LOCUS       NM_027556               8125 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus centrosomal protein 192 (Cep192), mRNA.
ACCESSION   NM_027556
VERSION     NM_027556.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8125)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8125)
  AUTHORS   Guo,J., He,W.B., Dai,L., Tian,F., Luo,Z., Shen,F., Tu,M., Zheng,Y.,
            Zhao,L., Tan,C., Guo,Y., Meng,L.L., Liu,W., Deng,M., Wu,X.,
            Peng,Y., Zhang,S., Lu,G.X., Lin,G., Wang,H., Tan,Y.Q. and Yang,Y.
  TITLE     Mosaic variegated aneuploidy syndrome with tetraploid, and
            predisposition to male infertility triggered by mutant CEP192
  JOURNAL   HGG Adv 5 (1), 100256 (2024)
   PUBMED   37981762
  REMARK    GeneRIF: Mosaic variegated aneuploidy syndrome with tetraploid, and
            predisposition to male infertility triggered by mutant CEP192.
REFERENCE   3  (bases 1 to 8125)
  AUTHORS   Siguero-Alvarez,M., Salguero-Jimenez,A., Grego-Bessa,J., de la
            Barrera,J., MacGrogan,D., Prados,B., Sanchez-Saez,F.,
            Pineiro-Sabaris,R., Felipe-Medina,N., Torroja,C., Gomez,M.J.,
            Sabater-Molina,M., Escriba,R., Richaud-Patin,I.,
            Iglesias-Garcia,O., Sbroggio,M., Callejas,S., O'Regan,D.P.,
            McGurk,K.A., Dopazo,A., Giovinazzo,G., Ibanez,B., Monserrat,L.,
            Perez-Pomares,J.M., Sanchez-Cabo,F., Pendas,A.M., Raya,A.,
            Gimeno-Blanes,J.R. and de la Pompa,J.L.
  TITLE     A Human Hereditary Cardiomyopathy Shares a Genetic Substrate With
            Bicuspid Aortic Valve
  JOURNAL   Circulation 147 (1), 47-65 (2023)
   PUBMED   36325906
  REMARK    Erratum:[Circulation. 2023 Jan 17;147(3):e63. doi:
            10.1161/CIR.0000000000001129. PMID: 36649398]
REFERENCE   4  (bases 1 to 8125)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8125)
  AUTHORS   Lee,I.W., Jo,Y.J., Jung,S.M., Wang,H.Y., Kim,N.H. and Namgoong,S.
  TITLE     Distinct roles of Cep192 and Cep152 in acentriolar MTOCs and
            spindle formation during mouse oocyte maturation
  JOURNAL   FASEB J 32 (2), 625-638 (2018)
   PUBMED   28970258
  REMARK    GeneRIF: results demonstrate the different roles of Cep192 and
            Cep152 in MTOC remodeling and a novel regulatory mechanism during
            meiotic spindle formation in mouse oocytes.
REFERENCE   6  (bases 1 to 8125)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   7  (bases 1 to 8125)
  AUTHORS   Zhu,F., Lawo,S., Bird,A., Pinchev,D., Ralph,A., Richter,C.,
            Muller-Reichert,T., Kittler,R., Hyman,A.A. and Pelletier,L.
  TITLE     The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis
  JOURNAL   Curr Biol 18 (2), 136-141 (2008)
   PUBMED   18207742
REFERENCE   8  (bases 1 to 8125)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (bases 1 to 8125)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 8125)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052420.1, AK158414.1, BE982606.1, CO045915.1, AC127236.3,
            CD538408.1, CK391255.1, BC064462.1 and CK639048.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1557              AK052420.1         3-1559
            1558-2106           AK158414.1         1533-2081
            2107-2143           BE982606.1         49-85
            2144-2730           CO045915.1         8-594
            2731-3127           AC127236.3         50177-50573
            3128-3242           AC127236.3         50664-50778
            3243-3287           AC127236.3         53172-53216
            3288-3541           CD538408.1         1-254
            3542-3954           CK391255.1         31-443
            3955-4511           BC064462.1         1-557
            4512-5172           CK639048.1         1-661
            5173-8125           BC064462.1         1215-4167
FEATURES             Location/Qualifiers
     source          1..8125
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 40.11 cM"
     gene            1..8125
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /note="centrosomal protein 192"
                     /db_xref="GeneID:70799"
                     /db_xref="MGI:MGI:1918049"
     exon            1..80
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            81..251
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            252..419
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..7800
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /codon_start=1
                     /product="centrosomal protein of 192 kDa"
                     /protein_id="NP_081832.1"
                     /db_xref="CCDS:CCDS50313.1"
                     /db_xref="GeneID:70799"
                     /db_xref="MGI:MGI:1918049"
                     /translation="MEDFRGIAEESFPSFLANSLLGNSEVLGNVTLSSNFGLPIAVST
                     LARSRPSTDNRCPDVQESYLIEERFSVPSASSPSCQSDNPEPRERLRLSFQGDDSALR
                     KKNYIESPDLSHALMKPRAEEKQANAASVQGQSLLGGVSPLQQVPDSALDFHLKSWTN
                     HEEHNIAMPDPKKHFEAVNPNRDFSHTSLLDNEKLLTLTNLDSSSDDDINDEEFYDDH
                     LEAYFEQLAIPGMMYEAGGQESPADDFKFPANEDSILNCEFQSENNSPRLPHDACTSG
                     NSPTAHTESEGGHGCPPGTSGCVGTVDNKMQVDNVMSLYSHAWRNEKEAAHNLKDIVP
                     NQSRGCGGEEIVVKRLCAVDETLRSTYRHSTETEDGFDPADYIKQDSESPHQNKHFAS
                     DLETVPNVDRCLNTETPTVFIQKDGDIAASSKTNGDNGINSPDTLWSPTSERRACGLY
                     ESDSKTSDKGELSQNVVYKSEDGRWVTDLAYYTSFIDQQDLQMSPNNEMNEDFRSGSD
                     ALDLIAKDEEEFNKEHPFIQDEKIDVQNTPVALGDNSWVATVNYHLLRKSLGTSDFDK
                     DNGSYLRLSLGEFFAERSEALGCLGGGKDVKRPSFGYFIRSPEEREPVALIKSDLSRS
                     DLEKEATQPYRGFSSGDLNEQSQVQLSEGSVMLKAEELQRNSQVDEDDITLTASRNQT
                     EDTLCSNNKLQEYKNTLSGGEDSVLRISTIASAFADVSVSTDPAQLVTMMKALRNKGR
                     SKPFQDDGTQEDCPNISHVLLNDLEKSNRSNAFDMEKYLTKTEFSSCEGAREPLSRAG
                     TSDMWDLCSPERQTVQDRSMVNVCATNSREAEETTAAIFCAENIESDTQESLRTIASS
                     DSVLTSTRENRNSAMGRMPPSVDTLLDVRNSEKAASVSIAASRSDSLLRNPRVPSFSI
                     VEQCEEIQDNRDHGRKKECVSETSSSDKHVTFEDGLVVLPKSVDLKTASPESGRSGFQ
                     DEESFRLSPLSHSSPSEISGNFAGCVLESLDSAYHQRPHLESELSQLACSHADMSRLT
                     YVSEQENTFPVTAADESSEDHKSDLTSELSTTIVRASPTPPREQAVEKPRDKIPGQNA
                     EKVSMPWVIQSKSGLANMRETPSLRTGFEDGEPNFTSSQDISSESREPLEAGKMMDST
                     SGSSEQDLIGQALLDKPALNHRSGPAVPNLPELIQKTVDQGQRLSSTRLSAASSEASS
                     QVPNPGASGTQHNPAPHISAHASVAKVMNQPAVCPALWTGHSLYIAPGAPSGNATLSQ
                     CHAGMQVCGISGYSPYPAAAPELVASGLYLGPSLASGLMAPSSLYNLCSTAAPQNLLS
                     TAKPFPMVTNCETEPRDSGMMPAFGNARVPEELRFPHACCVGIASQTLLSVLNPTDHW
                     LQVSIRVLSIWVNGEKVDLSTQTCLVFKNKVVIRPQATEEIKILFIPTSSGIFRCTFS
                     VASWLFSADADTVGQAEALGSRVTLTAIAETPVIEVETEKKGVLDFGDLTYAGWKALP
                     LKLINRTHATVPIRLIINANAVAWRCFTFSKEPIHVSLKAAPHADITAQLAAPSVVSH
                     VMPASYDGKDPEFLVVWVIFHSPKKLLTSEILGSAEEFLARVDIEVDSPNPIPVLRSV
                     ALRARAGVARIHAPRDLQTVYLLADVNSSTKHPLPLKNAGNIEVHLDIKVAEQGSQFS
                     VDPESLFLRPGEEHEVTISFTPKDSKACEERILIIFVQPLGPQYEVVLRGEVISSGSK
                     PLPPGPHCSDIPLILSNKQFLTWGGIPLGRTQLQKLALRNSSTTTAQNLRLFIKGQDQ
                     DCFQIQNTFGSEERLTSNCEIRICPGEDFVISVLFAPTRLSCMLAKLEIKQLGSRSQP
                     GIKFMIPLSGYGGTSNLILEDVKKLSDSYLITMNDLIPGKESKVVFSIRNTGSRAAFV
                     RAVCFKESQRKVLLDPKVLRIFPDKFVLKERTQEHITLVYTPSSRKNGEKPATELLTV
                     YMFGGDEISRQQYRRAQMHTPGILKQILPEHSVLQHIDFTEAFQDEPLIDEVCDLPQR
                     PNDIELFYGSMRKITLSVIGEFRGTICSREFLQPSSSAESKSNFSSDSKTSGKQSGNV
                     LLDVLPVKGPQGPPFLSQSAHPAQDTAASEEGWAVHPEHLILVAPSSCDLAKTGCFQI
                     INNSVILLKFELYWPAHCLTVTPQHGCIMPESKIQILVSPNFSVSTKESVCPWTGLIY
                     IHCDNGQKKIVKVQIREDLTQEPLPHLPSSGTSGILAPAPEPSISRLTKLITKPPSTK
                     VEIRSKTVIFPPTEPGRTSENYLELENCGPTDVKWHLSSFAPPYVKGVDETEDVFRAT
                     YTTFRCSPISGTLEGHGIQKVSIIFLPRDKGNYAQFWDVECHPAKEPHMKHTLRFQLS
                     GQSIRAENDPEDSCSSRDALIKVDTAVTSRRRAVSETAAHTPGQLNSSHHGVYAPKDV
                     YTFLPTKLGESRTLKINLRNNSFSTHALKFLSPREPFHIRHSKYTLRARHYIHIPVHF
                     RPEAVGRFEALLVIQTDEGKSIAIRLIGESLGKS"
     exon            420..548
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            549..697
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            698..750
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            751..871
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            872..999
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1141
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1269
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1630
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1774
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1839
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..2049
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2173
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2304
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..3127
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3128..3242
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3411
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..4288
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4289..4437
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4438..4668
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4669..4794
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4795..4938
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4939..4999
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5000..5139
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5140..5232
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5233..5351
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5352..5528
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5529..5619
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5620..5796
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5797..6057
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6058..6173
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6174..6283
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6284..6428
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6429..6619
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6620..6743
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6744..6849
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6850..7057
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7058..7137
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7138..7233
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7234..7353
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7354..7475
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7476..7602
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7603..7661
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7662..8093
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8070..8075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      8093
                     /gene="Cep192"
                     /gene_synonym="4631422C13Rik; D430014P18Rik"
                     /note="major polyA site"
ORIGIN      
        1 actgccgcgc cgcggatccg cccctttagc ggacgttttc ctggcgctcg tggctggcgg
       61 atcttggggg tcgtggccgg actttgtgtc gtgaaacatg aggtcccttc tgacacagtc
      121 gtttggaggc cagctgtcta taggacagtg cattcgttcg cacttaccct tttgaagaca
      181 tgcttctggt attttcattt cgaccgaacc aactttttct tcagatttca gcgttgtggg
      241 cgaacttcac atgagatgga agatttccga ggaatagcag aagagtcatt tccaagcttt
      301 ttagccaatt cactacttgg taatagtgag gttttgggaa atgtcactct ttcatcaaat
      361 tttggcttgc ccattgctgt ttctacactt gccaggagca gacccagcac tgacaacagg
      421 tgtcctgatg tccaggaatc atacttaatt gaagagaggt tttcagttcc ttctgcatca
      481 tctcccagtt gccagagtga caaccctgag ccaagagaaa gattacgact cagctttcag
      541 ggtgatgatt ctgctctaag gaaaaagaac tacatagaaa gtccagattt gtcacatgct
      601 ctcatgaaac caagagcaga agagaagcaa gctaacgctg cgtctgttca gggccagagc
      661 cttctgggtg gagtttctcc tctgcaacag gtaccagatt cagctcttga tttccactta
      721 aaatcatgga caaatcatga agagcacaat attgccatgc ctgatcctaa gaagcatttc
      781 gaagccgtga atccaaaccg tgatttcagc cataccagct tattagacaa tgaaaaactg
      841 ttaacactga caaacttgga cagttcctct gatgatgata ttaatgatga agaattttat
      901 gatgatcatt tagaagcata ttttgagcaa ctagccattc cagggatgat gtatgaagca
      961 ggaggacagg agtcgccagc agatgatttt aagttccccg caaatgaaga cagtatctta
     1021 aactgtgagt ttcaatcaga aaataacagt cctcggcttc ctcatgatgc atgcacctca
     1081 ggaaattctc ctactgctca cacagagtct gagggaggcc atggttgtcc gccgggaact
     1141 agtggctgtg taggtactgt cgataataaa atgcaggtag ataatgtgat gtcactttat
     1201 tctcatgcct ggagaaatga gaaggaagcg gcacacaatt tgaaggatat tgttccaaat
     1261 caaagcagag gatgtggagg agaggagatt gtggtgaaga ggctgtgtgc tgtggatgag
     1321 accctcagat ctacttatcg tcacagcaca gaaacagaag acggctttga cccagctgac
     1381 tatatcaaac aggattcaga atctcctcac caaaataagc attttgcttc agatttagaa
     1441 acagttccga acgtggatag atgtttaaat acagagactc ctacagtgtt tattcaaaaa
     1501 gatggagaca ttgctgcatc ttcgaagact aatggtgaca atggaattaa ttctcctgat
     1561 acgctttggt caccaacttc tgaaaggaga gcatgtggac tttatgagtc cgattcaaag
     1621 actagtgaca aaggagagct ctcacagaat gtcgtctaca aaagtgagga cggaagatgg
     1681 gtcactgacc ttgcctacta cacatctttt attgatcaac aagatttaca gatgtctcca
     1741 aataatgaaa tgaatgaaga cttcagatct ggttctgacg cattggactt aattgcaaaa
     1801 gatgaagaag aattcaataa agaacatcca tttatacagg atgaaaaaat agatgttcag
     1861 aacactccag tggcacttgg tgataattcc tgggtagcga cagttaatta ccatttattg
     1921 agaaaatcac ttggcacatc agattttgat aaagacaatg gcagttatct acgcctttca
     1981 ttaggagagt tctttgcaga aagatctgaa gctcttggtt gccttggtgg tggtaaggat
     2041 gtgaaaagac catcatttgg ttattttatt agatcaccag aggagagaga acctgttgcg
     2101 ttaataaaat ctgatttgtc aagaagtgat ttggagaaag aagcaactca gccttaccgt
     2161 ggtttctctt caggagactt aaatgaacag tcccaggtac agctaagtga aggatcggtt
     2221 atgctcaagg ctgaagaact gcagagaaat tcccaggtgg atgaagatga cattacacta
     2281 actgccagca gaaaccagac agaggacact ctctgtagta ataacaagct tcaggaatat
     2341 aagaacacac tgtctggtgg tgaagattct gtacttagaa taagcaccat tgcttccgcc
     2401 ttcgcagacg tgtcagtgag cactgatcct gcccagcttg ttaccatgat gaaagcactc
     2461 agaaataagg gaagaagcaa gccttttcag gatgatggga cacaagagga ctgtccaaac
     2521 atctctcatg tcttacttaa tgatttagaa aaaagtaata gatccaatgc atttgatatg
     2581 gagaaatacc ttacaaaaac agaatttagt agctgtgaag gtgcacgaga gcccctttca
     2641 agagcaggca catctgacat gtgggattta tgttcgcccg aacggcagac tgttcaagac
     2701 aggagtatgg tgaacgtttg tgctactaat tcaagggaag cagaagaaac tacagctgct
     2761 attttctgtg cagaaaatat agagagtgat actcaagaat cccttagaac aatagcctcc
     2821 tcagattcag tcctcacaag cacgagagag aatagaaact cagccatggg gaggatgcca
     2881 ccctctgttg acactttact ggatgtgcgg aacagtgaga aagctgcctc agtttccatt
     2941 gcagcgtcca ggagtgactc actactgagg aaccccagag taccttcctt tagcatcgta
     3001 gaacagtgtg aggaaataca agataaccga gaccatggaa ggaagaaaga gtgtgtcagc
     3061 gagacaagca gcagtgacaa gcacgtcacc tttgaagacg gtcttgtggt cttacctaaa
     3121 agtgttgatt tgaaaactgc ctctcctgag agtggtagat ctggctttca agacgaggag
     3181 agcttcaggc tgtcaccact cagtcattct tctcccagtg aaatttctgg aaacttcgca
     3241 ggatgtgttc tggagtctct tgattcagct taccaccaga gaccccactt agagagtgag
     3301 ttgtctcagt tggcatgttc ccatgctgac atgagcaggc tgacttacgt atctgagcag
     3361 gaaaatacct ttcctgtcac agctgctgat gaaagctcag aggaccacaa gagtgatctc
     3421 accagtgagc tgagtaccac aattgtccga gccagtccta ctccaccaag ggaacaagct
     3481 gtggaaaaac caagagacaa aattccaggt cagaatgcag aaaaagtatc catgccctgg
     3541 gttatccaga gtaaatctgg tttagcaaac atgagagaaa ctccttctct gaggaccgga
     3601 tttgaagatg gagaacctaa ctttacatcc agtcaagata tttcttccga aagtagggaa
     3661 cccttggaag ctggtaagat gatggattca acatctggct ccagtgagca ggacctgatt
     3721 ggccaagctc tcctggacaa gccagctcta aaccaccggt ctgggccagc tgtaccgaac
     3781 ctccctgagt tgatccagaa gactgtggat caaggtcaaa gattatcatc tactcgtctg
     3841 tcagctgcca gcagtgaagc tagcagccag gttcctaatc cgggtgcctc tggaacccag
     3901 cacaatcctg caccccacat ttcagctcat gcttctgttg ctaaggtgat gaaccagcct
     3961 gctgtgtgtc ctgccctctg gactgggcac tctctataca tagctcctgg cgccccatct
     4021 gggaatgcca ccttgtcaca gtgccatgca ggcatgcagg tctgtgggat ttcagggtat
     4081 tctccgtatc ctgctgctgc accagagctt gtggcttctg ggctgtactt aggaccaagt
     4141 cttgcctctg gattgatggc tccctcttct ctttacaacc tgtgctctac tgctgcaccc
     4201 cagaacttgc ttagtacagc aaagccattt cctatggtta caaactgtga aactgagcca
     4261 cgggactcag ggatgatgcc tgcgtttggg aatgccagag tgcccgagga gctgaggttc
     4321 cctcacgctt gctgtgtagg cattgcttca cagaccctcc ttagtgtcct caaccccact
     4381 gaccactggc tgcaagtcag catcagagtt ctcagtatct gggtgaatgg tgagaaggtg
     4441 gatctttcaa cacagacctg tttagttttc aagaataaag ttgtgataag acctcaagct
     4501 acagaagaga taaaaattct ttttatcccc acaagttctg ggattttcag atgcacgttc
     4561 agtgttgctt cttggttgtt ttcagcagat gctgacacgg tagggcaggc agaggctctg
     4621 ggaagcagag ttactctcac tgccattgct gaaacccctg ttatcgaggt agaaacagaa
     4681 aagaaaggtg ttctggattt tggtgacttg acctatgcag gctggaaagc tctcccactc
     4741 aagttaataa ataggacaca tgctactgtg ccaatcagat tgattattaa tgctaatgcc
     4801 gtagcctggc gctgtttcac gttttccaaa gagcccatcc atgtgtctct gaaagctgct
     4861 ccgcatgctg acattactgc tcagctagca gccccgtccg tagtcagtca cgtgatgcct
     4921 gccagttacg acggaaagga tccagaattt ctggtagttt gggttatttt ccatagccca
     4981 aagaaactcc tcacttcaga aattctaggc tcagcagaag aattcttggc cagagtggat
     5041 atagaagtgg acagcccaaa ccctattcct gttctgagaa gcgtggccct ccgagcacga
     5101 gcaggagtag ctaggatcca tgcccctcgg gatttgcaga ctgtgtattt gttggctgat
     5161 gtgaattcct caacaaagca tcccttgcct ttgaaaaatg ctgggaatat tgaagttcat
     5221 ctagatatca aggtcgctga gcaaggaagt cagttttcag tggacccaga gagtttgttt
     5281 cttagacctg gagaagaaca tgaagttaca atttccttta caccaaagga ttccaaagcc
     5341 tgtgaggaaa ggatcctgat aatatttgtg cagccgttag gacctcagta tgaagtggtg
     5401 ttacgaggtg aagtcatttc ttctgggagt aaacctctgc cacctgggcc tcactgctca
     5461 gatattccac tgatactgtc caataagcag tttctgactt ggggtggcat ccctctcggc
     5521 aggacacagc tccagaaact agctttaaga aacagttcta caactacagc ccaaaatttg
     5581 cgactattta tcaaaggaca agatcaggat tgctttcaga ttcagaacac ttttggctca
     5641 gaagagcggc tgaccagcaa ttgtgagatc aggatttgcc caggggagga ctttgtaatc
     5701 tctgtgttat ttgcacctac tcgattatct tgcatgttgg ctaaacttga aatcaagcaa
     5761 cttggaagtc gatctcagcc aggcattaag tttatgatac cattgtctgg atatggagga
     5821 acaagtaatc ttattttaga agatgttaag aaattatctg acagttactt gataacaatg
     5881 aatgacttaa ttcctggcaa agaaagtaaa gttgtttttt ctattcgcaa cactggctcc
     5941 agagcagcct ttgttagagc agtatgtttt aaagagtctc aaagaaaagt tttgctggat
     6001 cctaaagtat tgaggatttt tccagataaa tttgtactta aggaaagaac ccaagaacat
     6061 attactttag tgtacactcc atcaagcaga aagaatggcg aaaaacctgc aacagagctg
     6121 ttaactgtct acatgtttgg tggtgatgaa atctccagac agcagtatcg cagagctcag
     6181 atgcatacac caggaatcct aaagcagatc cttccagaac acagtgtgct acagcacatc
     6241 gacttcacgg aggcatttca ggatgagcct ctcattgatg aagtgtgtga tcttcctcag
     6301 cggcctaatg acattgagct cttctatgga agcatgcgga aaattaccct gtcagtaatt
     6361 ggagaattca gaggtaccat ttgtagccga gaatttcttc agccttcctc cagtgctgaa
     6421 tccaaaagta atttctccag tgactctaaa acttctggaa aacaaagtgg caatgtcctg
     6481 ttggatgttt taccggttaa aggccctcaa ggccctcctt ttctctcaca gtctgcccac
     6541 ccagcccagg acacagcagc ctctgaagaa ggctgggctg tccatccaga acacttgatt
     6601 ctggtggctc cttcctcttg tgatttggca aaaactggat gtttccaaat tataaataat
     6661 tctgttattt tactgaaatt tgagctgtac tggcctgcac attgcctgac agtcacacca
     6721 caacatggat gtatcatgcc agagagtaaa atacaaattc tcgtgagtcc taatttttcc
     6781 gtgtccacaa aagagtcagt gtgcccatgg actggtttga tctacataca ctgtgataac
     6841 ggacagaaga aaattgtaaa agttcaaatt cgagaagatt tgactcaaga acctttacct
     6901 cacttgccct cctccggtac atctggaatt cttgcccctg cacccgagcc ttccattagt
     6961 cgtttgacaa aactaataac aaaaccacct tccacaaaag ttgaaattag aagcaagaca
     7021 gtgatttttc ctccaacaga acctggtaga acctcagaga actatctgga actggagaat
     7081 tgtggcccca cagatgtaaa gtggcacctg tcatcttttg cacccccgta tgtcaaggga
     7141 gttgatgaaa ctgaagatgt ttttcgagct acctacacaa ccttcagatg ttctcccatt
     7201 tctggcacac tagaaggcca tggaatccaa aaggtctcca tcatattttt gcccagagac
     7261 aaagggaatt atgcccagtt ttgggatgtt gagtgccacc ctgctaaaga acctcacatg
     7321 aaacatacat tgagattcca gctctctggc cagagcatca gagcagagaa tgaccctgaa
     7381 gactcatgct cctccagaga tgccctcatt aaagtagata ccgcagtcac atcccggagg
     7441 cgcgctgtgt ctgagacagc tgctcacacg cctgggcagc tcaactcgag ccatcatgga
     7501 gtatatgccc caaaggatgt ctacacgttc ctgccaacca aacttgggga atccaggaca
     7561 ctgaaaatca atttgagaaa taattctttt tccactcatg cactgaagtt tttgagcccc
     7621 agagaacctt tccacattag acactccaag tacactttga gggcccgaca ttatatccac
     7681 atcccggtgc acttcagacc agaggcagtg ggcagatttg aagctttact tgtgatccaa
     7741 acagatgaag gcaagagtat tgctattcga ctaatcggtg aatcccttgg aaaaagttaa
     7801 ctagaataca tattgtgtaa atgacctgct tatattttgg caatctcatt tttctacacc
     7861 aaaattatgc tgttgtatat attttgtacg ataaattcaa tgtgtataaa ttatagattt
     7921 gttttataaa gaatttattt ctgaagccct cactaaatat catgtaccta gctcacagta
     7981 ttaacattta caagggagaa gttctatttt tacattgatt atgacattct gaataaatgt
     8041 ggcatatgtt ttgatatggt gtatttacaa ataaagttga tatttaaatt gaaaaaaaaa
     8101 aaaaaaaaaa aaaaaaaaaa aaaaa
//
