LOCUS       NM_001416014            1738 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus centrosomal protein 19 (Cep19), transcript variant 2,
            mRNA.
ACCESSION   NM_001416014 XM_036160093
VERSION     NM_001416014.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1738)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1738)
  AUTHORS   Rutkowski,T.P., Purcell,R.H., Pollak,R.M., Grewenow,S.M.,
            Gafford,G.M., Malone,T., Khan,U.A., Schroeder,J.P., Epstein,M.P.,
            Bassell,G.J., Warren,S.T., Weinshenker,D., Caspary,T. and
            Mulle,J.G.
  TITLE     Behavioral changes and growth deficits in a CRISPR engineered mouse
            model of the schizophrenia-associated 3q29 deletion
  JOURNAL   Mol Psychiatry 26 (3), 772-783 (2021)
   PUBMED   30976085
REFERENCE   3  (bases 1 to 1738)
  AUTHORS   Shalata,A., Ramirez,M.C., Desnick,R.J., Priedigkeit,N.,
            Buettner,C., Lindtner,C., Mahroum,M., Abdul-Ghani,M., Dong,F.,
            Arar,N., Camacho-Vanegas,O., Zhang,R., Camacho,S.C., Chen,Y.,
            Ibdah,M., DeFronzo,R., Gillespie,V., Kelley,K., Dynlacht,B.D.,
            Kim,S., Glucksman,M.J., Borochowitz,Z.U. and Martignetti,J.A.
  TITLE     Morbid obesity resulting from inactivation of the ciliary protein
            CEP19 in humans and mice
  JOURNAL   Am J Hum Genet 93 (6), 1061-1071 (2013)
   PUBMED   24268657
  REMARK    GeneRIF: loss of the ciliary protein CEP19 in humans and mice
            causes morbid obesity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135962.4.
            
            On Jan 10, 2023 this sequence version replaced XM_036160093.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.115057.1,
                                           SRR17784645.171112.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-312               AC135962.4         125365-125676
            313-422             AC135962.4         128500-128609
            423-586             AC135962.4         129449-129612
            587-1738            AC135962.4         132471-133622
FEATURES             Location/Qualifiers
     source          1..1738
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 22.4 cM"
     gene            1..1738
                     /gene="Cep19"
                     /gene_synonym="1500031L02Rik"
                     /note="centrosomal protein 19"
                     /db_xref="GeneID:66994"
                     /db_xref="MGI:MGI:1914244"
     exon            1..312
                     /gene="Cep19"
                     /gene_synonym="1500031L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            313..422
                     /gene="Cep19"
                     /gene_synonym="1500031L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            423..586
                     /gene="Cep19"
                     /gene_synonym="1500031L02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..948
                     /gene="Cep19"
                     /gene_synonym="1500031L02Rik"
                     /codon_start=1
                     /product="centrosomal protein of 19 kDa"
                     /protein_id="NP_001402943.1"
                     /db_xref="GeneID:66994"
                     /db_xref="MGI:MGI:1914244"
                     /translation="MKYIAKKCGVRFQPPAVILIYENETEGKSRQRIMPVRNFSKFSD
                     CTRAAEQLKNNPRHKSYLEQVPLKQLEKLFVFLRGSLQGQSLAETMEQIRRETTIDPE
                     EDLNKLDDKELAKRKSIMDELFEKNQKRKDDPTFVYDVEVEFPQDEQLLSCSWDTASV
                     DDF"
     exon            587..1738
                     /gene="Cep19"
                     /gene_synonym="1500031L02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1720..1725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep19"
                     /gene_synonym="1500031L02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1738
                     /gene="Cep19"
                     /gene_synonym="1500031L02Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagagccttc tgttgccttg ggaacgatcc tcggggcgcc taggtgggcc cttggaccgg
       61 gcgagctgcc ttaggaccgc actccccgcg ctcagccccg cttcctgccc acaaccggat
      121 gcgtgcgggc tgagccccct gcctctgagt tcaccccatg gttattcctg taggctatgg
      181 ctatcgccgt ttcctgcagc gtcaggctcc acctcgcctc aaagtcgacc taagctcctc
      241 tgtgcagtgc agtaggatgg aaaccacccc ctcactgctg ttcagatgtg cacttcctgt
      301 acttcttcaa ggcattgaac aagattaccc ttactatgtt ccagacttgt actgagagct
      361 taatgaaaat ggacacaatt cctgccttcc tagagcaaac agactaacag ggaagatacc
      421 tggtttcttc cagtttaccc tgagttacac gagaagatga aatacattgc caagaaatgt
      481 ggagttaggt tccagcctcc agctgtgatc ttgatttatg agaatgaaac cgaaggaaag
      541 agccgccagc gtatcatgcc tgtccgaaac ttttcaaagt tctcagattg caccagagct
      601 gcggaacagt taaagaataa cccacggcac aagagttacc tggaacaggt gcccctgaag
      661 cagctggaga agctgtttgt ttttttgcga ggttccttgc aggggcagag cttggcagaa
      721 acaatggaac agattcggcg ggaaacgacc atcgatcccg aggaagacct gaacaaactg
      781 gacgacaagg agctcgccaa aaggaagagc atcatggatg agcttttcga gaaaaatcag
      841 aagagaaagg acgaccccac ttttgtgtac gacgtcgagg tggagttccc tcaggatgaa
      901 cagctgctgt cctgcagctg ggacacagcg tcagtggatg acttctgagg aagcgctcca
      961 cgtttcctca gagaacaaag atcagttcta gaaaacgctg aaacactagc gatctataaa
     1021 accaggacac ttccatgtgc tacgtaggcc tatgagaaac acagaaatac aaggtgggaa
     1081 tctgccttca aggcgttgac aggcgacagc aaagggaact caaggacttg taaaaagata
     1141 ttttaataat attactcagg aaaaagataa gagccagatt ttgacaaagg ggaggctttc
     1201 cctcagcgga aaggggccca tgcttggccc tgaaatgcta cagatgtttt tgtagaaatc
     1261 aagatgaagc aaagagggaa gggtgtggta aagagacaag aaatgggaga atctgagaaa
     1321 tggtgagtaa ttatagtttg acaagattgg aattaacctg tgttcttcag gactctatgt
     1381 gcattaactc tggggtagac aggagcacct gtaaatgcag aacgtctcac agctacgagt
     1441 acatgtggcg gatggcaggc agttctactc cgcaatcagg aaatatggtc taacgttact
     1501 ctgaaaccca gagccacttc ctgcgaaagg ctggtttgta cagtggcaag tcctcccaca
     1561 atgagtgata ggtactactg ttcagacctg tttgtgagtt tagatgtaca aagatctcgg
     1621 cctcacaaat cctctgtgtg cagatgtgtt tgttcttact agaatattat ctgattgata
     1681 gaaatcgtat gttttctaca aggaaactat tattcattga ataaagctgt gaccgtaa
//
