LOCUS       NM_001164362            2762 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus centrosomal protein 55 (Cep55), transcript variant 1,
            mRNA.
ACCESSION   NM_001164362
VERSION     NM_001164362.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2762)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2762)
  AUTHORS   Fu,L., Li,Z., Wu,Y., Zhu,T., Ma,Z., Dong,L., Ding,J., Zhang,C. and
            Yu,G.
  TITLE     Hsa-miR-195-5p Inhibits Autophagy and Gemcitabine Resistance of
            Lung Adenocarcinoma Cells via E2F7/CEP55
  JOURNAL   Biochem Genet 61 (4), 1528-1547 (2023)
   PUBMED   36658310
  REMARK    GeneRIF: Hsa-miR-195-5p Inhibits Autophagy and Gemcitabine
            Resistance of Lung Adenocarcinoma Cells via E2F7/CEP55.
REFERENCE   3  (bases 1 to 2762)
  AUTHORS   Tang,Y., Thiess,L., Weiler,S.M.E., Toth,M., Rose,F., Merker,S.,
            Ruppert,T., Schirmacher,P. and Breuhahn,K.
  TITLE     alpha-catenin interaction with YAP/FoxM1/TEAD-induced CEP55
            supports liver cancer cell migration
  JOURNAL   Cell Commun Signal 21 (1), 162 (2023)
   PUBMED   37381005
  REMARK    GeneRIF: alpha-catenin interaction with YAP/FoxM1/TEAD-induced
            CEP55 supports liver cancer cell migration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2762)
  AUTHORS   Rashidieh,B., Shohayeb,B., Bain,A.L., Fortuna,P.R.J., Sinha,D.,
            Burgess,A., Mills,R., Adams,R.C., Lopez,J.A., Blumbergs,P.,
            Finnie,J., Kalimutho,M., Piper,M., Hudson,J.E., Ng,D.C.H. and
            Khanna,K.K.
  TITLE     Cep55 regulation of PI3K/Akt signaling is required for neocortical
            development and ciliogenesis
  JOURNAL   PLoS Genet 17 (10), e1009334 (2021)
   PUBMED   34710087
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2762)
  AUTHORS   Kumar,A., Rajendran,V., Sethumadhavan,R. and Purohit,R.
  TITLE     CEP proteins: the knights of centrosome dynasty
  JOURNAL   Protoplasma 250 (5), 965-983 (2013)
   PUBMED   23456457
  REMARK    Review article
REFERENCE   6  (bases 1 to 2762)
  AUTHORS   Agromayor,M. and Martin-Serrano,J.
  TITLE     Knowing when to cut and run: mechanisms that control cytokinetic
            abscission
  JOURNAL   Trends Cell Biol 23 (9), 433-441 (2013)
   PUBMED   23706391
  REMARK    Review article
REFERENCE   7  (bases 1 to 2762)
  AUTHORS   Kuo,T.C., Chen,C.T., Baron,D., Onder,T.T., Loewer,S., Almeida,S.,
            Weismann,C.M., Xu,P., Houghton,J.M., Gao,F.B., Daley,G.Q. and
            Doxsey,S.
  TITLE     Midbody accumulation through evasion of autophagy contributes to
            cellular reprogramming and tumorigenicity
  JOURNAL   Nat Cell Biol 13 (10), 1214-1223 (2011)
   PUBMED   21909099
  REMARK    Erratum:[Nat Cell Biol. 2011 Dec;13(12):1467]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2762)
  AUTHORS   Iwamori,T., Iwamori,N., Ma,L., Edson,M.A., Greenbaum,M.P. and
            Matzuk,M.M.
  TITLE     TEX14 interacts with CEP55 to block cell abscission
  JOURNAL   Mol Cell Biol 30 (9), 2280-2292 (2010)
   PUBMED   20176808
  REMARK    GeneRIF: TEX14 prevents the completion of cytokinesis by altering
            the destiny of CEP55 from a nidus for abscission to an integral
            component of the intercellular bridge.
REFERENCE   9  (bases 1 to 2762)
  AUTHORS   Chang,Y.C., Chen,Y.J., Wu,C.H., Wu,Y.C., Yen,T.C. and Ouyang,P.
  TITLE     Characterization of centrosomal proteins Cep55 and pericentrin in
            intercellular bridges of mouse testes
  JOURNAL   J Cell Biochem 109 (6), 1274-1285 (2010)
   PUBMED   20186884
  REMARK    GeneRIF: The results suggest that Cep55 and pericentrin are
            required for the stable bridge between germ cells during
            spermatogenesis and spermiogenesis.
REFERENCE   10 (bases 1 to 2762)
  AUTHORS   van der Horst,A. and Khanna,K.K.
  TITLE     The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through
            Cep55
  JOURNAL   Cancer Res 69 (16), 6651-6659 (2009)
   PUBMED   19638580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101774.6, AK004655.1 and AW538141.2.
            
            On Feb 9, 2018 this sequence version replaced NM_001164362.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004655.1, SRR11927937.5227023.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC101774.6         74793-74793         c
            2-2724              AK004655.1         3-2725
            2725-2762           AW538141.2         1-38                c
FEATURES             Location/Qualifiers
     source          1..2762
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 32.69 cM"
     gene            1..2762
                     /gene="Cep55"
                     /gene_synonym="1200008O12Rik; 2700032M20Rik"
                     /note="centrosomal protein 55"
                     /db_xref="GeneID:74107"
                     /db_xref="MGI:MGI:1921357"
     exon            1..277
                     /gene="Cep55"
                     /gene_synonym="1200008O12Rik; 2700032M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            278..434
                     /gene="Cep55"
                     /gene_synonym="1200008O12Rik; 2700032M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            435..629
                     /gene="Cep55"
                     /gene_synonym="1200008O12Rik; 2700032M20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             447..1835
                     /gene="Cep55"
                     /gene_synonym="1200008O12Rik; 2700032M20Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centrosomal protein of 55 kDa"
                     /codon_start=1
                     /product="centrosomal protein of 55 kDa isoform 1"
                     /protein_id="NP_001157834.1"
                     /db_xref="CCDS:CCDS50429.1"
                     /db_xref="GeneID:74107"
                     /db_xref="MGI:MGI:1921357"
                     /translation="MSSRSPKDLIKSKWGSRPSSSKSDTALEKFKGEIAAFKTSLDEI
                     TSGKGKMAEKGRSRLLEKIQVLEAEREKNVYYLLEKDKEIQRLKDHLRSRYSSSSLFE
                     QLEEKTKECEKKQQLLESLSKETDVLKNQLSATTKRLSELESKASTLHLSQSMPANCF
                     NSSMNSIHEKEMQLKDALEKNQQWLVYDQQREAYVKGLLAKIFELEKRTETAAASLTQ
                     QMKKIESEGYLQVEKQKYDHLLENAKKDLEVERQAVTQLRLELDEFRRKYEEARKEVE
                     DLNQLLSSQRKADIQHLEEDKQKTERIQKLREESSIFKGKLEEERKRSEELLSQVRIL
                     YDSLLKHQEEQARVALLEQQMQACTLDFENEKLDRQNMQHQLYVILKELRKAKSQITQ
                     LESLKQLHGFTITEQPFPLQREPESRVKATSPKSPSAALNDSLVECPKCSVQYPATEH
                     RDLLVHVEYCMK"
     exon            630..905
                     /gene="Cep55"
                     /gene_synonym="1200008O12Rik; 2700032M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            906..974
                     /gene="Cep55"
                     /gene_synonym="1200008O12Rik; 2700032M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1125
                     /gene="Cep55"
                     /gene_synonym="1200008O12Rik; 2700032M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1436
                     /gene="Cep55"
                     /gene_synonym="1200008O12Rik; 2700032M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1508
                     /gene="Cep55"
                     /gene_synonym="1200008O12Rik; 2700032M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1634
                     /gene="Cep55"
                     /gene_synonym="1200008O12Rik; 2700032M20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..2762
                     /gene="Cep55"
                     /gene_synonym="1200008O12Rik; 2700032M20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2738..2743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep55"
                     /gene_synonym="1200008O12Rik; 2700032M20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2761
                     /gene="Cep55"
                     /gene_synonym="1200008O12Rik; 2700032M20Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtggtctgc ggcggcgacg cgagcgctgt gtttgtctca ggtagtgagt ggtcccggcc
       61 tcggccgggg agggagggga ggacagccgg ggctcgttag cccctgggca ggactagacc
      121 tcccgggagg agcgctggtg agcagatcac gccgcaggac tccgtctccc ctggctggaa
      181 tcgctggaac acatgctggc tccctgagag accccgcgct gcgttcctgt cgaccgccgg
      241 cccgcaggcc atcctttcgg ctcctttgaa cttggcggtg cctgtaaacc tataacctgg
      301 gaggctgaag caggaggcct gtgagttcgg tgccacccaa gttacgtagt gagttccaga
      361 ctctcctggg ctgccttgag agatctgttc gcaaatatca gcaaaaacaa gtatgcaaat
      421 tatatttcta gaagatcatt gcaacgatgt cttcaagaag tcccaaagat ttaattaaaa
      481 gcaaatgggg atcaaggcct agtagctcca agtcagacac tgcattagag aaatttaagg
      541 gagaaattgc agcctttaaa acatccctgg atgaaatcac ctctgggaaa ggaaaaatgg
      601 ccgaaaaagg cagaagcaga ctcttggaga aaatccaagt tcttgaagcc gagagagaaa
      661 agaatgttta ttacctcctg gagaaggaca aagaaataca gagactcaaa gaccacctaa
      721 ggtcaagata tagctcttct tcattgttcg agcagctgga agagaaaaca aaggaatgtg
      781 agaagaagca gcagttgctg gagtccctat ccaaagagac agatgtcctg aaaaaccagc
      841 tgtccgccac gacgaaaaga ctttctgaac ttgaaagcaa agccagtaca ctccacctgt
      901 cacagagcat gcctgcaaac tgcttcaact cctcaatgaa tagtattcat gaaaaggaga
      961 tgcagctgaa agatgctctg gagaaaaacc agcaatggct tgtgtatgat cagcagcgag
     1021 aggcctacgt taaagggctt ttagcaaaga tcttcgagct ggaaaagaga acagagacag
     1081 ccgctgcttc cctcacacag cagatgaaga agattgaatc agaaggttat cttcaagtgg
     1141 agaagcaaaa atatgatcat ctcttggaaa atgccaaaaa agatctcgaa gttgagcgac
     1201 aagccgtgac tcagttgcgt ttagaactcg atgaatttcg aaggaaatac gaagaagctc
     1261 gaaaagaagt tgaagactta aatcagctgt tgagctctca gcgaaaggca gacatccagc
     1321 acctggagga ggacaagcag aagacggaga ggatccaaaa gctgagggaa gagagcagta
     1381 tcttcaaggg aaagctggaa gaggagagga agaggtcgga ggagctctta tcccaggtcc
     1441 gaattctcta cgattctctg ttaaagcacc aagaggagca ggccagggta gctctactgg
     1501 aacagcagat gcaggcatgt actctagact ttgaaaatga aaaactcgac cgccagaata
     1561 tgcagcatca actctatgtg attcttaagg aactccgaaa agcaaaaagt caaataacac
     1621 agttggaatc cttgaagcag ctacatgggt ttaccatcac agagcagcca ttcccactcc
     1681 agagagaacc tgaaagcaga gtgaaagcta cctcacccaa aagtcccagt gctgcactca
     1741 atgacagcct agtggaatgt cccaagtgca gcgtacagta cccagccacc gagcatcgag
     1801 acctgcttgt ccatgtcgaa tactgcatga agtagcagaa ccattcttgc ctttgtgctg
     1861 aaaaagtcca cactgtattc tatgtttctt tataggcact ttaaaccaca gatgacatct
     1921 tttatacaag aaactccatc tgcccttggc actctggcat atgagggcat ccttgtattt
     1981 ttctggccac tttgcatttc cttggtagcc attcctccct gagttggttc gtcatcaggc
     2041 tgcagtgaca gattgtggtg agcagtggct atccaaactt gtagcacttc acgctgttgt
     2101 aatgactagc atttcacacg gttcttctac ttgataaaca gagctatttg ggtttttggt
     2161 tatggcttaa agctactgag cagtaagcaa acattttatg ctttgggggt tttaagagaa
     2221 tcagaaggta attaaccatg gatcttactg ttttgttttt tttaaataag tgctttgtat
     2281 actgacactt ccatttgata cctcttgcta ttgtagaacg gttactagca aagttgggaa
     2341 gttttgtaat gttgagtgct gttaactgtt ctaagcacaa agcaggtttt gtttgaagaa
     2401 tgcctttaag tggctgtata tttttactcc tattacctgg ccataacttt gacttaaatt
     2461 tcattagtac aggtcagttt cctaaaatgc caaaatgaac aaaactttag caaaactatc
     2521 ttgcctcatt tgatttgcag ggattttatt atatcatttt gttttgtttt gttttttagc
     2581 actcttaaag atggttgggc agtgtaatta tcagatgttt gttttctaaa tagatatttt
     2641 tatatatgct ttatgtaaac caaaatgtgt tttattcctt cagattttct aacatgctta
     2701 cacttgggct actatttagc aatatgaagg aggaaataat aaaattattt aataagtttt
     2761 ac
//
