LOCUS       NM_031998               3460 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus centrosomal protein 41 (Cep41), transcript variant 1,
            mRNA.
ACCESSION   NM_031998
VERSION     NM_031998.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3460)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3460)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3460)
  AUTHORS   Ishikawa,H., Thompson,J., Yates,J.R. 3rd and Marshall,W.F.
  TITLE     Proteomic analysis of mammalian primary cilia
  JOURNAL   Curr Biol 22 (5), 414-419 (2012)
   PUBMED   22326026
REFERENCE   4  (bases 1 to 3460)
  AUTHORS   Lee,J.E., Silhavy,J.L., Zaki,M.S., Schroth,J., Bielas,S.L.,
            Marsh,S.E., Olvera,J., Brancati,F., Iannicelli,M., Ikegami,K.,
            Schlossman,A.M., Merriman,B., Attie-Bitach,T., Logan,C.V.,
            Glass,I.A., Cluckey,A., Louie,C.M., Lee,J.H., Raynes,H.R.,
            Rapin,I., Castroviejo,I.P., Setou,M., Barbot,C., Boltshauser,E.,
            Nelson,S.F., Hildebrandt,F., Johnson,C.A., Doherty,D.A.,
            Valente,E.M. and Gleeson,J.G.
  TITLE     CEP41 is mutated in Joubert syndrome and is required for tubulin
            glutamylation at the cilium
  JOURNAL   Nat Genet 44 (2), 193-199 (2012)
   PUBMED   22246503
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3460)
  AUTHORS   Lee,Y.J., Park,C.W., Hahn,Y., Park,J., Lee,J., Yun,J.H., Hyun,B.
            and Chung,J.H.
  TITLE     Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely
            linked to Peg1/Mest(1)
  JOURNAL   FEBS Lett 472 (2-3), 230-234 (2000)
   PUBMED   10788617
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC155656.10 and BC031892.1.
            
            On Feb 3, 2015 this sequence version replaced NM_031998.2.
            
            Summary: This gene encodes a centrosomal protein which may be
            required for tubulin glutamylation in cilia during ciliogenesis.
            Mutations in a similar gene in human have been associated with
            Joubert Syndrome 15, an autosomal recessive ciliopathy and
            neurological disorder. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Feb 2015].
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031892.1, AK132495.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC155656.10        158447-158513       c
            68-3460             BC031892.1         1-3393
FEATURES             Location/Qualifiers
     source          1..3460
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.52 cM"
     gene            1..3460
                     /gene="Cep41"
                     /gene_synonym="1700017E11Rik; 2810431D15Rik; Tsga14"
                     /note="centrosomal protein 41"
                     /db_xref="GeneID:83922"
                     /db_xref="MGI:MGI:1891414"
     exon            1..113
                     /gene="Cep41"
                     /gene_synonym="1700017E11Rik; 2810431D15Rik; Tsga14"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1202
                     /gene="Cep41"
                     /gene_synonym="1700017E11Rik; 2810431D15Rik; Tsga14"
                     /note="testis specific gene A14"
                     /codon_start=1
                     /product="centrosomal protein of 41 kDa"
                     /protein_id="NP_114387.1"
                     /db_xref="CCDS:CCDS19978.1"
                     /db_xref="GeneID:83922"
                     /db_xref="MGI:MGI:1891414"
                     /translation="MSARRHIGNPEYLTRRIPQNPRYQHVKSRLDTGNSMTKYIEKLE
                     EIKKNYRYKKDELFKRLKVTTFAQLVIQVASLSDQTLEVTAEEIQRLEDNDSATSEAD
                     AEIAAKTNGKGSPEEQSPSPVQFINSTGAGDSSRSTLQSVISGVGELDVDKGLVKKEE
                     PNGKDKPYPDCPFLLLDVRDRDSYQQCHIVGAYSYPIATLSRTMNPYSNDILEYKNAH
                     GKIIILYDEDERLASQAATTMCERGFENLFMLSGGLKVLAQKFPEGLVTGSLPASCQQ
                     ALPFGSVRKRRGPKMPALPAENKWRFTPEDLKKIECYLEEDQGPADNPSRLNQNNSAG
                     KDSKVAACRGGQNLPTSCPASHSSPRTLTSGHLQGKPWK"
     exon            114..177
                     /gene="Cep41"
                     /gene_synonym="1700017E11Rik; 2810431D15Rik; Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            178..225
                     /gene="Cep41"
                     /gene_synonym="1700017E11Rik; 2810431D15Rik; Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            226..287
                     /gene="Cep41"
                     /gene_synonym="1700017E11Rik; 2810431D15Rik; Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            288..357
                     /gene="Cep41"
                     /gene_synonym="1700017E11Rik; 2810431D15Rik; Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            358..502
                     /gene="Cep41"
                     /gene_synonym="1700017E11Rik; 2810431D15Rik; Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            503..654
                     /gene="Cep41"
                     /gene_synonym="1700017E11Rik; 2810431D15Rik; Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            655..722
                     /gene="Cep41"
                     /gene_synonym="1700017E11Rik; 2810431D15Rik; Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            723..837
                     /gene="Cep41"
                     /gene_synonym="1700017E11Rik; 2810431D15Rik; Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1053
                     /gene="Cep41"
                     /gene_synonym="1700017E11Rik; 2810431D15Rik; Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..3447
                     /gene="Cep41"
                     /gene_synonym="1700017E11Rik; 2810431D15Rik; Tsga14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3427..3432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep41"
                     /gene_synonym="1700017E11Rik; 2810431D15Rik; Tsga14"
                     /note="hexamer: ATTAAA"
     polyA_site      3447
                     /gene="Cep41"
                     /gene_synonym="1700017E11Rik; 2810431D15Rik; Tsga14"
                     /note="major polyA site"
ORIGIN      
        1 gggggctgga ggggggtagg aagctagatt agtagccaga cgtgaggcta gaaccccgag
       61 cgtggtcggt tggagcaaat atgtctgccc ggaggcacat tgggaatcct gagtatctga
      121 ccagacggat accacagaac ccaaggtatc aacatgtcaa gtcaagactg gatactggta
      181 acagcatgac caaatacatt gagaagctag aagagattaa aaaaaattat agatacaaaa
      241 aagatgaact tttcaagaga ctaaaagtta ccacttttgc ccagctggtc attcaagtcg
      301 cttccctgtc agatcaaaca ctggaagtga cagctgagga gatccaaagg ctcgaagaca
      361 atgattctgc aacttcagag gctgatgctg aaattgctgc caagacaaat gggaaaggga
      421 gccctgagga acagtcaccc agccctgtcc agttcatcaa cagcacggga gcaggggact
      481 ccagccgctc cactctgcag agcgtcatca gtggcgttgg ggaactggat gtagacaaag
      541 ggctcgtaaa gaaagaagaa cccaatggca aagacaagcc ttatccggac tgtcccttcc
      601 tgctgctaga tgttcgagac agagattctt atcagcagtg tcacattgtc ggggcttaca
      661 gttaccccat tgcaactcta tccaggacaa tgaaccccta ttcaaatgac attcttgagt
      721 acaagaacgc ccacggcaag atcatcatct tatacgacga ggacgagagg ctggccagcc
      781 aggcggccac caccatgtgt gagcgtgggt ttgaaaacct cttcatgctt tccgggggtc
      841 tgaaagtctt agctcagaag ttcccagaag gactggtcac tggttccctg ccagcctctt
      901 gccagcaggc cctccctttt ggttctgtcc ggaaacgacg tggccccaaa atgccagccc
      961 tgccagctga gaacaagtgg agatttaccc cagaagactt aaaaaagata gaatgttacc
     1021 tggaagagga ccagggacca gcagacaacc ctagccgact gaaccagaat aactctgctg
     1081 gaaaagactc gaaggtggct gcttgccgcg gtggccagaa cctgcccacc agctgtcctg
     1141 ccagccactc gagcccccgc acgctcacca gcggtcacct gcaaggcaaa ccctggaagt
     1201 gaaggcctgt gttgtttact caaataaatg cccccctcct ttcggaaccc tcagcgctcc
     1261 caacttggtc cttttcagaa ctgctgtaga gaaacagcca tgctacacgg gctggaccag
     1321 gcccacttgt ccgtctgcag ctccactccc ttcactcagg aaggagtctg acagatgacc
     1381 acaaaaacca gaggcttggc aggctctagt tgccctccat tgtttacaga agattcatgt
     1441 cttttgaaat tgaataggaa aaaagaaaga tactttcttt taaataaggt ccagcctgtt
     1501 tggtctgtaa ccagtgttgt tctgtaaata attcagtcac atctgctggt gtgttcttcc
     1561 cagctagctt ttttcattca ctgttgattc atgaaagatt ctccaggtgg gcctggaatt
     1621 ggccgctgtc cccacaggtg cagatgagtt cttggtttct gcagcccaca gtcctcacac
     1681 tgagtcttag ctcgctctgg aggctgcagg ctctgctggg catttgaagc tgaggggtgg
     1741 tctgtgagca tgggtgcatc ttgctggttt agcagagagg ctctgtgcaa aatgatcctc
     1801 tccttaaatg gtttcctggg accacaaaga tgtgtgttca gctttcctca ccagaaggag
     1861 ggcccagtac aggaagaccc cagcaacctg cgggtctgtg ctgagagcct tggaaggcca
     1921 ccacagctgt ccccttcata atgagcctta tatcaattaa aatttcccat tgcctgatgt
     1981 gagtccagct atgttaaagg gatagaaatc acagtcattt gaaagcatca gcttcacacg
     2041 gacaagggga cacacaggtg agggggactc aggagtcctt tgtcggggct gacaacccct
     2101 taagcccttg cttaaaaata cagtattagt ctaattgagt aattagtgca atttcctgct
     2161 tgcttttcat tctcagactg agctgtgatt aggaggctgt gattatagat tctggttttg
     2221 gccggaattt tgaatcggca ttaattgaat tgctagatga ctgacatcca ttctatttaa
     2281 ttgggggaac aaaagacctc aggtaaggat gaggcccatg aagtcagagg gaaggacgag
     2341 ccttgttaat ttttatggtc tgtgatcgta gctgtgataa gggactaaag aataaattgt
     2401 gctctttgtc atggcaacca gcttctgaaa agccagctga aaattgccta cccttaggtt
     2461 actgctgctg ggtgagagtc gccttaacag tgctattttc tcaccacttt aggaaaaaaa
     2521 gaaaaaggca aaggcccaca gtatttctag cagggaggct gtgtttgtaa gagaaataaa
     2581 cgtaataaat atctcatgga gacatatgga aaaataactc agtcaaccca gccccgcttc
     2641 agagtatgtt tattcttctc cacttgattt ccagagtgca acattttcca atgctttaga
     2701 aatcaaacaa accagggaca ttgttcagat gtcaggccgt gcccaaattt ccacaagatt
     2761 caagaatcgt gtataaaatt cagccaacgt acacatagct ttaatgagga gcctgtcgtg
     2821 tttccccata aatttattgc ctgagagctt ggttcagcct tttgctaatg ccaacatgca
     2881 ctggcttttt attttcttta cagcatagat caaaaaatgc aaatttttcc acactcaact
     2941 ttcccctagc atggacaaga ttttcagtca tctttgacac gtatacattt gtaatgaaaa
     3001 tacctttcct cggtgacaga gttctggttt gccagtttaa catcagccag tcaggaggta
     3061 gacctctaca cccaattctg ttttggaagt ctctgtctgt tcctgatctg cattcccacc
     3121 aatggatgtt agtgttggaa atgactgtat atacgtacag agactgtttc ggcaaagctg
     3181 ttagaattgc tgtgtattta ctggcgtggt ctagcaggct gaatgtattt ccatgtgttt
     3241 ctccatagct ctttgccctg ttggcaagag tctcaaactt caagagagcc gaccccttct
     3301 gcactcagtg ttcctctcca acactgttgc ttcctaacgt tccactttac cagtttcttc
     3361 attagattat ttgacatgta ttatttaaat gatcagtgat actttgtgca attatgaatg
     3421 ttgaagatta aagaacgtag ttactaaaaa aaaaaaaaaa
//
