LOCUS       NM_021440               1993 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus CEP295 N-terminal like (Cep295nl), mRNA.
ACCESSION   NM_021440
VERSION     NM_021440.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1993)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1993)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1993)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1993)
  AUTHORS   Shi,Y.Q., Li,Y.C., Hu,X.Q., Liu,T., Liao,S.Y., Guo,J., Huang,L.,
            Hu,Z.Y., Tang,A.Y., Lee,K.F., Yeung,W.S., Han,C.S. and Liu,Y.X.
  TITLE     Male germ cell-specific protein Trs4 binds to multiple proteins
  JOURNAL   Biochem Biophys Res Commun 388 (3), 583-588 (2009)
   PUBMED   19706271
REFERENCE   5  (bases 1 to 1993)
  AUTHORS   Turner,L.M., Chuong,E.B. and Hoekstra,H.E.
  TITLE     Comparative analysis of testis protein evolution in rodents
  JOURNAL   Genetics 179 (4), 2075-2089 (2008)
   PUBMED   18689890
REFERENCE   6  (bases 1 to 1993)
  AUTHORS   Jaworski,D.M., Beem-Miller,M., Lluri,G. and Barrantes-Reynolds,R.
  TITLE     Potential regulatory relationship between the nested gene DDC8 and
            its host gene tissue inhibitor of metalloproteinase-2
  JOURNAL   Physiol Genomics 28 (2), 168-178 (2007)
   PUBMED   16985004
  REMARK    GeneRIF: Results show Dcd8 was not testis specific.
REFERENCE   7  (bases 1 to 1993)
  AUTHORS   Catalano,R.D., Hillhouse,E.W. and Vlad,M.
  TITLE     Developmental expression and characterization of FS39, a testis
            complementary DNA encoding an intermediate filament-related protein
            of the sperm fibrous sheath
  JOURNAL   Biol Reprod 65 (1), 277-287 (2001)
   PUBMED   11420250
REFERENCE   8  (bases 1 to 1993)
  AUTHORS   Catalano,R.D., Vlad,M. and Kennedy,R.C.
  TITLE     Differential display to identify and isolate novel genes expressed
            during spermatogenesis
  JOURNAL   Mol Hum Reprod 3 (3), 215-221 (1997)
   PUBMED   9237247
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC100451.1, AK132657.1 and BX520604.1.
            
            On Oct 27, 2007 this sequence version replaced NM_021440.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100451.1, Y09878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1454              BC100451.1         1-1454
            1455-1976           AK132657.1         1263-1784
            1977-1993           BX520604.1         414-430
FEATURES             Location/Qualifiers
     source          1..1993
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.09 cM"
     gene            1..1993
                     /gene="Cep295nl"
                     /gene_synonym="Ddc8; FS39; Kiaa1731nl"
                     /note="CEP295 N-terminal like"
                     /db_xref="GeneID:58251"
                     /db_xref="MGI:MGI:1929713"
     exon            1..222
                     /gene="Cep295nl"
                     /gene_synonym="Ddc8; FS39; Kiaa1731nl"
                     /inference="alignment:Splign:2.1.0"
     exon            223..319
                     /gene="Cep295nl"
                     /gene_synonym="Ddc8; FS39; Kiaa1731nl"
                     /inference="alignment:Splign:2.1.0"
     exon            320..1978
                     /gene="Cep295nl"
                     /gene_synonym="Ddc8; FS39; Kiaa1731nl"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1923
                     /gene="Cep295nl"
                     /gene_synonym="Ddc8; FS39; Kiaa1731nl"
                     /note="testis specific protein, Ddc8; testis-specific
                     protein DDC8; differential display clone 8; KIAA1731
                     N-terminal like protein"
                     /codon_start=1
                     /product="CEP295 N-terminal-like protein"
                     /protein_id="NP_067415.2"
                     /db_xref="CCDS:CCDS25700.1"
                     /db_xref="GeneID:58251"
                     /db_xref="MGI:MGI:1929713"
                     /translation="MQRDTERAAQLSPSSEDEALVLRQKPLEMPAQEEDSTTLQQWKA
                     RQLQRLAEELKAEWQEARLQQVRQAERLYLSHLLDEAAERSMGNDPSVHEQNQRRTAK
                     HTRAKERNRAAFREERGRREEHPRQHPKSRKKAPCSERRSSAKARGPASGEKGKRRRV
                     SSSKDHDGYQGPRVTRRVGVAKLNPFFDGDTDCMEDVQKEFFREGRRPSAKGTHNLRD
                     QSLQGKTTALTQPLLHGPTCKQEAAAQEPPSKYNKNLWHKEIESTFEELFNMNRKLKK
                     HLNLHLEQRLKADQNPDEQQSYSEIRSETFGTPREERTEEVETAEESGSPTEVETTEM
                     WSKVNLKQILSDSEYPRYQQIAKYPLKSESLVPVKAGTSREQDDLLSLSPESGQEPPK
                     SPLLEDESLKPYLQKQADSVASWMALRQKQKAELEQRRQKALLELTEHPNMSLEIHYK
                     AELEEERRARRRMRLALLKSNSTGICALPPDRNNLSLDNGLLDEDKQNQMIRDLQQQI
                     LEQNKLHQEFLEKARKRLQEFQKSF"
     regulatory      1944..1949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep295nl"
                     /gene_synonym="Ddc8; FS39; Kiaa1731nl"
                     /note="hexamer: AATACA"
     polyA_site      1978
                     /gene="Cep295nl"
                     /gene_synonym="Ddc8; FS39; Kiaa1731nl"
                     /note="major polyA site"
ORIGIN      
        1 agggcagaca gggctgctgg cagaggtggg gagtggtaat tccacctaac ctgggtcagt
       61 gacccctgaa accccacttg gaccacctta ggacaagatt gcggtgtctg ccccttctcc
      121 gctgggaggg ggggtctttt gtgccggctg ttgggggaga acgtgtgacc aggccacgtg
      181 acctgatgca gatttaaaag tccgtcttac cagcaagaat agacagctcc atagaaagtg
      241 cctcctttca cccggccagc ctttgcctcc ctgtaatgtg tcctcattgg cctggctcag
      301 tcatctggag acgcatacca aatgcagaga gacacggagc gagcagctca gctgagccct
      361 tcttccgaag atgaagcctt agttttgagg cagaagccgt tagagatgcc agcccaagag
      421 gaggacagta ccactctgca gcagtggaaa gcacggcagc tgcaacgcct ggctgaggag
      481 ttaaaggcag agtggcagga ggcccggctg cagcaggtcc gacaggctga acgcctctac
      541 ttatcccacc tgttggacga ggcagccgag cggagcatgg gaaacgatcc cagcgtgcat
      601 gaacagaacc agagaagaac agcaaaacac acaagggcta aagagagaaa ccgagcagct
      661 ttcagagagg agcggggccg cagggaggag caccccaggc agcaccccaa gtcccggaaa
      721 aaggcaccat gctcagagag acgcagttct gccaaagccc ggggcccagc ctccggtgag
      781 aagggtaaaa ggagacgggt gtcttcaagt aaggaccacg atggctacca gggccctcgg
      841 gtgaccagaa gggtaggtgt ggcaaagctc aacccattct ttgatggaga cactgactgc
      901 atggaggacg tgcagaagga attcttccgg gaggggaggc ggccctcggc aaaggggact
      961 cacaacctca gggaccagag tctacagggc aaaacaacag ccctaactca gcccttgctc
     1021 cacggcccca cctgcaaaca agaggctgca gcccaggagc ccccaagcaa gtacaacaag
     1081 aatctgtggc acaaagaaat cgaatctacc tttgaagaat tgtttaacat gaataggaag
     1141 ctgaagaaac atttgaattt gcacctggaa cagaggctca aggcagacca gaatccagat
     1201 gagcagcaga gctactcaga gattcggagt gagacctttg gcaccccgag agaggagagg
     1261 acggaggagg tagaaaccgc cgaggagtct gggagcccaa ccgaggtgga gaccactgag
     1321 atgtggtcca aagtcaatct gaaacagata ctgagtgact cagagtaccc cagataccag
     1381 cagatagcaa agtacccgtt aaagagtgaa agcctagtgc ctgtcaaggc agggacatct
     1441 agagaacaag atgacttact ctcactaagc ccagagtcag gacaggagcc gcccaagtca
     1501 cctttgttgg aggacgaaag cctcaagcct tacctgcaga aacaggcaga ctctgtagca
     1561 agctggatgg ctttgaggca aaagcagaag gcagagttgg agcagagaag gcaaaaggca
     1621 cttttggagc tgacagaaca ccccaacatg agcttggaga tccactacaa ggctgagctg
     1681 gaggaagaac gccgggcgcg tagacggatg cgcttggctc tcctcaaatc taattccact
     1741 gggatctgtg ccctgccccc tgaccgaaac aacctgtccc tggacaacgg ccttctcgat
     1801 gaggacaaac agaaccagat gattcgtgac ctccagcagc agatcttaga gcaaaacaag
     1861 ttacaccagg agtttttgga aaaagccagg aaacgcttgc aagagtttca aaaatcattt
     1921 taaaagcaga cccacccatg ataaatacat ccctgatggc tgctttgcct gcaccgtgaa
     1981 aaaaaaaaaa aaa
//
