LOCUS       NM_026665               2529 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus centrosomal protein 57 (Cep57), transcript variant 1,
            mRNA.
ACCESSION   NM_026665
VERSION     NM_026665.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2529)
  AUTHORS   Aziz,K., Sieben,C.J., Jeganathan,K.B., Hamada,M., Davies,B.A.,
            Velasco,R.O.F., Rahman,N., Katzmann,D.J. and van Deursen,J.M.
  TITLE     Mosaic-variegated aneuploidy syndrome mutation or
            haploinsufficiency in Cep57 impairs tumor suppression
  JOURNAL   J Clin Invest 128 (8), 3517-3534 (2018)
   PUBMED   30035751
  REMARK    GeneRIF: This study identifies Cep57 as a haploinsufficient tumor
            suppressor with biologically diverse roles in centrosome maturation
            and Fgf2-mediated bone formation.
REFERENCE   2  (bases 1 to 2529)
  AUTHORS   He,R., Wu,Q., Zhou,H., Huang,N., Chen,J. and Teng,J.
  TITLE     Cep57 protein is required for cytokinesis by facilitating central
            spindle microtubule organization
  JOURNAL   J Biol Chem 288 (20), 14384-14390 (2013)
   PUBMED   23569207
  REMARK    GeneRIF: Cep57 is essential for cytokinesis via regulation of
            central spindle assembly and formation of the midbody
REFERENCE   3  (bases 1 to 2529)
  AUTHORS   Ruiz-Miro,M., Colomina,N., Fernandez,R.M., Gari,E., Gallego,C. and
            Aldea,M.
  TITLE     Translokin (Cep57) interacts with cyclin D1 and prevents its
            nuclear accumulation in quiescent fibroblasts
  JOURNAL   Traffic 12 (5), 549-562 (2011)
   PUBMED   21306487
  REMARK    GeneRIF: Data suggest that translokin acts as a key negative
            regulator in the pathway that drives nuclear import of cyclin D1,
            thus contributing to prevent pRB inactivation and to maintain
            cellular quiescence.
REFERENCE   4  (bases 1 to 2529)
  AUTHORS   Meunier,S., Navarro,M.G., Bossard,C., Laurell,H., Touriol,C.,
            Lacazette,E. and Prats,H.
  TITLE     Pivotal role of translokin/CEP57 in the unconventional secretion
            versus nuclear translocation of FGF2
  JOURNAL   Traffic 10 (12), 1765-1772 (2009)
   PUBMED   19804566
  REMARK    GeneRIF: report the identification of four Translokin partners:
            sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and
            KIF3B
REFERENCE   5  (bases 1 to 2529)
  AUTHORS   Momotani,K., Khromov,A.S., Miyake,T., Stukenberg,P.T. and
            Somlyo,A.V.
  TITLE     Cep57, a multidomain protein with unique microtubule and
            centrosomal localization domains
  JOURNAL   Biochem J 412 (2), 265-273 (2008)
   PUBMED   18294141
  REMARK    GeneRIF: Data suggest that Cep57 serves as a link with its
            N-terminus anchored to the centriole or centromatrix and its
            C-terminus to microtubules.
REFERENCE   6  (bases 1 to 2529)
  AUTHORS   Kim,Y.S., Nakanishi,G., Oudes,A.J., Kim,K.H., Wang,H.,
            Kilpatrick,D.L. and Jetten,A.M.
  TITLE     Tsp57: a novel gene induced during a specific stage of
            spermatogenesis
  JOURNAL   Biol Reprod 70 (1), 106-113 (2004)
   PUBMED   12954732
  REMARK    GeneRIF: Tsp57 protein plays a role in the postmeiotic phase of
            germ cell differentiation
REFERENCE   7  (bases 1 to 2529)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 2529)
  AUTHORS   Bossard,C., Laurell,H., Van den Berghe,L., Meunier,S.,
            Zanibellato,C. and Prats,H.
  TITLE     Translokin is an intracellular mediator of FGF-2 trafficking
  JOURNAL   Nat Cell Biol 5 (5), 433-439 (2003)
   PUBMED   12717444
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB846596.1, AK129053.1, BC050785.1 and AK028458.1.
            
            On Dec 7, 2010 this sequence version replaced NM_026665.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028458.1, AK019414.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                BB846596.1         2-52
            52-980              AK129053.1         1-929
            981-2133            BC050785.1         492-1644
            2134-2529           AK028458.1         1962-2357
FEATURES             Location/Qualifiers
     source          1..2529
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 3.49 cM"
     gene            1..2529
                     /gene="Cep57"
                     /gene_synonym="3110002L15Rik; 4921510P06Rik;
                     4931428M20Rik; mKIAA0092; Tsp57"
                     /note="centrosomal protein 57"
                     /db_xref="GeneID:74360"
                     /db_xref="MGI:MGI:1915551"
     exon            1..252
                     /gene="Cep57"
                     /gene_synonym="3110002L15Rik; 4921510P06Rik;
                     4931428M20Rik; mKIAA0092; Tsp57"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1710
                     /gene="Cep57"
                     /gene_synonym="3110002L15Rik; 4921510P06Rik;
                     4931428M20Rik; mKIAA0092; Tsp57"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centrosomal protein of 57 kDa; testis-specific protein 57;
                     translokin"
                     /codon_start=1
                     /product="centrosomal protein of 57 kDa isoform 1"
                     /protein_id="NP_080941.3"
                     /db_xref="CCDS:CCDS52724.1"
                     /db_xref="GeneID:74360"
                     /db_xref="MGI:MGI:1915551"
                     /translation="MAAASVSAASDSQFSSVLAEPSRSNGNMVRHSSSPYVLYPPDKP
                     FLNSDLRRSPNKPTFAYPESNSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETI
                     EYKKVLDEQIQERENSKNEESKHNQELASQLVAAENKCNLLEKQLEYMRNMIKHAEME
                     RTSVLEKQVSLERERQHDQTHVQSQLEKLDLLEQEYNKLTAMQALAEKKMQELESKLR
                     EEEQERKRMQARAAELQSGLEANRLIFEDKTTSCVSTSTRKIKKKKSKPPEKKGSRTY
                     FGAQPHYRLCLGDMPFVAGTSTSPSHAVVANVQHVLHLMKHHSKALCNDRVVNSVPLA
                     KQACSRVSKSKKSVVPPSSSVNEELSDVLQTLQDEFGQMSFDHQQLTKLIQESPTVEL
                     KDNLECELEALVGRMEAKANQITKVRKYQAQLEKQNIDKQKKELKANKKTLDEEGNSS
                     GRSSGVPRTASKKDLAKQRPGEKSRKNLQLLKDMQTIQNSLQSSNLCWDY"
     exon            253..409
                     /gene="Cep57"
                     /gene_synonym="3110002L15Rik; 4921510P06Rik;
                     4931428M20Rik; mKIAA0092; Tsp57"
                     /inference="alignment:Splign:2.1.0"
     exon            410..589
                     /gene="Cep57"
                     /gene_synonym="3110002L15Rik; 4921510P06Rik;
                     4931428M20Rik; mKIAA0092; Tsp57"
                     /inference="alignment:Splign:2.1.0"
     exon            590..711
                     /gene="Cep57"
                     /gene_synonym="3110002L15Rik; 4921510P06Rik;
                     4931428M20Rik; mKIAA0092; Tsp57"
                     /inference="alignment:Splign:2.1.0"
     exon            712..828
                     /gene="Cep57"
                     /gene_synonym="3110002L15Rik; 4921510P06Rik;
                     4931428M20Rik; mKIAA0092; Tsp57"
                     /inference="alignment:Splign:2.1.0"
     exon            829..906
                     /gene="Cep57"
                     /gene_synonym="3110002L15Rik; 4921510P06Rik;
                     4931428M20Rik; mKIAA0092; Tsp57"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1017
                     /gene="Cep57"
                     /gene_synonym="3110002L15Rik; 4921510P06Rik;
                     4931428M20Rik; mKIAA0092; Tsp57"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1095
                     /gene="Cep57"
                     /gene_synonym="3110002L15Rik; 4921510P06Rik;
                     4931428M20Rik; mKIAA0092; Tsp57"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1331
                     /gene="Cep57"
                     /gene_synonym="3110002L15Rik; 4921510P06Rik;
                     4931428M20Rik; mKIAA0092; Tsp57"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1476
                     /gene="Cep57"
                     /gene_synonym="3110002L15Rik; 4921510P06Rik;
                     4931428M20Rik; mKIAA0092; Tsp57"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..2529
                     /gene="Cep57"
                     /gene_synonym="3110002L15Rik; 4921510P06Rik;
                     4931428M20Rik; mKIAA0092; Tsp57"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2111..2116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep57"
                     /gene_synonym="3110002L15Rik; 4921510P06Rik;
                     4931428M20Rik; mKIAA0092; Tsp57"
                     /note="hexamer: ATTAAA"
     polyA_site      2133
                     /gene="Cep57"
                     /gene_synonym="3110002L15Rik; 4921510P06Rik;
                     4931428M20Rik; mKIAA0092; Tsp57"
                     /note="major polyA site"
     regulatory      2267..2272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep57"
                     /gene_synonym="3110002L15Rik; 4921510P06Rik;
                     4931428M20Rik; mKIAA0092; Tsp57"
                     /note="hexamer: AATAAA"
     polyA_site      2297
                     /gene="Cep57"
                     /gene_synonym="3110002L15Rik; 4921510P06Rik;
                     4931428M20Rik; mKIAA0092; Tsp57"
ORIGIN      
        1 actggaaggc gtctatcaag acgcgttgcc tttcccgtgc gcgctgagtg tggcgtcctt
       61 gtggtttgcg agaccgaggc tcctataggg ttcgcagctc gcccgcccct tccatcgggg
      121 acttggattc cgcttgcccc aggcgggcgg ctgtcgaatc cggaggagga gctcaaggac
      181 ggcgtctggg gttgcgcagg tgggaagatg gcggcagcct cggtctcggc ggcttctgat
      241 tctcagtttt cgagcgtcct agctgaacca tcaaggtcta atggaaatat ggttcgtcat
      301 tcttcgtctc catatgtatt gtatccacct gataagcctt tccttaacag tgatctgaga
      361 cgctccccaa ataagcccac atttgcctat ccggaaagca acagcagagc catattttct
      421 gctcttaaga atcttcaaga taagattcga cgcctggaac tggaaaggat tcaggcagaa
      481 gaaagtgtga aaaccttgtc tagggaaacc attgagtaca agaaagtatt ggatgaacag
      541 atccaagaga gggagaactc aaagaatgaa gaatcaaagc acaatcaaga actggcatcc
      601 cagttggtag ctgcagaaaa taaatgtaat cttctagaaa aacaattgga atacatgcga
      661 aatatgataa agcatgcaga aatggagagg acatctgtgt tagaaaagca ggtttctcta
      721 gaaagagaac ggcagcatga tcaaacccat gttcagagcc agctggaaaa actggatctt
      781 cttgaacagg aatacaacaa actcaccgcc atgcaggccc ttgcagaaaa aaagatgcag
      841 gagttggagt ccaaactccg tgaagaagag caggaaagga agcggatgca ggcccgggca
      901 gcagagttac agagtggtct agaagcaaat agacttattt ttgaagataa gactacttca
      961 tgtgtttcaa ccagcactag aaaaataaaa aaaaagaagt caaaaccacc agaaaagaaa
     1021 ggttctagga cctattttgg tgcacagcca cattacagat tgtgcttagg tgatatgcct
     1081 tttgttgctg gaacgtccac cagtcccagc catgccgtgg tagccaatgt tcagcatgtc
     1141 ttgcatctga tgaaacacca cagtaaagcc ctgtgcaatg atcgagttgt taacagtgtt
     1201 cccttggcaa agcaagcttg ctcacgagtt agtaagagta agaagtcagt ggtgcctcct
     1261 tccagcagtg ttaatgaaga actttcggat gtcttgcaga ctttacagga tgaatttggg
     1321 caaatgagct ttgatcatca gcagcttact aaactcatac aggaatcacc aactgtggaa
     1381 ctaaaagaca acctggagtg tgaattggag gcattagtgg gaagaatgga agcgaaggcc
     1441 aatcagataa ctaaagttcg aaaataccaa gcccagctgg agaaacaaaa catagataag
     1501 cagaagaagg aattaaaagc taacaaaaag actcttgatg aagaagggaa cagcagcggt
     1561 cgttcatctg gagtcccaag gaccgcaagt aagaaggatc tggccaaaca gagacctgga
     1621 gaaaaaagca ggaaaaatct tcagttactg aaggacatgc agaccataca gaattcactg
     1681 cagagcagta atctgtgttg ggattactga caccaggtca taaatgatgt acctcactgg
     1741 tcataaacga tgtacgtact ggacatgagc agactttcca ggtctcatgc ttgctaagct
     1801 gccattactg gcaggtgtta ggggccaagc ttcattacag tctattgtgc tatgtagcac
     1861 aactgatgga gatggagttc tgcggcagag aagcctcact gtctttgaat ttgctgtact
     1921 cattcactgc actttgtaaa caaatgacca gttttttact catgggtgtg ttttttaaac
     1981 taggtatata tgtaaattgg gtttgaaaat tcagaatatg agatagtccc catagtcagt
     2041 gcttgaagtc ttgtttttta aatcttccca cagcatgaag tgaccactac tctcccttct
     2101 ccagatgacc attaaatgta ctgttttcaa gaagactttg ttttgctttg gtattttaga
     2161 cattgatcaa tcataaattc acttaagtca gttatccatg aaatatgtca caatgtcttc
     2221 agaaaaacta tataaacagt tgttactgaa gtaaatgaaa ttttggaata aagaatgaga
     2281 acgtgggtat tgtaaaatgt acacgtttac agtttttaga cagtatctat ttgtaatcat
     2341 gttaagcact gtttaatctt gacttaagag aagctcatgc ttttagcata cagtatgtga
     2401 attgaataca cacatctatc atgccaatgt aaattattta actttgagta gatcgacatg
     2461 ttataatctt tataaatttg gtacttcaaa tcaataaagc agtttttaaa ctttgcttaa
     2521 cagccagct
//
