LOCUS       NM_001099637            6930 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus centrosomal protein 170 (Cep170), transcript variant
            1, mRNA.
ACCESSION   NM_001099637 XM_915056
VERSION     NM_001099637.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6930)
  AUTHORS   Qin,Y., Zhou,Y., Shen,Z., Xu,B., Chen,M., Li,Y., Chen,M.,
            Behrens,A., Zhou,J., Qi,X., Meng,W., Wang,Y. and Gao,F.
  TITLE     WDR62 is involved in spindle assembly by interacting with CEP170 in
            spermatogenesis
  JOURNAL   Development 146 (20) (2019)
   PUBMED   31533924
  REMARK    GeneRIF: WDR62 is involved in spindle assembly by interacting with
            CEP170 in spermatogenesis
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6930)
  AUTHORS   Zhang,W., Yang,S.L., Yang,M., Herrlinger,S., Shao,Q., Collar,J.L.,
            Fierro,E., Shi,Y., Liu,A., Lu,H., Herring,B.E., Guo,M.L., Buch,S.,
            Zhao,Z., Xu,J., Lu,Z. and Chen,J.F.
  TITLE     Modeling microcephaly with cerebral organoids reveals a
            WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural
            progenitors
  JOURNAL   Nat Commun 10 (1), 2612 (2019)
   PUBMED   31197141
  REMARK    GeneRIF: Study in mutant mice and human cerebral organoids showed
            that WDR62 deletion resulted in a reduction in the size of mouse
            brains and organoids due to the disruption of neural progenitor
            cells. WDR62 interacts with and promotes CEP170 localization to the
            basal body of primary cilium, where CEP170 recruits KIF2A to
            disassemble cilium.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6930)
  AUTHORS   Wilkinson,B., Evgrafov,O.V., Zheng,D., Hartel,N., Knowles,J.A.,
            Graham,N.A., Ichida,J.K. and Coba,M.P.
  TITLE     Endogenous Cell Type-Specific Disrupted in Schizophrenia 1
            Interactomes Reveal Protein Networks Associated With
            Neurodevelopmental Disorders
  JOURNAL   Biol Psychiatry 85 (4), 305-316 (2019)
   PUBMED   29961565
REFERENCE   4  (bases 1 to 6930)
  AUTHORS   Copeland,S.J., McRae,A., Guarguaglini,G., Trinkle-Mulcahy,L. and
            Copeland,J.W.
  TITLE     Actin-dependent regulation of cilia length by the inverted formin
            FHDC1
  JOURNAL   Mol Biol Cell 29 (13), 1611-1627 (2018)
   PUBMED   29742020
REFERENCE   5  (bases 1 to 6930)
  AUTHORS   Valnegri,P., Huang,J., Yamada,T., Yang,Y., Mejia,L.A., Cho,H.Y.,
            Oldenborg,A. and Bonni,A.
  TITLE     RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the
            mammalian brain
  JOURNAL   Nat Commun 8 (1), 1271 (2017)
   PUBMED   29097665
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6930)
  AUTHORS   Kobayashi,T., Kim,S., Lin,Y.C., Inoue,T. and Dynlacht,B.D.
  TITLE     The CP110-interacting proteins Talpid3 and Cep290 play overlapping
            and distinct roles in cilia assembly
  JOURNAL   J Cell Biol 204 (2), 215-229 (2014)
   PUBMED   24421332
REFERENCE   7  (bases 1 to 6930)
  AUTHORS   Kodani,A., Salome Sirerol-Piquer,M., Seol,A., Garcia-Verdugo,J.M.
            and Reiter,J.F.
  TITLE     Kif3a interacts with Dynactin subunit p150 Glued to organize
            centriole subdistal appendages
  JOURNAL   EMBO J 32 (4), 597-607 (2013)
   PUBMED   23386061
REFERENCE   8  (bases 1 to 6930)
  AUTHORS   Guarguaglini,G., Duncan,P.I., Stierhof,Y.D., Holmstrom,T.,
            Duensing,S. and Nigg,E.A.
  TITLE     The forkhead-associated domain protein Cep170 interacts with
            Polo-like kinase 1 and serves as a marker for mature centrioles
  JOURNAL   Mol Biol Cell 16 (3), 1095-1107 (2005)
   PUBMED   15616186
  REMARK    GeneRIF: Cep170 interacts with Polo-like kinase 1 in mature
            centrioles [Cep170]
REFERENCE   9  (bases 1 to 6930)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC144905.10 and AC113311.9.
            
            On Sep 15, 2007 this sequence version replaced NM_001099637.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164139,
                              SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AC144905.10        172084-172209
            127-271             AC113311.9         7481-7625
            272-361             AC113311.9         8505-8594
            362-440             AC113311.9         12585-12663
            441-499             AC113311.9         18575-18633
            500-659             AC113311.9         18720-18879
            660-794             AC113311.9         20735-20869
            795-1271            AC113311.9         26220-26696
            1272-1429           AC113311.9         31260-31417
            1430-1723           AC113311.9         31604-31897
            1724-1873           AC113311.9         39630-39779
            1874-1994           AC113311.9         42613-42733
            1995-3812           AC113311.9         44147-45964
            3813-4047           AC113311.9         50970-51204
            4048-4195           AC113311.9         58482-58629
            4196-4366           AC113311.9         61041-61211
            4367-4455           AC113311.9         61961-62049
            4456-4549           AC113311.9         63509-63602
            4550-4601           AC113311.9         64235-64286
            4602-6930           AC113311.9         65149-67477
FEATURES             Location/Qualifiers
     source          1..6930
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 82.6 cM"
     gene            1..6930
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /note="centrosomal protein 170"
                     /db_xref="GeneID:545389"
                     /db_xref="MGI:MGI:1918348"
     exon            1..126
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            127..271
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            272..361
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            362..440
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            441..499
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            500..659
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            660..794
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1271
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1429
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1723
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1873
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1994
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..3812
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3813..4047
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4048..4195
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4196..4366
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4367..4455
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4456..4549
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4550..4601
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4602..6930
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6899..6904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6921
                     /gene="Cep170"
                     /gene_synonym="4933426L22Rik; A330004A13Rik"
                     /note="major polyA site"
ORIGIN      
        1 tcactgcaca ctcactgtat cttgaatgct gttacttctg agtgtttgag aaatgagtct
       61 tcagaaacag tgctcaccac cccaccccga tatttaacat tccagtagaa gtgggggaag
      121 acacacgata atgtagcttt gctaaggatt cagaagctaa gcagaaatga gcctaacatc
      181 ctggtttttg gtgagcagtg gaggcactcg ccacaggctg ccacgagaaa tgattttcgt
      241 tggaagagac gactgtgagc tcatgcttca gtcccgaagt gtggataaac aacatgcagt
      301 aatcaattat gatgcatcta tggatgaaca tttggtgaaa gatttaggca gcctaaatgg
      361 gacctttgtg aatgatgtaa ggataccaga gcagacgtac atcactttga agcttgaaga
      421 taagctgaga tttggatatg atacaaatct cttcactgta gtacgaggag aaatgagggt
      481 ccctgaagaa gctcttaagc acgagaagtt taccattcag cttcaattgt cccagaagtc
      541 ttcagaatca gaattaccaa aatcagcaag tgccaaaggc acagactcaa aagtggaggc
      601 tgctgcagaa gtgcagccca gagccacaga agcactgaaa tctgaagaga aacccatgga
      661 tgtctctgct atgccccgag gcactccatt atatgggcag ccgtcctggt ggggagacgc
      721 cgaggaggat gaacaaagag ctttcaaggc caatggcaag cctgagggaa aaagtcagga
      781 agctggggct tcagggtgca gcacagaggc caagcacgtg gagggacagt ctgcggctgc
      841 aagtgaagaa gcactttttc ccttctgtag ggagccaagt tattttgaaa ttcctacaaa
      901 agaattccag cagccatcac aaatagcaga gagcactatt catgagattc caacaaaaga
      961 cacaccaagt tcccatacag caggtgcagg gcatgcttca tttaccattg aatttgatga
     1021 cagtacgcca ggaaaagtaa ctattagaga ccatgtgaca aaattcactt ctgaccagcg
     1081 ccacaagtca aagaaggcct ctccaggaac tcaagacttg ccaggaattc agacaggaat
     1141 gatggcacca gaaaataaag tagctgactg gctagcccaa aacaaccctc ctcaaatggt
     1201 gtgggaaaga acagaggagg attccaagag cattaaaagt gatgttcctg tgtacttgaa
     1261 aaggttgaaa ggaaacaaac atgatgatgg tacacagagt gattcagaga atgctggggc
     1321 acacaggcgc tgtagcaagc gtgcaactct ggaggaacat ttacgccgcc atcactcaga
     1381 gcagaaaaag aaggcccagt ccaccgagaa gcatcaagaa caggctgcta ctagctctac
     1441 gcatcacaga ggggggcatg gtgttccaca tgggaaattg ttaaaacaga aatcagagga
     1501 gccatcggtg tcactaccct tcctacaaac tgcattatta agaagttcag ggagtcttgg
     1561 gcacagacca agccaggaga tggatgtaat gttaaaaaat caagctactt ctgcctcttc
     1621 agaaaaggat aatgatgatg accaaagtga caagggtact tataccattg agttagagaa
     1681 tcccaacagt gaggaggtgg aagcaagaaa aatgattgac aaggtatttg gagtagatga
     1741 caatcaggat tataataggc ctattatcaa tgaaaagcat aaaggtctca taaaagactg
     1801 ggctctcaac tctgctgcag tagtaatgga agaaagaaag ccattgagta cacctgggtt
     1861 tcataactca gaggaagcca tatcttcatc tggaagcaaa cgttgggttt cacaatgggc
     1921 tagtttggct gctaatcata caaggcatga tccagaagaa aggttaatgg aattgtctgc
     1981 aactgtagaa aacgagacag atactggtga cgctggtgtt tccctaagaa gtactagttg
     2041 tacaacttcc ttggctagtc agggagagag gaagaggcga actcttcccc agctcccaaa
     2101 tgaagagaag ctactcgaga gctccagagc gaaggtcgtt ccacagaggt cagagatagg
     2161 agaaaagcaa gacacggaac tgcaggaaaa agaagcccag gtataccaaa gcgagaagca
     2221 cgatgcagac cgaggcctga gtaaaatgag cagggcagtc aatggtgaga gtcctaaaac
     2281 tggtggagat ggtaaagccc tccttcactc aggaagctca tctagcaagg agaagagtga
     2341 gacggaaaag gaaacttctt tggtaaaaca aacattggct aaaatgcagc agcaagagca
     2401 aaaggagcag gcccagtgga ctcctactaa gtttccttca aaaaatgctt taggccatat
     2461 agataaatgt agggaggaat cttctaagca agagtcccaa ctcttagaaa aagtttcagg
     2521 acattctacg agcaaaggag acagagtaat acaaaatgaa agcaagagaa gaaaagctga
     2581 ggaaattcca aaatgccagg cctcaaaagg agacaagaaa gagtcttcca aatcgttagt
     2641 gcgccaaggg agtttcacca tagacaagcc cagttccaac atccccatag aacttatccc
     2701 ccatatcaat aagcagaatt catctgtacc cactgcctta gcactgacgt ctgcaagtag
     2761 actccgagaa aggagtgact ctttggatac tgattctagc atggacacaa ccttgattct
     2821 aaaagacaca gaagcagtga tggcttttct agaagctaaa ctgcgagaag ataataataa
     2881 aactgatgaa ggcccagata ctcccagtta caatagagac aattcaattt ccccagagtc
     2941 tgatgtagac acagccagta caattagtct ggttactgga gagacagaaa gaaagtccac
     3001 gcaaaagcgg aagagtttca ctagtctcta taaagacagg tgttccacga gttccccatc
     3061 caaagatgtt actaagtcag gcagtaggga gaaaattgaa aagaaagcaa aaagccgctc
     3121 tgcagatata ggtgcaagag cagatggtcg caaatttgtg cagtccagtg gaagaatccg
     3181 gcagccttcc atagacttaa cagacgatga ccagacctct agtgtgcctc attctgctat
     3241 ttctgacatt atgtcatctg accaggaaac atactcctgc aaatctcatg gacggactcc
     3301 acttacctca gccgatgaac acaacataca ttccaaactg gagggaggca aagcaacaaa
     3361 gtctaagact tctcctgttg cctctggttc aacaagcaaa tccactactc tcccaaggcc
     3421 acggcccacc cggacttccc tcctgcgaag agcccggctt ggtgaagctt ctgacagtga
     3481 acttgctgat gctgacaaag catctgttgc ttctgaagtg tccactacaa gttccacatc
     3541 aaaaccaccc acaggaaggc gaaccatctc taggattgat ttattggctc agcctcgaag
     3601 aacaagactt ggctcattat ctgcccgtag tgactctgaa gcaacaattt caagaagcag
     3661 cgcatctgca cgcaccgcag aagctgtcat taggagcgga gccaggctag tgccatcaga
     3721 taaactttct cctagaactc gagctaacag tatctctcgg ctctccgact ccaaggtcaa
     3781 gagcatgagc tccactcacg gctctccttc agtaaattca agatggaggc gctttcctac
     3841 tgattatgct tccacctcag aagatgaatt tggatcaaac cgtaattccc ctaaacatac
     3901 tcgtctacgt acttctccag ccctgaaaac cactcgcatg cagagtactg gatcagcaat
     3961 gcctgctagt tcttcattca agcaccgaat taaagaacag gaagattata tccgagattg
     4021 gactgcccat cgagaagaga tagccaggat cagccaagat cttgctctca ttgctcggga
     4081 gatcaacgac gtagcaggag aaatagattc agtgacttcc tcaggcacgg ccccgagtac
     4141 cacagtaagc actgcagcca ccacccctgg ctctgccata gacactagag aagagttggt
     4201 tgatcgtgtt tttgatgaaa gtctcaactt ccgaaagata cctccattag ttcattctaa
     4261 aacaccagaa ggaaacaacg gtcggtctgt tgactcgagg cctcagccag ccgagcatcc
     4321 tgatcactta acaattacaa gacggagaac ctggagtagg gatgaagtca tgggagataa
     4381 tctgctattg tcatcagtct ttcagttctc taggaagatt agacaatcca ttgataaaac
     4441 agctgggaaa atcagaatat tgtttaaaga caaagaccgg aactgggatg acatagaaaa
     4501 caagctaaga gctgaaagtg aagtccctat cgttaaaact tcaagcatgg agatttcttc
     4561 tattttacag gagcttaaaa gagttgaaaa acagttgcaa gtgataaatg ccatgattga
     4621 cccagatggg actttggagg ctcttaacaa catgggattt cccaatgcta tcctgccatc
     4681 tccaccaaaa cagaagtcca gccctgttaa taaccacagc agccctagtc agacgccagc
     4741 actttgccca ccagaaacta gagccctaca ccctgctgct gcgggagtgg cagcagcagc
     4801 ctccactgag tttgagaatg ctgaatctga ggctgatttc agtatccatt tcaataggtt
     4861 caaccctgat ggggaagagg aggatgttac agtacacgaa tgacgtttcc ttatttgtta
     4921 gagacattac ccatggagta agtaggggca ttggaagcag cataatgttg acatacaaaa
     4981 caagagagct tggtcagcaa caatcttgtt atctttgtct tcttgattta tttatttatt
     5041 tttacttcta atgtgtcaca ccagtctttt caaaccactc agacagccac ttgaagcaca
     5101 ctcagcagag gcagcttata tcggcttcgc cttttgtggt tctgtgattt tcagatgaaa
     5161 tcatatcatt tcatcctttc ccttcatagt ttttttttgt tgttgtttgt ttgttttaag
     5221 ccatgctgtg acctacaaac aaactaaaat atccacattt ctgagcccct gtgtctcctg
     5281 tgccaagctg ccccctgaga tgaactttgg cacccgctgt acagattgtt aaacctttca
     5341 atttgcttct taatactagg gtttatatta ttcctcacag tcactggaca cagcgccgcc
     5401 ctgctctgta gagtgaagca gaccctccac agcagccgtc ctgcgttcta agactttcca
     5461 acatagtgtg atttataact gttgctaagt aacttgtctt ggggtttatg gaaattaatt
     5521 attatgtttg cactaagatt tactgggagt gatagatggg cgtatgcata tatcactaag
     5581 gactgacatt tgtacatagg aagttgacaa tactgtattg ttttaacccc acagtgtttt
     5641 actccacttt tcatacaaag ctatttggca cttttctttt tttccttttt ttcttttctt
     5701 ctgtttttct ttttaaggaa atacgatttt gtctctcctt ttagattaaa ttgctaggaa
     5761 ggttaaattt gacagatagt ttaggtggag tatattttta aaattaagaa catgtatatt
     5821 tgtcctgtgt taccaagttt ttatgttaca gaaatgcccc tcaaatgatc atgaggttaa
     5881 tttttcttca ttaggagacg tgaagatcag tagttgtgag agtagttgat agttgcactc
     5941 ccagtcattg aattgcttct gtgtttccct gtaggtccat agtaaccctt tgtcagtctt
     6001 acacatttgt aaggaccctg caagacagca acaacgacta aggctttggg cttatcgcta
     6061 ctaaaaagaa agcctgtgaa aaatatcttc tctaaacttg gtttttgtta ctgttttgtt
     6121 ttctttccag taagctcaca tttcaataag tttttaaata aaggaattat ttttgtgttt
     6181 ccagaacact ataatttggg tgaatcttaa ttcttttaaa tatattaata ggcctggatt
     6241 tactcaaagg ctctaagtct ataaagagta aactgcagct ttgtgatgtg gtctttgata
     6301 tcttagcaat aacctacgct acatttgttt taaggaaaag gtaactgctc ttcaaggttt
     6361 tttttttttt aggatctaag aaatcctatg atgttggatc agttaataaa aatgcaaaat
     6421 gtttttgtaa gatgtaaaac ataagtctgc tgtgtaatgg atctcatatt tttctttaaa
     6481 ttaaaaaaca gaaaaggatt tgttctcctt gtaaagctaa attcacagct ctcatgaagt
     6541 aaaacttcaa aaggatttta acaaatgtaa aagggaagtg agatgctttg aaggaacaaa
     6601 caaaacatcg aagcagggtc agtccatttc aagaaaaagt tatgcataat aatcatgatt
     6661 gttcccccct ttagttaacg tttggtactg agtctatcta catgaagaat acaagataag
     6721 gagtctaaga aggtattaaa ttatctactt acgttattgt ttgtttacac agttttgttc
     6781 aattataaac atttggcctt ttactatgtt atttttattt tatatgaata cattctcctt
     6841 atttattttt gttacattta ttactttatt ttgttatgca tttacaactc catttttaaa
     6901 taaagtgttt ctggaacttt atgcaatgat
//
