LOCUS       NM_001400997            9040 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus centrosomal protein 290 (Cep290), transcript variant
            1, mRNA.
ACCESSION   NM_001400997
VERSION     NM_001400997.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9040)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 9040)
  AUTHORS   Larson,D.R., Kimber,A.J., Meyer,K.J. and Anderson,M.G.
  TITLE     Anterior chamber depth in mice is controlled by several
            quantitative trait loci
  JOURNAL   PLoS One 18 (8), e0286897 (2023)
   PUBMED   37624784
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9040)
  AUTHORS   Chen,H.Y., Swaroop,M., Papal,S., Mondal,A.K., Song,H.B.,
            Campello,L., Tawa,G.J., Regent,F., Shimada,H., Nagashima,K., de
            Val,N., Jacobson,S.G., Zheng,W. and Swaroop,A.
  TITLE     Reserpine maintains photoreceptor survival in retinal ciliopathy by
            resolving proteostasis imbalance and ciliogenesis defects
  JOURNAL   Elife 12, e83205 (2023)
   PUBMED   36975211
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9040)
  AUTHORS   Potter,V.L., Moye,A.R., Robichaux,M.A. and Wensel,T.G.
  TITLE     Super-resolution microscopy reveals photoreceptor-specific
            subciliary location and function of ciliopathy-associated protein
            CEP290
  JOURNAL   JCI Insight 6 (20), e145256 (2021)
   PUBMED   34520396
  REMARK    GeneRIF: Super-resolution microscopy reveals photoreceptor-specific
            subciliary location and function of ciliopathy-associated protein
            CEP290.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9040)
  AUTHORS   Saltykova,I.V., Elahi,A., Pitale,P.M., Gorbatyuk,O.S., Athar,M. and
            Gorbatyuk,M.S.
  TITLE     Tribbles homolog 3-mediated targeting the AKT/mTOR axis in mice
            with retinal degeneration
  JOURNAL   Cell Death Dis 12 (7), 664 (2021)
   PUBMED   34215725
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9040)
  AUTHORS   McEwen,D.P., Koenekoop,R.K., Khanna,H., Jenkins,P.M., Lopez,I.,
            Swaroop,A. and Martens,J.R.
  TITLE     Hypomorphic CEP290/NPHP6 mutations result in anosmia caused by the
            selective loss of G proteins in cilia of olfactory sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 104 (40), 15917-15922 (2007)
   PUBMED   17898177
  REMARK    GeneRIF: CEP290 is a key mediator involved in G protein
            trafficking. The assessment of olfactory function can, therefore,
            serve as a useful diagnostic tool for genetic screening of certain
            syndromic ciliary diseases.
REFERENCE   7  (bases 1 to 9040)
  AUTHORS   Chang,B., Khanna,H., Hawes,N., Jimeno,D., He,S., Lillo,C.,
            Parapuram,S.K., Cheng,H., Scott,A., Hurd,R.E., Sayer,J.A.,
            Otto,E.A., Attanasio,M., O'Toole,J.F., Jin,G., Shou,C.,
            Hildebrandt,F., Williams,D.S., Heckenlively,J.R. and Swaroop,A.
  TITLE     In-frame deletion in a novel centrosomal/ciliary protein
            CEP290/NPHP6 perturbs its interaction with RPGR and results in
            early-onset retinal degeneration in the rd16 mouse
  JOURNAL   Hum Mol Genet 15 (11), 1847-1857 (2006)
   PUBMED   16632484
  REMARK    GeneRIF: a CEP290/NPHP6 mutation perturbs its interaction with RPGR
            and results in early-onset retinal degeneration
REFERENCE   8  (bases 1 to 9040)
  AUTHORS   Sayer,J.A., Otto,E.A., O'Toole,J.F., Nurnberg,G., Kennedy,M.A.,
            Becker,C., Hennies,H.C., Helou,J., Attanasio,M., Fausett,B.V.,
            Utsch,B., Khanna,H., Liu,Y., Drummond,I., Kawakami,I., Kusakabe,T.,
            Tsuda,M., Ma,L., Lee,H., Larson,R.G., Allen,S.J., Wilkinson,C.J.,
            Nigg,E.A., Shou,C., Lillo,C., Williams,D.S., Hoppe,B., Kemper,M.J.,
            Neuhaus,T., Parisi,M.A., Glass,I.A., Petry,M., Kispert,A., Gloy,J.,
            Ganner,A., Walz,G., Zhu,X., Goldman,D., Nurnberg,P., Swaroop,A.,
            Leroux,M.R. and Hildebrandt,F.
  TITLE     The centrosomal protein nephrocystin-6 is mutated in Joubert
            syndrome and activates transcription factor ATF4
  JOURNAL   Nat Genet 38 (6), 674-681 (2006)
   PUBMED   16682973
REFERENCE   9  (bases 1 to 9040)
  AUTHORS   Valente,E.M., Silhavy,J.L., Brancati,F., Barrano,G.,
            Krishnaswami,S.R., Castori,M., Lancaster,M.A., Boltshauser,E.,
            Boccone,L., Al-Gazali,L., Fazzi,E., Signorini,S., Louie,C.M.,
            Bellacchio,E., Bertini,E., Dallapiccola,B. and Gleeson,J.G.
  CONSRTM   International Joubert Syndrome Related Disorders Study Group
  TITLE     Mutations in CEP290, which encodes a centrosomal protein, cause
            pleiotropic forms of Joubert syndrome
  JOURNAL   Nat Genet 38 (6), 623-625 (2006)
   PUBMED   16682970
  REMARK    GeneRIF: identified mutations in the CEP290 gene in five families
            with variable neurological, retinal and renal manifestations
REFERENCE   10 (bases 1 to 9040)
  AUTHORS   Chang,B., Hawes,N.L., Hurd,R.E., Wang,J., Howell,D., Davisson,M.T.,
            Roderick,T.H., Nusinowitz,S. and Heckenlively,J.R.
  TITLE     Mouse models of ocular diseases
  JOURNAL   Vis Neurosci 22 (5), 587-593 (2005)
   PUBMED   16332269
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153501.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN01766828 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AC153501.2         87583-87753
            172-301             AC153501.2         88280-88409
            302-379             AC153501.2         88563-88640
            380-449             AC153501.2         89321-89390
            450-496             AC153501.2         90148-90194
            497-640             AC153501.2         92649-92792
            641-694             AC153501.2         94902-94955
            695-715             AC153501.2         95642-95662
            716-868             AC153501.2         95824-95976
            869-1051            AC153501.2         96690-96872
            1052-1141           AC153501.2         97941-98030
            1142-1264           AC153501.2         99063-99185
            1265-1388           AC153501.2         100148-100271
            1389-1561           AC153501.2         101104-101276
            1562-1724           AC153501.2         108665-108827
            1725-1825           AC153501.2         110488-110588
            1826-1913           AC153501.2         110663-110750
            1914-2026           AC153501.2         112288-112400
            2027-2785           AC153501.2         112585-113343
            2786-2878           AC153501.2         113562-113654
            2879-2963           AC153501.2         113921-114005
            2964-3106           AC153501.2         114459-114601
            3107-3271           AC153501.2         115135-115299
            3272-3421           AC153501.2         116155-116304
            3422-3537           AC153501.2         117778-117893
            3538-3640           AC153501.2         118455-118557
            3641-3871           AC153501.2         118646-118876
            3872-4045           AC153501.2         123231-123404
            4046-4157           AC153501.2         128550-128661
            4158-4363           AC153501.2         130019-130224
            4364-4515           AC153501.2         131102-131253
            4516-4627           AC153501.2         136807-136918
            4628-5083           AC153501.2         137437-137892
            5084-5248           AC153501.2         138927-139091
            5249-5356           AC153501.2         139985-140092
            5357-5491           AC153501.2         140337-140471
            5492-5758           AC153501.2         141551-141817
            5759-5866           AC153501.2         142418-142525
            5867-6066           AC153501.2         143243-143442
            6067-6280           AC153501.2         144918-145131
            6281-6418           AC153501.2         146376-146513
            6419-6640           AC153501.2         148729-148950
            6641-6763           AC153501.2         149254-149376
            6764-6909           AC153501.2         151365-151510
            6910-7065           AC153501.2         151818-151973
            7066-7189           AC153501.2         154412-154535
            7190-7324           AC153501.2         158072-158206
            7325-7411           AC153501.2         159606-159692
            7412-7576           AC153501.2         161241-161405
            7577-7699           AC153501.2         162110-162232
            7700-7872           AC153501.2         163267-163439
            7873-8014           AC153501.2         167012-167153
            8015-8088           AC153501.2         168082-168155
            8089-8183           AC153501.2         168816-168910
            8184-8263           AC153501.2         172064-172143
            8264-9040           AC153501.2         172881-173657
FEATURES             Location/Qualifiers
     source          1..9040
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 51.48 cM"
     gene            1..9040
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /note="centrosomal protein 290"
                     /db_xref="GeneID:216274"
                     /db_xref="MGI:MGI:2384917"
     exon            1..171
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            172..301
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..8491
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centrosomal protein of 290 kDa; nephrocystin-6;
                     Bardet-Biedl syndrome 14 protein homolog"
                     /codon_start=1
                     /product="centrosomal protein of 290 kDa isoform 1"
                     /protein_id="NP_001387926.1"
                     /db_xref="GeneID:216274"
                     /db_xref="MGI:MGI:2384917"
                     /translation="MPPNIKWKELIKVDPDDLPRQEELADKLLISLSKVEVNELKNED
                     QENMIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQ
                     QSAGGRDTRFLRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENS
                     KLRRENKRLKKKNEQLRQDIIDYQKQIDSQKESLLSRRGEDSDYRSQLSKKNYELVQY
                     LDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKALVHQSDAVMDQIKK
                     ENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEWKLILSSKDDEIIEYQQMLQSL
                     RGKLKNAQLDADKSNIMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNEL
                     QKDKGTSNFYQQTHYMKIHSKVQILEEKTKEAERIAELAEADAREKDKELVEALKRLK
                     DYESGVYGLEDAVIEIKNCKAQIKIRDGEMEVLTKEINKLEMKINDILDENEALRERA
                     GLEPKTMIDLTEFRNSKRLKQQQYRAENQVLLKEIESLEEERLDLKRKIRQMAQERGK
                     RNAASGLTIDDLNLSETFSHENKIEGRKLNFMSLNNMNETQSKIKSSAKTELLHRRPS
                     FSVVQSDQSEAEENMATRSLSRMLSGIHQSVGSAGDPIVSLTRCSSFMQVKDSSATPE
                     AITIREIFKAPCLRSLRKLESLVSTFSKDGSEELSEYLCSLSDDHMKRGSGNHRGLEK
                     TRFLQKSSSSFQVSPAAAELMQKLSHRQSSAIFPQQSYDRDVDKVTSEDNQVYSQIEH
                     AVLSLKDDKGQSELPSQTEMLSSKTQVNLSDLVPITAQSKPSLIHPLEKLIGQPQRQL
                     AFLRSQNETIVQDLPIQEEQSRNAELELDHQRSQAEQNEFLSRELAEKEKDLERSRTV
                     IAKFQSKLKELVEENKQLEEGMKEILQAIKDMPKDSDVKGGETSLIIPSLERLVNAME
                     SKNAEGIFDASLHLKAQVDQLTGRNEELRQELRQSRKEAVNYSQQLVKANLKIDHLEK
                     ETDLLRQSAGSNVVYKGIDLPDGIAPSSAYIINSQNEYLIHLLQELDNKEKKLKHLED
                     SLEDYNRKFAVIRHQQSLLYKEYLSEKDIWKTDSEMIREEKRKLEDQAEQDAVKVKEY
                     NNLLSALQMDSNEMKKMLSENSRKITVLQVNEKSLIRQYTTLVEMERHLRKENGKHRN
                     DVIAMEAEVTEKLGSLQRFKEMAIFKIAALQKVIDNSVSLSELELANKQYNELTTKYR
                     DILQKDNMLVQRTSNLEHLECENASLKEQMEAISKELEITKEKLHTIEQAWEQETKLG
                     NDSNMDKAKKSMTNSDIVSISKKITVLEMKELNERQRAEHCQKMYEHLRTSLKQMEER
                     NFELETKFTELTKINLDAQKVEQMLRDELADSVTKAVSDADRQRILELEKSEVELKVE
                     VSKLREISDIAKRQVDFLNSQQQSREKEVESLRTQLLDFQAQSDEKALIAKLHQHVVS
                     LQISEATALGKLESVTSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTI
                     QSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLELELKL
                     KGLEELISTLKDARGAQKVINWHVKIEELRLQELKLNRELVKGKEEIKYLNNIISEYE
                     HTINSLEEEIVQQSKFHEERQMAWDQREVELERQLDIFDHQQNEILSAAQKFEDSTGS
                     MPDPSLPLPNQLEIALRKIKENIQVILKTQATCKSLEEKLKEKESALRLAEQNILSRD
                     KVINELRLRLPATADREKLIAELERKELEPKSHHTMKIAHQTIANMQARLNHKEEVLK
                     KYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQADNSLNKFRQTAQDLLKQSPAPVP
                     TNKHFIRLAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITELKVREFENTKLRLQ
                     ETHASEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEANSRAPTTTMRNLVDRLK
                     SQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVERHTRELKS
                     QIEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGIDQEN
                     DELRRQIKRLSSGLQSKTLIDNKQSLIDELQKKVKKLESQLERKVDDVDIKPVKEKSS
                     KEELIRWEEGKKWQTKVEGLRNRLKEKEGEAHGLAKQLNTLKELFAKADKEKLTLQKK
                     LKTTGMTVDQVLGVRALESEKELEELKKKNLDLENDILYMRTQQALPRDSVVEDLHLQ
                     NKYLQEKLHTLEKKLSKEKYSQSLTSEIESDDHCQKEQELQKENLKLSSENIELKFQL
                     EQANKDLPRLKNQVKDLKEMCEFLKKGKLELERKLGQVRGAGRSGKTIPELEKTIGLM
                     KKVVEKVQRENEQLKKASGILTSEKMATIEEENRNLKAELEKLKAHFGRQLSMQFESK
                     NKGTEKIVAENERLRKELKKEIEASEKLRIAKNNLELVNDKMAAQLEETGKRLQFAES
                     RAPQLEGADSKSWKSIVVSRVYETKMKELESDIAKKNQSITDLKQLVREATEREQKAK
                     KYTEDLEQQIEILKNVPEGAETEQELIRELQLLRLANNQMDKERAELIHQIEINKDQT
                     RADSSIPDSDQLKEKINDLETQLRKLELEKQHSKEEVKKLKKELENFDPSFFEEIEDL
                     KYNYKEEVKKNILLEEKLKKLSEQFGFELPSPLAASEHSEDGESPHSFPIY"
     exon            302..379
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            380..449
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            450..496
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            497..640
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            641..694
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            695..715
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            716..868
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1051
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1141
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1264
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1388
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1561
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1724
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1825
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1913
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2026
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2785
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2878
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..2963
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3106
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3271
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3272..3421
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3422..3537
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3640
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3641..3871
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3872..4045
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            4046..4157
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            4158..4363
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            4364..4515
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            4516..4627
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            4628..5083
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            5084..5248
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            5249..5356
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            5357..5491
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            5492..5758
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            5759..5866
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            5867..6066
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            6067..6280
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            6281..6418
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            6419..6640
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            6641..6763
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            6764..6909
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            6910..7065
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            7066..7189
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            7190..7324
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            7325..7411
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            7412..7576
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            7577..7699
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            7700..7872
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            7873..8014
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            8015..8088
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            8089..8183
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            8184..8263
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     exon            8264..9040
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      8556
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /note="major polyA site"
     regulatory      9017..9022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
                     /note="hexamer: AACAAA"
     polyA_site      9040
                     /gene="Cep290"
                     /gene_synonym="b2b1454Clo; b2b1752Clo; Nphp6"
ORIGIN      
        1 gagtggtgtc gcctagcagc cggcgccgct tcggctcggt cgggaagagt tggcgggagc
       61 agcctgagtg cgcgaggacc gctctgggaa gcgtgaggcc ggggcggtgg ccgaacccgg
      121 aggtggtcgc tgtagatgag tgactgctgc tggtggcagg tcttggtttc gaggctgaga
      181 gacagtgaaa gaattcaaga tgccacctaa tataaagtgg aaagaattaa tcaaagttga
      241 tccagatgac ctgccacggc aagaagagtt agcagataaa ttattgatat ctttatccaa
      301 ggtggaagta aatgaactaa aaaatgaaga ccaagaaaac atgatacatc tattcagaat
      361 tacccagtct ctaatgaaga tgaaagccca ggaagtagag ctcgctttgg aagaagttga
      421 aaaggctgga gaagaacaag caaaatttga aaatcaatta aagacaaaag taatgaaact
      481 ggaaaatgaa ctggagatgg ctcagcagtc tgcaggggga cgtgacactc ggtttttacg
      541 tgacgaaatt cgccaacttg agaagcagct ggaacaaaaa gatagagaat tagaggatat
      601 ggaaaaagaa ttggataaag aaaagaaggt taatgaacaa ttggctcttc gaaatgagga
      661 ggcagaaaat gaaaacagca aattaagaag agagaacaaa cgtctaaaga aaaagaatga
      721 gcagcttcgg caggacatta ttgactacca gaaacaaata gattcacaga aagaatcact
      781 tctgtcaagg agaggagaag acagtgacta ccgatcacag ttgtctaaaa agaactatga
      841 acttgttcaa tatctggacg aaatacagac cttaacagaa gctaatgaga agattgaagt
      901 tcagaaccaa gaaatgagga aaaacctgga agagtctgtg caggagatgg agaagatgac
      961 tgatgagtac aacaggatga aagcgcttgt gcatcagtcg gatgctgtca tggaccagat
     1021 caagaaggag aatgagcact atcgcctgca agttcgagag ctcacggatc ttctgaaggc
     1081 gaaggatgaa gaggacgatc cagtcatgat ggctgttaac gcaaaagtgg aagagtggaa
     1141 gttaattttg tcttctaaag atgatgaaat cattgaatat cagcaaatgc tacagagtct
     1201 gagagggaaa cttaaaaatg cccaacttga tgcagacaaa agtaacatca tggctctgaa
     1261 acagggtatc caggagcgag acagtcaaat taagatgctt actgagcaag tagaacagta
     1321 tacgaaagaa atggaaaaaa atacgtttat tattgaagat ttgaaaaatg aactccaaaa
     1381 agacaaaggt acttcaaact tttatcagca gactcattat atgaaaattc actcaaaagt
     1441 acaaatttta gaagagaaaa caaaagaggc cgagagaata gctgagctgg ctgaggctga
     1501 tgccagggag aaggacaaag aattggttga ggctctgaag agattaaaag attatgaatc
     1561 tggagtatat ggcttagaag atgctgttat cgaaataaag aattgtaaag cccaaattaa
     1621 aataagagat ggagagatgg aagtgttgac caaggagatc aataagcttg agatgaagat
     1681 caatgacatc cttgatgaaa acgaagccct tagagagcgg gctggccttg aacccaagac
     1741 aatgattgat ttgactgaat ttagaaacag caaacggtta aagcagcaac agtacagagc
     1801 tgagaaccag gttcttttga aagagatcga aagtctagag gaggagcgtc ttgacttgaa
     1861 aagaaagatt cgtcaaatgg ctcaagaaag aggcaaaagg aacgcagcct caggattaac
     1921 cattgacgac ttgaacttat ctgaaacctt ttctcatgaa aataaaatag aaggaagaaa
     1981 actaaatttt atgagcctca ataatatgaa tgaaacacaa tcaaagatta agagttcagc
     2041 taaaacagag ctgctgcata ggaggccatc attcagtgtt gtacagtcag atcaaagtga
     2101 ggcagaggag aacatggcca cacgatcctt atcgagaatg ctgtctggaa tccatcagag
     2161 tgtaggcagt gcaggggacc ctattgtctc cttaaccaga tgctcctcat ttatgcaagt
     2221 gaaagacagc agtgcaactc cagaagctat tacaataagg gagattttta aagcaccatg
     2281 cctacgatct ttgagaaagc tagaatcgtt agtcagtacc ttcagtaagg acggcagtga
     2341 agaactaagt gaatacttat gctctctctc tgatgaccat atgaagagag ggtcaggaaa
     2401 ccatcgaggt ctagagaaaa ccaggttcct acagaagagc agttcatctt ttcaagtgtc
     2461 accagcagct gcagaattaa tgcagaaact atcacatagg cagagctccg caatatttcc
     2521 tcaacagtcg tatgaccgtg atgtggataa agtaacgtca gaagataacc aggtctattc
     2581 tcaaatagag catgccgttc tcagtttgaa agacgataaa ggacaaagtg aattaccctc
     2641 ccaaactgag atgctgagca gtaagaccca agtgaatctt tcagatcttg tgcccattac
     2701 tgcccagtcc aaaccgtctc tgatacaccc ccttgaaaag ctcatagggc agccacagcg
     2761 ccagctagcg ttccttaggt ctcagaacga aaccatagtt caggacttac cgatccaaga
     2821 agagcagagt agaaatgcag aattagaact tgaccatcag agaagccagg cagaacagaa
     2881 tgagtttctt tcaagagaat tggctgaaaa ggaaaaagat ttagaaagaa gtaggacagt
     2941 aattgctaaa ttccagagta aactaaaaga attagtcgaa gaaaataagc aacttgaaga
     3001 aggtatgaaa gaaattttgc aagctattaa ggacatgccg aaggattctg atgtgaaagg
     3061 aggtgaaaca tctttaatca tcccgagtct tgaaagactg gttaacgcta tggaatcaaa
     3121 gaatgcagaa ggaatcttcg atgccagctt gcatctaaaa gcccaagttg accaacttac
     3181 aggaaggaat gaagaattaa ggcaagaact caggcaatct cggaaagagg ctgtaaatta
     3241 ttcacagcag ttggtaaaag caaacttaaa gattgaccac cttgagaagg aaactgacct
     3301 tctacgtcag tctgcaggct ccaatgtagt atacaaaggc atagacttac ccgatgggat
     3361 agcaccatcc agtgcctata tcatcaattc tcagaatgaa tacttaatac atcttttgca
     3421 ggaactagac aataaagaaa agaaattaaa acatttagaa gattcccttg aagattataa
     3481 cagaaagttt gcagtgattc gtcatcaaca aagtttatta tataaagaat acctaagtga
     3541 aaaggatatt tggaaaacag actctgagat gataagagag gagaagagaa aactggaaga
     3601 tcaagctgag caggatgctg tgaaagtaaa agagtacaac aatttgctca gtgctcttca
     3661 gatggattcg aacgagatga agaaaatgct ctcagaaaac agtaggaaaa tcaccgttct
     3721 gcaagtgaac gagaagtccc tcatccggca gtacaccacc ttagtggaga tggagcggca
     3781 cctgagaaag gaaaacggga aacacaggaa tgacgtcata gccatggaag ccgaagtcac
     3841 tgaaaaactt ggaagtttgc aaagattcaa ggaaatggcc atcttcaaga ttgcagctct
     3901 tcagaaggtt atagataata gtgtttcttt gtctgaatta gaactagcca ataaacagta
     3961 caatgagctg actactaagt acagggacat cttgcagaaa gataatatgc ttgttcaaag
     4021 aacaagtaac ttagaacacc tggagtgtga gaatgcatcg ctaaaagaac agatggaggc
     4081 tatcagtaaa gagctggaga ttacaaagga aaaactccat accattgaac aggcctggga
     4141 acaagaaacg aagttaggaa atgactcaaa catggataag gctaagaaat caatgacaaa
     4201 cagtgacatt gtttctattt caaagaaaat cactgtgttg gagatgaagg aattaaatga
     4261 aaggcagagg gctgaacact gtcagaaaat gtatgagcac ttaaggactt cattaaagca
     4321 aatggaagaa cgtaattttg aattggaaac caagttcact gagcttacta aaatcaacct
     4381 ggatgcacaa aaggtggagc agatgttgag agacgaatta gctgatagtg tgaccaaggc
     4441 agtaagtgat gctgaccgac agcggattct agaactagag aagagtgaag tggagctcaa
     4501 agttgaagtg tccaagctga gagagatttc agatattgcc aaaagacaag ttgatttttt
     4561 gaattcgcaa caacagtcca gggaaaagga agtggaatcc ctcagaacgc agctgctgga
     4621 cttccaggca caatctgacg aaaaggctct aattgccaaa ttgcaccaac atgttgtctc
     4681 tcttcaaatt agtgaggcca ctgccctcgg taagttagag tcagttacgt ccaaactcca
     4741 gaagatggaa gcctacaatt tgcgcttaga acagaaactg gatgaaaaag agcaggcgct
     4801 ctactatgct cgtttggaag gtagaaacag agcaaaacac ctgcgccaaa ccattcagtc
     4861 gcttcgaaga cagttcagtg gagctctacc cttagcacag caggaaaagt tctccaaaac
     4921 gatgattcag ttgcaaaatg acaaacttaa gataatgcaa gaaatgaaga attcgcaaca
     4981 ggaacacaga aatatggaaa acaaaacact ggagttggaa ttaaaattaa aaggcttaga
     5041 agaattgatc agtactttaa aggatgccag gggagcccag aaggtaatca attggcatgt
     5101 gaaaatagaa gaacttcgcc tccaagaact taagctaaat agagaactag tcaagggtaa
     5161 agaagaaatc aaatatttga ataatatcat ctctgaatat gagcatacaa tcaacagtct
     5221 agaggaagaa attgttcagc aaagcaagtt ccatgaagaa agacagatgg cttgggatca
     5281 aagagaagtt gagctggaac gccagttaga catttttgat catcagcaaa atgaaatact
     5341 cagtgcagca caaaagtttg aagactctac aggatcaatg ccagacccca gcttgcctct
     5401 tccaaaccaa cttgaaattg ctctaagaaa aattaaggag aatattcaag taattcttaa
     5461 aacacaagca acttgcaagt cactagaaga gaaactaaaa gaaaaagaat ctgctttacg
     5521 gttggcagag caaaatattc tgtcaagaga caaagtaatc aatgaactga ggcttcgatt
     5581 gcctgccacg gctgatcgag aaaaacttat agctgagcta gaaagaaaag agctggagcc
     5641 gaaatctcat cacacaatga aaattgccca ccaaactatt gccaacatgc aggcaaggtt
     5701 aaatcacaag gaagaagtat tgaagaaata ccagcacctt ctggagaagg ccagagagga
     5761 gcaaagagaa attgttaaga agcatgagga agaccttcat gttcttcatc acaaattaga
     5821 acaacaggcc gataattcac tcaataaatt cagacagaca gctcaggatt tacttaagca
     5881 gtctcctgct ccagttccca ccaacaaaca tttcattcgt ctggccgaga tggagcagac
     5941 agtagcagaa caagatgact ctctgtcctc acttttgacc aaactaaaga aagtatcaaa
     6001 agatttggaa aaacaaaaag aaatcactga gttaaaagtc agagagtttg aaaataccaa
     6061 actacggctc caagaaactc atgccagtga ggtaaagaaa gtgaaagcag aggtagagga
     6121 cttaaggcat gctctagccc aagcacacaa ggactcccag agtttaaagt ctgaactcca
     6181 ggctcagaaa gaagcaaact ccagagctcc aacaaccaca atgaggaatc ttgtagacag
     6241 gctaaagagc caactagcct tgaaagagaa gcaacaaaag gcacttagtc gagccctgtt
     6301 ggaacttcgg tcggaaatga cagcagcagc tgaggaacgt ataatcgctg taacttctca
     6361 aaaagaggca aatctcaatg ttcaacaagt tgttgagcgc catactagag agctaaagtc
     6421 acaaattgaa gatttaaatg aaaatctttt aaaattgaaa gaagctctta aaacaagtaa
     6481 gaacaaagaa aattcactag ctgatgattt aaatgaatta aataatgaac tgcaaaaaaa
     6541 gcaaaaagct tataataaaa tccttagaga gaaagatgga attgatcaag aaaatgatga
     6601 actgagaaga cagattaaaa gactgtccag tggactgcag agcaaaactt tgatagataa
     6661 caagcaaagt ttaatcgatg aacttcaaaa gaaagttaaa aaacttgaaa gccaactgga
     6721 aagaaaggtg gatgacgtag acataaagcc ggtgaaggaa aagagtagta aagaagaatt
     6781 aattaggtgg gaagaaggta agaaatggca aaccaaagta gagggactac gaaacagact
     6841 aaaggagaag gaaggagaag cccacggcct ggcaaagcag ctgaatacct taaaggaact
     6901 ttttgccaaa gctgataaag agaaacttac tttgcagaag aaactgaaaa caacaggaat
     6961 gactgttgac caggttttag gagtgcgagc tttggaatct gaaaaagagt tggaagagct
     7021 aaaaaagaaa aatctggacc tagaaaatga catattatac atgaggaccc agcaggctct
     7081 tccacgagat tctgttgtgg aagacttaca tttacaaaat aaataccttc aagaaaaact
     7141 tcatacttta gaaaaaaaac tttcaaagga gaaatattct cagtctttga cttcagaaat
     7201 agagtcagat gatcactgtc aaaaagaaca agaacttcag aaggaaaatt tgaagttgtc
     7261 atctgaaaac atcgagctga aatttcaact tgaacaagca aataaagatt tgccaagact
     7321 aaagaatcaa gtgaaagatt tgaaggaaat gtgtgaattt cttaagaaag gaaaactgga
     7381 acttgagcgg aagcttggtc aggtcagagg ggctggtaga agtgggaaga caatcccaga
     7441 actagaaaaa accattgggt taatgaagaa agtagttgaa aaagtccaaa gagaaaatga
     7501 acaattgaaa aaggcatcag gaatactgac tagtgaaaaa atggctacta ttgaggaaga
     7561 aaatagaaac ttaaaggctg aactagaaaa gcttaaagct cactttggac gtcagttgag
     7621 tatgcagttt gaatctaaga acaaaggtac tgagaaaatt gttgccgaaa atgaacggct
     7681 tcggaaagaa cttaagaaag aaatagaagc ctctgagaaa ctgcggatag ctaagaacaa
     7741 cttagagctg gtgaacgaca agatggcagc tcaactcgaa gaaactggga agagactaca
     7801 gtttgcagaa agtagagccc cacagctgga aggtgctgac agcaagagct ggaagtcaat
     7861 tgtggtctca agagtgtatg agaccaagat gaaagagctt gaaagtgaca ttgccaaaaa
     7921 gaatcaaagt atcactgacc ttaaacagct tgtaagagaa gcaacagaga gagaacagaa
     7981 agctaagaaa tacactgaag accttgaaca acagattgag atcctcaaaa atgttcctga
     8041 aggtgccgag acagagcaag agcttatacg ggaactccag cttcttagat tagccaataa
     8101 tcagatggat aaagaaaggg cagaattaat ccatcagata gaaattaaca aggaccaaac
     8161 cagagctgac agtagcatac ctgattctga tcaactaaag gaaaagataa atgacctgga
     8221 gacacaactc agaaagttgg agctagaaaa gcaacattcg aaggaggaag ttaaaaagct
     8281 gaaaaaagaa ctggaaaatt ttgatccttc attttttgaa gaaattgaag acctgaagta
     8341 taattataag gaagaagtga aaaagaatat cctattagaa gagaagctaa aaaaactgtc
     8401 ggaacagttt ggatttgaac tgcctagtcc tcttgctgct tctgaacact cggaagatgg
     8461 agaaagtcct catagtttcc ctatttatta gtgccctcgt gtaactgcag gtttaaaact
     8521 attttatgag tgaaaaaagt ttcagctgga aatcaagcag tctctgtgtt atagaattta
     8581 cagctcaaaa tattgtattt tttttgttta aaaaaatcat atttagtttt aacttgttag
     8641 aaaagtatat ttttgaagac ttcattaatt tatgactata cagtgcacaa tgagctatga
     8701 taaatattac tattttcata ataacttaaa ttttcaaaaa gcataaaggt aagcttatat
     8761 caatttacta tttaaaattg attattttat atttattttt gtgttaagat agtcaaatcc
     8821 taacgatgat ttctataaat acctagaaac atgtttagaa gttgacaggt tttgccaaac
     8881 agctagcaaa attaaatgca aactattcag tcttagaaaa tcacaataat ctcaacaatt
     8941 agttccattt tatacatcaa gtattatgtc tttgagtctc tcaaatttct gtttatctat
     9001 ttttgaaaac tgattaaaca aagactggtt atcaaaagca
//
