573150.6         131434-131556
            815-928             CT573150.6         137412-137525
            929-1162            CT573150.6         141776-142009
            1163-1293           CT573150.6         142303-142433
            1294-1431           CT573150.6         143397-143534
            1432-1546           CT573150.6         146568-146682
            1547-1744           AL450317.13        1335-1532
            1745-1831           AL450317.13        3060-3146
            1832-2037           AL450317.13        7121-7326
            2038-2317           AL450317.13        8667-8946
            2318-4745           AL450317.13        10642-13069
FEATURES             Location/Qualifiers
     source          1..4745
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 54.61 cM"
     gene            1..4745
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /note="centrosomal protein 63"
                     /db_xref="GeneID:28135"
                     /db_xref="MGI:MGI:2158560"
     exon            1..315
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2476
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     centrosomal protein of 63 kDa; centrosome protein Cep63"
                     /codon_start=1
                     /product="centrosomal protein of 63 kDa isoform 3"
                     /protein_id="NP_001394628.1"
                     /db_xref="GeneID:28135"
                     /db_xref="MGI:MGI:2158560"
                     /translation="MARGRSSLRPTCRGAFQCRVAAARSSRPWVPPPPYGTLGWPARW
                     KSRSSRTQSCCQNKEDLEMEALLEGIQNRGHSGGFLTSCEAELQELMKQIDIMVAHKK
                     SEWEGQTHALETCLDIRDRELKALRSQLDMKHKEVGILHQQIEEHEKTKQEMAMEYKE
                     ELLKLQEELSRLKRSYEKLQKKQLREFRGNTKSFREDRSEIERLTGKIEEFRQKSLDW
                     EKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLANRKQKLESVELSSQSEIQHLNSKLE
                     RAKDTICANELEIERLNIRVNDLMGTNMTILQDHRQKEEKLRESEKLLEALQEEQKEL
                     KASLQSQETFILEAKMQEKLQTTLKAVGTQQSVERPLEDCQKERKYSSPGQGVLDNVL
                     SQLDFSHSSEELLQAEVTRLEGSLESVSATCKQLSQELMEKYEELKRMEGHNNEYRTE
                     IKKLKEQILQADQTYSSALEGMKMEISQLTRELHQRDITIASAKCSSSDMEKQLKAEM
                     QKAEEKAVEHKEILSQLESLKLENHRLSETVMKLELGLHEAKEISLADLQENYIEALN
                     KLVSENQQLQKDLMSTKSELEHATNMCKKKDGEIFNPAHSRAAGFKNAELKPIHGQHR
                     HDGIKTEQYKTGHHSPRGQTLDSIDPVARGPSPLSSHISPGSSTVSLPSNFLFEAHSL
                     PSVLDINDVNFSDSLSDCMNDQEEFVSSGSLPTSPLGSIATRFLEEEELRSHHILERL
                     DAHIEELKRESEKTVRQFTALV"
     exon            316..348
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /inference="alignment:Splign:2.1.0"
     exon            349..417
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /inference="alignment:Splign:2.1.0"
     exon            418..595
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /inference="alignment:Splign:2.1.0"
     exon            596..691
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /inference="alignment:Splign:2.1.0"
     exon            692..814
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /inference="alignment:Splign:2.1.0"
     exon            815..928
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1162
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1293
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1431
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1546
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1744
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1831
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..2037
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2317
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..4745
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2721..2726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /note="hexamer: AATAAA"
     polyA_site      2748
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /note="major polyA site"
     regulatory      4717..4722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
                     /note="hexamer: AATATA"
     polyA_site      4745
                     /gene="Cep63"
                     /gene_synonym="4921501M07; AL450317.13gm1; CD20R; D9Mgc41;
                     D9Mgc48e; ET2"
ORIGIN      
        1 gttgtgactt gcgcgcatcc ccggccggag gaacggcggg caggcccggg ggcgcgctcc
       61 gccggaggcg cgctctgccg ggggcgcgct ctgtaaccga ccgcatgccc caaagacggg
      121 cgagctgcgg ctaactgtgg tgcggtctcg gccctggcca cggtggtgcc gctaggctcc
      181 aggcctcatg gcccgcggcc gcagctcgtt gcggcccacc tgccgcgggg ctttccaatg
      241 ccgggttgcg gctgcccggt cgtcgcgccc ctgggttcct cctcctccct atgggactct
      301 gggctggccg gccagatgga aaagccgaag ttcgaggaca cagagctgtt gccaaaacaa
      361 agaggattta gagatggagg ctttgttgga aggaatacaa aatcgggggc atagtggggg
      421 atttttgaca tcctgtgaag cagaactgca agagctcatg aaacagatcg atataatggt
      481 ggctcataag aagtcggagt gggaggggca gacgcacgct ctggagactt gcttggacat
      541 ccgtgatcgg gagctgaagg ctctgaggag tcagctggac atgaagcaca aagaggttgg
      601 aatattgcat cagcagatag aagaacatga gaaaaccaag caagaaatgg ccatggagta
      661 caaggaggag ttactgaagc tgcaggagga attaagcaga ctgaagagaa gctatgaaaa
      721 gctgcagaaa aagcaactaa gagaatttag aggaaatacc aaaagttttc gagaggatcg
      781 gtctgagatt gagaggctaa ctggaaaaat agaggaattc cgacagaagt ctctggactg
      841 ggagaagcag cgtctgattt atcagcaaca ggtatcttct ctggaagcac agaggaaggc
      901 tctggctgaa cagtcggaga taatccaggc tcagcttgcc aaccggaaac agaaattaga
      961 gtccgtggaa ctatctagcc agtcagaaat tcaacacctg aacagtaagc ttgagcgggc
     1021 taaggacacc atctgtgcca atgagctgga aatagagcgc cttaacataa gggtcaacga
     1081 cctgatggga accaatatga ctatcctgca ggaccatcgg cagaaggagg agaaactaag
     1141 ggaatctgag aagttactag aggctctgca ggaagaacag aaagagttga aggcaagtct
     1201 tcaatctcaa gaaaccttca tccttgaggc aaaaatgcag gagaaactgc aaacgacatt
     1261 aaaggcagtt ggcactcagc agtccgtaga aaggcctctg gaggactgtc agaaggaaag
     1321 gaagtacagc tctccagggc aaggagtctt ggataatgtg ctctcccagc tggacttcag
     1381 ccacagcagt gaagaactcc tgcaggcaga ggtgacgcgt cttgaaggca gtttagaatc
     1441 tgtgagtgca acatgcaaac agctgagcca agaactaatg gaaaaatacg aagagctgaa
     1501 gaggatggaa gggcataaca atgagtaccg gacagagata aagaagttga aggaacagat
     1561 tctgcaggct gatcagacct acagttctgc cctggaagga atgaagatgg aaatctccca
     1621 gctaactcgg gagttgcacc agcgagatat cactattgct tctgccaagt gttcctcctc
     1681 agacatggaa aagcagctga aggcagagat gcagaaggca gaagaaaagg ctgtagagca
     1741 taaggagatt ctaagtcagc tggaatctct caaattagaa aatcatcgtc tttctgaaac
     1801 agtgatgaag ctggaactgg gcttgcatga ggcaaaagag atttcactag cagaccttca
     1861 ggagaattat attgaggcct taaataaatt agtgtctgaa aatcaacaac tgcagaaaga
     1921 tttgatgagc accaaatctg agctggagca tgctactaac atgtgcaaaa aaaaagatgg
     1981 cgagatcttt aacccagcac acagcagagc tgccgggttc aagaatgcag agcttaagcc
     2041 aatccatggc cagcacagac atgacggaat aaagaccgag cagtacaaaa caggtcacca
     2101 ctcgcctcga ggacaaacgt tggatagcat agaccctgtg gccaggggtc ccagccccct
     2161 gagttctcac atcagccccg gcagctccac cgtctctctg ccttccaact ttctatttga
     2221 ggctcactct ttgccttcag tgctagatat aaatgatgtc aacttttctg acagtctgtc
     2281 tgactgtatg aatgaccaag aagagtttgt atcttcgggc tcgctgccca cctctcctct
     2341 gggatcgata gctaccaggt ttctggaaga ggaggagctg aggtctcacc atattctaga
     2401 gcgcctggac gcccacattg aagaactgaa aagagagagt gagaagacgg tgaggcagtt
     2461 cacagccctc gtgtagccct gcacagccac agacggaaga ctggattata aagttgtaat
     2521 gaagcaatgc tcgcaagggc ggcactgagg agtctgcaga ctgggcactt gggtattttc
     2581 actgcgttgt gtggaggact gcttccatag gaacttgtga gaataaaccg ctttgcagac
     2641 ttttctcaca tgaatgttta ttaccacaga gcaatgcttt ctctttccga cttacatgtg
     2701 aatagctgtg tactactgaa aataaagatt gtactataca gtttgaaact agagtaacta
     2761 cagagcttcc cttaaaggaa gtatgcagtg gaagcatggc tgtgaagttg ctcagctagc
     2821 ttctcaggcg ttctcacctt tttaggtgca aagtctggct acaagtgtgt caaggggcca
     2881 tggggagtcc ttggcacgga ggcttttgca cacattcaca aagagaggac tgtataggtt
     2941 ggagctggat tcagtgtatg cagctcatgg gatgtccgaa tgcttagcat tcgcatgctg
     3001 aggagaggtc agagggggga gaggatttga agccacattg ttgacaacca aggagggcat
     3061 ggacagagga gagcaggggt ctaggcagct gaggcgcata ggagccacac cagtgcagaa
     3121 gtggaccgtg cagtcagggc aaggagaagg cacatgctgg acttgtcagc tcaaggaccc
     3181 agctcctccc attctccctg ctagagggtc tttcccatca gcacgtaaac atcccgggat
     3241 tcttcttttc aaaagaaaca gaaaaagtgc ccatctactc catatatttg cttctctctg
     3301 gcaaacattt ctagaaatag gtggctgtgg tgatggtttc tgggttgtct cctctttctg
     3361 agccctcttc accctggagc tgctgtcctg ccttggaggt tactaatgtc ctcatctccg
     3421 gacatcattc cacacattct tcccaccctc ccttgactcc tatgacctgg tgctgctgac
     3481 ccccttctgt ctgcctggtc tctgctctag aactttccct ctgttcccaa gctcttatga
     3541 ccatgtgtag cccagtgttc tctatagtca agcaatcaga catacctctg tttttgtgag
     3601 atgcctttat ttggtagtct gaggagagaa ctcttgactt tccctctggc caaggttcca
     3661 cctcagaaat gaaatctgtg attgccagtt cctccatgcc actcctggct ccttagaaca
     3721 tcttctgccc agttcactgg gaggccctgc ggcttctgct tctctcagat ccacccactg
     3781 cgctcttgcg ctaacacaag ccactctcat atagaatcta ggcgtggcct ccctcctggt
     3841 accattctgg tatccaacac caattacttc acctccacag agtgtccaga acatgaatgc
     3901 aatgttactg cttcctgctt tgcaatccac agaggcttct tactgtactc agaataaaat
     3961 cccatgatgg gtcatgctca cagggtctcc atggtctggg cctgtgcaca gcacagtgct
     4021 gcccgcagtg agctgctcac atgaggtttc ctgaagggct tcctccgtgg gctcttcacc
     4081 ctctaagaag gttttgttac ttggattatg actcttggag acaggggctt ctcacacccc
     4141 gcacaagccc gtctaggagg tagacccagg agtaaatgtc gtccttaaga tgcccacata
     4201 ctgcccttat gctgcgacac atgctgacct cctgctgtct tcttcccaca gtctgttact
     4261 gctcttttgc tttcgtgacc gccctatccc acgtggtatg cactggccag gggcagggag
     4321 cggctcacac tctcacagca tccccagtgt gcccatcacg gcactgggcg cagctgctgc
     4381 cttccttgct ctctgtgccc caggactgga cagcatgctg cccatatggg ggcactcagt
     4441 aaccatggtg ggcacgtaac agtcctaacc agcagccttc gcttgttctt ctctctagaa
     4501 tgagaatact ggggttaaga gggtctcctg aagttaggtt tctaaagggc tcaggttcca
     4561 agatgctaca cctgtgggga tgaaagagtt tgaatttcag agtctcccaa gcttcagatc
     4621 aaagatttct gtctgatgtc atcactggga ggagcaggga cagatcagtc cctgggagca
     4681 ctcaaggaat cacgaggtgc gatgaatttc cttaaaaata tactgtgttc ttacaaaagc
     4741 tgaaa
//
