LOCUS       NM_001243074            2233 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus centrosomal protein 57-like 1 (Cep57l1), transcript
            variant 3, mRNA.
ACCESSION   NM_001243074
VERSION     NM_001243074.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2233)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2233)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 2233)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   4  (bases 1 to 2233)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115297.7, AK012710.1, AK010530.1 and AC161426.5.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            contains multiple differences in the coding region, compared to
            variant 1. It initiates translation at an alternate upstream start
            codon. The encoded isoform (3) has a distinct N-terminus and is
            shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021375.1, SRR13422598.725741.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC115297.7         139631-139711       c
            82-137              AC115297.7         139451-139506       c
            138-323             AK012710.1         3-188
            324-503             AC115297.7         72885-73064         c
            504-551             AC115297.7         70757-70804         c
            552-820             AK012710.1         189-457
            821-1758            AK012710.1         545-1482
            1759-2227           AK010530.1         1783-2251
            2228-2233           AC161426.5         237858-237863       c
FEATURES             Location/Qualifiers
     source          1..2233
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 22.69 cM"
     gene            1..2233
                     /gene="Cep57l1"
                     /gene_synonym="2410017P07Rik; 4930484D11Rik; cep57R"
                     /note="centrosomal protein 57-like 1"
                     /db_xref="GeneID:103268"
                     /db_xref="MGI:MGI:1915511"
     exon            1..81
                     /gene="Cep57l1"
                     /gene_synonym="2410017P07Rik; 4930484D11Rik; cep57R"
                     /inference="alignment:Splign:2.1.0"
     exon            82..172
                     /gene="Cep57l1"
                     /gene_synonym="2410017P07Rik; 4930484D11Rik; cep57R"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1378
                     /gene="Cep57l1"
                     /gene_synonym="2410017P07Rik; 4930484D11Rik; cep57R"
                     /note="isoform 3 is encoded by transcript variant 3;
                     cep57-related protein; centrosomal protein CEP57L1;
                     centrosomal protein of 57 kDa-related protein; centrosomal
                     protein 57kDa-like protein 1"
                     /codon_start=1
                     /product="centrosomal protein CEP57L1 isoform 3"
                     /protein_id="NP_001230003.1"
                     /db_xref="GeneID:103268"
                     /db_xref="MGI:MGI:1915511"
                     /translation="MPPRHLSLPANQRFWRPWLTGSVHLTMDSELSQSMVGSYLNPPE
                     RMHLPSFTQNEAFQNCHPGTPPKMFNSPNNQALVSALKTLQEKIRRLELERTQAEDNL
                     NLLSREAAQYKKALEEETNERNLAHQELIKQKKDISIQLSSAQSRCILLEKQLEYTKR
                     MVLNVEREKTMILEQQAQLQREKEQDQMKLHAKLEKLHVLEKECLRLTATRQTAEDKI
                     KCLEEKLKEEEHQRRLFQDRACEKTNCLKREPPQQRDHKFRTPTFERKKPFRTTSQAR
                     ANPQSSGEPVSICDSLSELLMTMEEELDQMNMEHRELLRQMMQPGNHSVSEDIEQELE
                     QLAKKMESKGDQISKLKKHQDSVRKLQEKIENSRINESSGIHGNPKGSKNLKTSPRKC
                     VSETSSFQRDRGFQPVQVHSLQSKLRRDDIKWEQ"
     exon            173..323
                     /gene="Cep57l1"
                     /gene_synonym="2410017P07Rik; 4930484D11Rik; cep57R"
                     /inference="alignment:Splign:2.1.0"
     exon            324..503
                     /gene="Cep57l1"
                     /gene_synonym="2410017P07Rik; 4930484D11Rik; cep57R"
                     /inference="alignment:Splign:2.1.0"
     exon            504..625
                     /gene="Cep57l1"
                     /gene_synonym="2410017P07Rik; 4930484D11Rik; cep57R"
                     /inference="alignment:Splign:2.1.0"
     exon            626..742
                     /gene="Cep57l1"
                     /gene_synonym="2410017P07Rik; 4930484D11Rik; cep57R"
                     /inference="alignment:Splign:2.1.0"
     exon            743..820
                     /gene="Cep57l1"
                     /gene_synonym="2410017P07Rik; 4930484D11Rik; cep57R"
                     /inference="alignment:Splign:2.1.0"
     exon            821..898
                     /gene="Cep57l1"
                     /gene_synonym="2410017P07Rik; 4930484D11Rik; cep57R"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1020
                     /gene="Cep57l1"
                     /gene_synonym="2410017P07Rik; 4930484D11Rik; cep57R"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1165
                     /gene="Cep57l1"
                     /gene_synonym="2410017P07Rik; 4930484D11Rik; cep57R"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..2233
                     /gene="Cep57l1"
                     /gene_synonym="2410017P07Rik; 4930484D11Rik; cep57R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2203..2208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep57l1"
                     /gene_synonym="2410017P07Rik; 4930484D11Rik; cep57R"
                     /note="hexamer: AATAAA"
     polyA_site      2232
                     /gene="Cep57l1"
                     /gene_synonym="2410017P07Rik; 4930484D11Rik; cep57R"
                     /note="major polyA site"
ORIGIN      
        1 ggtttgaaga aggggaaaga aaagtaagga gtacagatgc ccggagatgt ttatcgaaca
       61 agaaaagccg aacaaataaa gaaactacaa ttcccagatg ccaccgcgac acttgtcttt
      121 gcccgcgaac caacggttct ggaggccgtg gttaactggg agcgtccatc tgacaatgga
      181 ttctgaatta tcacagagta tggttgggag ctatcttaac cctccagaaa gaatgcatct
      241 tccatcattc acgcaaaatg aagcatttca gaattgccac cctgggaccc ctcctaaaat
      301 gtttaatagt ccaaacaacc aagcacttgt ttcagcatta aaaactctcc aggaaaagat
      361 tcgtcgtctc gagctggaga ggacacaggc tgaagacaac ctgaaccttc tgtccagaga
      421 agcagcgcag tataagaagg ccctagagga ggagaccaac gagaggaacc tcgcacacca
      481 ggagctgatt aaacaaaaga aagatataag catacaatta agctcagccc agtctcgttg
      541 tattcttcta gagaagcaat tggaatatac aaaaagaatg gttctcaatg tagaacgaga
      601 aaagactatg atcctagaac aacaggccca gcttcaaagg gaaaaagaac aagatcagat
      661 gaagctgcac gctaaacttg aaaagctcca tgtcctagag aaagagtgtc tgagactgac
      721 ggcgactcgg cagactgcgg aggacaagat taaatgtcta gaagaaaaac tgaaggagga
      781 ggagcatcag cgcaggctgt ttcaagacag agcctgtgag aaaactaact gcttaaaacg
      841 agagccgcct cagcaaaggg accacaagtt tagaacacca acttttgaga gaaagaagcc
      901 tttcagaaca acttcccagg ctagagctaa ccctcagagc tcaggagagc ccgtttccat
      961 ttgtgacagt ttgtctgaac tcttgatgac aatggaagag gagctggacc aaatgaatat
     1021 ggagcacaga gagctcctga gacagatgat gcagcctggg aaccactcgg tctctgagga
     1081 catagagcag gagctggagc agttagccaa gaagatggaa agcaaaggtg accagatctc
     1141 caagctcaag aagcatcaag acagtgtccg taaactgcag gaaaaaattg agaactcaag
     1201 gataaatgaa tcttcaggta tccatggcaa ccctaaagga tctaagaact taaaaaccag
     1261 cccccggaaa tgtgtgagtg aaaccagctc ttttcagaga gacagaggct ttcaaccagt
     1321 gcaggtccac agcctgcagt cgaagctgag gcgcgatgac atcaagtggg agcagtgacc
     1381 aaggcaaact gtctgtcatc taaatgaacc tcaccagtga gaccgcacgc cgtctccgtg
     1441 gtttttattt catatgctct taaggaaccc ttgaattatg tttctgactg ctataaagtg
     1501 tgaagtcgta cattttcaga ataatggcta atgacctacc agggttcctg gcatctaaat
     1561 gactgctttt cattgttgtt aaccaaaggc cttgacctca tgaagctctt tagaagcatc
     1621 tgttttgcag ctcccataag gtaaatccaa gaagctgtac tgaatggatg gatgctcact
     1681 gaaatcaagg gagtctgacc tgtgggtact attccacagt ttgatttttg caggctgtct
     1741 gtcacctgta gatccacacg gaatgagcag aattccagac gtttgtttgg tgtccctgga
     1801 actgccacct tcccttgtct cagcggtgct catgcttgct ctgtttggaa agggagggca
     1861 cagtaattgt gcagttttgt gaaaatgacc ttaactcagc tctgctatga cagccactaa
     1921 atgagatgca taactgatta acctttgaag acagttctaa ttcgtcttcc ttcctctgct
     1981 acgccctgtc tccttttaaa ctccaacaat tgattttatc ttatatgtta tatgtgattt
     2041 acatccatat atgacaatgt aatagatgtc taggacccaa aaaggtaata ggattctata
     2101 agaccacagg aaaacatgaa ttaggtaaat gtggtatcat cttttatact ttaaaattag
     2161 tgatgtcaca atggatttct ctgttgtata cacatgttac ataataaatt tatacttttt
     2221 gcctttctaa aag
//
